Docetaxel_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0483131
PDE4D phosphodiesterase 4D, cAMP-specific 0.0466828
MBNL1 muscleblind-like splicing regulator 1 0.0420944
INTS6 integrator complex subunit 6 0.0411192
MACF1 microtubule-actin crosslinking factor 1 0.0404492
DOK5 docking protein 5 0.0395707
BCAR3 breast cancer anti-estrogen resistance 3 0.03795
SMAD3 SMAD family member 3 0.036588
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0351194
AOPEP aminopeptidase O (putative) 0.0320681
FNDC3B fibronectin type III domain containing 3B 0.0313648
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0308473
ZSWIM6 zinc finger, SWIM-type containing 6 0.0295319
PRELID2 PRELI domain containing 2 0.028998
MYOF myoferlin 0.0287414
LAMA5 laminin, alpha 5 0.0287168
LMO7 LIM domain 7 0.0282392
PDLIM5 PDZ and LIM domain 5 0.0279972
EFNA5 ephrin-A5 0.0267875
HMGA2 high mobility group AT-hook 2 0.0266329
MYH9 myosin, heavy chain 9, non-muscle 0.0262853
ASPH aspartate beta-hydroxylase 0.0260592
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0259816
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0258102
SMYD3 SET and MYND domain containing 3 0.0253342
PLEC plectin 0.0250722
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.024313
RAD51B RAD51 paralog B 0.0243078
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0242533
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0240336
FOXP1 forkhead box P1 0.0232489
MAML2 mastermind-like 2 (Drosophila) 0.0231991
DST dystonin 0.0228513
PTK2 protein tyrosine kinase 2 0.0227033
VCL vinculin 0.0224585
ATXN1 ataxin 1 0.0223559
PICALM phosphatidylinositol binding clathrin assembly protein 0.0217779
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0217608
AKAP13 A kinase (PRKA) anchor protein 13 0.0216282
SH3PXD2A SH3 and PX domains 2A 0.0216165
MSN moesin 0.0214191
CEMIP cell migration inducing protein, hyaluronan binding 0.0213652
RICTOR RPTOR independent companion of MTOR, complex 2 0.0211578
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0211216
SDCCAG8 serologically defined colon cancer antigen 8 0.0203574
KLF5 Kruppel-like factor 5 (intestinal) 0.0198915
CTBP2 C-terminal binding protein 2 0.0193716
JAG1 jagged 1 0.0182145
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0179303
SETBP1 SET binding protein 1 0.0179297
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0179187
ACTN1 actinin, alpha 1 0.0179088
FRMD6 FERM domain containing 6 0.0177779
FMNL2 formin-like 2 0.0177581
WWTR1 WW domain containing transcription regulator 1 0.0177004
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0175577
MEGF6 multiple EGF-like-domains 6 0.0174297
RNF217 ring finger protein 217 0.017284
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0170114
CDK17 cyclin-dependent kinase 17 0.0168892
IRAK2 interleukin-1 receptor-associated kinase 2 0.0166308
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0165093
FLNA filamin A, alpha 0.0164931
DOCK4 dedicator of cytokinesis 4 0.0163826
PLS3 plastin 3 0.0162991
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.016023
MEF2A myocyte enhancer factor 2A 0.015995
RABGAP1L RAB GTPase activating protein 1-like 0.0159254
CMIP c-Maf inducing protein 0.0157057
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0155747
BARX2 BARX homeobox 2 0.0154219
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0154072
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0153721
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0152544
ARHGAP21 Rho GTPase activating protein 21 0.0151749
FAF1 Fas (TNFRSF6) associated factor 1 0.0150892
ARHGAP24 Rho GTPase activating protein 24 0.0149847
AMOTL1 angiomotin like 1 0.0148873
AGO2 argonaute RISC catalytic component 2 0.0145675
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0145356
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.014367
LPP LIM domain containing preferred translocation partner in lipoma 0.0140113
ZMIZ1 zinc finger, MIZ-type containing 1 0.0137606
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0134956
RASAL2 RAS protein activator like 2 0.0133665
KDM4C lysine (K)-specific demethylase 4C 0.0132938
BCR breakpoint cluster region 0.0130633
MED13L mediator complex subunit 13-like 0.0129576
EXOC4 exocyst complex component 4 0.0129539
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0128363
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0127378
LRP1B low density lipoprotein receptor-related protein 1B 0.0126802
TENM4 teneurin transmembrane protein 4 0.0126683
FER fer (fps/fes related) tyrosine kinase 0.0126658
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0126179
SULF2 sulfatase 2 0.0126071
KIAA1217 KIAA1217 0.0124934
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.012256
