Docetaxel (Trihydrate)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel (Trihydrate) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel (Trihydrate)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CALR calreticulin 0.0391282
SRRM2 serine/arginine repetitive matrix 2 0.0324693
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0291649
RPS6 ribosomal protein S6 0.0286753
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0273649
UBC ubiquitin C 0.0261565
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0249642
VEGFA vascular endothelial growth factor A 0.0247228
PDIA3 protein disulfide isomerase family A, member 3 0.0245778
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0241673
RPL21 ribosomal protein L21 0.0227977
GOLGA4 golgin A4 0.0206854
NFE2L1 nuclear factor, erythroid 2-like 1 0.019607
RPS27A ribosomal protein S27a 0.0195654
DST dystonin 0.0191091
ADM adrenomedullin 0.0190775
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0188539
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0179206
AKAP9 A kinase (PRKA) anchor protein 9 0.0174195
KTN1 kinectin 1 (kinesin receptor) 0.0172826
EEF2 eukaryotic translation elongation factor 2 0.0171011
RPS12 ribosomal protein S12 0.0170762
VIM vimentin 0.01701
IGFBP3 insulin-like growth factor binding protein 3 0.0167913
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0166569
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0161544
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0160836
HM13 histocompatibility (minor) 13 0.0160303
EIF1 eukaryotic translation initiation factor 1 0.0158403
RPL3 ribosomal protein L3 0.0150272
PRRC2C proline-rich coiled-coil 2C 0.0148792
FDPS farnesyl diphosphate synthase 0.0147413
SEC16A SEC16 homolog A (S. cerevisiae) 0.0147205
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.0146483
PNN pinin, desmosome associated protein 0.0146171
PDIA6 protein disulfide isomerase family A, member 6 0.01447
RPS8 ribosomal protein S8 0.0144518
BRD2 bromodomain containing 2 0.0144093
KMT2E lysine (K)-specific methyltransferase 2E 0.0139084
RPL5 ribosomal protein L5 0.0138547
SRRM1 serine/arginine repetitive matrix 1 0.0138233
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0138042
GRB10 growth factor receptor-bound protein 10 0.0136633
USP53 ubiquitin specific peptidase 53 0.0135077
SET SET nuclear proto-oncogene 0.0134756
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0133974
NUCB2 nucleobindin 2 0.0133839
DSTN destrin (actin depolymerizing factor) 0.0130623
TSPYL2 TSPY-like 2 0.0128879
PGM3 phosphoglucomutase 3 0.0127575
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0126558
SFTPA2 surfactant protein A2 0.0125791
RPL26 ribosomal protein L26 0.0125116
IRS2 insulin receptor substrate 2 0.0124798
RPL37A ribosomal protein L37a 0.0122291
ATF4 activating transcription factor 4 0.0121593
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0121493
RPLP2 ribosomal protein, large, P2 0.0120982
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0120487
RPL23 ribosomal protein L23 0.0119451
SRP54 signal recognition particle 54kDa 0.0117893
USP8 ubiquitin specific peptidase 8 0.0116761
TMEM41B transmembrane protein 41B 0.0115299
GPC6 glypican 6 0.0113228
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0112194
HILPDA hypoxia inducible lipid droplet-associated 0.011147
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0110477
FTH1 ferritin, heavy polypeptide 1 0.0110208
SERF2 small EDRK-rich factor 2 0.0108299
FBXO32 F-box protein 32 0.0108274
EGFR epidermal growth factor receptor 0.0106842
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0106349
HYOU1 hypoxia up-regulated 1 0.0105342
RPS17 ribosomal protein S17 0.0103858
GARS1 glycyl-tRNA synthetase 1 0.0103437
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0102075
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0101432
TUBB4B tubulin, beta 4B class IVb 0.0100893
GDI2 GDP dissociation inhibitor 2 0.0100208
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.00998802
DIDO1 death inducer-obliterator 1 0.00997512
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00989417
NUP58 nucleoporin 58 0.00988885
SEC63 SEC63 homolog (S. cerevisiae) 0.00986228
PTMA prothymosin, alpha 0.00981347
EIF5 eukaryotic translation initiation factor 5 0.0098134
MKI67 marker of proliferation Ki-67 0.00981184
RAB6A RAB6A, member RAS oncogene family 0.00980142
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.00977651
RPL19 ribosomal protein L19 0.00967538
MESD mesoderm development LRP chaperone 0.00963302
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.00954108
PTPRM protein tyrosine phosphatase, receptor type, M 0.00949472
RPL9 ribosomal protein L9 0.00948112
FN1 fibronectin 1 0.00944214
ATP5F1E ATP synthase F1 subunit epsilon 0.00943957
TMSB4X thymosin beta 4, X-linked 0.00936154
PABPC1 poly(A) binding protein, cytoplasmic 1 0.00926989
RPS3A ribosomal protein S3A 0.00926031
RPS14 ribosomal protein S14 0.00925324

decreased expression

Symbol Name Standardized Value
