Docetaxel (Trihydrate)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel (Trihydrate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel (Trihydrate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS3 ribosomal protein S3 0.0813466
FAM13A family with sequence similarity 13, member A 0.0622685
RPS12 ribosomal protein S12 0.0564791
SRRM2 serine/arginine repetitive matrix 2 0.0484992
RPL37A ribosomal protein L37a 0.0437778
MKI67 marker of proliferation Ki-67 0.0420752
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0383721
CES1 carboxylesterase 1 0.037237
CAMTA1 calmodulin binding transcription activator 1 0.0326006
RPS23 ribosomal protein S23 0.0312138
UBA6 ubiquitin-like modifier activating enzyme 6 0.0310308
NCKAP1 NCK-associated protein 1 0.029447
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0290853
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0288478
NGLY1 N-glycanase 1 0.0284126
KMT2E lysine (K)-specific methyltransferase 2E 0.0276658
ARRDC3 arrestin domain containing 3 0.0272892
RPLP2 ribosomal protein, large, P2 0.0261924
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0260487
RNF145 ring finger protein 145 0.0255248
RICTOR RPTOR independent companion of MTOR, complex 2 0.0252039
RPS6 ribosomal protein S6 0.0250795
RPS17 ribosomal protein S17 0.0249766
UBC ubiquitin C 0.0244371
RPL5 ribosomal protein L5 0.0234119
RPS25 ribosomal protein S25 0.0233209
ARGLU1 arginine and glutamate rich 1 0.0225871
CSNK1A1 casein kinase 1, alpha 1 0.0222218
ZFC3H1 zinc finger, C3H1-type containing 0.0219514
PTMA prothymosin, alpha 0.0215938
HYOU1 hypoxia up-regulated 1 0.0212765
SLMAP sarcolemma associated protein 0.0205887
ADAM17 ADAM metallopeptidase domain 17 0.0204843
KCMF1 potassium channel modulatory factor 1 0.0203904
PDIA6 protein disulfide isomerase family A, member 6 0.0198897
UVRAG UV radiation resistance associated 0.0196727
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0196276
NUP58 nucleoporin 58 0.0195618
MXD1 MAX dimerization protein 1 0.0194959
TFG TRK-fused gene 0.018672
ARL8B ADP-ribosylation factor-like 8B 0.0186222
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0183589
RPL3 ribosomal protein L3 0.018209
RPL21 ribosomal protein L21 0.0181322
RPL19 ribosomal protein L19 0.0179501
RPL31 ribosomal protein L31 0.0174282
TENT5A terminal nucleotidyltransferase 5A 0.0172952
STRN3 striatin, calmodulin binding protein 3 0.0172842
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0172168
EEF2 eukaryotic translation elongation factor 2 0.0170568
GCLC glutamate-cysteine ligase, catalytic subunit 0.0170328
KMT5B lysine methyltransferase 5B 0.0169962
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.016933
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0166804
CSDE1 cold shock domain containing E1, RNA-binding 0.0165637
KDM6A lysine (K)-specific demethylase 6A 0.0159385
RPS27A ribosomal protein S27a 0.0159091
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0157903
PDE8A phosphodiesterase 8A 0.0154426
HILPDA hypoxia inducible lipid droplet-associated 0.0152884
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0152786
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0152589
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0151845
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0151338
TPD52 tumor protein D52 0.015093
MYH9 myosin, heavy chain 9, non-muscle 0.0150278
RPS15A ribosomal protein S15a 0.0150217
CCNL1 cyclin L1 0.0148797
ARHGAP21 Rho GTPase activating protein 21 0.0148297
SEM1 SEM1 26S proteasome subunit 0.0147936
RPL36A ribosomal protein L36a 0.0147677
CLU clusterin 0.0147334
RPS8 ribosomal protein S8 0.0147077
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0146206
PDIA4 protein disulfide isomerase family A, member 4 0.0145312
ATG14 autophagy related 14 0.0144551
IGFBP3 insulin-like growth factor binding protein 3 0.0144272
CALR calreticulin 0.0141178
CKAP2 cytoskeleton associated protein 2 0.0141141
WDR49 WD repeat domain 49 0.0140318
HELZ helicase with zinc finger 0.0140225
RUNX1 runt-related transcription factor 1 0.0136173
RPL8 ribosomal protein L8 0.0135088
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0134197
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0134082
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0133384
FTL ferritin, light polypeptide 0.0128882
RPS2 ribosomal protein S2 0.0128744
RAD23B RAD23 homolog B (S. cerevisiae) 0.0127765
GOLGA4 golgin A4 0.0127489
SUCO SUN domain containing ossification factor 0.0127143
PCBP2 poly(rC) binding protein 2 0.0127125
CEP192 centrosomal protein 192kDa 0.0125378
CYLD cylindromatosis (turban tumor syndrome) 0.0124786
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0123629
SRP54 signal recognition particle 54kDa 0.0122379
SCFD1 sec1 family domain containing 1 0.0119669
CDC73 cell division cycle 73 0.0119312
COG6 component of oligomeric golgi complex 6 0.0118795
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0117423

