| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Docetaxel (Trihydrate) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Docetaxel (Trihydrate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.135391 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0770513 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0607298 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0580451 |
| RTN4 | reticulon 4 | 0.0579808 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0578942 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0573153 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0518584 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0479648 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0470214 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0455418 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0437376 |
| TPM3 | tropomyosin 3 | 0.0433524 |
| MKI67 | marker of proliferation Ki-67 | 0.0428574 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0426425 |
| CCNL1 | cyclin L1 | 0.0402862 |
| PCBP2 | poly(rC) binding protein 2 | 0.0392225 |
| NUP153 | nucleoporin 153kDa | 0.0381366 |
| NCKAP1 | NCK-associated protein 1 | 0.037908 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0374901 |
| SRPK1 | SRSF protein kinase 1 | 0.0364339 |
| XPO1 | exportin 1 | 0.035877 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0348309 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0345569 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0344244 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0342336 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0338104 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0336927 |
| MED13L | mediator complex subunit 13-like | 0.0336121 |
| CAPRIN1 | cell cycle associated protein 1 | 0.0332949 |
| JMJD1C | jumonji domain containing 1C | 0.0328222 |
| SRPK2 | SRSF protein kinase 2 | 0.0327554 |
| PTK2 | protein tyrosine kinase 2 | 0.0324429 |
| WDR43 | WD repeat domain 43 | 0.0315937 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0312345 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0312257 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.031018 |
| CDYL | chromodomain protein, Y-like | 0.0309464 |
| CPNE8 | copine VIII | 0.0302851 |
| COG5 | component of oligomeric golgi complex 5 | 0.030216 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0297198 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0295482 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0292108 |
| FOXJ3 | forkhead box J3 | 0.0290146 |
| NUP58 | nucleoporin 58 | 0.0286955 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0286726 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0286703 |
| IL6ST | interleukin 6 signal transducer | 0.0284312 |
| SPAG9 | sperm associated antigen 9 | 0.0283118 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0282746 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0277569 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0276304 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0276264 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0275991 |
| TBK1 | TANK-binding kinase 1 | 0.0275826 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0273844 |
| UBC | ubiquitin C | 0.0269734 |
| CUL3 | cullin 3 | 0.0267511 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0264422 |
| CLTC | clathrin, heavy chain (Hc) | 0.0262904 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0262479 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0261576 |
| BBX | bobby sox homolog (Drosophila) | 0.0259933 |
| ZNF292 | zinc finger protein 292 | 0.0259828 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0259448 |
| CENPF | centromere protein F, 350/400kDa | 0.0258303 |
| MSH6 | mutS homolog 6 | 0.0256734 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0256473 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0256163 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0255314 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0254047 |
| ENO1 | enolase 1, (alpha) | 0.0250297 |
| NOP58 | NOP58 ribonucleoprotein | 0.0249243 |
| MEMO1 | mediator of cell motility 1 | 0.0248079 |
| MELK | maternal embryonic leucine zipper kinase | 0.0246263 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0245848 |
| RASAL2 | RAS protein activator like 2 | 0.0243321 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0243253 |
| SLMAP | sarcolemma associated protein | 0.024072 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0240003 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0239584 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0238874 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0238396 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0237787 |
| GPHN | gephyrin | 0.0237025 |
| ATXN2 | ataxin 2 | 0.0233702 |
| TFG | TRK-fused gene | 0.0232932 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.023103 |
| MSN | moesin | 0.0230707 |
| PTEN | phosphatase and tensin homolog | 0.0230591 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0228137 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0227686 |
| FAM168A | family with sequence similarity 168, member A | 0.0227457 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0227173 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0226769 |
