Docetaxel_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SAMD4A sterile alpha motif domain containing 4A 0.24375
EFNA5 ephrin-A5 0.131453
EXT1 exostosin glycosyltransferase 1 0.128522
LPP LIM domain containing preferred translocation partner in lipoma 0.103179
ZSWIM6 zinc finger, SWIM-type containing 6 0.0982763
NAV2 neuron navigator 2 0.082371
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0814182
LIMCH1 LIM and calponin homology domains 1 0.081149
RNF213 ring finger protein 213 0.0733134
SMAD3 SMAD family member 3 0.0634336
INTS6 integrator complex subunit 6 0.0598003
ATXN1 ataxin 1 0.0571488
AHNAK AHNAK nucleoprotein 0.0558768
PLEC plectin 0.0538673
UBC ubiquitin C 0.0524812
MX1 MX dynamin-like GTPase 1 0.0517605
IGFBP3 insulin-like growth factor binding protein 3 0.0512363
GRB10 growth factor receptor-bound protein 10 0.0506721
PGBD5 piggyBac transposable element derived 5 0.0487446
VCL vinculin 0.0485517
GOLGB1 golgin B1 0.047965
RIGI RNA sensor RIG-I 0.0478121
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0477827
ZBTB20 zinc finger and BTB domain containing 20 0.047525
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0462701
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0461514
TRIO trio Rho guanine nucleotide exchange factor 0.0460624
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.045363
AKAP13 A kinase (PRKA) anchor protein 13 0.0441146
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0437942
ETV6 ets variant 6 0.0427211
MX2 MX dynamin-like GTPase 2 0.0421298
CTBP2 C-terminal binding protein 2 0.0414829
ATP11A ATPase, class VI, type 11A 0.0404908
MYO1E myosin IE 0.0404701
RBM47 RNA binding motif protein 47 0.040196
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0401151
FNIP1 folliculin interacting protein 1 0.0396051
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0393414
OCLN occludin 0.0390926
RAD51B RAD51 paralog B 0.0382368
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0380644
FLNA filamin A, alpha 0.0376955
ARHGAP20 Rho GTPase activating protein 20 0.0373509
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0371971
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0367913
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0365993
ERBIN erbb2 interacting protein 0.0359968
AHNAK2 AHNAK nucleoprotein 2 0.0353086
PATJ PATJ crumbs cell polarity complex component 0.0348463
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0346176
PLSCR1 phospholipid scramblase 1 0.0339646
SVIL supervillin 0.0338681
TIMP2 TIMP metallopeptidase inhibitor 2 0.0338621
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0336426
EEF2 eukaryotic translation elongation factor 2 0.0335057
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0333822
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0332251
PRKCA protein kinase C, alpha 0.0328988
TTC3 tetratricopeptide repeat domain 3 0.0327961
ENO1 enolase 1, (alpha) 0.0325918
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0321666
MACF1 microtubule-actin crosslinking factor 1 0.0319642
PPARD peroxisome proliferator-activated receptor delta 0.0311585
LMO7 LIM domain 7 0.03099
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0305691
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0305237
FBXO34 F-box protein 34 0.030414
VGLL3 vestigial-like family member 3 0.0303252
APLP2 amyloid beta (A4) precursor-like protein 2 0.0301896
MYH9 myosin, heavy chain 9, non-muscle 0.0300792
KIAA1217 KIAA1217 0.0297879
HDAC9 histone deacetylase 9 0.0297195
MYO5B myosin VB 0.0296813
MCL1 myeloid cell leukemia 1 0.0295665
FBXO32 F-box protein 32 0.0295267
MACC1 metastasis associated in colon cancer 1 0.0292869
SP100 SP100 nuclear antigen 0.0291663
TJP1 tight junction protein 1 0.0290723
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0290116
PALLD palladin, cytoskeletal associated protein 0.0288462
ZBTB38 zinc finger and BTB domain containing 38 0.0288013
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.028406
SH3RF1 SH3 domain containing ring finger 1 0.0284001
ZNF638 zinc finger protein 638 0.0280544
AEBP2 AE binding protein 2 0.0280046
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0278954
IFI16 interferon, gamma-inducible protein 16 0.0277998
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0277366
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.027684
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0275917
SEC31A SEC31 homolog A (S. cerevisiae) 0.0275756
PDLIM5 PDZ and LIM domain 5 0.0273402
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0271861
TBC1D22A TBC1 domain family, member 22A 0.0270682
EGFR epidermal growth factor receptor 0.027065
PARP9 poly (ADP-ribose) polymerase family, member 9 0.0269066
WARS1 tryptophanyl-tRNA synthetase 1 0.0267319
EXOC4 exocyst complex component 4 0.0265749
ANKRD17 ankyrin repeat domain 17 0.0264164

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.219739
