Docetaxel (Trihydrate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel (Trihydrate) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel (Trihydrate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.0873682
RPS6 ribosomal protein S6 0.0794633
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0753901
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0620774
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0545948
MKI67 marker of proliferation Ki-67 0.0528497
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0486133
GOLGA4 golgin A4 0.0479084
RPS3 ribosomal protein S3 0.044405
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0429956
RPLP2 ribosomal protein, large, P2 0.0413024
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0396093
RPS12 ribosomal protein S12 0.03928
SRRM2 serine/arginine repetitive matrix 2 0.0383074
RPL37A ribosomal protein L37a 0.0374807
RPS27A ribosomal protein S27a 0.0373695
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0368484
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0336938
FTL ferritin, light polypeptide 0.0323456
RPL23 ribosomal protein L23 0.0318256
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0294803
EEF2 eukaryotic translation elongation factor 2 0.0293422
RPL21 ribosomal protein L21 0.0284185
RPL5 ribosomal protein L5 0.0280553
CALR calreticulin 0.0279858
SET SET nuclear proto-oncogene 0.0276789
RBM25 RNA binding motif protein 25 0.0275602
RPL19 ribosomal protein L19 0.0267032
CENPF centromere protein F, 350/400kDa 0.0265825
RPS25 ribosomal protein S25 0.0265248
RPS8 ribosomal protein S8 0.0256973
EIF5B eukaryotic translation initiation factor 5B 0.0255583
RPL3 ribosomal protein L3 0.0250047
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0249837
RPL12 ribosomal protein L12 0.0246661
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0245095
EIF5 eukaryotic translation initiation factor 5 0.0243357
TPT1 tumor protein, translationally-controlled 1 0.0232786
ANKRD11 ankyrin repeat domain 11 0.023168
KIF5B kinesin family member 5B 0.0230944
EIF1 eukaryotic translation initiation factor 1 0.0229351
RPS19 ribosomal protein S19 0.0228413
PNN pinin, desmosome associated protein 0.0227253
RPL7A ribosomal protein L7a 0.0224484
RPL26 ribosomal protein L26 0.0219915
RPS17 ribosomal protein S17 0.0216911
CKAP2 cytoskeleton associated protein 2 0.0216785
TOP1 topoisomerase (DNA) I 0.0215153
RPS14 ribosomal protein S14 0.0214583
TMSB10 thymosin beta 10 0.0213259
RPS29 ribosomal protein S29 0.0209747
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0209213
RPL38 ribosomal protein L38 0.0208903
HYOU1 hypoxia up-regulated 1 0.0202632
GARS1 glycyl-tRNA synthetase 1 0.0201886
RPL31 ribosomal protein L31 0.0201022
VIM vimentin 0.0200203
RPL34 ribosomal protein L34 0.0198995
RPL11 ribosomal protein L11 0.0198224
PDIA4 protein disulfide isomerase family A, member 4 0.0192778
ATF4 activating transcription factor 4 0.0191775
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0191297
HDGF hepatoma-derived growth factor 0.0185571
TUBB4B tubulin, beta 4B class IVb 0.0184789
SRRM1 serine/arginine repetitive matrix 1 0.0184327
TMF1 TATA element modulatory factor 1 0.0184322
PDE4D phosphodiesterase 4D, cAMP-specific 0.0183989
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0183878
NUP58 nucleoporin 58 0.0183179
KTN1 kinectin 1 (kinesin receptor) 0.0182519
RPS3A ribosomal protein S3A 0.017925
SRSF4 serine/arginine-rich splicing factor 4 0.0178928
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0177834
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0175789
RPL32 ribosomal protein L32 0.0175367
H2AZ1 H2A.Z variant histone 1 0.0174228
SMC4 structural maintenance of chromosomes 4 0.0174226
RPL36A ribosomal protein L36a 0.0172856
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0172545
RPL37 ribosomal protein L37 0.0170951
RPS11 ribosomal protein S11 0.0170022
PRRC2C proline-rich coiled-coil 2C 0.0169475
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0168672
TMSB4X thymosin beta 4, X-linked 0.0167796
RPL36 ribosomal protein L36 0.016568
UBC ubiquitin C 0.016545
FUBP1 far upstream element (FUSE) binding protein 1 0.0165429
CCNL1 cyclin L1 0.0160561
XPOT exportin, tRNA 0.0159521
RPL18 ribosomal protein L18 0.0157661
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0156239
CBX3 chromobox homolog 3 0.0152051
AKAP12 A kinase (PRKA) anchor protein 12 0.0151869
FN1 fibronectin 1 0.0150452
ZFC3H1 zinc finger, C3H1-type containing 0.0149942
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.0149553
SLK STE20-like kinase 0.0149066
MTDH metadherin 0.0146361
RPS26 ribosomal protein S26 0.0144893
GCC2 GRIP and coiled-coil domain containing 2 0.0144807

decreased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 -0.169996
AHNAK AHNAK nucleoprotein -0.169896
