Docetaxel (Trihydrate)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel (Trihydrate) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel (Trihydrate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.143373
KMT2E lysine (K)-specific methyltransferase 2E 0.0624274
NDRG1 N-myc downstream regulated 1 0.0613722
TUBA1B tubulin, alpha 1b 0.0581467
RPL37A ribosomal protein L37a 0.0486849
ADM adrenomedullin 0.0473454
BHLHE40 basic helix-loop-helix family, member e40 0.0470262
HILPDA hypoxia inducible lipid droplet-associated 0.0449963
RPS19 ribosomal protein S19 0.0419322
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0418169
KMT2C lysine (K)-specific methyltransferase 2C 0.0402968
TMSB10 thymosin beta 10 0.0389515
DDIT4 DNA-damage-inducible transcript 4 0.0384694
RPLP2 ribosomal protein, large, P2 0.0378623
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.0369395
GDF15 growth differentiation factor 15 0.0358448
RPS12 ribosomal protein S12 0.0312712
TUBB tubulin, beta class I 0.030921
KMT2A lysine (K)-specific methyltransferase 2A 0.0305038
CD44 CD44 molecule (Indian blood group) 0.0300569
RPS8 ribosomal protein S8 0.0297537
TPT1 tumor protein, translationally-controlled 1 0.0287046
RPL32 ribosomal protein L32 0.0283908
RPL38 ribosomal protein L38 0.02835
PTMA prothymosin, alpha 0.0280956
AKAP9 A kinase (PRKA) anchor protein 9 0.0277511
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0276188
CDC73 cell division cycle 73 0.0263404
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0262231
RPL19 ribosomal protein L19 0.0261268
FTL ferritin, light polypeptide 0.0260212
MKI67 marker of proliferation Ki-67 0.0259805
TUBB4B tubulin, beta 4B class IVb 0.0258547
PTTG1 pituitary tumor-transforming 1 0.0258309
RPS6 ribosomal protein S6 0.0256917
NPC1 Niemann-Pick disease, type C1 0.0252692
IFITM3 interferon induced transmembrane protein 3 0.0251039
TPI1 triosephosphate isomerase 1 0.0249557
WSB1 WD repeat and SOCS box containing 1 0.0249395
BRWD3 bromodomain and WD repeat domain containing 3 0.0238721
RPL5 ribosomal protein L5 0.0237406
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0231495
TNPO3 transportin 3 0.0231013
SETBP1 SET binding protein 1 0.0230352
RPS20 ribosomal protein S20 0.0229436
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0228555
RPLP0 ribosomal protein, large, P0 0.0223573
SDC3 syndecan 3 0.0222523
RAB6A RAB6A, member RAS oncogene family 0.0222204
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0221387
NBEA neurobeachin 0.022069
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0217942
NUP58 nucleoporin 58 0.0217121
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0217056
VEGFA vascular endothelial growth factor A 0.0214777
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0214696
RPL30 ribosomal protein L30 0.0212704
RPS27 ribosomal protein S27 0.0212388
ICAM1 intercellular adhesion molecule 1 0.0208613
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0207253
TMSB4X thymosin beta 4, X-linked 0.0205382
QKI QKI, KH domain containing, RNA binding 0.0203635
RPS13 ribosomal protein S13 0.0198609
RPS2 ribosomal protein S2 0.0195755
RPL12 ribosomal protein L12 0.0195325
SAMTOR S-adenosylmethionine sensor upstream of mTORC1 0.0194183
CEP128 centrosomal protein 128kDa 0.0190767
RPS16 ribosomal protein S16 0.0190373
TMF1 TATA element modulatory factor 1 0.0188177
RNF145 ring finger protein 145 0.0187503
RNF130 ring finger protein 130 0.0185752
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.0184571
RIOK3 RIO kinase 3 0.0182568
RPL21 ribosomal protein L21 0.0182377
TUBA1A tubulin, alpha 1a 0.0180071
KTN1 kinectin 1 (kinesin receptor) 0.0178958
ZNF385D zinc finger protein 385D 0.0177996
RPL27 ribosomal protein L27 0.0177305
RPL9 ribosomal protein L9 0.0175145
RPS23 ribosomal protein S23 0.0175047
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0174197
LGALS8 lectin, galactoside-binding, soluble, 8 0.0172222
ANKRD11 ankyrin repeat domain 11 0.0170845
SRRM2 serine/arginine repetitive matrix 2 0.0169451
CPED1 cadherin-like and PC-esterase domain containing 1 0.0169314
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.0168221
RPL18 ribosomal protein L18 0.016645
TTC28 tetratricopeptide repeat domain 28 0.0165804
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0162299
CTTNBP2 cortactin binding protein 2 0.0159625
RICTOR RPTOR independent companion of MTOR, complex 2 0.0158804
CSDE1 cold shock domain containing E1, RNA-binding 0.0157623
FOSL1 FOS-like antigen 1 0.0157477
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0156732
RPL36 ribosomal protein L36 0.0156481
NCKAP1 NCK-associated protein 1 0.015628
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0155667
GARS1 glycyl-tRNA synthetase 1 0.0155577
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.015544
RPL11 ribosomal protein L11 0.0155331

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.118289
FN1 fibronectin 1 -0.112593
