Docetaxel_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Docetaxel perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Docetaxel_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GLIS3 GLIS family zinc finger 3 0.106363
HMGA2 high mobility group AT-hook 2 0.105521
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.09206
AKAP12 A kinase (PRKA) anchor protein 12 0.0874169
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0803894
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0799474
HDAC9 histone deacetylase 9 0.0782125
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0723328
DST dystonin 0.0595416
CDH13 cadherin 13 0.0582063
TRIO trio Rho guanine nucleotide exchange factor 0.0572891
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0543199
VEGFA vascular endothelial growth factor A 0.0526783
FTH1 ferritin, heavy polypeptide 1 0.0503747
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0490426
MACF1 microtubule-actin crosslinking factor 1 0.048834
NDRG1 N-myc downstream regulated 1 0.0472252
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0469887
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0466468
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0461473
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.045711
SDK1 sidekick cell adhesion molecule 1 0.0446639
EXT1 exostosin glycosyltransferase 1 0.0441002
ZSWIM6 zinc finger, SWIM-type containing 6 0.0416714
VCAN versican 0.041152
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0393084
KYNU kynureninase 0.0391794
VCL vinculin 0.0383305
EGR1 early growth response 1 0.0372584
ZBTB38 zinc finger and BTB domain containing 38 0.034161
RAD51B RAD51 paralog B 0.0338129
INTS6 integrator complex subunit 6 0.0330871
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0329074
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0327681
SMYD3 SET and MYND domain containing 3 0.0326055
TUBB tubulin, beta class I 0.0323803
IGFBP3 insulin-like growth factor binding protein 3 0.0321556
FRMPD4 FERM and PDZ domain containing 4 0.0318625
INHBA inhibin, beta A 0.0318247
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0317293
FTL ferritin, light polypeptide 0.0315518
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0315284
STC2 stanniocalcin 2 0.030884
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0305018
RNF213 ring finger protein 213 0.0301842
PSD3 pleckstrin and Sec7 domain containing 3 0.0299034
FBXL7 F-box and leucine-rich repeat protein 7 0.0292328
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0285405
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0283906
PLIN2 perilipin 2 0.0283046
SFRP1 secreted frizzled-related protein 1 0.0281873
NRP1 neuropilin 1 0.028059
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0277184
EPAS1 endothelial PAS domain protein 1 0.0274044
TMEM132D transmembrane protein 132D 0.0273779
SEPTIN9 septin 9 0.0272009
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0270207
ASPH aspartate beta-hydroxylase 0.0267894
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0266451
FMNL2 formin-like 2 0.0266114
IFI6 interferon, alpha-inducible protein 6 0.0265712
WWOX WW domain containing oxidoreductase 0.0260968
LOC102724023 ES1 protein homolog, mitochondrial 0.0260669
SAMD9 sterile alpha motif domain containing 9 0.0256939
ATXN1 ataxin 1 0.0253201
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0253107
PMP22 peripheral myelin protein 22 0.0250885
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0245418
SP100 SP100 nuclear antigen 0.0244706
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0241433
NCKAP5 NCK-associated protein 5 0.0239179
PCLO piccolo presynaptic cytomatrix protein 0.0238703
WFDC10B WAP four-disulfide core domain 10B 0.0236212
DIAPH2 diaphanous-related formin 2 0.0234712
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0233125
BICC1 BicC family RNA binding protein 1 0.0233014
HLA-A major histocompatibility complex, class I, A 0.0229714
DPYD dihydropyrimidine dehydrogenase 0.0228554
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0227211
FHIT fragile histidine triad 0.0223778
ADAM12 ADAM metallopeptidase domain 12 0.021999
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0219342
JARID2 jumonji, AT rich interactive domain 2 0.0216968
SAMD3 sterile alpha motif domain containing 3 0.0216942
TRIP12 thyroid hormone receptor interactor 12 0.0216004
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0211669
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0211559
ADORA2B adenosine A2b receptor 0.0210997
SOX5 SRY (sex determining region Y)-box 5 0.0209982
B2M beta-2-microglobulin 0.0209918
SH2B3 SH2B adaptor protein 3 0.0209069
RND3 Rho family GTPase 3 0.0206313
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0201789
MYO1B myosin IB 0.0200657
COL6A3 collagen, type VI, alpha 3 0.0199252
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0195239
GPC6 glypican 6 0.0195134