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0122015
NECTIN1 nectin cell adhesion molecule 1 0.0121651

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.227758
B2M beta-2-microglobulin -0.107785
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0992196
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0893146
PTMA prothymosin, alpha -0.0876091
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0845959
TMSB10 thymosin beta 10 -0.0811846
FLNB filamin B, beta -0.0757213
TMSB4X thymosin beta 4, X-linked -0.0702291
ENO1 enolase 1, (alpha) -0.0633953
LDHA lactate dehydrogenase A -0.0596475
PGK1 phosphoglycerate kinase 1 -0.0593986
TPT1 tumor protein, translationally-controlled 1 -0.0592181
CLU clusterin -0.0590293
NDRG1 N-myc downstream regulated 1 -0.0584846
MT2A metallothionein 2A -0.0584281
RPS21 ribosomal protein S21 -0.0584037
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0576188
NAMPT nicotinamide phosphoribosyltransferase -0.0552794
RPS8 ribosomal protein S8 -0.0545723
EMP1 epithelial membrane protein 1 -0.0540444
SULF1 sulfatase 1 -0.0516849
S100A10 S100 calcium binding protein A10 -0.0512982
HLA-B major histocompatibility complex, class I, B -0.0501616
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0481211
IFITM3 interferon induced transmembrane protein 3 -0.0460122
RPS6 ribosomal protein S6 -0.0458269
RPS3 ribosomal protein S3 -0.0452935
CANX calnexin -0.0400442
LMNA lamin A/C -0.0397101
GOLGA4 golgin A4 -0.0397079
RPLP1 ribosomal protein, large, P1 -0.0394141
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0388728
RPL11 ribosomal protein L11 -0.0381862
GNAS GNAS complex locus -0.0375949
FTL ferritin, light polypeptide -0.0375898
KRT17 keratin 17, type I -0.0367685
RPS13 ribosomal protein S13 -0.0361005
IGF2 insulin-like growth factor 2 -0.0359396
IFITM1 interferon induced transmembrane protein 1 -0.0358861
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0358094
RACK1 receptor for activated C kinase 1 -0.0357016
HM13 histocompatibility (minor) 13 -0.0354022
HLA-E major histocompatibility complex, class I, E -0.0353161
EZR ezrin -0.0351497
RPL12 ribosomal protein L12 -0.0346997
PODXL podocalyxin-like -0.0343135
S100A6 S100 calcium binding protein A6 -0.0336452
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0336104
CALU calumenin -0.0334209
RPLP2 ribosomal protein, large, P2 -0.0333455
ALCAM activated leukocyte cell adhesion molecule -0.0325065
RPS12 ribosomal protein S12 -0.0323102
RPS19 ribosomal protein S19 -0.032233
S100A11 S100 calcium binding protein A11 -0.031286
ANXA2 annexin A2 -0.0311274
RPL35A ribosomal protein L35a -0.0300964
PRRC2C proline-rich coiled-coil 2C -0.0295504
GARS1 glycyl-tRNA synthetase 1 -0.0291559
RPS25 ribosomal protein S25 -0.0288904
RPL37 ribosomal protein L37 -0.0286221
RPL34 ribosomal protein L34 -0.0279273
S100A9 S100 calcium binding protein A9 -0.027852
EIF1 eukaryotic translation initiation factor 1 -0.0277852
ABI3BP ABI family, member 3 (NESH) binding protein -0.0276481
SQLE squalene epoxidase -0.0276175
CD44 CD44 molecule (Indian blood group) -0.0275872
CALR calreticulin -0.0272441
MORF4L2 mortality factor 4 like 2 -0.0272001
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.027018
RPL37A ribosomal protein L37a -0.0266999
RPLP0 ribosomal protein, large, P0 -0.0259869
RPS24 ribosomal protein S24 -0.0259348
RPL26 ribosomal protein L26 -0.0255281
AHNAK AHNAK nucleoprotein -0.0255026
LMAN1 lectin, mannose-binding, 1 -0.0254691
ZMYND8 zinc finger, MYND-type containing 8 -0.0254075
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0253945
CAV1 caveolin 1, caveolae protein, 22kDa -0.0251253
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0251087
RPL31 ribosomal protein L31 -0.0249088
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0249046
H1-0 H1.0 linker histone -0.0246483
WASF2 WAS protein family, member 2 -0.0245574
CD9 CD9 molecule -0.0244348
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0244166
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0243927
CAVIN1 caveolae associated protein 1 -0.0241459
HLA-A major histocompatibility complex, class I, A -0.024118
RAI14 retinoic acid induced 14 -0.0241151
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0239711
RPL19 ribosomal protein L19 -0.0239624
RPS27A ribosomal protein S27a -0.0238157
SEC31A SEC31 homolog A (S. cerevisiae) -0.0236591
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0236563
PKM pyruvate kinase, muscle -0.0235403
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.023507
DSTN destrin (actin depolymerizing factor) -0.0232596
IFI27 interferon, alpha-inducible protein 27 -0.0231821
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.023169