Docetaxel (Trihydrate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel (Trihydrate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel (Trihydrate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0543313
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0254405
FLNA filamin A, alpha 0.0225364
GOLGA4 golgin A4 0.0222302
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.022193
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0216781
IARS1 isoleucyl-tRNA synthetase 1 0.0185113
TMSB4X thymosin beta 4, X-linked 0.0175676
IGFBP3 insulin-like growth factor binding protein 3 0.0173829
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0169771
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0166137
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0157907
SFPQ splicing factor proline/glutamine-rich 0.0147193
CANX calnexin 0.0143605
KDM3A lysine (K)-specific demethylase 3A 0.013292
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 0.0131495
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0129566
NCKAP1 NCK-associated protein 1 0.012856
EIF4H eukaryotic translation initiation factor 4H 0.0127803
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0127248
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0125423
TOP2B topoisomerase (DNA) II beta 180kDa 0.0124956
KDM6A lysine (K)-specific demethylase 6A 0.0120349
RANBP2 RAN binding protein 2 0.0119038
CALR calreticulin 0.0117224
APP amyloid beta (A4) precursor protein 0.0112329
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0110428
STC2 stanniocalcin 2 0.0109927
PAPOLA poly(A) polymerase alpha 0.0108128
WDR43 WD repeat domain 43 0.0107032
CLIP2 CAP-GLY domain containing linker protein 2 0.010693
HSPA8 heat shock 70kDa protein 8 0.0106826
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0105278
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0105156
H1-4 H1.4 linker histone, cluster member 0.0104415
MYH9 myosin, heavy chain 9, non-muscle 0.0104005
RPS3A ribosomal protein S3A 0.0102703
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0102288
KMT2E lysine (K)-specific methyltransferase 2E 0.0100192
SEC24D SEC24 family member D 0.0099125
KDM5C lysine (K)-specific demethylase 5C 0.00989957
GARS1 glycyl-tRNA synthetase 1 0.00985362
AFDN afadin, adherens junction formation factor 0.00978856
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.00973515
ANKRD11 ankyrin repeat domain 11 0.00949972
SRRM2 serine/arginine repetitive matrix 2 0.00944919
PNN pinin, desmosome associated protein 0.00942344
AUH AU RNA binding protein/enoyl-CoA hydratase 0.00940171
XPOT exportin, tRNA 0.00938439
RSL1D1 ribosomal L1 domain containing 1 0.00936342
USP53 ubiquitin specific peptidase 53 0.00930937
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.00928733
VCAN versican 0.00925515
CLINT1 clathrin interactor 1 0.00922801
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.00884909
PDIA4 protein disulfide isomerase family A, member 4 0.00881269
RPL3 ribosomal protein L3 0.008792
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.00859154
SET SET nuclear proto-oncogene 0.00857721
UIMC1 ubiquitin interaction motif containing 1 0.00848142
NFE2L1 nuclear factor, erythroid 2-like 1 0.00829405
ANK2 ankyrin 2, neuronal 0.00827659
WAC WW domain containing adaptor with coiled-coil 0.00819104
SAFB scaffold attachment factor B 0.00812753
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.00811049
QKI QKI, KH domain containing, RNA binding 0.00810992
ZFAND3 zinc finger, AN1-type domain 3 0.00804282
CHD3 chromodomain helicase DNA binding protein 3 0.00798155
RYK receptor-like tyrosine kinase 0.00793463
USP24 ubiquitin specific peptidase 24 0.00792646
SRSF1 serine/arginine-rich splicing factor 1 0.00790548
ZFC3H1 zinc finger, C3H1-type containing 0.00788696
AHNAK AHNAK nucleoprotein 0.0078424
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.00776433
ITCH itchy E3 ubiquitin protein ligase 0.0077212
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.00769911
NAMPT nicotinamide phosphoribosyltransferase 0.00765012
RBM26 RNA binding motif protein 26 0.00761877
PDIA5 protein disulfide isomerase family A, member 5 0.00760475
MDN1 MDN1, midasin homolog (yeast) 0.00758805
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.00758482
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.00757399
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.00755605
DSPP dentin sialophosphoprotein 0.00751453
UBQLN1 ubiquilin 1 0.007495
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.00747738
RPL14 ribosomal protein L14 0.00747569
RAD23B RAD23 homolog B (S. cerevisiae) 0.00742005
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.00738066
SEC63 SEC63 homolog (S. cerevisiae) 0.0073567
CKAP5 cytoskeleton associated protein 5 0.00730774
