| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group. (Chemical Entities of Biological Interest Ontology, CHEBI_18243) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/681 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Dopamine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC41A3 | solute carrier family 41, member 3 | 2.07 |
| HMOX1 | heme oxygenase 1 | 1.89 |
| RPL36AL | ribosomal protein L36a-like | 0.69 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.66 |
| KLHL23 | kelch-like family member 23 | 0.63 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.62 |
| MISP3 | MISP family member 3 | 0.61 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.58 |
| PRDX1 | peroxiredoxin 1 | 0.53 |
| DUSP22 | dual specificity phosphatase 22 | 0.53 |
| DSTYK | dual serine/threonine and tyrosine protein kinase | 0.53 |
| RNF17 | ring finger protein 17 | 0.53 |
| PLEKHA6 | pleckstrin homology domain containing, family A member 6 | 0.5 |
| LRP1 | low density lipoprotein receptor-related protein 1 | 0.49 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.48 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | 0.48 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.48 |
| SDR16C5 | short chain dehydrogenase/reductase family 16C, member 5 | 0.48 |
| MED30 | mediator complex subunit 30 | 0.47 |
| ADCY10 | adenylate cyclase 10 (soluble) | 0.47 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.47 |
| RPL18A | ribosomal protein L18a | 0.47 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.46 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.46 |
| ACVR1B | activin A receptor, type IB | 0.46 |
| ZNF483 | zinc finger protein 483 | 0.46 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.46 |
| ZNF395 | zinc finger protein 395 | 0.46 |
| MIEN1 | migration and invasion enhancer 1 | 0.45 |
| KDM5D | lysine (K)-specific demethylase 5D | 0.45 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 0.44 |
| ETV6 | ets variant 6 | 0.44 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.44 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.44 |
| BCL9 | B-cell CLL/lymphoma 9 | 0.44 |
| ZNF503 | zinc finger protein 503 | 0.42 |
| IFI30 | interferon, gamma-inducible protein 30 | 0.42 |
| B4GALNT1 | beta-1,4-N-acetyl-galactosaminyl transferase 1 | 0.42 |
| FAM177A1 | family with sequence similarity 177, member A1 | 0.41 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.41 |
| SASH1 | SAM and SH3 domain containing 1 | 0.41 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.41 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.41 |
| RPL3L | ribosomal protein L3-like | 0.4 |
| SLC2A4RG | SLC2A4 regulator | 0.4 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.4 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.4 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.4 |
| RPS19 | ribosomal protein S19 | 0.39 |
| STMN2 | stathmin 2 | 0.39 |
| VSNL1 | visinin-like 1 | 0.39 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | 0.39 |
| CLCN6 | chloride channel, voltage-sensitive 6 | 0.38 |
| OSTF1 | osteoclast stimulating factor 1 | 0.38 |
| GPRC5C | G protein-coupled receptor, class C, group 5, member C | 0.38 |
| FAM102B | family with sequence similarity 102, member B | 0.38 |
| TPM2 | tropomyosin 2 (beta) | 0.38 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.38 |
| LRRC59 | leucine rich repeat containing 59 | 0.38 |
| FOXO1 | forkhead box O1 | 0.37 |
| RNF123 | ring finger protein 123 | 0.36 |
| CNTNAP4 | contactin associated protein-like 4 | 0.36 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.36 |
| SOD1 | superoxide dismutase 1, soluble | 0.36 |
| MT1X | metallothionein 1X | 0.36 |
| TRIM7 | tripartite motif containing 7 | 0.36 |
| TPM4 | tropomyosin 4 | 0.36 |
| RPL12 | ribosomal protein L12 | 0.35 |
| RGS20 | regulator of G-protein signaling 20 | 0.35 |
| PEX12 | peroxisomal biogenesis factor 12 | 0.35 |
| HPCAL4 | hippocalcin like 4 | 0.35 |
| TPM1 | tropomyosin 1 (alpha) | 0.35 |
| CRTC1 | CREB regulated transcription coactivator 1 | 0.34 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.34 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.33 |
| MXRA7 | matrix-remodelling associated 7 | 0.33 |
| FANCC | Fanconi anemia, complementation group C | 0.33 |
| NUDT8 | nudix (nucleoside diphosphate linked moiety X)-type motif 8 | 0.33 |
| YAP1 | Yes-associated protein 1 | 0.33 |
| LMOD1 | leiomodin 1 (smooth muscle) | 0.33 |
| APBA3 | amyloid beta (A4) precursor protein-binding, family A, member 3 | 0.33 |
| PLD3 | phospholipase D family, member 3 | 0.32 |
| CBY1 | chibby homolog 1 (Drosophila) | 0.32 |
| MYOM2 | myomesin 2 | 0.32 |
| ZNF714 | zinc finger protein 714 | 0.32 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.32 |
| FDX1 | ferredoxin 1 | 0.32 |
| PTMA | prothymosin, alpha | 0.32 |
| ADM | adrenomedullin | 0.32 |
| KCTD12 | potassium channel tetramerization domain containing 12 | 0.32 |
| ENO1 | enolase 1, (alpha) | 0.31 |
| HMBOX1 | homeobox containing 1 | 0.31 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.31 |
| B2M | beta-2-microglobulin | 0.31 |
| SH3PXD2A | SH3 and PX domains 2A | 0.31 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 0.31 |
| S100PBP | S100P binding protein | 0.31 |
| H2AZ1 | H2A.Z variant histone 1 | 0.31 |
| ALDOA | aldolase A, fructose-bisphosphate | 0.3 |
