Docetaxel_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Docetaxel_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMAD3 SMAD family member 3 0.0979537
SOD2 superoxide dismutase 2, mitochondrial 0.0715486
GRB10 growth factor receptor-bound protein 10 0.0649241
NAV2 neuron navigator 2 0.0562459
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.048137
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0463499
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0448398
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0433659
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0413686
RUNX1 runt-related transcription factor 1 0.0390581
PCBP2 poly(rC) binding protein 2 0.0346213
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0317477
KDM2A lysine (K)-specific demethylase 2A 0.0306624
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0287861
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0286529
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0284929
HMGA2 high mobility group AT-hook 2 0.0276
EEF2 eukaryotic translation elongation factor 2 0.0275584
KSR1 kinase suppressor of ras 1 0.0270268
IRAK2 interleukin-1 receptor-associated kinase 2 0.0265212
ZEB2 zinc finger E-box binding homeobox 2 0.0262109
LOXL2 lysyl oxidase-like 2 0.0259814
JARID2 jumonji, AT rich interactive domain 2 0.0257149
CEP250 centrosomal protein 250kDa 0.0257122
HIPK2 homeodomain interacting protein kinase 2 0.0255822
AKAP12 A kinase (PRKA) anchor protein 12 0.025035
SIK3 SIK family kinase 3 0.0247514
SHB Src homology 2 domain containing adaptor protein B 0.0242093
TRIO trio Rho guanine nucleotide exchange factor 0.0242037
OPTN optineurin 0.0235326
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0232301
DUSP16 dual specificity phosphatase 16 0.0227657
UBA6 ubiquitin-like modifier activating enzyme 6 0.0224892
FTH1 ferritin, heavy polypeptide 1 0.0224081
WLS wntless Wnt ligand secretion mediator 0.0215498
SAMD9 sterile alpha motif domain containing 9 0.0213192
FAM13A family with sequence similarity 13, member A 0.0212957
ZNF638 zinc finger protein 638 0.0209865
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0209152
VEGFC vascular endothelial growth factor C 0.0207113
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0203463
HDAC9 histone deacetylase 9 0.0203119
APLP2 amyloid beta (A4) precursor-like protein 2 0.0201687
PFKP phosphofructokinase, platelet 0.0199328
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0197953
TUBB tubulin, beta class I 0.0197386
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0194906
SPTBN1 spectrin, beta, non-erythrocytic 1 0.019343
ELL2 elongation factor, RNA polymerase II, 2 0.0191558
RAB8B RAB8B, member RAS oncogene family 0.019084
APP amyloid beta (A4) precursor protein 0.0189159
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0188923
CA12 carbonic anhydrase XII 0.0187694
TGM2 transglutaminase 2 0.0185597
RUNX2 runt-related transcription factor 2 0.0184129
FMNL2 formin-like 2 0.0181819
KDM7A lysine (K)-specific demethylase 7A 0.0181151
IL1R1 interleukin 1 receptor, type I 0.0180356
MAP2K1 mitogen-activated protein kinase kinase 1 0.0178327
BIRC3 baculoviral IAP repeat containing 3 0.0175363
RHCG Rh family, C glycoprotein 0.0173182
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0170015
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0168925
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0168763
KYNU kynureninase 0.0167792
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0165741
FBXL13 F-box and leucine-rich repeat protein 13 0.0164773
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0164282
AMPD3 adenosine monophosphate deaminase 3 0.0161284
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0158677
MX1 MX dynamin-like GTPase 1 0.0158265
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0158127
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0157972
MYO1B myosin IB 0.0156914
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0156555
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.01565
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.015603
RNF213 ring finger protein 213 0.01558
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0155007
PTPRM protein tyrosine phosphatase, receptor type, M 0.0153219
LGALS12 lectin, galactoside-binding, soluble, 12 0.0152021
SLTM SAFB-like, transcription modulator 0.015168
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0149417
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.014896
EXT1 exostosin glycosyltransferase 1 0.0147695
FHIT fragile histidine triad 0.0147441
ECE1 endothelin converting enzyme 1 0.0147398
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0147323
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0145489
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0143047
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0141967
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0141243
GLS2 glutaminase 2 (liver, mitochondrial) 0.0140601
LPP LIM domain containing preferred translocation partner in lipoma 0.0140394
ARHGAP26 Rho GTPase activating protein 26 0.0138458