EPSTI1 epithelial stromal interaction 1 (breast) -0.156221
BTBD9 BTB (POZ) domain containing 9 -0.143127
ZMYND8 zinc finger, MYND-type containing 8 -0.115974
STAT1 signal transducer and activator of transcription 1, 91kDa -0.107477
B2M beta-2-microglobulin -0.10174
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0909572
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0903712
RUNX1 runt-related transcription factor 1 -0.0873399
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0855941
MACC1 metastasis associated in colon cancer 1 -0.0840892
EXT1 exostosin glycosyltransferase 1 -0.0823603
VCL vinculin -0.0808863
GMDS GDP-mannose 4,6-dehydratase -0.078312
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0781781
ARHGAP26 Rho GTPase activating protein 26 -0.0761959
RNF213 ring finger protein 213 -0.0756264
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0753199
LCN2 lipocalin 2 -0.0700731
HLA-B major histocompatibility complex, class I, B -0.069236
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0677586
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.067157
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0670385
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0659318
NCKAP5 NCK-associated protein 5 -0.0637318
RHOBTB3 Rho-related BTB domain containing 3 -0.0630202
MYO1E myosin IE -0.0629093
STK24 serine/threonine kinase 24 -0.0605399
ERBIN erbb2 interacting protein -0.0598004
EPHB2 EPH receptor B2 -0.0594152
PRKCA protein kinase C, alpha -0.0592654
MEIS2 Meis homeobox 2 -0.0589098
STS steroid sulfatase (microsomal), isozyme S -0.0575909
PHF3 PHD finger protein 3 -0.0575104
ITGA6 integrin, alpha 6 -0.0573857
PLSCR1 phospholipid scramblase 1 -0.0565389
RNF43 ring finger protein 43 -0.0559023
SAMD12 sterile alpha motif domain containing 12 -0.0558592
SERINC5 serine incorporator 5 -0.0531749
ATP11A ATPase, class VI, type 11A -0.0524855
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0519666
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0505939
ACTN4 actinin, alpha 4 -0.0502346
SORBS1 sorbin and SH3 domain containing 1 -0.0491531
RAD51B RAD51 paralog B -0.0486726
SPATA13 spermatogenesis associated 13 -0.0484581
ANKRD10 ankyrin repeat domain 10 -0.048069
ANXA2 annexin A2 -0.0478944
IFI6 interferon, alpha-inducible protein 6 -0.0473955
PATJ PATJ crumbs cell polarity complex component -0.0472789
TMEM62 transmembrane protein 62 -0.0469722
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0468457
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0466618
FOXP1 forkhead box P1 -0.0464316
ETV6 ets variant 6 -0.0463138
MX2 MX dynamin-like GTPase 2 -0.0463124
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0459749
XAF1 XIAP associated factor 1 -0.0456459
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0451164
PERP PERP, TP53 apoptosis effector -0.0449782
IGF1R insulin-like growth factor 1 receptor -0.0449442
MX1 MX dynamin-like GTPase 1 -0.0442406
TRIO trio Rho guanine nucleotide exchange factor -0.043649
ZBTB20 zinc finger and BTB domain containing 20 -0.0434001
KLF5 Kruppel-like factor 5 (intestinal) -0.0433765
RABGAP1L RAB GTPase activating protein 1-like -0.0430469
TSC22D1 TSC22 domain family, member 1 -0.0418867
RIGI RNA sensor RIG-I -0.0408915
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0403847
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0402825
C6ORF132 chromosome 6 open reading frame 132 -0.0394442
IFNGR1 interferon gamma receptor 1 -0.0393616
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0387381
ABHD2 abhydrolase domain containing 2 -0.0383381
MSI2 musashi RNA-binding protein 2 -0.0378644
GCLC glutamate-cysteine ligase, catalytic subunit -0.037856
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0377231
PGK1 phosphoglycerate kinase 1 -0.0375831
PRELID2 PRELI domain containing 2 -0.0375771
ATXN1 ataxin 1 -0.0374525
MECOM MDS1 and EVI1 complex locus -0.0374427
NF1 neurofibromin 1 -0.0369863
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.036376
PTBP3 polypyrimidine tract binding protein 3 -0.0363489
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0361183
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0359251
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0356383
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0353593
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0352424
MAP7 microtubule-associated protein 7 -0.0350228
LPP LIM domain containing preferred translocation partner in lipoma -0.0348562
NCOA7 nuclear receptor coactivator 7 -0.0345746
MED13 mediator complex subunit 13 -0.0345715
NKD1 naked cuticle homolog 1 (Drosophila) -0.0345589
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0345316
SMAD3 SMAD family member 3 -0.0342799
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0341382
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0340678
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0336901
EZR ezrin -0.0331436
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0330717