Docetaxel (Trihydrate)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel (Trihydrate) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel (Trihydrate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.214575
PTMA prothymosin, alpha 0.0956256
VIM vimentin 0.0956029
RPS6 ribosomal protein S6 0.0839835
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0755586
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0671066
ADM adrenomedullin 0.065933
TMSB10 thymosin beta 10 0.0652619
RPL12 ribosomal protein L12 0.0644316
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0639029
RPLP2 ribosomal protein, large, P2 0.062424
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0556132
FTL ferritin, light polypeptide 0.0555378
RPS19 ribosomal protein S19 0.0504755
RPL23 ribosomal protein L23 0.0502931
RPS12 ribosomal protein S12 0.0483114
RPL37A ribosomal protein L37a 0.0470496
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0441633
RPL19 ribosomal protein L19 0.0428097
FAM13A family with sequence similarity 13, member A 0.042458
RPS8 ribosomal protein S8 0.0415034
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0405873
RPS3 ribosomal protein S3 0.038945
RPL11 ribosomal protein L11 0.0383948
RPS27A ribosomal protein S27a 0.0380876
EIF1 eukaryotic translation initiation factor 1 0.0377
RPL32 ribosomal protein L32 0.0352885
TPT1 tumor protein, translationally-controlled 1 0.0346948
RPS16 ribosomal protein S16 0.0322861
TIMP1 TIMP metallopeptidase inhibitor 1 0.0322357
RPS17 ribosomal protein S17 0.0310863
RPL31 ribosomal protein L31 0.0310771
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0309686
RPL9 ribosomal protein L9 0.0295927
DDIT4 DNA-damage-inducible transcript 4 0.0294595
G0S2 G0/G1 switch 2 0.029359
RPL8 ribosomal protein L8 0.0288428
RPS13 ribosomal protein S13 0.0286634
RPL5 ribosomal protein L5 0.0283108
TUBA1B tubulin, alpha 1b 0.0275104
RPL36A ribosomal protein L36a 0.0268532
CALR calreticulin 0.0268372
RPS27 ribosomal protein S27 0.0264135
YBX1 Y box binding protein 1 0.0245908
RPS23 ribosomal protein S23 0.0245534
RPS14 ribosomal protein S14 0.024511
MKI67 marker of proliferation Ki-67 0.024498
SRRM2 serine/arginine repetitive matrix 2 0.0242721
RPLP0 ribosomal protein, large, P0 0.0242344
RPL26 ribosomal protein L26 0.0237195
CENPF centromere protein F, 350/400kDa 0.023582
RPL21 ribosomal protein L21 0.0234842
RPL37 ribosomal protein L37 0.0234463
RACK1 receptor for activated C kinase 1 0.0231555
GOLGA4 golgin A4 0.0231548
RPLP1 ribosomal protein, large, P1 0.022734
RPL38 ribosomal protein L38 0.0225279
HILPDA hypoxia inducible lipid droplet-associated 0.0225229
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0222942
RPL7A ribosomal protein L7a 0.0219282
RPL36 ribosomal protein L36 0.0217678
RPL28 ribosomal protein L28 0.0216823
CKAP2 cytoskeleton associated protein 2 0.0216504
RPL35 ribosomal protein L35 0.0210707
ASTN2 astrotactin 2 0.0209479
RPS10 ribosomal protein S10 0.0206572
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0206306
TPI1 triosephosphate isomerase 1 0.0203582
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0202583
RPL34 ribosomal protein L34 0.0200784
RPL30 ribosomal protein L30 0.0200489
RPS25 ribosomal protein S25 0.0199567
SET SET nuclear proto-oncogene 0.0199436
RPL10A ribosomal protein L10a 0.0198383
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0196146
PNISR PNN-interacting serine/arginine-rich protein 0.0187656
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0182091
EEF2 eukaryotic translation elongation factor 2 0.0180241
RPS29 ribosomal protein S29 0.0179742
FAM162A family with sequence similarity 162, member A 0.0178227
TUBB4B tubulin, beta 4B class IVb 0.0177105
RPS4X ribosomal protein S4, X-linked 0.0176148
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0174333
RPL15 ribosomal protein L15 0.0173556
RAB13 RAB13, member RAS oncogene family 0.0172718
S100A9 S100 calcium binding protein A9 0.0166805
IER3 immediate early response 3 0.0166451
RPL3 ribosomal protein L3 0.0166181
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0165309
PRRC2C proline-rich coiled-coil 2C 0.0164948
RPS2 ribosomal protein S2 0.0164758
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0163636
SFTPA2 surfactant protein A2 0.0160992
NAMPT nicotinamide phosphoribosyltransferase 0.0160571
RPS15 ribosomal protein S15 0.0158928
RPL35A ribosomal protein L35a 0.0158867
TUBB tubulin, beta class I 0.0157989
RPS11 ribosomal protein S11 0.0157086
ARRDC3 arrestin domain containing 3 0.0157042
FOSL1 FOS-like antigen 1 0.015662

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.264081
HMGA2 high mobility group AT-hook 2 -0.15721
COL5A1 collagen, type V, alpha 1 -0.136861