| SPPL3 | signal peptide peptidase like 3 | 0.0226095 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.022606 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0225683 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0224414 |
| NEK7 | NIMA-related kinase 7 | 0.0223244 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.172426 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.122132 |
| PTMA | prothymosin, alpha | -0.11274 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.112334 |
| TMSB10 | thymosin beta 10 | -0.108212 |
| YBX3 | Y box binding protein 3 | -0.0980986 |
| MCL1 | myeloid cell leukemia 1 | -0.0648888 |
| PDE10A | phosphodiesterase 10A | -0.0621237 |
| RPS21 | ribosomal protein S21 | -0.0617604 |
| RPS8 | ribosomal protein S8 | -0.0616202 |
| ACTG1 | actin gamma 1 | -0.0602627 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0581857 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0569002 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0563239 |
| PRELID2 | PRELI domain containing 2 | -0.05606 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0556788 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0547519 |
| RPL35A | ribosomal protein L35a | -0.0544322 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0544315 |
| RPL26 | ribosomal protein L26 | -0.0528703 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0498593 |
| RPLP1 | ribosomal protein, large, P1 | -0.0493364 |
| WWOX | WW domain containing oxidoreductase | -0.0480615 |
| MT2A | metallothionein 2A | -0.0470472 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0459456 |
| HLA-B | major histocompatibility complex, class I, B | -0.0456197 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0448509 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0443919 |
| RPS3 | ribosomal protein S3 | -0.0433346 |
| RPLP2 | ribosomal protein, large, P2 | -0.0431306 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0422312 |
| RPS29 | ribosomal protein S29 | -0.0421758 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0417211 |
| RYR3 | ryanodine receptor 3 | -0.0412928 |
| RPS19 | ribosomal protein S19 | -0.0412851 |
| AEBP2 | AE binding protein 2 | -0.0410348 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0403582 |
| RNF213 | ring finger protein 213 | -0.0402396 |
| VIM | vimentin | -0.040215 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0396882 |
| RPL37A | ribosomal protein L37a | -0.0395002 |
| RPL34 | ribosomal protein L34 | -0.0390479 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.038969 |
| RPL11 | ribosomal protein L11 | -0.0387144 |
| RAD51B | RAD51 paralog B | -0.0386753 |
| EGR1 | early growth response 1 | -0.03863 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.038498 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0384627 |
| HMGA2 | high mobility group AT-hook 2 | -0.0383855 |
| PFN1 | profilin 1 | -0.0381947 |
| RPL9 | ribosomal protein L9 | -0.0377457 |
| RPL36 | ribosomal protein L36 | -0.0367918 |
| RPL23 | ribosomal protein L23 | -0.0361348 |
| RPL12 | ribosomal protein L12 | -0.0353732 |
| RPL38 | ribosomal protein L38 | -0.0348985 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0348602 |
| RPS27A | ribosomal protein S27a | -0.0344086 |
| RPS15 | ribosomal protein S15 | -0.0338611 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0337266 |
| RPS12 | ribosomal protein S12 | -0.0335698 |
| ATG7 | autophagy related 7 | -0.0327066 |
| CAVIN1 | caveolae associated protein 1 | -0.0326889 |
| RPS27 | ribosomal protein S27 | -0.0326452 |
| RPL5 | ribosomal protein L5 | -0.0323996 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0320233 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0318063 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0311801 |
| INTS6 | integrator complex subunit 6 | -0.0309216 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0307211 |
| RPS6 | ribosomal protein S6 | -0.0306896 |
| ATP11A | ATPase, class VI, type 11A | -0.0303693 |
| VCL | vinculin | -0.0299568 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0298726 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0295709 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0292093 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.029068 |
| GRAMD1B | GRAM domain containing 1B | -0.029015 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0288953 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0288816 |
| RPL31 | ribosomal protein L31 | -0.0288441 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.028768 |
| RPL32 | ribosomal protein L32 | -0.0282734 |
| RPS4X | ribosomal protein S4, X-linked | -0.0282724 |
| RPL37 | ribosomal protein L37 | -0.0276869 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0274698 |
| ATXN1 | ataxin 1 | -0.0274292 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0270835 |
| RPL19 | ribosomal protein L19 | -0.0269205 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0268787 |
| IER3 | immediate early response 3 | -0.0267012 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0264106 |
| HDAC4 | histone deacetylase 4 | -0.0256266 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0255394 |
| TPI1 | triosephosphate isomerase 1 | -0.0253404 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0252144 |
| DENND5B | DENN/MADD domain containing 5B | -0.0250392 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0250165 |
| SVIL | supervillin | -0.024781 |
| LOXL2 | lysyl oxidase-like 2 | -0.0246191 |
| RPL30 | ribosomal protein L30 | -0.0245583 |