TRIM55 tripartite motif containing 55 0.0194901
RACK1 receptor for activated C kinase 1 0.0193418
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0191789

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.157814
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0997722
NAMPT nicotinamide phosphoribosyltransferase -0.0945847
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.085134
UBC ubiquitin C -0.0823769
RPS27A ribosomal protein S27a -0.0757968
PTMA prothymosin, alpha -0.0737067
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0687759
ANXA2 annexin A2 -0.0655384
AHNAK AHNAK nucleoprotein -0.0652388
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0604341
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0597352
TMSB10 thymosin beta 10 -0.0591933
MYH9 myosin, heavy chain 9, non-muscle -0.0591152
SOD2 superoxide dismutase 2, mitochondrial -0.0561799
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0557309
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0532242
RPS24 ribosomal protein S24 -0.0523505
KDM3A lysine (K)-specific demethylase 3A -0.0499825
MKI67 marker of proliferation Ki-67 -0.0488625
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.048345
CENPF centromere protein F, 350/400kDa -0.0480325
EEF2 eukaryotic translation elongation factor 2 -0.0476792
OGA O-GlcNAcase -0.0457214
THBS1 thrombospondin 1 -0.0454856
MYOF myoferlin -0.0442695
ANLN anillin, actin binding protein -0.043916
RPL23 ribosomal protein L23 -0.0420937
SDC4 syndecan 4 -0.0401647
NAP1L1 nucleosome assembly protein 1-like 1 -0.0391579
RPS3 ribosomal protein S3 -0.0389026
ELL2 elongation factor, RNA polymerase II, 2 -0.0382094
CANX calnexin -0.0380576
COL1A1 collagen, type I, alpha 1 -0.0378622
RPLP2 ribosomal protein, large, P2 -0.0375284
PCBP2 poly(rC) binding protein 2 -0.0374117
RPL26 ribosomal protein L26 -0.0358273
RPLP1 ribosomal protein, large, P1 -0.0354517
KLF6 Kruppel-like factor 6 -0.0349945
KIF4A kinesin family member 4A -0.0347583
TPM4 tropomyosin 4 -0.0338178
ARRDC3 arrestin domain containing 3 -0.0337731
APP amyloid beta (A4) precursor protein -0.0335297
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0334733
RPL36A ribosomal protein L36a -0.0326784
UGCG UDP-glucose ceramide glucosyltransferase -0.0325286
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0321726
ENO1 enolase 1, (alpha) -0.0320886
CALU calumenin -0.0317053
CKAP5 cytoskeleton associated protein 5 -0.0311321
RTN4 reticulon 4 -0.0309615
CD44 CD44 molecule (Indian blood group) -0.030579
ACTG1 actin gamma 1 -0.030236
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0300188
ZNF292 zinc finger protein 292 -0.0299297
TPT1 tumor protein, translationally-controlled 1 -0.0297096
TPX2 TPX2, microtubule-associated -0.0296119
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.029213
NAV2 neuron navigator 2 -0.0288914
SMC4 structural maintenance of chromosomes 4 -0.0283772
HLA-B major histocompatibility complex, class I, B -0.028362
LCORL ligand dependent nuclear receptor corepressor-like -0.0278116
DIAPH3 diaphanous-related formin 3 -0.0275525
EEF1G eukaryotic translation elongation factor 1 gamma -0.0274321
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0269988
GOLGA4 golgin A4 -0.0269871
SBF2 SET binding factor 2 -0.0268231
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0262902
RPS12 ribosomal protein S12 -0.0261016
NT5C2 5'-nucleotidase, cytosolic II -0.0259941
HMGB2 high mobility group box 2 -0.0259866
GAS2L3 growth arrest-specific 2 like 3 -0.0252942
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0250358
PGK1 phosphoglycerate kinase 1 -0.0248413
CADM1 cell adhesion molecule 1 -0.0248192
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0247931
MXI1 MAX interactor 1, dimerization protein -0.024624
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.024415
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0242026
DLG1 discs, large homolog 1 (Drosophila) -0.0241906
RPS8 ribosomal protein S8 -0.0241899
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.02409
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0239394
TNIP1 TNFAIP3 interacting protein 1 -0.0239325
SRGN serglycin -0.0238089
RPS16 ribosomal protein S16 -0.023657
LAMP2 lysosomal-associated membrane protein 2 -0.023121
RPS25 ribosomal protein S25 -0.0227684
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0227668
SPAG9 sperm associated antigen 9 -0.0223875
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0223008
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0222131
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0221503
FNDC3B fibronectin type III domain containing 3B -0.0218452
AFDN afadin, adherens junction formation factor -0.0215784
HDLBP high density lipoprotein binding protein -0.0214311
DEK DEK proto-oncogene -0.0212527
FLNB filamin B, beta -0.0211222
TMEM123 transmembrane protein 123 -0.0208255
RPLP0 ribosomal protein, large, P0 -0.0207942