TRIO trio Rho guanine nucleotide exchange factor -0.12319
EXT1 exostosin glycosyltransferase 1 -0.120698
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.120466
CDH13 cadherin 13 -0.0966144
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0955335
NAV1 neuron navigator 1 -0.0942819
ASPH aspartate beta-hydroxylase -0.092566
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0908568
CD44 CD44 molecule (Indian blood group) -0.0837112
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0721822
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0720488
AHNAK AHNAK nucleoprotein -0.069908
MYO10 myosin X -0.0697437
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0688015
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0683819
GLIS3 GLIS family zinc finger 3 -0.0683729
COL6A3 collagen, type VI, alpha 3 -0.0658881
VCL vinculin -0.0642047
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.062906
FNDC3B fibronectin type III domain containing 3B -0.0626546
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0618308
COL6A1 collagen, type VI, alpha 1 -0.0611913
TENM2 teneurin transmembrane protein 2 -0.0575318
RAI14 retinoic acid induced 14 -0.0563815
COL6A2 collagen, type VI, alpha 2 -0.05418
SEPTIN9 septin 9 -0.052106
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0483933
DST dystonin -0.048089
EGR1 early growth response 1 -0.0474873
LOXL2 lysyl oxidase-like 2 -0.043569
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0430758
JARID2 jumonji, AT rich interactive domain 2 -0.0428559
CLMP CXADR-like membrane protein -0.0426961
TAS2R14 taste receptor, type 2, member 14 -0.0424163
LOX lysyl oxidase -0.0418428
NALF1 NALCN channel auxiliary factor 1 -0.0398457
ANXA2 annexin A2 -0.0396153
CCND1 cyclin D1 -0.0393474
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0389001
ACTN4 actinin, alpha 4 -0.0388829
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0386681
CLIC4 chloride intracellular channel 4 -0.0378042
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.037412
COL7A1 collagen, type VII, alpha 1 -0.0366797
ANKRD28 ankyrin repeat domain 28 -0.0364254
EFNA5 ephrin-A5 -0.0358328
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0351121
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0351011
PRKCA protein kinase C, alpha -0.0345624
ACTG1 actin gamma 1 -0.0344668
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0342753
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0341484
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0336706
EGFR epidermal growth factor receptor -0.0323595
BICD1 bicaudal D homolog 1 (Drosophila) -0.0316718
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0313768
LPP LIM domain containing preferred translocation partner in lipoma -0.0310696
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0310406
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.030845
IGF1R insulin-like growth factor 1 receptor -0.0302705
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0299817
SMYD3 SET and MYND domain containing 3 -0.0299609
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0295766
ATXN1 ataxin 1 -0.0295458
WNK1 WNK lysine deficient protein kinase 1 -0.0289788
SMAD3 SMAD family member 3 -0.0289373
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0287235
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0287044
USP34 ubiquitin specific peptidase 34 -0.0282043
LAMB3 laminin, beta 3 -0.0279961
ZBTB20 zinc finger and BTB domain containing 20 -0.0279464
DIAPH2 diaphanous-related formin 2 -0.0278999
ARHGAP22 Rho GTPase activating protein 22 -0.0278806
PDLIM5 PDZ and LIM domain 5 -0.0277218
PCBP3 poly(rC) binding protein 3 -0.0275482
DTNA dystrobrevin, alpha -0.0272763
SEC24D SEC24 family member D -0.0272458
RRBP1 ribosome binding protein 1 -0.0271393
PRELID2 PRELI domain containing 2 -0.0270578
FMN1 formin 1 -0.0269768
FBXO11 F-box protein 11 -0.0268795
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0267246
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0266786
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0266462
LDHA lactate dehydrogenase A -0.0266054
AFF3 AF4/FMR2 family, member 3 -0.0265934
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0265285
SEC31A SEC31 homolog A (S. cerevisiae) -0.0264854
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0264506
FRMD4A FERM domain containing 4A -0.0260246
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0259648
CAPN2 calpain 2, (m/II) large subunit -0.0258193
NUMB numb homolog (Drosophila) -0.0256214
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0255945
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0255881
RTN4 reticulon 4 -0.0253895
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0252797