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0138449
BACE2 beta-site APP-cleaving enzyme 2 0.0137606
KMT2C lysine (K)-specific methyltransferase 2C 0.0136656
CTNNBL1 catenin, beta like 1 0.0136369
PIAS2 protein inhibitor of activated STAT, 2 0.013442

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.154174
TMSB10 thymosin beta 10 -0.148186
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.147817
VIM vimentin -0.145417
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.110077
PTMA prothymosin, alpha -0.0811743
DPYD dihydropyrimidine dehydrogenase -0.0732034
TFPI2 tissue factor pathway inhibitor 2 -0.0665411
S100A6 S100 calcium binding protein A6 -0.0602848
FN1 fibronectin 1 -0.0598181
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0532655
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0530615
TM4SF1 transmembrane 4 L six family member 1 -0.045631
WSB1 WD repeat and SOCS box containing 1 -0.0452714
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0439451
TPT1 tumor protein, translationally-controlled 1 -0.0438094
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0437372
GPC6 glypican 6 -0.0407832
NRG1 neuregulin 1 -0.0407742
AHNAK AHNAK nucleoprotein -0.0384368
USP34 ubiquitin specific peptidase 34 -0.0372
RPL35A ribosomal protein L35a -0.0361697
RAB1A RAB1A, member RAS oncogene family -0.035394
TMEM263 transmembrane protein 263 -0.0353167
RPS24 ribosomal protein S24 -0.0349445
RPS21 ribosomal protein S21 -0.034923
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0347512
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -0.0346271
EIF1 eukaryotic translation initiation factor 1 -0.0345027
EGR1 early growth response 1 -0.0343141
MTSS1 metastasis suppressor 1 -0.0331396
MAML3 mastermind-like 3 (Drosophila) -0.0330818
ZMYND8 zinc finger, MYND-type containing 8 -0.033055
ARHGAP5 Rho GTPase activating protein 5 -0.0330538
RPLP2 ribosomal protein, large, P2 -0.032691
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0313103
TAS2R14 taste receptor, type 2, member 14 -0.0308882
S100A10 S100 calcium binding protein A10 -0.0303922
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0299267
FTL ferritin, light polypeptide -0.029748
RAP1B RAP1B, member of RAS oncogene family -0.0297206
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0294231
RPL34 ribosomal protein L34 -0.0293502
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.028935
LOX lysyl oxidase -0.0289019
RPLP1 ribosomal protein, large, P1 -0.0287804
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0284196
IER3 immediate early response 3 -0.0281803
OSMR oncostatin M receptor -0.0280738
CP ceruloplasmin (ferroxidase) -0.0280579
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0279821
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0278569
NUMB numb homolog (Drosophila) -0.0272405
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0270241
TMSB4X thymosin beta 4, X-linked -0.0262306
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0260724
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0257054
MECOM MDS1 and EVI1 complex locus -0.0257024
NAP1L1 nucleosome assembly protein 1-like 1 -0.0254454
PCNX4 pecanex 4 -0.0251259
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0248659
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0247573
TMEM165 transmembrane protein 165 -0.0246146
RPS19 ribosomal protein S19 -0.0242726
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.024165
RPL31 ribosomal protein L31 -0.0240859
ASPH aspartate beta-hydroxylase -0.0237119
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0236952
DLG1 discs, large homolog 1 (Drosophila) -0.0235587
RPL37A ribosomal protein L37a -0.0234867
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0234664
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0232106
POTEF POTE ankyrin domain family, member F -0.0228174
ANKRD28 ankyrin repeat domain 28 -0.022682
IL1B interleukin 1, beta -0.022373
RPS25 ribosomal protein S25 -0.0223482
TTC3 tetratricopeptide repeat domain 3 -0.0222713
FAM20C family with sequence similarity 20, member C -0.0220869
CUX1 cut-like homeobox 1 -0.0218373
ANTXR2 anthrax toxin receptor 2 -0.0217458
H1-0 H1.0 linker histone -0.0217301
RPL32 ribosomal protein L32 -0.021716
RPS8 ribosomal protein S8 -0.0217112
BTG1 B-cell translocation gene 1, anti-proliferative -0.0216071
PRSS23 protease, serine, 23 -0.0214729
SEC31A SEC31 homolog A (S. cerevisiae) -0.0211251
THBD thrombomodulin -0.0210429
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0210355
VCL vinculin -0.0210033
ENO2 enolase 2 (gamma, neuronal) -0.0209517
NLK nemo-like kinase -0.0206442
PCNX1 pecanex 1 -0.0205768
ANXA2 annexin A2 -0.0205571
VRK2 vaccinia related kinase 2 -0.0203193
BMAL2 basic helix-loop-helix ARNT like 2 -0.0203074
RHOBTB3 Rho-related BTB domain containing 3 -0.0201249
PDGFA platelet-derived growth factor alpha polypeptide -0.0200515
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0199121
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0197346
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0196651