ASPH aspartate beta-hydroxylase -0.0940937
UBC ubiquitin C -0.0925058
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0877875
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0763257
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0762951
IFRD1 interferon-related developmental regulator 1 -0.0749998
FRMD4A FERM domain containing 4A -0.0720414
AHNAK AHNAK nucleoprotein -0.0684483
FMN1 formin 1 -0.0651932
WWTR1 WW domain containing transcription regulator 1 -0.062502
FNDC3B fibronectin type III domain containing 3B -0.0599124
VGF VGF nerve growth factor inducible -0.0581305
TAGLN2 transgelin 2 -0.0565014
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0561954
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0547813
IFI16 interferon, gamma-inducible protein 16 -0.0537677
S100A6 S100 calcium binding protein A6 -0.0532518
POTEF POTE ankyrin domain family, member F -0.0516832
ZYX zyxin -0.0497792
LOC112694756 uncharaterized LOC112694756 -0.0491216
LDHA lactate dehydrogenase A -0.0482891
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0480463
PCDH7 protocadherin 7 -0.0475674
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0460429
ZMYND8 zinc finger, MYND-type containing 8 -0.044782
EEF2 eukaryotic translation elongation factor 2 -0.0442407
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0431712
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.042079
CALU calumenin -0.0414868
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0403223
NPAS2 neuronal PAS domain protein 2 -0.0401124
IGFBP5 insulin-like growth factor binding protein 5 -0.0400897
RO60 Ro60, Y RNA binding protein -0.0399149
DSCAM Down syndrome cell adhesion molecule -0.0392484
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0391722
VCL vinculin -0.0385001
GSN gelsolin -0.038091
DCT dopachrome tautomerase -0.037465
COL19A1 collagen, type XIX, alpha 1 -0.0374242
PCBP2 poly(rC) binding protein 2 -0.0372053
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0371909
KDM3A lysine (K)-specific demethylase 3A -0.0365581
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0364879
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0357975
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0353547
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0353315
HMCN1 hemicentin 1 -0.0345361
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0338635
ANKRD12 ankyrin repeat domain 12 -0.0334552
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0330944
NAMPT nicotinamide phosphoribosyltransferase -0.0329354
TMEM178B transmembrane protein 178B -0.032385
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0322203
ENO1 enolase 1, (alpha) -0.0320002
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0310061
LPP LIM domain containing preferred translocation partner in lipoma -0.030972
APP amyloid beta (A4) precursor protein -0.0308517
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.030796
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0306409
GAS7 growth arrest-specific 7 -0.0306253
ACTN1 actinin, alpha 1 -0.0300525
GLG1 golgi glycoprotein 1 -0.030004
ACTN4 actinin, alpha 4 -0.029897
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0298173
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0294564
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0291486
NPR2 natriuretic peptide receptor 2 -0.0291034
SDC2 syndecan 2 -0.0290586
EMP1 epithelial membrane protein 1 -0.0288366
TRIM2 tripartite motif containing 2 -0.0287529
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0286089
BTBD9 BTB (POZ) domain containing 9 -0.0284859
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0282218
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0281403
MACROD2 MACRO domain containing 2 -0.0278491
LRMDA leucine rich melanocyte differentiation associated -0.0277515
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0275836
ACTG1 actin gamma 1 -0.0271773
PI15 peptidase inhibitor 15 -0.0271592
ANKRD28 ankyrin repeat domain 28 -0.0269323
LEF1 lymphoid enhancer-binding factor 1 -0.0268792
RBM33 RNA binding motif protein 33 -0.026862
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0263572
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0263423
RHEB Ras homolog enriched in brain -0.0261122
B2M beta-2-microglobulin -0.0257867
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0257599
RHOA ras homolog family member A -0.0256227
DIAPH2 diaphanous-related formin 2 -0.0254873
JUN jun proto-oncogene -0.0254729
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0253966
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0251757
TSC22D1 TSC22 domain family, member 1 -0.0250261
ZFAND3 zinc finger, AN1-type domain 3 -0.0250112
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0241789
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0239687
AKAP13 A kinase (PRKA) anchor protein 13 -0.0239004
ADNP activity-dependent neuroprotector homeobox -0.0236784