Docetaxel (Trihydrate)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel (Trihydrate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Docetaxel (Trihydrate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.0892621
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0504951
RPS12 ribosomal protein S12 0.0473681
TM4SF1 transmembrane 4 L six family member 1 0.0459304
ARHGAP21 Rho GTPase activating protein 21 0.0458694
CALR calreticulin 0.0431225
RPS3 ribosomal protein S3 0.0412822
TPT1 tumor protein, translationally-controlled 1 0.040782
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0406528
HMGA2 high mobility group AT-hook 2 0.0405732
EIF3A eukaryotic translation initiation factor 3, subunit A 0.03869
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0381054
RPS8 ribosomal protein S8 0.0375852
MKI67 marker of proliferation Ki-67 0.0370556
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0354653
RPLP2 ribosomal protein, large, P2 0.035121
RPL37A ribosomal protein L37a 0.0345304
RPL38 ribosomal protein L38 0.0311573
RPS27A ribosomal protein S27a 0.0299288
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0297856
RPL26 ribosomal protein L26 0.0290137
ADM adrenomedullin 0.027195
TUBA1B tubulin, alpha 1b 0.0269439
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0258474
RPL12 ribosomal protein L12 0.0251706
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0247856
RPL23 ribosomal protein L23 0.0242792
MYH9 myosin, heavy chain 9, non-muscle 0.0242475
RPS17 ribosomal protein S17 0.0238404
FLNA filamin A, alpha 0.0237718
EIF5B eukaryotic translation initiation factor 5B 0.0235775
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0232781
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0226425
RPS6 ribosomal protein S6 0.0225987
TUBB4B tubulin, beta 4B class IVb 0.0218877
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0218742
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.021391
RAB13 RAB13, member RAS oncogene family 0.0204959
CKAP2 cytoskeleton associated protein 2 0.0204053
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.020348
CENPE centromere protein E, 312kDa 0.0201205
SRRM2 serine/arginine repetitive matrix 2 0.0200512
RPL11 ribosomal protein L11 0.0200287
TMSB4X thymosin beta 4, X-linked 0.0199434
TMSB10 thymosin beta 10 0.0187788
NAV2 neuron navigator 2 0.0186122
ZBTB38 zinc finger and BTB domain containing 38 0.0185618
EIF1 eukaryotic translation initiation factor 1 0.0180087
LMO7 LIM domain 7 0.0174256
NAP1L1 nucleosome assembly protein 1-like 1 0.0172932
RPL36 ribosomal protein L36 0.017278
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0170697
RPL31 ribosomal protein L31 0.0169846
RPL13A ribosomal protein L13a 0.0169685
RPL37 ribosomal protein L37 0.0165512
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0164782
TXNRD1 thioredoxin reductase 1 0.0164477
RPL19 ribosomal protein L19 0.0163989
RPL7A ribosomal protein L7a 0.016345
RPL5 ribosomal protein L5 0.0163333
AKAP9 A kinase (PRKA) anchor protein 9 0.0161201
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0160381
LMNA lamin A/C 0.0158073
ZC3H13 zinc finger CCCH-type containing 13 0.0157317
PDCD5 programmed cell death 5 0.0156937
SP100 SP100 nuclear antigen 0.0155359
CENPF centromere protein F, 350/400kDa 0.0151652
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0150749
RPS24 ribosomal protein S24 0.0147481
SET SET nuclear proto-oncogene 0.0139908
DOCK5 dedicator of cytokinesis 5 0.013859
SCLT1 sodium channel and clathrin linker 1 0.0137642
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0136841
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0132499
HSPA8 heat shock 70kDa protein 8 0.0130965
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0128676
STC2 stanniocalcin 2 0.0127574
RASA3 RAS p21 protein activator 3 0.0126617
NCKAP5 NCK-associated protein 5 0.0126286
ANTXR2 anthrax toxin receptor 2 0.0124877
RPL3 ribosomal protein L3 0.0124791
TPX2 TPX2, microtubule-associated 0.0122997
H2AZ1 H2A.Z variant histone 1 0.0122972
ARHGAP22 Rho GTPase activating protein 22 0.0122832
IGF1R insulin-like growth factor 1 receptor 0.0122803
HIPK2 homeodomain interacting protein kinase 2 0.0122724
RPS19 ribosomal protein S19 0.0121935
RPL21 ribosomal protein L21 0.0121365
SAMD4A sterile alpha motif domain containing 4A 0.0120096
OR51B5 olfactory receptor, family 51, subfamily B, member 5 0.0119774
UBC ubiquitin C 0.0119762
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0119512
SMC4 structural maintenance of chromosomes 4 0.0119133
FRMPD4 FERM and PDZ domain containing 4 0.0119055
SON SON DNA binding protein 0.0116961
FNBP4 formin binding protein 4 0.0116501
TBCA tubulin folding cofactor A 0.0115579
RPL9 ribosomal protein L9 0.0115568
RBBP6 retinoblastoma binding protein 6 0.0115517
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0115305

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.27129
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.216538