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.00717793
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.00717078
EIF5 eukaryotic translation initiation factor 5 0.00715151
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.00714917
AMBRA1 autophagy/beclin-1 regulator 1 0.00712211
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.00706707
RPN1 ribophorin I 0.00703296
SLTM SAFB-like, transcription modulator 0.00702185
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.00698944

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.232702
MT2A metallothionein 2A -0.172635
FTL ferritin, light polypeptide -0.130778
TMSB10 thymosin beta 10 -0.122962
B2M beta-2-microglobulin -0.0898193
ACTG1 actin gamma 1 -0.0892842
RPL35A ribosomal protein L35a -0.0826393
RPS19 ribosomal protein S19 -0.078225
POTEF POTE ankyrin domain family, member F -0.0675671
PKM pyruvate kinase, muscle -0.0647985
LDHA lactate dehydrogenase A -0.0614294
RPLP1 ribosomal protein, large, P1 -0.0576613
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0563046
EGR1 early growth response 1 -0.05549
CCND1 cyclin D1 -0.052836
PRELID2 PRELI domain containing 2 -0.0523936
ENO1 enolase 1, (alpha) -0.0520699
NDRG1 N-myc downstream regulated 1 -0.0512753
RPS6 ribosomal protein S6 -0.0498959
RPL31 ribosomal protein L31 -0.0494236
ZBTB20 zinc finger and BTB domain containing 20 -0.0469821
RPL19 ribosomal protein L19 -0.0462243
RPL32 ribosomal protein L32 -0.0441619
RPL28 ribosomal protein L28 -0.0432691
RPS8 ribosomal protein S8 -0.0421281
RPL23 ribosomal protein L23 -0.0404691
RPL12 ribosomal protein L12 -0.0387266
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0385042
S100A9 S100 calcium binding protein A9 -0.0380161
MACROD2 MACRO domain containing 2 -0.0379621
SEPTIN7 septin 7 -0.0378418
TPT1 tumor protein, translationally-controlled 1 -0.0373454
MT1X metallothionein 1X -0.0372588
RPLP0 ribosomal protein, large, P0 -0.0358365
RPS11 ribosomal protein S11 -0.0352531
TPI1 triosephosphate isomerase 1 -0.0348551
ALCAM activated leukocyte cell adhesion molecule -0.034604
RPL34 ribosomal protein L34 -0.0341654
CDCP1 CUB domain containing protein 1 -0.0338052
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0336755
RPL35 ribosomal protein L35 -0.0335741
RPS5 ribosomal protein S5 -0.0334182
ITGB8 integrin, beta 8 -0.033033
VCL vinculin -0.0329642
RPL11 ribosomal protein L11 -0.0327208
RPLP2 ribosomal protein, large, P2 -0.0326181
RPS13 ribosomal protein S13 -0.0323632
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0322259
LOC112694756 uncharaterized LOC112694756 -0.0320856
ASPH aspartate beta-hydroxylase -0.0319606
S100A10 S100 calcium binding protein A10 -0.0318421
RPS29 ribosomal protein S29 -0.0315701
HMGA1 high mobility group AT-hook 1 -0.0315691
RPL9 ribosomal protein L9 -0.030986
TPM4 tropomyosin 4 -0.0305057
RPS14 ribosomal protein S14 -0.0303998
RAD51B RAD51 paralog B -0.0298784
BPTF bromodomain PHD finger transcription factor -0.0296956
S100A6 S100 calcium binding protein A6 -0.0294906
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0294797
KRT7 keratin 7, type II -0.0294243
GNAS GNAS complex locus -0.0293084
DEK DEK proto-oncogene -0.0292325
RPS16 ribosomal protein S16 -0.0289172
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0277806
RPS4X ribosomal protein S4, X-linked -0.0276187
RPS23 ribosomal protein S23 -0.0274327
PGK1 phosphoglycerate kinase 1 -0.0273966
EIF1 eukaryotic translation initiation factor 1 -0.0272599
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0271061
RPL7 ribosomal protein L7 -0.0269673
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0265885
PATJ PATJ crumbs cell polarity complex component -0.0264736
VDAC1 voltage-dependent anion channel 1 -0.026324
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0260626
SMC4 structural maintenance of chromosomes 4 -0.024713
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0245997
RPL36 ribosomal protein L36 -0.0245964
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0238615
PAX8 paired box 8 -0.0234655
RACK1 receptor for activated C kinase 1 -0.0233806
RPS10 ribosomal protein S10 -0.0231857
PFN1 profilin 1 -0.0230063
TXNRD1 thioredoxin reductase 1 -0.022695
FHIT fragile histidine triad -0.0219328
RPL7A ribosomal protein L7a -0.0218655
RPL18 ribosomal protein L18 -0.021778
ACTN4 actinin, alpha 4 -0.021714
RPL37A ribosomal protein L37a -0.0215158
RPS24 ribosomal protein S24 -0.0213977
RPS3 ribosomal protein S3 -0.021286
FTH1 ferritin, heavy polypeptide 1 -0.0210524
RPS20 ribosomal protein S20 -0.020813
RPS15 ribosomal protein S15 -0.0207768
CLDN4 claudin 4 -0.020551
FOSL1 FOS-like antigen 1 -0.020404
ATXN1 ataxin 1 -0.0201303
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0200304
PCBP2 poly(rC) binding protein 2 -0.0197925
RPS21 ribosomal protein S21 -0.0196154