| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dorzolamide (hydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.13227 |
| AREG | amphiregulin | 0.0986849 |
| RPL4 | ribosomal protein L4 | 0.0844308 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0793498 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0660071 |
| RPS2 | ribosomal protein S2 | 0.059977 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0587364 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.058339 |
| RPL23 | ribosomal protein L23 | 0.0525037 |
| KIF5B | kinesin family member 5B | 0.0522441 |
| PRRC2C | proline-rich coiled-coil 2C | 0.051638 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0514717 |
| RPS12 | ribosomal protein S12 | 0.0489168 |
| SET | SET nuclear proto-oncogene | 0.0455273 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0448456 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0433449 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0432872 |
| YBX3 | Y box binding protein 3 | 0.0411016 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0408696 |
| RPL26 | ribosomal protein L26 | 0.0384092 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0374902 |
| RPL12 | ribosomal protein L12 | 0.0351595 |
| ATP11A | ATPase, class VI, type 11A | 0.0350753 |
| RBM39 | RNA binding motif protein 39 | 0.0349263 |
| OGA | O-GlcNAcase | 0.0337344 |
| HMGB2 | high mobility group box 2 | 0.033604 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0328442 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0320094 |
| RACK1 | receptor for activated C kinase 1 | 0.031426 |
| RPS3 | ribosomal protein S3 | 0.0304956 |
| EDN1 | endothelin 1 | 0.0298592 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.0293368 |
| CBX3 | chromobox homolog 3 | 0.0292426 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0290621 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0288261 |
| RPL5 | ribosomal protein L5 | 0.0286289 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0281706 |
| PCDH7 | protocadherin 7 | 0.0279744 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0277166 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0267216 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0264558 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0263928 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0257927 |
| EXOC6B | exocyst complex component 6B | 0.0256034 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0255884 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0255442 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0238077 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0237948 |
| USP53 | ubiquitin specific peptidase 53 | 0.0236379 |
| SQSTM1 | sequestosome 1 | 0.0232036 |
| YBX1 | Y box binding protein 1 | 0.0228674 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0227713 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0226978 |
| DST | dystonin | 0.0225627 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0225603 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0225128 |
| HLA-A | major histocompatibility complex, class I, A | 0.0221162 |
| NEK7 | NIMA-related kinase 7 | 0.0220177 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0215529 |
| RPL18 | ribosomal protein L18 | 0.0214391 |
| RPS27A | ribosomal protein S27a | 0.0212145 |
| CEP95 | centrosomal protein 95kDa | 0.0210456 |
| RPS19 | ribosomal protein S19 | 0.0209963 |
| RPL37A | ribosomal protein L37a | 0.0208911 |
| TXNRD1 | thioredoxin reductase 1 | 0.020845 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0204323 |
| SERINC1 | serine incorporator 1 | 0.0203587 |
| CLDN1 | claudin 1 | 0.0203518 |
| GOLGA4 | golgin A4 | 0.0200937 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0197851 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0192377 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.019221 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0192148 |
| ZNF217 | zinc finger protein 217 | 0.0190479 |
| TPI1 | triosephosphate isomerase 1 | 0.0188875 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.018765 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0182966 |
| IWS1 | IWS1 homolog (S. cerevisiae) | 0.0182631 |
| GASK1B | golgi associated kinase 1B | 0.0180715 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0180466 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0179213 |
| EFNA5 | ephrin-A5 | 0.017768 |
| THOC1 | THO complex 1 | 0.0177665 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0177167 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0176991 |
| PRPF4B | pre-mRNA processing factor 4B | 0.0175718 |
| YTHDC1 | YTH domain containing 1 | 0.0175122 |
| OXR1 | oxidation resistance 1 | 0.0174512 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0172546 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.017143 |
| RPS18 | ribosomal protein S18 | 0.0169635 |
| SON | SON DNA binding protein | 0.0165328 |
| RPS15A | ribosomal protein S15a | 0.0164896 |
| PHF3 | PHD finger protein 3 | 0.0163768 |
| RPS4X | ribosomal protein S4, X-linked | 0.0163433 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0162387 |
| CCDC47 | coiled-coil domain containing 47 | 0.0161496 |
| MTAP | methylthioadenosine phosphorylase | 0.0159982 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.015844 |
