Docetaxel (Trihydrate)_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel (Trihydrate) perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel (Trihydrate)_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.110026
PTMA prothymosin, alpha 0.10767
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.106724
TPT1 tumor protein, translationally-controlled 1 0.0888824
RPS3 ribosomal protein S3 0.0823099
RPS12 ribosomal protein S12 0.0780672
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0763675
RPL23 ribosomal protein L23 0.0659272
RPS19 ribosomal protein S19 0.0597529
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0588742
TMSB10 thymosin beta 10 0.0573989
SRRM2 serine/arginine repetitive matrix 2 0.0529628
GOLGA4 golgin A4 0.0527319
RPL37A ribosomal protein L37a 0.0514392
RPL26 ribosomal protein L26 0.050222
RPS8 ribosomal protein S8 0.0486486
FTL ferritin, light polypeptide 0.0484639
RPLP2 ribosomal protein, large, P2 0.0473813
CALR calreticulin 0.0472535
RPS25 ribosomal protein S25 0.0457292
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0446469
RPS27A ribosomal protein S27a 0.0442892
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.042614
ANKRD11 ankyrin repeat domain 11 0.0424246
RPL12 ribosomal protein L12 0.0422847
RPS17 ribosomal protein S17 0.0413487
MKI67 marker of proliferation Ki-67 0.0403863
RPL11 ribosomal protein L11 0.0400196
EIF1 eukaryotic translation initiation factor 1 0.0392413
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0381784
RPL19 ribosomal protein L19 0.0379883
AREG amphiregulin 0.037923
LCN2 lipocalin 2 0.0366371
EEF2 eukaryotic translation elongation factor 2 0.0360449
PDIA4 protein disulfide isomerase family A, member 4 0.0357561
RPL13A ribosomal protein L13a 0.0341812
RPL38 ribosomal protein L38 0.0339497
VEGFA vascular endothelial growth factor A 0.0337328
HYOU1 hypoxia up-regulated 1 0.0321856
TMSB4X thymosin beta 4, X-linked 0.0310881
NFE2L1 nuclear factor, erythroid 2-like 1 0.0304802
MYH9 myosin, heavy chain 9, non-muscle 0.0300665
RPL5 ribosomal protein L5 0.0300007
NDRG1 N-myc downstream regulated 1 0.029569
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0295414
RPL21 ribosomal protein L21 0.029466
RPS29 ribosomal protein S29 0.0287365
RPS27 ribosomal protein S27 0.0286734
RPL7A ribosomal protein L7a 0.0282524
SET SET nuclear proto-oncogene 0.0278788
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0277606
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0277312
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0274911
HKDC1 hexokinase domain containing 1 0.0274537
TUBB4B tubulin, beta 4B class IVb 0.026915
RPL36A ribosomal protein L36a 0.0264513
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.026289
DSTN destrin (actin depolymerizing factor) 0.0260032
RPS11 ribosomal protein S11 0.0259786
RPL27 ribosomal protein L27 0.0259589
ENO1 enolase 1, (alpha) 0.0259179
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0257683
AKAP9 A kinase (PRKA) anchor protein 9 0.0257287
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0251617
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0250982
RPL31 ribosomal protein L31 0.0248276
PNISR PNN-interacting serine/arginine-rich protein 0.0243869
RPL36 ribosomal protein L36 0.0243247
FAM13A family with sequence similarity 13, member A 0.0242972
RPS14 ribosomal protein S14 0.0242155
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0241717
RPL9 ribosomal protein L9 0.0239903
RPL32 ribosomal protein L32 0.0239808
HM13 histocompatibility (minor) 13 0.0235677
KLHL29 kelch-like family member 29 0.0235667
RPS16 ribosomal protein S16 0.0235454
PGM3 phosphoglucomutase 3 0.022982
APLP2 amyloid beta (A4) precursor-like protein 2 0.0227214
NUPR1 nuclear protein, transcriptional regulator, 1 0.0226996
RPS21 ribosomal protein S21 0.0223733
KDM3A lysine (K)-specific demethylase 3A 0.022246
SEC61G Sec61 gamma subunit 0.0222189
RPL34 ribosomal protein L34 0.0219028
RPL37 ribosomal protein L37 0.0218518
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.021514
HDGF hepatoma-derived growth factor 0.0213771
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0213286
UQCRB ubiquinol-cytochrome c reductase binding protein 0.021266
RPS10 ribosomal protein S10 0.0210343
KTN1 kinectin 1 (kinesin receptor) 0.0209866
RPL28 ribosomal protein L28 0.0208542
ERRFI1 ERBB receptor feedback inhibitor 1 0.0206866
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0204879
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0204576
RPL35 ribosomal protein L35 0.0201532
ESRP1 epithelial splicing regulatory protein 1 0.0201081
RPL18 ribosomal protein L18 0.0201011
HSPA8 heat shock 70kDa protein 8 0.0198493
EIF5 eukaryotic translation initiation factor 5 0.0198212
PNN pinin, desmosome associated protein 0.0195604

decreased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 -0.424845
