Docetaxel (Trihydrate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel (Trihydrate) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel (Trihydrate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.130159
FTL ferritin, light polypeptide 0.101138
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0966138
RPLP2 ribosomal protein, large, P2 0.06291
RPS6 ribosomal protein S6 0.0604016
CALR calreticulin 0.0603967
FAM13A family with sequence similarity 13, member A 0.0585712
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0580193
HILPDA hypoxia inducible lipid droplet-associated 0.0574737
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0500614
RPL37A ribosomal protein L37a 0.0499301
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0482889
ADM adrenomedullin 0.0454617
RPS3 ribosomal protein S3 0.0449601
RPS8 ribosomal protein S8 0.0424256
RPS27A ribosomal protein S27a 0.0413874
TMSB10 thymosin beta 10 0.0411335
RPS19 ribosomal protein S19 0.0405537
RPS12 ribosomal protein S12 0.0396558
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0382752
VIM vimentin 0.0379742
CXCL8 chemokine (C-X-C motif) ligand 8 0.0359518
RPL23 ribosomal protein L23 0.0337329
GDF15 growth differentiation factor 15 0.0321134
RPS17 ribosomal protein S17 0.0302063
EEF2 eukaryotic translation elongation factor 2 0.0298862
RPL19 ribosomal protein L19 0.0279575
RPL12 ribosomal protein L12 0.0273747
RPL28 ribosomal protein L28 0.0273089
RPL34 ribosomal protein L34 0.027308
RPL31 ribosomal protein L31 0.0272236
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0271082
DDIT4 DNA-damage-inducible transcript 4 0.0269155
MKI67 marker of proliferation Ki-67 0.0269151
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0263372
MXI1 MAX interactor 1, dimerization protein 0.0260164
KDM3A lysine (K)-specific demethylase 3A 0.0258598
RPL7A ribosomal protein L7a 0.0256866
GOLGA4 golgin A4 0.0255017
HDGF hepatoma-derived growth factor 0.0248229
RPS25 ribosomal protein S25 0.0239921
RPL38 ribosomal protein L38 0.0238037
RPL32 ribosomal protein L32 0.0237563
EIF1 eukaryotic translation initiation factor 1 0.0236324
TPT1 tumor protein, translationally-controlled 1 0.0228273
TPM3 tropomyosin 3 0.0224241
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.022261
RPL5 ribosomal protein L5 0.0222394
RPL35 ribosomal protein L35 0.0217124
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0214022
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0212253
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0212032
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0209203
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0207018
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0206134
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0205421
KMT2E lysine (K)-specific methyltransferase 2E 0.0204368
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0203706
PDIA4 protein disulfide isomerase family A, member 4 0.0203207
PDIA6 protein disulfide isomerase family A, member 6 0.0202143
RPL26 ribosomal protein L26 0.0199095
UPP1 uridine phosphorylase 1 0.0198068
RPL36 ribosomal protein L36 0.0197586
YBX1 Y box binding protein 1 0.0195634
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0194419
KIF5B kinesin family member 5B 0.0193406
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0190777
MIMS1 mitochondrial inner membrane scaffold 1 0.0189304
RPL37 ribosomal protein L37 0.0188161
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0185996
EIF3A eukaryotic translation initiation factor 3, subunit A 0.018574
RPS13 ribosomal protein S13 0.018502
RPL11 ribosomal protein L11 0.0184578
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0184134
RPS23 ribosomal protein S23 0.018387
RPL13A ribosomal protein L13a 0.018126
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.018072
LMNA lamin A/C 0.0179274
RPL21 ribosomal protein L21 0.0175802
NUP58 nucleoporin 58 0.017394
RPL18 ribosomal protein L18 0.0173252
HOOK2 hook microtubule-tethering protein 2 0.0172049
RPLP1 ribosomal protein, large, P1 0.0171717
RPS2 ribosomal protein S2 0.0170477
RPS27 ribosomal protein S27 0.01704
RPS11 ribosomal protein S11 0.0170055
RPS24 ribosomal protein S24 0.0169871
SET SET nuclear proto-oncogene 0.0169611
ANLN anillin, actin binding protein 0.0168158
TPI1 triosephosphate isomerase 1 0.0167996
LCORL ligand dependent nuclear receptor corepressor-like 0.0167198
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0166922
TUBA1B tubulin, alpha 1b 0.0166599
CADM1 cell adhesion molecule 1 0.0166513
RAB6A RAB6A, member RAS oncogene family 0.0164891
TPX2 TPX2, microtubule-associated 0.0164858
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0164745
CYCS cytochrome c, somatic 0.0164403
RPL9 ribosomal protein L9 0.0163607
NAP1L1 nucleosome assembly protein 1-like 1 0.0163371

