Docetaxel_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.188646
EXT1 exostosin glycosyltransferase 1 0.0999487
ZSWIM6 zinc finger, SWIM-type containing 6 0.0997022
RACK1 receptor for activated C kinase 1 0.0887363
BPTF bromodomain PHD finger transcription factor 0.0685527
VMP1 vacuole membrane protein 1 0.0684766
TLE4 transducin-like enhancer of split 4 0.0678919
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0611548
IGF2 insulin-like growth factor 2 0.0603021
TPM1 tropomyosin 1 (alpha) 0.0598367
SLIT2 slit homolog 2 (Drosophila) 0.0598338
ANTXR1 anthrax toxin receptor 1 0.0571242
EGR1 early growth response 1 0.0551503
HOMER1 homer scaffolding protein 1 0.051943
MCL1 myeloid cell leukemia 1 0.0515158
TPM4 tropomyosin 4 0.0508281
LPP LIM domain containing preferred translocation partner in lipoma 0.0503295
ENAH enabled homolog (Drosophila) 0.0486851
THSD4 thrombospondin, type I, domain containing 4 0.0484732
CRH corticotropin releasing hormone 0.0471032
SIK2 salt-inducible kinase 2 0.046319
PDE4D phosphodiesterase 4D, cAMP-specific 0.0459771
TIMP3 TIMP metallopeptidase inhibitor 3 0.0459752
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0449236
STK38L serine/threonine kinase 38 like 0.0444281
GREM2 gremlin 2, DAN family BMP antagonist 0.0437939
PDE10A phosphodiesterase 10A 0.0436492
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0429667
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0429405
PDLIM5 PDZ and LIM domain 5 0.0429271
RIGI RNA sensor RIG-I 0.0425772
PACS1 phosphofurin acidic cluster sorting protein 1 0.0417198
INTS6 integrator complex subunit 6 0.0409178
CENPF centromere protein F, 350/400kDa 0.0408055
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0406902
FNDC3A fibronectin type III domain containing 3A 0.0405866
TIMP2 TIMP metallopeptidase inhibitor 2 0.0399872
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0399279
MYO1E myosin IE 0.0393957
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0383539
FN1 fibronectin 1 0.0379984
B2M beta-2-microglobulin 0.0358295
PLAT plasminogen activator, tissue 0.0356623
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0356096
ZBTB20 zinc finger and BTB domain containing 20 0.0353643
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0350558
NPAS2 neuronal PAS domain protein 2 0.0341671
SP100 SP100 nuclear antigen 0.0340038
SLC38A2 solute carrier family 38, member 2 0.0337481
AHR aryl hydrocarbon receptor 0.0334007
RPS12 ribosomal protein S12 0.0322263
FERMT2 fermitin family member 2 0.0322181
SMC4 structural maintenance of chromosomes 4 0.0320016
RPS3 ribosomal protein S3 0.031966
LINGO2 leucine rich repeat and Ig domain containing 2 0.0318706
R3HDM2 R3H domain containing 2 0.0314726
HMGA2 high mobility group AT-hook 2 0.0311824
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0310047
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0308935
SETBP1 SET binding protein 1 0.0307921
THBS1 thrombospondin 1 0.0307021
PTPRD protein tyrosine phosphatase, receptor type, D 0.0304439
APLP2 amyloid beta (A4) precursor-like protein 2 0.0303268
ZNF644 zinc finger protein 644 0.0301787
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0301653
TUBB4B tubulin, beta 4B class IVb 0.0295893
ASPH aspartate beta-hydroxylase 0.0294567
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0293729
LIMA1 LIM domain and actin binding 1 0.0293556
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0292773
PALLD palladin, cytoskeletal associated protein 0.0287683
EEF2 eukaryotic translation elongation factor 2 0.0286287
GLCCI1 glucocorticoid induced 1 0.0286161
SKIL SKI-like proto-oncogene 0.0283229
RPL26 ribosomal protein L26 0.0282638
ITPRID2 ITPR interacting domain containing 2 0.0279359
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.027847
FLNA filamin A, alpha 0.0277825
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0277672
ACTN1 actinin, alpha 1 0.0274586
RNF213 ring finger protein 213 0.0274349
GPBP1 GC-rich promoter binding protein 1 0.0273619
CEP112 centrosomal protein 112kDa 0.0272776
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0271435
SH3PXD2A SH3 and PX domains 2A 0.0269776
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0260586
BICD1 bicaudal D homolog 1 (Drosophila) 0.0260398
SFPQ splicing factor proline/glutamine-rich 0.0258951
SLITRK6 SLIT and NTRK-like family, member 6 0.0254862
FHL2 four and a half LIM domains 2 0.0254522
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0251882
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0247999
N4BP2L2 NEDD4 binding protein 2-like 2 0.0245487
GOLGB1 golgin B1 0.0244227
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0243856
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0241891
AKAP9 A kinase (PRKA) anchor protein 9 0.0241507
TUBB tubulin, beta class I 0.0241138
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0236793