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.160171
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.14388
NAMPT nicotinamide phosphoribosyltransferase -0.13563
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.12472
TSC22D2 TSC22 domain family, member 2 -0.102758
FTL ferritin, light polypeptide -0.0920464
NDRG1 N-myc downstream regulated 1 -0.0898015
FN1 fibronectin 1 -0.0721781
ELL2 elongation factor, RNA polymerase II, 2 -0.0712221
PTMA prothymosin, alpha -0.0702762
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0670258
GOLGA4 golgin A4 -0.0651748
RNF145 ring finger protein 145 -0.0641312
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0637211
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0635309
TFG TRK-fused gene -0.0622126
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0607615
RPS6 ribosomal protein S6 -0.0587165
S100A6 S100 calcium binding protein A6 -0.0586433
POTEF POTE ankyrin domain family, member F -0.0552719
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0544873
HMGA1 high mobility group AT-hook 1 -0.0526911
ASPH aspartate beta-hydroxylase -0.0526099
RAD21 RAD21 homolog (S. pombe) -0.0504067
ZNF292 zinc finger protein 292 -0.0467913
MATR3 matrin 3 -0.0455982
FAM13A family with sequence similarity 13, member A -0.0455289
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0453383
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0449371
USP3 ubiquitin specific peptidase 3 -0.0442974
FAM162A family with sequence similarity 162, member A -0.0440649
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0437729
CCNL1 cyclin L1 -0.0434556
RPS2 ribosomal protein S2 -0.0432622
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0420726
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0415275
MARCHF6 membrane associated ring-CH-type finger 6 -0.0412535
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0410152
KMT2E lysine (K)-specific methyltransferase 2E -0.0405877
PGK1 phosphoglycerate kinase 1 -0.0405244
DSTN destrin (actin depolymerizing factor) -0.040422
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0400146
MT2A metallothionein 2A -0.0396863
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0383418
PAPOLA poly(A) polymerase alpha -0.0383412
GARS1 glycyl-tRNA synthetase 1 -0.0377811
NPEPPS aminopeptidase puromycin sensitive -0.0373996
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0373811
CLINT1 clathrin interactor 1 -0.0364836
SLMAP sarcolemma associated protein -0.0352391
EIF1 eukaryotic translation initiation factor 1 -0.0351869
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0350764
RLF rearranged L-myc fusion -0.035063
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0349715
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0349381
YBX3 Y box binding protein 3 -0.0348821
MSMO1 methylsterol monooxygenase 1 -0.0342799
TMSB4X thymosin beta 4, X-linked -0.0342605
HMGB2 high mobility group box 2 -0.0342569
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0341615
RTN4 reticulon 4 -0.0339444
UGCG UDP-glucose ceramide glucosyltransferase -0.0339212
ADAM9 ADAM metallopeptidase domain 9 -0.0338414
BHLHE40 basic helix-loop-helix family, member e40 -0.0336498
TXNRD1 thioredoxin reductase 1 -0.0333982
SLC38A1 solute carrier family 38, member 1 -0.0332692
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0322991
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0322212
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0321199
VEZT vezatin, adherens junctions transmembrane protein -0.0316647
RPL32 ribosomal protein L32 -0.0315621
CDK17 cyclin-dependent kinase 17 -0.0314699
RBM39 RNA binding motif protein 39 -0.0313087
KDM3A lysine (K)-specific demethylase 3A -0.030479
CDC73 cell division cycle 73 -0.0304506
RIOK3 RIO kinase 3 -0.0300759
RASA2 RAS p21 protein activator 2 -0.0299795
RYBP RING1 and YY1 binding protein -0.0296421
FAM3C family with sequence similarity 3, member C -0.0289385
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0286947
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0286494
ANXA5 annexin A5 -0.0283818
WAC WW domain containing adaptor with coiled-coil -0.028253
LMAN1 lectin, mannose-binding, 1 -0.0278899
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0277591
RPL34 ribosomal protein L34 -0.0276342
RSRC2 arginine/serine-rich coiled-coil 2 -0.0275853
SEPTIN7 septin 7 -0.027568
MIS18BP1 MIS18 binding protein 1 -0.0274626
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0270139
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0269567
KTN1 kinectin 1 (kinesin receptor) -0.0267001
RPL11 ribosomal protein L11 -0.0266232
EPCAM epithelial cell adhesion molecule -0.0266147
MSN moesin -0.0266028
QKI QKI, KH domain containing, RNA binding -0.0265766
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0264176
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0264064
PRRC1 proline-rich coiled-coil 1 -0.0263693