| Symbol | Name | Standardized Value |
|---|---|---|
| C7 | complement component 7 | -1.22 |
| HMCN1 | hemicentin 1 | -1.17 |
| MNX1 | motor neuron and pancreas homeobox 1 | -1.07 |
| PIP | prolactin-induced protein | -0.94 |
| BACH1 | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | -0.88 |
| DXO | decapping exoribonuclease | -0.85 |
| CFAP410 | cilia and flagella associated protein 410 | -0.66 |
| DEPDC7 | DEP domain containing 7 | -0.57 |
| SYCP1 | synaptonemal complex protein 1 | -0.56 |
| IER5 | immediate early response 5 | -0.56 |
| CD82 | CD82 molecule | -0.53 |
| SPTA1 | spectrin, alpha, erythrocytic 1 | -0.5 |
| SLC43A2 | solute carrier family 43 (amino acid system L transporter), member 2 | -0.5 |
| CNTLN | centlein, centrosomal protein | -0.46 |
| MYBPC1 | myosin binding protein C, slow type | -0.45 |
| FN1 | fibronectin 1 | -0.44 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.44 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.43 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | -0.41 |
| PLD6 | phospholipase D family, member 6 | -0.4 |
| CCDC9B | coiled-coil domain containing 9B | -0.4 |
| APOB | apolipoprotein B | -0.39 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -0.38 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | -0.38 |
| DNAL4 | dynein, axonemal, light chain 4 | -0.38 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.38 |
| DOLK | dolichol kinase | -0.37 |
| PAH | phenylalanine hydroxylase | -0.37 |
| TBC1D14 | TBC1 domain family, member 14 | -0.36 |
| TMEM63C | transmembrane protein 63C | -0.36 |
| MCPH1 | microcephalin 1 | -0.35 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | -0.35 |
| MFAP3 | microfibrillar-associated protein 3 | -0.35 |
| CNTRL | centriolin | -0.34 |
| CNEP1R1 | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | -0.33 |
| ITFG2 | integrin alpha FG-GAP repeat containing 2 | -0.32 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.32 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | -0.32 |
| UBN1 | ubinuclein 1 | -0.32 |
| JRK | Jrk homolog (mouse) | -0.32 |
| CBR1 | carbonyl reductase 1 | -0.32 |
| MMGT1 | membrane magnesium transporter 1 | -0.31 |
| SIAH2 | siah E3 ubiquitin protein ligase 2 | -0.31 |
| NRP1 | neuropilin 1 | -0.31 |
| FBXO17 | F-box protein 17 | -0.31 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | -0.31 |
| NCOA1 | nuclear receptor coactivator 1 | -0.31 |
| ODC1 | ornithine decarboxylase 1 | -0.31 |
| RNASE4 | ribonuclease, RNase A family, 4 | -0.31 |
| F8 | coagulation factor VIII, procoagulant component | -0.3 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.3 |
| ABHD17C | abhydrolase domain containing 17C | -0.3 |
| L1RE1 | LINE1 retrotransposable element 1 | -0.3 |
| TP53 | tumor protein p53 | -0.3 |
| PPP4R4 | protein phosphatase 4, regulatory subunit 4 | -0.29 |
| PRSS23 | protease, serine, 23 | -0.29 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.29 |
| LENG9 | leukocyte receptor cluster (LRC) member 9 | -0.29 |
| CES2 | carboxylesterase 2 | -0.29 |
| DUSP5 | dual specificity phosphatase 5 | -0.29 |
| UPP1 | uridine phosphorylase 1 | -0.29 |
| ADCY7 | adenylate cyclase 7 | -0.29 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | -0.29 |
| KLHL15 | kelch-like family member 15 | -0.28 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.28 |
| PYGM | phosphorylase, glycogen, muscle | -0.28 |
| EEF2KMT | eukaryotic elongation factor 2 lysine methyltransferase | -0.28 |
| SLC43A3 | solute carrier family 43, member 3 | -0.28 |
| RPL37 | ribosomal protein L37 | -0.28 |
| KLHL22 | kelch-like family member 22 | -0.28 |
| OPA3 | optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) | -0.27 |
| PIP5K1C | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma | -0.27 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.27 |
| LMX1B | LIM homeobox transcription factor 1, beta | -0.27 |
| AP4S1 | adaptor-related protein complex 4, sigma 1 subunit | -0.27 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.27 |
| ARHGEF19 | Rho guanine nucleotide exchange factor (GEF) 19 | -0.27 |
| SLC30A3 | solute carrier family 30 (zinc transporter), member 3 | -0.27 |
| GJB3 | gap junction protein, beta 3, 31kDa | -0.27 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.27 |
| ZNF581 | zinc finger protein 581 | -0.26 |
| TMEM208 | transmembrane protein 208 | -0.26 |
| JAK2 | Janus kinase 2 | -0.26 |
| NFYA | nuclear transcription factor Y, alpha | -0.26 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.26 |
| CCDC115 | coiled-coil domain containing 115 | -0.26 |
| RRAGC | Ras-related GTP binding C | -0.26 |
| PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 | -0.26 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.26 |
| SERINC1 | serine incorporator 1 | -0.26 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -0.25 |
| ARSB | arylsulfatase B | -0.25 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | -0.25 |
| CRIP2 | cysteine-rich protein 2 | -0.25 |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | -0.24 |
| HGFAC | HGF activator | -0.24 |
| ZNF444 | zinc finger protein 444 | -0.24 |
| MRPL34 | mitochondrial ribosomal protein L34 | -0.24 |
| LACC1 | laccase (multicopper oxidoreductase) domain containing 1 | -0.24 |
| AGTRAP | angiotensin II receptor-associated protein | -0.23 |