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.223193
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.192488
MT2A metallothionein 2A -0.118091
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.116398
ASPH aspartate beta-hydroxylase -0.11153
LMO7 LIM domain 7 -0.107121
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0846391
PTPRM protein tyrosine phosphatase, receptor type, M -0.0815931
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0753118
LDHA lactate dehydrogenase A -0.0735789
ZMYND8 zinc finger, MYND-type containing 8 -0.0701127
EGR1 early growth response 1 -0.0683154
EFNA5 ephrin-A5 -0.0674334
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0655707
OSMR oncostatin M receptor -0.0643915
LOC112694756 uncharaterized LOC112694756 -0.0603437
THSD4 thrombospondin, type I, domain containing 4 -0.0560055
RNF213 ring finger protein 213 -0.0543191
LPP LIM domain containing preferred translocation partner in lipoma -0.0539703
ANXA2 annexin A2 -0.0533878
MYOF myoferlin -0.0526601
PDE4D phosphodiesterase 4D, cAMP-specific -0.0525284
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0513179
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0506188
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0502821
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0502614
DOCK5 dedicator of cytokinesis 5 -0.0500201
FNDC3B fibronectin type III domain containing 3B -0.049526
ACTG1 actin gamma 1 -0.0473103
PDLIM5 PDZ and LIM domain 5 -0.0461498
FOXP1 forkhead box P1 -0.0456051
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.043369
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0431763
CAV1 caveolin 1, caveolae protein, 22kDa -0.0429221
CCND1 cyclin D1 -0.0427495
MYO1E myosin IE -0.0426096
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.042243
MCTP1 multiple C2 domains, transmembrane 1 -0.0421377
B2M beta-2-microglobulin -0.041619
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0404739
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0394871
LAMC2 laminin, gamma 2 -0.0393278
RPLP1 ribosomal protein, large, P1 -0.0369776
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0367059
SMAD3 SMAD family member 3 -0.0366795
BIRC3 baculoviral IAP repeat containing 3 -0.0364136
BZW1 basic leucine zipper and W2 domains 1 -0.0358119
PGK1 phosphoglycerate kinase 1 -0.0354233
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0352241
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0350832
BLZF1 basic leucine zipper nuclear factor 1 -0.0349544
VCL vinculin -0.034665
NCOA7 nuclear receptor coactivator 7 -0.0344468
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0343346
AHNAK AHNAK nucleoprotein -0.0342361
DSCAM Down syndrome cell adhesion molecule -0.0341689
AKAP13 A kinase (PRKA) anchor protein 13 -0.0340771
GRAMD1B GRAM domain containing 1B -0.0331696
RPL35A ribosomal protein L35a -0.032927
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.032487
LAMA4 laminin, alpha 4 -0.0324179
JMJD1C jumonji domain containing 1C -0.0323138
SAMD4A sterile alpha motif domain containing 4A -0.0320943
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0319966
BCAR3 breast cancer anti-estrogen resistance 3 -0.0317725
BTG1 B-cell translocation gene 1, anti-proliferative -0.0314191
TJP1 tight junction protein 1 -0.0314185
TXNRD1 thioredoxin reductase 1 -0.0306456
PATJ PATJ crumbs cell polarity complex component -0.0303801
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0302355
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0298556
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.029738
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0297109
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0295691
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0294006
SMYD3 SET and MYND domain containing 3 -0.0290668
AREG amphiregulin -0.0290333
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0289611
EXT1 exostosin glycosyltransferase 1 -0.0289315
RAB10 RAB10, member RAS oncogene family -0.0284912
TES testin LIM domain protein -0.0284338
IGF1R insulin-like growth factor 1 receptor -0.0283924
NCOA3 nuclear receptor coactivator 3 -0.0279659
FRY furry homolog (Drosophila) -0.0278975
INTS6 integrator complex subunit 6 -0.0276548
LOC102724023 ES1 protein homolog, mitochondrial -0.0276156
NABP1 nucleic acid binding protein 1 -0.0275097
LGALS12 lectin, galactoside-binding, soluble, 12 -0.027454
AGO2 argonaute RISC catalytic component 2 -0.0274173
MT1X metallothionein 1X -0.0273093
KRT7 keratin 7, type II -0.0272874
EZR ezrin -0.0272829
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0272163
CMIP c-Maf inducing protein -0.0271666
HLA-B major histocompatibility complex, class I, B -0.0266943
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0266356
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0265058
SDC4 syndecan 4 -0.026247
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0261263
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0259448