decreased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B -0.177547
COL6A3 collagen, type VI, alpha 3 -0.135529
NALF1 NALCN channel auxiliary factor 1 -0.132476
CD44 CD44 molecule (Indian blood group) -0.126197
EXT1 exostosin glycosyltransferase 1 -0.119477
KYNU kynureninase -0.103506
ASPH aspartate beta-hydroxylase -0.0946201
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0920608
VCL vinculin -0.0905485
OSMR oncostatin M receptor -0.0864845
GLIS3 GLIS family zinc finger 3 -0.0803377
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0783
CALD1 caldesmon 1 -0.0751074
TRIO trio Rho guanine nucleotide exchange factor -0.0744201
WWTR1 WW domain containing transcription regulator 1 -0.0675264
TNS3 tensin 3 -0.066427
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0646312
DGKD diacylglycerol kinase, delta 130kDa -0.0627502
ATXN1 ataxin 1 -0.0624749
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0610393
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0601523
PDLIM5 PDZ and LIM domain 5 -0.0587768
ZBTB20 zinc finger and BTB domain containing 20 -0.0580674
ACTN4 actinin, alpha 4 -0.0577826
LPP LIM domain containing preferred translocation partner in lipoma -0.054
ACTN1 actinin, alpha 1 -0.0531192
AKAP12 A kinase (PRKA) anchor protein 12 -0.0531112
EGFR epidermal growth factor receptor -0.0523325
LDHA lactate dehydrogenase A -0.05126
EGR1 early growth response 1 -0.0510842
TGFBI transforming growth factor, beta-induced, 68kDa -0.0500943
SMAD3 SMAD family member 3 -0.0497844
PTK2 protein tyrosine kinase 2 -0.049168
NAV1 neuron navigator 1 -0.0482455
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0475747
PDE4D phosphodiesterase 4D, cAMP-specific -0.0470257
MYO10 myosin X -0.0465803
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0457436
LOX lysyl oxidase -0.0456721
RTN4 reticulon 4 -0.0454683
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0448215
SBF2 SET binding factor 2 -0.0448022
COL5A1 collagen, type V, alpha 1 -0.0447699
PHF14 PHD finger protein 14 -0.0441007
LOXL2 lysyl oxidase-like 2 -0.0438847
ANKRD28 ankyrin repeat domain 28 -0.0435347
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0424984
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0414883
VMP1 vacuole membrane protein 1 -0.0413129
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0408482
NAMPT nicotinamide phosphoribosyltransferase -0.040569
DST dystonin -0.0401254
AHNAK AHNAK nucleoprotein -0.0400814
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0399241
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0390236
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0389416
NABP1 nucleic acid binding protein 1 -0.0385563
FAM20C family with sequence similarity 20, member C -0.0376296
MCTP2 multiple C2 domains, transmembrane 2 -0.0369438
DOCK5 dedicator of cytokinesis 5 -0.0361571
SLC38A2 solute carrier family 38, member 2 -0.0355656
FBXL17 F-box and leucine-rich repeat protein 17 -0.0346543
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0340721
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0336799
MB21D2 Mab-21 domain containing 2 -0.0334261
TTC3 tetratricopeptide repeat domain 3 -0.0328197
ANO6 anoctamin 6 -0.0328081
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0326494
NCOA7 nuclear receptor coactivator 7 -0.0325348
NLGN1 neuroligin 1 -0.0321847
RNF216 ring finger protein 216 -0.0319972
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0312984
HDAC9 histone deacetylase 9 -0.0311643
BBS9 Bardet-Biedl syndrome 9 -0.0310653
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0310218
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0306395
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0305979
IL6ST interleukin 6 signal transducer -0.0303563
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0302276
NAV3 neuron navigator 3 -0.0299571
ANXA2 annexin A2 -0.0299527
NPC1 Niemann-Pick disease, type C1 -0.0296737
FER fer (fps/fes related) tyrosine kinase -0.0295795
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0292625
PALLD palladin, cytoskeletal associated protein -0.028877
MBD5 methyl-CpG binding domain protein 5 -0.0288372
STK17A serine/threonine kinase 17a -0.0287969
MAP1B microtubule-associated protein 1B -0.028674
TNNC1 troponin C type 1 (slow) -0.0286312
TPTE transmembrane phosphatase with tensin homology -0.0283131
HIPK2 homeodomain interacting protein kinase 2 -0.0283107
LYPD6B LY6/PLAUR domain containing 6B -0.0282418
ANKRD17 ankyrin repeat domain 17 -0.0281031
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0280806
IGFBP5 insulin-like growth factor binding protein 5 -0.027802
GPATCH2L G patch domain containing 2-like -0.027473
LOC112694756 uncharaterized LOC112694756 -0.0274666
AOPEP aminopeptidase O (putative) -0.0273856
FAF1 Fas (TNFRSF6) associated factor 1 -0.0273189
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.02722