Docetaxel (Trihydrate)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel (Trihydrate) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel (Trihydrate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.248352
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0996635
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0924121
RPS3 ribosomal protein S3 0.0727597
RPS6 ribosomal protein S6 0.0673607
MKI67 marker of proliferation Ki-67 0.0570467
RPL37A ribosomal protein L37a 0.0535119
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0534517
RPS27A ribosomal protein S27a 0.0518136
CENPF centromere protein F, 350/400kDa 0.0509676
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0508344
RPL26 ribosomal protein L26 0.0506494
SET SET nuclear proto-oncogene 0.0489539
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0488131
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0461466
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0440329
SMC1A structural maintenance of chromosomes 1A 0.0438346
TMSB4X thymosin beta 4, X-linked 0.0419787
RPS8 ribosomal protein S8 0.0406278
NAP1L1 nucleosome assembly protein 1-like 1 0.0395413
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0389608
RPS12 ribosomal protein S12 0.0385566
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.03549
RPL38 ribosomal protein L38 0.0345185
RPL23 ribosomal protein L23 0.0341513
SRRM2 serine/arginine repetitive matrix 2 0.0341092
CALR calreticulin 0.0333799
RPS25 ribosomal protein S25 0.0329227
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0326782
NIPSNAP2 nipsnap homolog 2 0.0307782
RPL37 ribosomal protein L37 0.0303712
TPT1 tumor protein, translationally-controlled 1 0.0302043
EIF5B eukaryotic translation initiation factor 5B 0.030189
RPL5 ribosomal protein L5 0.0299865
HMGB3 high mobility group box 3 0.029515
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0287688
PEG10 paternally expressed 10 0.0287242
CBX3 chromobox homolog 3 0.0285551
TUBA1B tubulin, alpha 1b 0.028426
CALCA calcitonin-related polypeptide alpha 0.0283126
RPL11 ribosomal protein L11 0.0280821
SCG3 secretogranin III 0.0278478
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0276846
TPM3 tropomyosin 3 0.027667
KPNB1 karyopherin (importin) beta 1 0.0275126
KTN1 kinectin 1 (kinesin receptor) 0.0274227
SINHCAF SIN3-HDAC complex associated factor 0.0273141
RAD21 RAD21 homolog (S. pombe) 0.0270259
HDGF hepatoma-derived growth factor 0.0269488
RPLP2 ribosomal protein, large, P2 0.026938
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.026349
RPL8 ribosomal protein L8 0.0263367
RPL12 ribosomal protein L12 0.0263165
RPS21 ribosomal protein S21 0.0261358
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0254189
RPLP0 ribosomal protein, large, P0 0.0252251
RPS17 ribosomal protein S17 0.0248383
MATR3 matrin 3 0.0243735
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0241377
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.024074
CKAP5 cytoskeleton associated protein 5 0.0234161
KIF1A kinesin family member 1A 0.0231283
KIF5B kinesin family member 5B 0.0231189
RPL7A ribosomal protein L7a 0.0230851
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0229926
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0228189
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0226509
PRRC2C proline-rich coiled-coil 2C 0.0226041
RPL32 ribosomal protein L32 0.0223766
S100A9 S100 calcium binding protein A9 0.0223253
ATP5F1E ATP synthase F1 subunit epsilon 0.0223101
RPS27 ribosomal protein S27 0.0222301
MIS18BP1 MIS18 binding protein 1 0.0222014
FUS FUS RNA binding protein 0.022022
COX6C cytochrome c oxidase subunit VIc 0.0216342
BRIX1 BRX1, biogenesis of ribosomes 0.0215832
RPL19 ribosomal protein L19 0.0215694
HMGB2 high mobility group box 2 0.0212671
EIF1 eukaryotic translation initiation factor 1 0.0211984
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0210796
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.020917
RPL36A ribosomal protein L36a 0.0206782
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 0.0206304
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0205877
GOLGA4 golgin A4 0.0203882
EIF4A1 eukaryotic translation initiation factor 4A1 0.0203708
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0203182
CENPE centromere protein E, 312kDa 0.0202175
PBK PDZ binding kinase 0.0202017
RPL31 ribosomal protein L31 0.019893
NUSAP1 nucleolar and spindle associated protein 1 0.0198308
RBM25 RNA binding motif protein 25 0.0196561
RSL1D1 ribosomal L1 domain containing 1 0.0195279
TXNRD1 thioredoxin reductase 1 0.0194799
KIF4A kinesin family member 4A 0.0192453
ATAD2 ATPase family, AAA domain containing 2 0.0189093
RACK1 receptor for activated C kinase 1 0.0187843
XPO1 exportin 1 0.0187138
STMN1 stathmin 1 0.0186963
RPL30 ribosomal protein L30 0.0186469

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.143237
PDE10A phosphodiesterase 10A -0.139677
