| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Docetaxel perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Docetaxel_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.146611 |
| PM20D1 | peptidase M20 domain containing 1 | 0.139942 |
| PDLIM5 | PDZ and LIM domain 5 | 0.115578 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.100154 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.098364 |
| PDE10A | phosphodiesterase 10A | 0.093912 |
| KYNU | kynureninase | 0.0714585 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.065255 |
| GDA | guanine deaminase | 0.0623338 |
| RACK1 | receptor for activated C kinase 1 | 0.0614886 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0599317 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0564305 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0555048 |
| CENPF | centromere protein F, 350/400kDa | 0.054173 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0490751 |
| GRAMD1B | GRAM domain containing 1B | 0.0490242 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.048507 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0462137 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0458082 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0404652 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0392587 |
| CD109 | CD109 molecule | 0.0390646 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0377786 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0375721 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0369538 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0362702 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0353372 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0352077 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0348545 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0344486 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0339104 |
| VCL | vinculin | 0.0327288 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0321169 |
| COL5A2 | collagen, type V, alpha 2 | 0.0317538 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0315388 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0314622 |
| ACTG1 | actin gamma 1 | 0.0313015 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0311039 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0302694 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0301542 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0294514 |
| POTEF | POTE ankyrin domain family, member F | 0.0279886 |
| MKI67 | marker of proliferation Ki-67 | 0.027765 |
| ATXN1 | ataxin 1 | 0.0277361 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0276028 |
| PDE7B | phosphodiesterase 7B | 0.0272356 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0271957 |
| RAD51B | RAD51 paralog B | 0.027105 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0269386 |
| SMAD2 | SMAD family member 2 | 0.0269293 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0268568 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0264848 |
| TUBA1B | tubulin, alpha 1b | 0.0261619 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0258236 |
| KIAA0825 | KIAA0825 | 0.0255535 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0254106 |
| COL4A5 | collagen, type IV, alpha 5 | 0.025317 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0250382 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0248645 |
| RPS4X | ribosomal protein S4, X-linked | 0.0245021 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0242126 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0238568 |
| CBX3 | chromobox homolog 3 | 0.0238391 |
| INTS6 | integrator complex subunit 6 | 0.023605 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0232927 |
| RPL26 | ribosomal protein L26 | 0.0232355 |
| NTN4 | netrin 4 | 0.0232174 |
| SET | SET nuclear proto-oncogene | 0.0231596 |
| LDHA | lactate dehydrogenase A | 0.0229907 |
| CTSL | cathepsin L | 0.0229906 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0225892 |
| TPM3 | tropomyosin 3 | 0.0219276 |
| PRSS23 | protease, serine, 23 | 0.0218716 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0217992 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0217116 |
| ASPH | aspartate beta-hydroxylase | 0.0216864 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0216052 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0215844 |
| RPL9 | ribosomal protein L9 | 0.0215167 |
| DST | dystonin | 0.0213405 |
| PTEN | phosphatase and tensin homolog | 0.0210953 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0210731 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0210178 |
| EXOC4 | exocyst complex component 4 | 0.0201276 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0200822 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0199958 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.0199637 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0198471 |
| PRDX1 | peroxiredoxin 1 | 0.0198244 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.019346 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.019252 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0189777 |
| FMNL2 | formin-like 2 | 0.0188251 |
| FLNA | filamin A, alpha | 0.0186576 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0185377 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0185062 |
| BMP6 | bone morphogenetic protein 6 | 0.0183687 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0183134 |
| RPS3 | ribosomal protein S3 | 0.0182366 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0179928 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.25193 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.233882 |
| FN1 | fibronectin 1 | -0.201066 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.150765 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.10497 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0757975 |
| CANX | calnexin | -0.0682218 |
| PTMA | prothymosin, alpha | -0.0579925 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0487534 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0442474 |
| UBC | ubiquitin C | -0.0439969 |
| RTN4 | reticulon 4 | -0.0430688 |
| RPS6 | ribosomal protein S6 | -0.0427926 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0397956 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0390935 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0371178 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0367188 |
| OGA | O-GlcNAcase | -0.036555 |
| GOLGA4 | golgin A4 | -0.0361814 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0358503 |
| FAM13A | family with sequence similarity 13, member A | -0.0349901 |
| RPLP1 | ribosomal protein, large, P1 | -0.0338235 |
| TMSB10 | thymosin beta 10 | -0.0333148 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0328106 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0325822 |
| VIM | vimentin | -0.0322369 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0319761 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0311428 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0309223 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0305376 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0298072 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0297041 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0291854 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0290635 |
| USP3 | ubiquitin specific peptidase 3 | -0.0285839 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.028352 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.028027 |
| PGK1 | phosphoglycerate kinase 1 | -0.0278791 |
| SPAG9 | sperm associated antigen 9 | -0.027556 |
| WDR45B | WD repeat domain 45B | -0.0274146 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0272987 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0272721 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.027012 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0263213 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0261632 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0258735 |
| ANXA1 | annexin A1 | -0.025733 |
| PTGR1 | prostaglandin reductase 1 | -0.0254736 |
| NUP58 | nucleoporin 58 | -0.0253253 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0252 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0246384 |
| AHNAK | AHNAK nucleoprotein | -0.0246149 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0246131 |
| RBM39 | RNA binding motif protein 39 | -0.0234709 |
| ATP13A3 | ATPase type 13A3 | -0.023275 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0232594 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.022633 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0222104 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0218037 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0217748 |
| TPD52 | tumor protein D52 | -0.0213164 |
| NGLY1 | N-glycanase 1 | -0.0212258 |
| S100A6 | S100 calcium binding protein A6 | -0.0208478 |
| COPA | coatomer protein complex, subunit alpha | -0.020218 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0200288 |
| MORF4L2 | mortality factor 4 like 2 | -0.0194569 |
| ZNF292 | zinc finger protein 292 | -0.019408 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0193897 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0193356 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0193006 |
| HELZ | helicase with zinc finger | -0.0191907 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0191496 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0190107 |
| HLA-B | major histocompatibility complex, class I, B | -0.0189234 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0188673 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.018658 |
| RYR2 | ryanodine receptor 2 (cardiac) | -0.0185739 |
| RIOK3 | RIO kinase 3 | -0.0184169 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.0183663 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0183453 |
| PHF21A | PHD finger protein 21A | -0.0182782 |
| NBAS | neuroblastoma amplified sequence | -0.0181184 |
| RPL12 | ribosomal protein L12 | -0.0180314 |
| ANXA2 | annexin A2 | -0.0180161 |
| EFNA5 | ephrin-A5 | -0.0178524 |
| CDC73 | cell division cycle 73 | -0.0178221 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0178155 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.017728 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0174921 |
| WTAP | Wilms tumor 1 associated protein | -0.0174558 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0174515 |
| RNF24 | ring finger protein 24 | -0.0174151 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.01732 |
| TBXT | T-box transcription factor T | -0.017304 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0170661 |
| RRBP1 | ribosome binding protein 1 | -0.0169311 |
| SUCO | SUN domain containing ossification factor | -0.0169211 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0169011 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0168799 |
| S100A10 | S100 calcium binding protein A10 | -0.0167605 |
