Docetaxel_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.121254
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.109579
KYNU kynureninase 0.105823
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0990089
LMO7 LIM domain 7 0.0989138
EXT1 exostosin glycosyltransferase 1 0.0945554
TRIO trio Rho guanine nucleotide exchange factor 0.0929167
LIMCH1 LIM and calponin homology domains 1 0.0918918
LAMB3 laminin, beta 3 0.0898976
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0783666
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0781781
TJP1 tight junction protein 1 0.0762377
FNDC3B fibronectin type III domain containing 3B 0.0724771
SMAD3 SMAD family member 3 0.0684224
IFIH1 interferon induced with helicase C domain 1 0.0676276
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0654704
TM4SF1 transmembrane 4 L six family member 1 0.060608
DSCAM Down syndrome cell adhesion molecule 0.0605582
TOP1 topoisomerase (DNA) I 0.0602862
ELL2 elongation factor, RNA polymerase II, 2 0.0586613
COL5A2 collagen, type V, alpha 2 0.0580128
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.057157
FOXO1 forkhead box O1 0.0570612
TRA2A transformer 2 alpha homolog (Drosophila) 0.0556885
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0530105
BIRC6 baculoviral IAP repeat containing 6 0.0526065
ATP11A ATPase, class VI, type 11A 0.0516232
HMGA2 high mobility group AT-hook 2 0.0515377
CHD1 chromodomain helicase DNA binding protein 1 0.0504259
ACSL3 acyl-CoA synthetase long-chain family member 3 0.050223
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0497756
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0489239
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0481236
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0470353
NALF1 NALCN channel auxiliary factor 1 0.0465952
FLNB filamin B, beta 0.0459512
GLS2 glutaminase 2 (liver, mitochondrial) 0.0457618
HSPH1 heat shock 105kDa/110kDa protein 1 0.0451474
MACF1 microtubule-actin crosslinking factor 1 0.0443327
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0436335
PHF3 PHD finger protein 3 0.0435398
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 0.0427233
OSBPL10 oxysterol binding protein-like 10 0.0423795
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0417481
SPAG9 sperm associated antigen 9 0.0416337
MYO10 myosin X 0.041319
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0412469
INHBA inhibin, beta A 0.0412049
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0411898
EZR ezrin 0.04098
PDLIM5 PDZ and LIM domain 5 0.0408728
DUSP5 dual specificity phosphatase 5 0.0397037
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0395534
RIGI RNA sensor RIG-I 0.0395418
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0390163
ALCAM activated leukocyte cell adhesion molecule 0.0387045
OFD1 oral-facial-digital syndrome 1 0.0384213
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.038089
ZC3H11A zinc finger CCCH-type containing 11A 0.038048
RORA RAR-related orphan receptor A 0.037322
NIBAN2 niban apoptosis regulator 2 0.0364637
MUC16 mucin 16, cell surface associated 0.0363422
MT2A metallothionein 2A 0.0361241
AKAP12 A kinase (PRKA) anchor protein 12 0.0359144
FMNL2 formin-like 2 0.0357168
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0353191
PTK2 protein tyrosine kinase 2 0.0350011
BRWD1 bromodomain and WD repeat domain containing 1 0.0344413
MYO5B myosin VB 0.0343937
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0342817
AFDN afadin, adherens junction formation factor 0.0341732
DST dystonin 0.0340702
KPNB1 karyopherin (importin) beta 1 0.0336895
OGA O-GlcNAcase 0.0334586
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0333795
MICU1 mitochondrial calcium uptake 1 0.0330535
MBNL1 muscleblind-like splicing regulator 1 0.0328777
MARCHF6 membrane associated ring-CH-type finger 6 0.0323394
SEPTIN9 septin 9 0.0322262
VCL vinculin 0.0320745
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0314954
NDRG1 N-myc downstream regulated 1 0.0313511
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.0312918
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0307739
ANO6 anoctamin 6 0.0304673
NPTN neuroplastin 0.0301188
ZNFX1 zinc finger, NFX1-type containing 1 0.0295186
ARHGAP21 Rho GTPase activating protein 21 0.0294907
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0294467
NAP1L1 nucleosome assembly protein 1-like 1 0.0292968
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0290535
RACK1 receptor for activated C kinase 1 0.0288191
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0285044
ZNF207 zinc finger protein 207 0.0284941
TEP1 telomerase-associated protein 1 0.028102
CLIP1 CAP-GLY domain containing linker protein 1 0.028
FNDC3A fibronectin type III domain containing 3A 0.0278685
KLF5 Kruppel-like factor 5 (intestinal) 0.0278213
DSPP dentin sialophosphoprotein 0.027635
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0274181

decreased expression

Symbol Name Standardized Value
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.135113
ATOSA atos homolog A -0.130425
