Docetaxel (Trihydrate)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel (Trihydrate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel (Trihydrate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LOC102724023 ES1 protein homolog, mitochondrial 0.152666
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.107102
MT2A metallothionein 2A 0.102471
TRIO trio Rho guanine nucleotide exchange factor 0.0903958
HLA-B major histocompatibility complex, class I, B 0.0898953
IGF2 insulin-like growth factor 2 0.0863398
PRRC2C proline-rich coiled-coil 2C 0.0857633
RPLP2 ribosomal protein, large, P2 0.0821581
FAM13A family with sequence similarity 13, member A 0.0806946
CANX calnexin 0.0806015
PTMA prothymosin, alpha 0.0745641
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0740192
RPL5 ribosomal protein L5 0.0692778
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0679036
RPL38 ribosomal protein L38 0.0666298
EGFR epidermal growth factor receptor 0.0645047
TMSB10 thymosin beta 10 0.063687
PNISR PNN-interacting serine/arginine-rich protein 0.0632342
RPS6 ribosomal protein S6 0.060142
NDRG1 N-myc downstream regulated 1 0.0591598
SCAPER S-phase cyclin A-associated protein in the ER 0.0589252
CSDE1 cold shock domain containing E1, RNA-binding 0.0585143
CTNND1 catenin (cadherin-associated protein), delta 1 0.0569388
EPS8 epidermal growth factor receptor pathway substrate 8 0.0568749
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0566918
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0566776
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0565227
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0559671
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0557957
SNX9 sorting nexin 9 0.054988
VIM vimentin 0.0546005
RPL28 ribosomal protein L28 0.0533796
CELF1 CUGBP, Elav-like family member 1 0.052966
RYBP RING1 and YY1 binding protein 0.0524954
RPL23 ribosomal protein L23 0.0524769
STAG2 stromal antigen 2 0.0523528
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0521658
RPL34 ribosomal protein L34 0.0519241
BHLHE40 basic helix-loop-helix family, member e40 0.0510998
SMC3 structural maintenance of chromosomes 3 0.0507842
RAB1A RAB1A, member RAS oncogene family 0.0507841
CTBP2 C-terminal binding protein 2 0.0504022
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0502414
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0497731
MYOF myoferlin 0.0495517
CD63 CD63 molecule 0.0494224
EML4 echinoderm microtubule associated protein like 4 0.0479712
NAP1L1 nucleosome assembly protein 1-like 1 0.047776
KMT2A lysine (K)-specific methyltransferase 2A 0.0474372
RPL36A ribosomal protein L36a 0.0470059
AFF4 AF4/FMR2 family, member 4 0.0465734
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0459953
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0456127
DCP1A decapping mRNA 1A 0.0452384
SDK1 sidekick cell adhesion molecule 1 0.0451778
RACK1 receptor for activated C kinase 1 0.0450695
RPL19 ribosomal protein L19 0.0444856
FNBP1 formin binding protein 1 0.0435528
CENPF centromere protein F, 350/400kDa 0.0434092
AKAP12 A kinase (PRKA) anchor protein 12 0.0432356
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0428753
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0428144
HILPDA hypoxia inducible lipid droplet-associated 0.0425794
CALR calreticulin 0.0425535
KDM3A lysine (K)-specific demethylase 3A 0.0421939
RPL9 ribosomal protein L9 0.0421232
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.041833
HELZ helicase with zinc finger 0.0417209
YY1 YY1 transcription factor 0.0407487
RPS5 ribosomal protein S5 0.040572
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0405358
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.040271
FAM162A family with sequence similarity 162, member A 0.04027
EIF1 eukaryotic translation initiation factor 1 0.0398642
RPLP1 ribosomal protein, large, P1 0.0393864
TNRC6B trinucleotide repeat containing 6B 0.0392812
B2M beta-2-microglobulin 0.038932
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0384745
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0382811
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0378235
TPT1 tumor protein, translationally-controlled 1 0.0378124
SCAF8 SR-related CTD-associated factor 8 0.0377457
USP3 ubiquitin specific peptidase 3 0.0375592
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0372003
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0371984
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0368197
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0366851
ZNF148 zinc finger protein 148 0.0364447
HIP1 huntingtin interacting protein 1 0.0360157
LOXL2 lysyl oxidase-like 2 0.0357842
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0354147
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0354077
ARRDC3 arrestin domain containing 3 0.0352659
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0352203
PTK2 protein tyrosine kinase 2 0.0352154
TXNRD1 thioredoxin reductase 1 0.0351269
SCAF11 SR-related CTD-associated factor 11 0.0351177
SET SET nuclear proto-oncogene 0.0350907