GPC6 glypican 6 -0.119055
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.104122
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0997641
NALF1 NALCN channel auxiliary factor 1 -0.0902951
SNAP25 synaptosomal-associated protein, 25kDa -0.0767639
NCKAP5 NCK-associated protein 5 -0.0752359
MCL1 myeloid cell leukemia 1 -0.0737559
RORA RAR-related orphan receptor A -0.0723635
NDRG1 N-myc downstream regulated 1 -0.0721775
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0660641
SMYD3 SET and MYND domain containing 3 -0.06332
STC1 stanniocalcin 1 -0.0577826
ESRRG estrogen-related receptor gamma -0.0552658
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0538815
EGR1 early growth response 1 -0.0518506
MT2A metallothionein 2A -0.0511763
EFNA5 ephrin-A5 -0.050889
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.050764
RIMS2 regulating synaptic membrane exocytosis 2 -0.0501216
SNTG1 syntrophin, gamma 1 -0.0496311
TSHZ2 teashirt zinc finger homeobox 2 -0.0470553
PDE4D phosphodiesterase 4D, cAMP-specific -0.0450622
MCTP1 multiple C2 domains, transmembrane 1 -0.0441017
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0431725
KIF26B kinesin family member 26B -0.0425599
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0419936
CNTNAP2 contactin associated protein-like 2 -0.0419867
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0411206
PTCHD4 patched domain containing 4 -0.0408821
FNDC3A fibronectin type III domain containing 3A -0.0392244
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0387411
PCSK1 proprotein convertase subtilisin/kexin type 1 -0.0386993
CNKSR3 CNKSR family member 3 -0.0384559
LSAMP limbic system-associated membrane protein -0.0377366
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -0.0376329
SMOC1 SPARC related modular calcium binding 1 -0.0375441
DOCK5 dedicator of cytokinesis 5 -0.0360164
AUTS2 autism susceptibility candidate 2 -0.0358037
NBEA neurobeachin -0.035432
KLHL29 kelch-like family member 29 -0.0353065
EXT1 exostosin glycosyltransferase 1 -0.0351444
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0347063
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0336055
ZBTB20 zinc finger and BTB domain containing 20 -0.0331818
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0330465
FGF14 fibroblast growth factor 14 -0.0330442
VGF VGF nerve growth factor inducible -0.0320613
TOX thymocyte selection-associated high mobility group box -0.031758
EPHA6 EPH receptor A6 -0.0307026
TENM1 teneurin transmembrane protein 1 -0.0304046
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0303294
BACE2 beta-site APP-cleaving enzyme 2 -0.0299993
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0299772
INHBA inhibin, beta A -0.0298235
NAV2 neuron navigator 2 -0.0297236
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0292435
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0289403
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0285713
ST18 suppression of tumorigenicity 18, zinc finger -0.0281133
CADM1 cell adhesion molecule 1 -0.0280329
TUSC3 tumor suppressor candidate 3 -0.0278399
GMDS GDP-mannose 4,6-dehydratase -0.0271379
SYT1 synaptotagmin I -0.0268855
GRB10 growth factor receptor-bound protein 10 -0.0267926
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0266501
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0262307
NELL1 NEL-like 1 (chicken) -0.026184
SDK1 sidekick cell adhesion molecule 1 -0.0258399
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0258272
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0257315
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 -0.0255013
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.025478
POU6F2 POU class 6 homeobox 2 -0.0252851
NAV1 neuron navigator 1 -0.0250967
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0249499
SIK2 salt-inducible kinase 2 -0.0248029
POTEF POTE ankyrin domain family, member F -0.0246583
GPC5 glypican 5 -0.0245395
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.024445
DOCK4 dedicator of cytokinesis 4 -0.0243761
MACROD2 MACRO domain containing 2 -0.0241249
DENND4A DENN/MADD domain containing 4A -0.023621
PBX3 pre-B-cell leukemia homeobox 3 -0.0232517
ANKRD36C ankyrin repeat domain 36C -0.0229332
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.02292
ASIC2 acid sensing (proton gated) ion channel 2 -0.0229112
ARFGEF3 ARFGEF family member 3 -0.0227894
MBNL2 muscleblind-like splicing regulator 2 -0.0224636
RPH3AL rabphilin 3A-like (without C2 domains) -0.0222086
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0218667
APP amyloid beta (A4) precursor protein -0.0217548
LIMCH1 LIM and calponin homology domains 1 -0.0216365
COL22A1 collagen, type XXII, alpha 1 -0.0213763
ZNF407 zinc finger protein 407 -0.0211761
RAP2A RAP2A, member of RAS oncogene family -0.0209907
ZFHX3 zinc finger homeobox 3 -0.020987
NLGN1 neuroligin 1 -0.020973
IRS2 insulin receptor substrate 2 -0.0208896