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.120383
FTH1 ferritin, heavy polypeptide 1 -0.101417
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0975248
CEMIP cell migration inducing protein, hyaluronan binding -0.0966489
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0899692
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0798967
S100A9 S100 calcium binding protein A9 -0.0791549
ANTXR2 anthrax toxin receptor 2 -0.0772125
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0756388
IGFBP3 insulin-like growth factor binding protein 3 -0.0659478
MCL1 myeloid cell leukemia 1 -0.0637623
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0632714
LAMC2 laminin, gamma 2 -0.0623423
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0591384
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0584014
GPC6 glypican 6 -0.057251
LOC112694756 uncharaterized LOC112694756 -0.0569254
STC1 stanniocalcin 1 -0.0536196
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0532167
WASF2 WAS protein family, member 2 -0.0518748
VIM vimentin -0.0518288
POTEF POTE ankyrin domain family, member F -0.05053
SOX4 SRY (sex determining region Y)-box 4 -0.050497
ITCH itchy E3 ubiquitin protein ligase -0.0496875
XRN1 5'-3' exoribonuclease 1 -0.0496312
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0495339
SBF2 SET binding factor 2 -0.0492617
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0490622
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0484267
CSTB cystatin B (stefin B) -0.0481177
CATSPERB catsper channel auxiliary subunit beta -0.0471873
NT5C2 5'-nucleotidase, cytosolic II -0.0471673
FN1 fibronectin 1 -0.0461561
CCNI cyclin I -0.0453835
DOCK9 dedicator of cytokinesis 9 -0.0451443
KDM7A lysine (K)-specific demethylase 7A -0.0448733
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0446919
UBE2H ubiquitin-conjugating enzyme E2H -0.0445126
HLA-B major histocompatibility complex, class I, B -0.0443296
SOS2 son of sevenless homolog 2 (Drosophila) -0.0442166
PRELID2 PRELI domain containing 2 -0.0429829
PDIA3 protein disulfide isomerase family A, member 3 -0.042462
ZMYND8 zinc finger, MYND-type containing 8 -0.0423008
IGFBP5 insulin-like growth factor binding protein 5 -0.0422823
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0413052
FBXL20 F-box and leucine-rich repeat protein 20 -0.0412295
ANKRD17 ankyrin repeat domain 17 -0.0410349
RAI14 retinoic acid induced 14 -0.0401849
PDIA4 protein disulfide isomerase family A, member 4 -0.0398826
RREB1 ras responsive element binding protein 1 -0.0393551
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0391122
RB1CC1 RB1-inducible coiled-coil 1 -0.0385427
SYNGAP1 synaptic Ras GTPase activating protein 1 -0.038345
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0381934
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0381878
CERS6 ceramide synthase 6 -0.0377934
LGALS8 lectin, galactoside-binding, soluble, 8 -0.0377152
CDCP1 CUB domain containing protein 1 -0.0376732
MRPS6 mitochondrial ribosomal protein S6 -0.0369396
RCOR1 REST corepressor 1 -0.0366335
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0365209
PRDM1 PR domain containing 1, with ZNF domain -0.0365103
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0363282
MBD5 methyl-CpG binding domain protein 5 -0.0363053
BAIAP2L1 BAI1-associated protein 2-like 1 -0.03604
FTL ferritin, light polypeptide -0.0359238
HOOK3 hook microtubule-tethering protein 3 -0.0355195
MXD1 MAX dimerization protein 1 -0.0352724
TBC1D5 TBC1 domain family, member 5 -0.0344781
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0343561
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0339293
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.033913
TANK TRAF family member-associated NFKB activator -0.0338127
DOCK4 dedicator of cytokinesis 4 -0.0337524
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0336554
TRIP12 thyroid hormone receptor interactor 12 -0.0334933
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0334759
CEP350 centrosomal protein 350kDa -0.0334747
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0331454
USP53 ubiquitin specific peptidase 53 -0.0328698
RPL31 ribosomal protein L31 -0.032572
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0325312
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0322963
COPA coatomer protein complex, subunit alpha -0.0322911
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0322897
RUFY1 RUN and FYVE domain containing 1 -0.0322321
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0319953
TNRC6B trinucleotide repeat containing 6B -0.0319699
SEC24D SEC24 family member D -0.0319614
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0319502
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0317977
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0317539
AUTS2 autism susceptibility candidate 2 -0.0316373
SDC4 syndecan 4 -0.0312291
SREBF2 sterol regulatory element binding transcription factor 2 -0.0307453
TXNRD1 thioredoxin reductase 1 -0.030484
TXNIP thioredoxin interacting protein -0.0304148
BPTF bromodomain PHD finger transcription factor -0.0303546