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0235446

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.272441
AKAP12 A kinase (PRKA) anchor protein 12 -0.128281
COL3A1 collagen, type III, alpha 1 -0.105098
MEIS2 Meis homeobox 2 -0.103482
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0936035
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0928235
COL1A1 collagen, type I, alpha 1 -0.0797401
TRIB2 tribbles pseudokinase 2 -0.0753831
PTMA prothymosin, alpha -0.0752742
LPIN1 lipin 1 -0.0718038
SOS1 son of sevenless homolog 1 (Drosophila) -0.0703413
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0661431
HELZ helicase with zinc finger -0.0597286
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0584109
NPEPPS aminopeptidase puromycin sensitive -0.0582168
OGA O-GlcNAcase -0.05734
FAM13A family with sequence similarity 13, member A -0.056295
NCAM2 neural cell adhesion molecule 2 -0.0558474
WDR45B WD repeat domain 45B -0.0552449
ZNF292 zinc finger protein 292 -0.0544285
HAND2 heart and neural crest derivatives expressed 2 -0.0538363
KDM3A lysine (K)-specific demethylase 3A -0.0525079
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0522572
FNBP1 formin binding protein 1 -0.0503416
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0493641
RPL38 ribosomal protein L38 -0.0490705
GOLGA4 golgin A4 -0.0486639
NAMPT nicotinamide phosphoribosyltransferase -0.0485665
AOPEP aminopeptidase O (putative) -0.0483441
NRP1 neuropilin 1 -0.0463157
KMT2C lysine (K)-specific methyltransferase 2C -0.0456791
C1ORF21 chromosome 1 open reading frame 21 -0.0443416
MAP1B microtubule-associated protein 1B -0.0435307
TAS2R14 taste receptor, type 2, member 14 -0.0433413
UBE2O ubiquitin-conjugating enzyme E2O -0.0424008
RPL4 ribosomal protein L4 -0.0422914
USP3 ubiquitin specific peptidase 3 -0.0417706
AHNAK AHNAK nucleoprotein -0.0399171
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0389616
LMNA lamin A/C -0.0385366
CSDE1 cold shock domain containing E1, RNA-binding -0.0384269
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.0376257
TRIO trio Rho guanine nucleotide exchange factor -0.037556
GARS1 glycyl-tRNA synthetase 1 -0.0366036
NALF1 NALCN channel auxiliary factor 1 -0.0364151
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0360879
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0357066
CANX calnexin -0.0354699
KPNB1 karyopherin (importin) beta 1 -0.0354322
SYT1 synaptotagmin I -0.0353269
LCORL ligand dependent nuclear receptor corepressor-like -0.0345508
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0344073
FOXK2 forkhead box K2 -0.0342277
RHOBTB3 Rho-related BTB domain containing 3 -0.0335663
GNG2 guanine nucleotide binding protein (G protein), gamma 2 -0.0335502
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0332232
SSBP2 single-stranded DNA binding protein 2 -0.0325363
VIM vimentin -0.0324873
SEC63 SEC63 homolog (S. cerevisiae) -0.0319569
HIP1 huntingtin interacting protein 1 -0.0310358
RPLP1 ribosomal protein, large, P1 -0.0308464
SEPTIN2 septin 2 -0.0307698
NEK7 NIMA-related kinase 7 -0.0291746
DNMBP dynamin binding protein -0.0289896
LMAN1 lectin, mannose-binding, 1 -0.0288742
MATR3 matrin 3 -0.0281177
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0277122
ARF1 ADP-ribosylation factor 1 -0.0271483
CD36 CD36 molecule (thrombospondin receptor) -0.0270964
CDC27 cell division cycle 27 -0.0270908
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0268178
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0267981
MARCHF6 membrane associated ring-CH-type finger 6 -0.0266762
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0264444
ANXA2 annexin A2 -0.0263826
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0263608
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0262206
KDM5B lysine (K)-specific demethylase 5B -0.026205
PHF3 PHD finger protein 3 -0.0260649
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0258298
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0254125
SQSTM1 sequestosome 1 -0.0254047
NREP neuronal regeneration related protein -0.0253354
GPHN gephyrin -0.0252395
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0250711
RPS19 ribosomal protein S19 -0.0249019
UNC5C unc-5 homolog C (C. elegans) -0.0248893
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0247565
TM9SF3 transmembrane 9 superfamily member 3 -0.0247431
RPS24 ribosomal protein S24 -0.0246886
S100A6 S100 calcium binding protein A6 -0.0246097
CEP95 centrosomal protein 95kDa -0.0245618
DDIT4 DNA-damage-inducible transcript 4 -0.0243193
KMT2E lysine (K)-specific methyltransferase 2E -0.0241618
RTN4 reticulon 4 -0.0238337
BIRC6 baculoviral IAP repeat containing 6 -0.0238107
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0234852
DPH6 diphthamine biosynthesis 6 -0.023445
RAD21 RAD21 homolog (S. pombe) -0.0233868
FBXL20 F-box and leucine-rich repeat protein 20 -0.0232486