GMDS GDP-mannose 4,6-dehydratase -0.16831
LMO7 LIM domain 7 -0.14638
TMC5 transmembrane channel-like 5 -0.116563
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0960434
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.094083
CEMIP cell migration inducing protein, hyaluronan binding -0.0887591
EMP1 epithelial membrane protein 1 -0.0849792
ANXA2 annexin A2 -0.0796815
POTEF POTE ankyrin domain family, member F -0.077176
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0737412
CD2AP CD2-associated protein -0.0703361
SEPTIN9 septin 9 -0.0643429
ACTN4 actinin, alpha 4 -0.0616998
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0609659
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0594801
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0590914
EZR ezrin -0.0533427
COBL cordon-bleu WH2 repeat protein -0.0532461
LOC112694756 uncharaterized LOC112694756 -0.0522837
PTPRK protein tyrosine phosphatase, receptor type, K -0.0517183
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0515842
MUC17 mucin 17, cell surface associated -0.0513812
PRSS3 protease, serine, 3 -0.050977
SH3RF1 SH3 domain containing ring finger 1 -0.0504719
MYOF myoferlin -0.0498162
FAT1 FAT atypical cadherin 1 -0.0496345
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0491996
BCL2L1 BCL2-like 1 -0.0491949
MCU mitochondrial calcium uniporter -0.0491444
SHROOM3 shroom family member 3 -0.0476903
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0460958
MACC1 metastasis associated in colon cancer 1 -0.0455536
B2M beta-2-microglobulin -0.0455361
MTUS1 microtubule associated tumor suppressor 1 -0.0445111
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0444974
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0443678
PLSCR1 phospholipid scramblase 1 -0.042943
MED13 mediator complex subunit 13 -0.0429358
AOPEP aminopeptidase O (putative) -0.042725
WWC1 WW and C2 domain containing 1 -0.0424597
GPX2 glutathione peroxidase 2 -0.0423055
MGAM2 maltase-glucoamylase 2 (putative) -0.0414868
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0410112
LOC102724023 ES1 protein homolog, mitochondrial -0.0409324
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0408956
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0405524
GDA guanine deaminase -0.0401869
MSI2 musashi RNA-binding protein 2 -0.0401038
HLA-E major histocompatibility complex, class I, E -0.0396689
TJP1 tight junction protein 1 -0.0381922
SAMD12 sterile alpha motif domain containing 12 -0.0381357
KRT8 keratin 8, type II -0.0378658
MYO1E myosin IE -0.0377437
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0377284
CLMN calmin (calponin-like, transmembrane) -0.0374124
KRT18 keratin 18, type I -0.0373686
TMEM45B transmembrane protein 45B -0.036639
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.036198
AGR3 anterior gradient 3 -0.0356463
INSIG1 insulin induced gene 1 -0.0350918
ACACA acetyl-CoA carboxylase alpha -0.0349231
ATP11A ATPase, class VI, type 11A -0.0341647
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0340272
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0336643
SIK3 SIK family kinase 3 -0.033367
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0329301
ETV6 ets variant 6 -0.0328383
UBE2H ubiquitin-conjugating enzyme E2H -0.0326619
PRKCA protein kinase C, alpha -0.0323387
ECT2 epithelial cell transforming 2 -0.0315263
PDIA3 protein disulfide isomerase family A, member 3 -0.0312798
AKAP13 A kinase (PRKA) anchor protein 13 -0.0311453
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0310665
EPCAM epithelial cell adhesion molecule -0.0308786
PHF14 PHD finger protein 14 -0.0306535
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0304851
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0302712
RBM47 RNA binding motif protein 47 -0.0301839
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0301832
CDK6 cyclin-dependent kinase 6 -0.0297549
CNKSR3 CNKSR family member 3 -0.0296568
TNIK TRAF2 and NCK interacting kinase -0.0296434
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0295892
TMEM123 transmembrane protein 123 -0.0295695
ARHGAP42 Rho GTPase activating protein 42 -0.0294287
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.029389
DLG1 discs, large homolog 1 (Drosophila) -0.0292835
STK24 serine/threonine kinase 24 -0.0292598
LPP LIM domain containing preferred translocation partner in lipoma -0.0290774
UGCG UDP-glucose ceramide glucosyltransferase -0.0288216
PGK1 phosphoglycerate kinase 1 -0.0285083
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0284253
NF1 neurofibromin 1 -0.0279779
RRBP1 ribosome binding protein 1 -0.0278375
RNF213 ring finger protein 213 -0.0278244
ITGB4 integrin, beta 4 -0.0277587
MECOM MDS1 and EVI1 complex locus -0.0276592
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0273833
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0272657