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0349196
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.034245

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.212003
FN1 fibronectin 1 -0.123991
SEC31A SEC31 homolog A (S. cerevisiae) -0.10299
S100A9 S100 calcium binding protein A9 -0.0974254
ZMYND8 zinc finger, MYND-type containing 8 -0.095118
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0906971
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0900281
EZR ezrin -0.0889823
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0874756
ASPH aspartate beta-hydroxylase -0.0800552
GPC6 glypican 6 -0.0796318
DSCAM Down syndrome cell adhesion molecule -0.0746728
KRT17 keratin 17, type I -0.0735615
EXT1 exostosin glycosyltransferase 1 -0.073268
JMJD1C jumonji domain containing 1C -0.0729704
KYNU kynureninase -0.0704857
MYO1E myosin IE -0.065942
THBS1 thrombospondin 1 -0.0656973
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0637765
MAML2 mastermind-like 2 (Drosophila) -0.0634583
NT5C2 5'-nucleotidase, cytosolic II -0.0632741
MBD5 methyl-CpG binding domain protein 5 -0.0618066
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0614731
NKD1 naked cuticle homolog 1 (Drosophila) -0.061331
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0612402
ERBIN erbb2 interacting protein -0.0597093
GOLGB1 golgin B1 -0.0595387
MED13L mediator complex subunit 13-like -0.0588826
SIK3 SIK family kinase 3 -0.0587489
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0573296
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0556218
CYRIB CYFIP related Rac1 interactor B -0.0553315
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -0.0550074
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0549248
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0543455
EXOC4 exocyst complex component 4 -0.0530478
EFNA5 ephrin-A5 -0.0524539
RCOR1 REST corepressor 1 -0.0521465
TSHZ2 teashirt zinc finger homeobox 2 -0.0520523
ELL2 elongation factor, RNA polymerase II, 2 -0.0517512
KMT2C lysine (K)-specific methyltransferase 2C -0.0511665
ADNP activity-dependent neuroprotector homeobox -0.0510334
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0508109
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0505825
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0503168
CAPN2 calpain 2, (m/II) large subunit -0.0501979
AGO2 argonaute RISC catalytic component 2 -0.0501103
CADM2 cell adhesion molecule 2 -0.0497844
RNF145 ring finger protein 145 -0.0495037
ARB2A ARB2 cotranscriptional regulator A -0.0484812
BIRC6 baculoviral IAP repeat containing 6 -0.0484191
LRMDA leucine rich melanocyte differentiation associated -0.0482164
ABHD17C abhydrolase domain containing 17C -0.0477479
DSPP dentin sialophosphoprotein -0.047645
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0472284
NPC1 Niemann-Pick disease, type C1 -0.0467093
CSNK1A1 casein kinase 1, alpha 1 -0.0462917
MAML3 mastermind-like 3 (Drosophila) -0.0461708
PARD3 par-3 family cell polarity regulator -0.0460119
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0442555
KDM6A lysine (K)-specific demethylase 6A -0.0440776
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0433541
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0433371
RORA RAR-related orphan receptor A -0.0432905
NIPBL Nipped-B homolog (Drosophila) -0.0431067
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0430623
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0428183
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0426163
GRAMD2B GRAM domain containing 2B -0.0424891
KDM2A lysine (K)-specific demethylase 2A -0.0422438
DIAPH1 diaphanous-related formin 1 -0.0421805
NCOA3 nuclear receptor coactivator 3 -0.0410776
SMC5 structural maintenance of chromosomes 5 -0.0407223
CMIP c-Maf inducing protein -0.0406236
RAB10 RAB10, member RAS oncogene family -0.0401463
MSI2 musashi RNA-binding protein 2 -0.0399832
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.03989
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0398726
CEMIP cell migration inducing protein, hyaluronan binding -0.0390463
SOS1 son of sevenless homolog 1 (Drosophila) -0.038661
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0383783
ESYT2 extended synaptotagmin-like protein 2 -0.0382959
INTS6 integrator complex subunit 6 -0.0382706
LOC112694756 uncharaterized LOC112694756 -0.0380773
ATOSA atos homolog A -0.0380768
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0372951
RAI14 retinoic acid induced 14 -0.0372883
SNX14 sorting nexin 14 -0.0371498
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0370127
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0368096
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0359383
ENO1 enolase 1, (alpha) -0.0358214
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0353958
ANXA2 annexin A2 -0.0349131
MAPK6 mitogen-activated protein kinase 6 -0.0348868
PRKCA protein kinase C, alpha -0.03446
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0340575
RPL35A ribosomal protein L35a -0.0339978
RNF213 ring finger protein 213 -0.0339537
PDIA3 protein disulfide isomerase family A, member 3 -0.0337912