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.14313
COL6A3 collagen, type VI, alpha 3 -0.132697
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.130533
NDRG1 N-myc downstream regulated 1 -0.125672
FNDC3B fibronectin type III domain containing 3B -0.116618
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.114216
NALF1 NALCN channel auxiliary factor 1 -0.107723
B2M beta-2-microglobulin -0.106334
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0869295
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0841562
MYO10 myosin X -0.0827446
COL1A2 collagen, type I, alpha 2 -0.0810112
ADGRB3 adhesion G protein-coupled receptor B3 -0.0790853
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0786444
SOD2 superoxide dismutase 2, mitochondrial -0.0758398
LDHA lactate dehydrogenase A -0.073493
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0682068
EMP1 epithelial membrane protein 1 -0.0675473
INHBA inhibin, beta A -0.0669132
STC1 stanniocalcin 1 -0.0655714
CD44 CD44 molecule (Indian blood group) -0.0633855
ELL2 elongation factor, RNA polymerase II, 2 -0.0622716
COL6A1 collagen, type VI, alpha 1 -0.0588008
FTL ferritin, light polypeptide -0.0582571
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0562994
AKAP12 A kinase (PRKA) anchor protein 12 -0.056087
COL1A1 collagen, type I, alpha 1 -0.0557569
OXR1 oxidation resistance 1 -0.0554009
CALD1 caldesmon 1 -0.0548883
ATP13A3 ATPase type 13A3 -0.0546544
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0546032
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0537301
NAV1 neuron navigator 1 -0.0534213
TGFBI transforming growth factor, beta-induced, 68kDa -0.0531011
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0528079
PKM pyruvate kinase, muscle -0.0523553
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0506603
PDIA3 protein disulfide isomerase family A, member 3 -0.046965
MMP1 matrix metallopeptidase 1 -0.04587
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0458089
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0446791
LOX lysyl oxidase -0.0445046
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0433982
LOXL2 lysyl oxidase-like 2 -0.0431834
POTEF POTE ankyrin domain family, member F -0.043125
FAM13A family with sequence similarity 13, member A -0.0430261
MED13L mediator complex subunit 13-like -0.041951
COL6A2 collagen, type VI, alpha 2 -0.0410317
NAMPT nicotinamide phosphoribosyltransferase -0.0399521
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0399449
VIM vimentin -0.039738
ADAM9 ADAM metallopeptidase domain 9 -0.0384975
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0384307
EGFR epidermal growth factor receptor -0.0380287
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0378047
CAV1 caveolin 1, caveolae protein, 22kDa -0.0374155
COL5A2 collagen, type V, alpha 2 -0.0373327
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0370478
LOC112694756 uncharaterized LOC112694756 -0.0362801
FTH1 ferritin, heavy polypeptide 1 -0.0360326
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0357239
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0356666
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0350584
SETD5 SET domain containing 5 -0.034473
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0343355
PDE8A phosphodiesterase 8A -0.0337181
JARID2 jumonji, AT rich interactive domain 2 -0.0331547
ABI3BP ABI family, member 3 (NESH) binding protein -0.0328403
RNF145 ring finger protein 145 -0.0325915
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.032482
UBA6 ubiquitin-like modifier activating enzyme 6 -0.032435
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0322775
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0320609
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0316364
RUNX1 runt-related transcription factor 1 -0.0311007
MYOF myoferlin -0.0310415
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0310294
SPAG9 sperm associated antigen 9 -0.0302153
PDE4D phosphodiesterase 4D, cAMP-specific -0.0299257
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0297218
SEPTIN11 septin 11 -0.0295509
PICALM phosphatidylinositol binding clathrin assembly protein -0.029478
CLTC clathrin, heavy chain (Hc) -0.0292385
RTN4 reticulon 4 -0.0289735
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0284984
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0283844
HELZ helicase with zinc finger -0.0282001
CD59 CD59 molecule, complement regulatory protein -0.0281737
ASPH aspartate beta-hydroxylase -0.028158
GLIS3 GLIS family zinc finger 3 -0.0277851
COPA coatomer protein complex, subunit alpha -0.0276736
HILPDA hypoxia inducible lipid droplet-associated -0.0275137
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0273574
LMAN1 lectin, mannose-binding, 1 -0.0265685
PFN1 profilin 1 -0.0265038
EGR1 early growth response 1 -0.0264465
USP3 ubiquitin specific peptidase 3 -0.026088
MT2A metallothionein 2A -0.0260663