| RPL14 | ribosomal protein L14 | 0.0158035 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.315768 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.143237 |
| MMP12 | matrix metallopeptidase 12 | -0.132489 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.120149 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0693772 |
| HMGA2 | high mobility group AT-hook 2 | -0.0681253 |
| EGR1 | early growth response 1 | -0.0656469 |
| POTEF | POTE ankyrin domain family, member F | -0.0555295 |
| NHSL1 | NHS-like 1 | -0.0534732 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0501574 |
| NLGN1 | neuroligin 1 | -0.0489749 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0487205 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0480241 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0436101 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0429857 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0421877 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0406695 |
| JMJD1C | jumonji domain containing 1C | -0.0386789 |
| ACTG1 | actin gamma 1 | -0.0377421 |
| TPM4 | tropomyosin 4 | -0.037516 |
| TUBA1B | tubulin, alpha 1b | -0.0375026 |
| USP34 | ubiquitin specific peptidase 34 | -0.0371103 |
| YAP1 | Yes-associated protein 1 | -0.0367157 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0365817 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0365795 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.036289 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0339371 |
| CANX | calnexin | -0.0330716 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0328673 |
| KCMF1 | potassium channel modulatory factor 1 | -0.032648 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0323525 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0320601 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0319013 |
| TMSB10 | thymosin beta 10 | -0.0318895 |
| HMGA1 | high mobility group AT-hook 1 | -0.0305801 |
| ERBIN | erbb2 interacting protein | -0.0305325 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0300875 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0293713 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0292163 |
| LDHB | lactate dehydrogenase B | -0.0290404 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0285109 |
| NAV3 | neuron navigator 3 | -0.0284764 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0284397 |
| CCNL1 | cyclin L1 | -0.0281626 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0280221 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0278379 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0276999 |
| ATP9A | ATPase, class II, type 9A | -0.0276843 |
| MGAT4C | MGAT4 family, member C | -0.0274235 |
| LDHA | lactate dehydrogenase A | -0.0274172 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0274149 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.0274061 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0273067 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0272304 |
| RPS23 | ribosomal protein S23 | -0.0270606 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0270449 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0268417 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0267921 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0259479 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0256393 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0252652 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0252057 |
| UBC | ubiquitin C | -0.0245316 |
| PCBP2 | poly(rC) binding protein 2 | -0.0244267 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0242157 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0240911 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0238027 |
| BCHE | butyrylcholinesterase | -0.0237937 |
| RHOA | ras homolog family member A | -0.0237254 |
| CALR | calreticulin | -0.0236162 |
| XPOT | exportin, tRNA | -0.0234516 |
| CUX1 | cut-like homeobox 1 | -0.0232698 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0226514 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.022358 |
| ADIPOR2 | adiponectin receptor 2 | -0.0223129 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0222008 |
| PFN1 | profilin 1 | -0.0220742 |
| TGM2 | transglutaminase 2 | -0.0219779 |
| MYADM | myeloid-associated differentiation marker | -0.0218982 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | -0.0211602 |
| SRSF3 | serine/arginine-rich splicing factor 3 | -0.0207414 |
| ZNF638 | zinc finger protein 638 | -0.0206588 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.020607 |
| CMIP | c-Maf inducing protein | -0.0206013 |
| FADS2 | fatty acid desaturase 2 | -0.020415 |
| SETD5 | SET domain containing 5 | -0.0202677 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0201732 |
| GCG | glucagon | -0.0201563 |
| S100A10 | S100 calcium binding protein A10 | -0.0198988 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0198779 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0197499 |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | -0.0196184 |
| KSR2 | kinase suppressor of ras 2 | -0.0195024 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0193537 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0191108 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0190032 |
| RTN4 | reticulon 4 | -0.0187705 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.018763 |
| SETX | senataxin | -0.0187514 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0185372 |