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.128672
NDRG1 N-myc downstream regulated 1 -0.124408
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.117435
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.10016
LDHA lactate dehydrogenase A -0.0882834
LOC112694756 uncharaterized LOC112694756 -0.0865132
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0841334
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0777235
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0694284
PATJ PATJ crumbs cell polarity complex component -0.0688861
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0676477
PRELID2 PRELI domain containing 2 -0.0651735
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0639887
FHIT fragile histidine triad -0.0629123
EZR ezrin -0.0616861
TBC1D22A TBC1 domain family, member 22A -0.0596422
EGR1 early growth response 1 -0.0581527
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0575479
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.05309
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.052561
VCL vinculin -0.0481732
CTBP2 C-terminal binding protein 2 -0.0474544
PKM pyruvate kinase, muscle -0.0472176
KDM4C lysine (K)-specific demethylase 4C -0.0470624
TPM4 tropomyosin 4 -0.0464239
ANXA2 annexin A2 -0.0461151
SMYD3 SET and MYND domain containing 3 -0.0459572
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0451821
NF1 neurofibromin 1 -0.0450545
MCL1 myeloid cell leukemia 1 -0.0431477
MED13L mediator complex subunit 13-like -0.0421065
SBF2 SET binding factor 2 -0.0414461
DSCAM Down syndrome cell adhesion molecule -0.0410512
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0407201
PGK1 phosphoglycerate kinase 1 -0.0396615
MBD5 methyl-CpG binding domain protein 5 -0.0395091
SERINC5 serine incorporator 5 -0.0390789
KRT19 keratin 19, type I -0.0388805
KRT8 keratin 8, type II -0.0384865
SEC31A SEC31 homolog A (S. cerevisiae) -0.0384033
ZNF638 zinc finger protein 638 -0.0376329
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0376047
ACTN4 actinin, alpha 4 -0.0369534
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0365595
TENM3 teneurin transmembrane protein 3 -0.0359035
RAD51B RAD51 paralog B -0.0356897
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0354825
ASPH aspartate beta-hydroxylase -0.0349816
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0346265
WWOX WW domain containing oxidoreductase -0.0345321
ARF4 ADP-ribosylation factor 4 -0.0342359
LMAN1 lectin, mannose-binding, 1 -0.033978
KIAA1217 KIAA1217 -0.0334648
BBX bobby sox homolog (Drosophila) -0.0323567
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0323265
SDC4 syndecan 4 -0.0321219
SPIDR scaffolding protein involved in DNA repair -0.0320102
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0312341
TAS2R14 taste receptor, type 2, member 14 -0.031127
MYO9A myosin IXA -0.0311243
MYOF myoferlin -0.0308498
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0306723
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0306425
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0303452
HMGA1 high mobility group AT-hook 1 -0.0300292
SLC38A2 solute carrier family 38, member 2 -0.029843
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.029558
UGDH UDP-glucose 6-dehydrogenase -0.0294592
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0293338
SUMF1 sulfatase modifying factor 1 -0.0291417
MYO1D myosin ID -0.0288807
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0286097
LPP LIM domain containing preferred translocation partner in lipoma -0.0285599
EXOC4 exocyst complex component 4 -0.0285158
RAB7A RAB7A, member RAS oncogene family -0.028396
WWC2 WW and C2 domain containing 2 -0.0280727
RAB1A RAB1A, member RAS oncogene family -0.0278704
RTN3 reticulon 3 -0.0278196
HDLBP high density lipoprotein binding protein -0.0277526
FAF1 Fas (TNFRSF6) associated factor 1 -0.0276525
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0273034
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0270077
LSR lipolysis stimulated lipoprotein receptor -0.0268384
CD2AP CD2-associated protein -0.026585
SCARB1 scavenger receptor class B, member 1 -0.0265111
PRRC2B proline-rich coiled-coil 2B -0.0263469
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0262199
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0260339
KRT18 keratin 18, type I -0.0260274
LASP1 LIM and SH3 protein 1 -0.0251789
ATXN1 ataxin 1 -0.0249224
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0249083
USP9Y ubiquitin specific peptidase 9, Y-linked -0.0247817
INTS6 integrator complex subunit 6 -0.0247607
WAC WW domain containing adaptor with coiled-coil -0.02456
KLF5 Kruppel-like factor 5 (intestinal) -0.0243452
POTEF POTE ankyrin domain family, member F -0.0243153
AFF4 AF4/FMR2 family, member 4 -0.0242957