| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dorzolamide (hydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UBC | ubiquitin C | 0.148646 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.133274 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.130388 |
| COL3A1 | collagen, type III, alpha 1 | 0.112564 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.106935 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.104111 |
| PTMA | prothymosin, alpha | 0.0864526 |
| OGA | O-GlcNAcase | 0.0837285 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0827646 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0724941 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0707307 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0692697 |
| SQSTM1 | sequestosome 1 | 0.0688642 |
| NAV2 | neuron navigator 2 | 0.0641557 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0622441 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0562758 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0542577 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0517085 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0512121 |
| FLNB | filamin B, beta | 0.050426 |
| MT2A | metallothionein 2A | 0.0486351 |
| AHNAK | AHNAK nucleoprotein | 0.0475342 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0472984 |
| TPM3 | tropomyosin 3 | 0.0469588 |
| TMSB4X | thymosin beta 4, X-linked | 0.0460053 |
| FBN1 | fibrillin 1 | 0.0448456 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0448294 |
| COL5A2 | collagen, type V, alpha 2 | 0.044433 |
| SBF2 | SET binding factor 2 | 0.0441771 |
| COL1A2 | collagen, type I, alpha 2 | 0.043962 |
| CALR | calreticulin | 0.0437739 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0424765 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0423377 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0421014 |
| CANX | calnexin | 0.0419806 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0417983 |
| APP | amyloid beta (A4) precursor protein | 0.0416088 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0408232 |
| GOLGA4 | golgin A4 | 0.0403685 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0402888 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0393317 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0383686 |
| HMGB2 | high mobility group box 2 | 0.0377659 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0368846 |
| ENO1 | enolase 1, (alpha) | 0.0367997 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0362117 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0356707 |
| RPS27A | ribosomal protein S27a | 0.0354617 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0352822 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0348553 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0347765 |
| ZNF292 | zinc finger protein 292 | 0.0342849 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0335182 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0334077 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0333603 |
| STC1 | stanniocalcin 1 | 0.0329731 |
| RAI1 | retinoic acid induced 1 | 0.0326297 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0322626 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0321579 |
| SET | SET nuclear proto-oncogene | 0.0320649 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0320174 |
| B2M | beta-2-microglobulin | 0.0317627 |
| RPS3 | ribosomal protein S3 | 0.0311603 |
| VIM | vimentin | 0.0310442 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0308598 |
| MATR3 | matrin 3 | 0.0307561 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0302592 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0302426 |
| RBM25 | RNA binding motif protein 25 | 0.0298818 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | 0.0296377 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0290711 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0286 |
| TLN1 | talin 1 | 0.0274198 |
| RPL4 | ribosomal protein L4 | 0.0273764 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.027366 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0272393 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0271767 |
| DENND5A | DENN/MADD domain containing 5A | 0.0270676 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0268641 |
| RACK1 | receptor for activated C kinase 1 | 0.0262602 |
| CD99 | CD99 molecule | 0.0261852 |
| ATP13A3 | ATPase type 13A3 | 0.0256331 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.025542 |
| RPL26 | ribosomal protein L26 | 0.0252802 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0252022 |
| RRBP1 | ribosome binding protein 1 | 0.0249355 |
| SUCO | SUN domain containing ossification factor | 0.0248567 |
| FNDC3B | fibronectin type III domain containing 3B | 0.024726 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0247236 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0246497 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0243591 |
| OPTN | optineurin | 0.0243371 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0240648 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0240496 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0240472 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0238576 |
| AFDN | afadin, adherens junction formation factor | 0.0236947 |
| EZR | ezrin | 0.0236574 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0236178 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0235434 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.191335 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.154568 |
| PODXL | podocalyxin-like | -0.120966 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.120459 |
| S100A10 | S100 calcium binding protein A10 | -0.0833057 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0810233 |
| PLAT | plasminogen activator, tissue | -0.0785735 |
| NDRG1 | N-myc downstream regulated 1 | -0.0776391 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0687792 |
| CDH13 | cadherin 13 | -0.0684103 |
| NAV1 | neuron navigator 1 | -0.0683114 |
| FN1 | fibronectin 1 | -0.057744 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0576713 |
| MAP1B | microtubule-associated protein 1B | -0.0547747 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0539342 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0527965 |
| POTEF | POTE ankyrin domain family, member F | -0.048941 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0471631 |
| COL5A1 | collagen, type V, alpha 1 | -0.0419369 |
| HLA-B | major histocompatibility complex, class I, B | -0.0403323 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0399172 |
| CUX1 | cut-like homeobox 1 | -0.0386535 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.038473 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0368571 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.036601 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0361872 |
| EFNA5 | ephrin-A5 | -0.0354219 |
| EGFR | epidermal growth factor receptor | -0.0351574 |
| RIGI | RNA sensor RIG-I | -0.0342707 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0336426 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0330173 |
| PRSS23 | protease, serine, 23 | -0.0325892 |
| SUCNR1 | succinate receptor 1 | -0.0325347 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0324806 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0324551 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0317254 |
| CAVIN1 | caveolae associated protein 1 | -0.0314554 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0304634 |
| MX2 | MX dynamin-like GTPase 2 | -0.028875 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0287769 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0277912 |
| S100A11 | S100 calcium binding protein A11 | -0.0275869 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0273412 |
| CSTB | cystatin B (stefin B) | -0.0269644 |
| RPL35A | ribosomal protein L35a | -0.0265251 |
| GLIS3 | GLIS family zinc finger 3 | -0.0265126 |
| VCL | vinculin | -0.0259322 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0257618 |
| ACTG1 | actin gamma 1 | -0.0256343 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0255337 |
| TENM3 | teneurin transmembrane protein 3 | -0.0247276 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0246918 |
| CD81 | CD81 molecule | -0.0243243 |
| KRT81 | keratin 81, type II | -0.0242175 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0241133 |
| RPS23 | ribosomal protein S23 | -0.0235788 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0233946 |
| DCLK2 | doublecortin-like kinase 2 | -0.0233941 |
| RPS15 | ribosomal protein S15 | -0.0227765 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0227041 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.022417 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0219311 |
| PLXNA2 | plexin A2 | -0.0219229 |
| BPTF | bromodomain PHD finger transcription factor | -0.021909 |
| CYTH3 | cytohesin 3 | -0.0217637 |
| HLA-C | major histocompatibility complex, class I, C | -0.0215441 |
| IL7R | interleukin 7 receptor | -0.0213171 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0212162 |
| CTSD | cathepsin D | -0.021148 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0211119 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0211089 |
| RNF213 | ring finger protein 213 | -0.0210454 |
| LRRC17 | leucine rich repeat containing 17 | -0.0204041 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0203997 |
| BSG | basigin (Ok blood group) | -0.0203927 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0201788 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0200008 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0198661 |
| INTS6 | integrator complex subunit 6 | -0.0196737 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0196643 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0194432 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0191952 |
| MEIS2 | Meis homeobox 2 | -0.0190184 |
| TPM4 | tropomyosin 4 | -0.0189547 |
| EGR1 | early growth response 1 | -0.0188244 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0188079 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0186679 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0184252 |
| FBXO11 | F-box protein 11 | -0.0183669 |
| IPO9 | importin 9 | -0.0180747 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0180066 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.0174011 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0173905 |
| KIAA1549L | KIAA1549-like | -0.0173747 |
| RPL38 | ribosomal protein L38 | -0.0169043 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0168886 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0168561 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0167802 |
| DEK | DEK proto-oncogene | -0.0167707 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0166882 |
