| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dorzolamide (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CCL2 | chemokine (C-C motif) ligand 2 | 0.155162 |
| ASPH | aspartate beta-hydroxylase | 0.125156 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.084624 |
| PTMA | prothymosin, alpha | 0.0689558 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0689554 |
| RPS2 | ribosomal protein S2 | 0.0675431 |
| RPL4 | ribosomal protein L4 | 0.0539542 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0528182 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0527626 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0444154 |
| NRP2 | neuropilin 2 | 0.0427894 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.040834 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0388049 |
| RPS12 | ribosomal protein S12 | 0.0383224 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0377032 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0361641 |
| RPS3 | ribosomal protein S3 | 0.0329987 |
| RPL26 | ribosomal protein L26 | 0.0327554 |
| RRBP1 | ribosome binding protein 1 | 0.0317867 |
| RBM25 | RNA binding motif protein 25 | 0.0312402 |
| ANLN | anillin, actin binding protein | 0.031173 |
| MT2A | metallothionein 2A | 0.0300318 |
| TPM3 | tropomyosin 3 | 0.029333 |
| RPL18 | ribosomal protein L18 | 0.0288299 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0287519 |
| RPS15A | ribosomal protein S15a | 0.0279689 |
| SET | SET nuclear proto-oncogene | 0.0269949 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0265359 |
| DAPK1 | death-associated protein kinase 1 | 0.0260127 |
| CP | ceruloplasmin (ferroxidase) | 0.0256757 |
| RPL37A | ribosomal protein L37a | 0.0252577 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0250536 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0249221 |
| HMGB2 | high mobility group box 2 | 0.0240117 |
| TLN1 | talin 1 | 0.0237973 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.023559 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0226296 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | 0.0223263 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0218472 |
| CBX3 | chromobox homolog 3 | 0.021645 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0216448 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.0211552 |
| HLA-A | major histocompatibility complex, class I, A | 0.0209873 |
| RBM39 | RNA binding motif protein 39 | 0.0205263 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0202675 |
| RPS17 | ribosomal protein S17 | 0.0197631 |
| DHFR | dihydrofolate reductase | 0.0195277 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0195167 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0193796 |
| MKI67 | marker of proliferation Ki-67 | 0.019257 |
| RPL36 | ribosomal protein L36 | 0.0191189 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.0190494 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0185121 |
| DENND2B | DENN domain containing 2B | 0.0184411 |
| NFIB | nuclear factor I/B | 0.0179179 |
| RANBP1 | RAN binding protein 1 | 0.0177971 |
| HGS | hepatocyte growth factor-regulated tyrosine kinase substrate | 0.0175875 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0175595 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0171937 |
| RRM2 | ribonucleotide reductase M2 | 0.0170948 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0170533 |
| GNA12 | guanine nucleotide binding protein (G protein) alpha 12 | 0.016847 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0168466 |
| TRIM56 | tripartite motif containing 56 | 0.01665 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.0165798 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0165094 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0164782 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0164473 |
| NUCB2 | nucleobindin 2 | 0.0163802 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0163069 |
| CENPF | centromere protein F, 350/400kDa | 0.016223 |
| MRPL33 | mitochondrial ribosomal protein L33 | 0.0161754 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0160859 |
| ETV6 | ets variant 6 | 0.0160586 |
| GLIS3 | GLIS family zinc finger 3 | 0.0158515 |
| BICC1 | BicC family RNA binding protein 1 | 0.0158251 |
| HMGB1 | high mobility group box 1 | 0.0155226 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0154126 |
| IFI44L | interferon-induced protein 44-like | 0.0152299 |
| RPS18 | ribosomal protein S18 | 0.0150974 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.0148927 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0147457 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0147257 |
| TGFB2 | transforming growth factor, beta 2 | 0.0145716 |
| TRIP10 | thyroid hormone receptor interactor 10 | 0.0144723 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0142341 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0141598 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0141478 |
| PON2 | paraoxonase 2 | 0.0140981 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0140788 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0138336 |
| RPL35 | ribosomal protein L35 | 0.0138301 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.0137004 |
| RPL37 | ribosomal protein L37 | 0.0136628 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0136201 |
| RPL13A | ribosomal protein L13a | 0.0136015 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0135913 |
| CLMB | calcimembrin | 0.0135489 |
| PHF14 | PHD finger protein 14 | 0.0134867 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0134788 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.288193 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.219654 |
| VIM | vimentin | -0.139474 |
| EXT1 | exostosin glycosyltransferase 1 | -0.118273 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.100131 |
| NDRG1 | N-myc downstream regulated 1 | -0.0966359 |
| UBC | ubiquitin C | -0.0947723 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0828213 |
| FTL | ferritin, light polypeptide | -0.0822454 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0785453 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0732481 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0713071 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0701546 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0688349 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.068823 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0665232 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0643328 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0636951 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0625346 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0613948 |
| SDCBP | syndecan binding protein (syntenin) | -0.0595754 |
| RHEB | Ras homolog enriched in brain | -0.0594244 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0583908 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0568724 |
| CD44 | CD44 molecule (Indian blood group) | -0.0565151 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0537175 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0533256 |
| RPL8 | ribosomal protein L8 | -0.0527987 |
| AHNAK | AHNAK nucleoprotein | -0.0524832 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0524044 |
| VCL | vinculin | -0.0524039 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0517358 |
| COG5 | component of oligomeric golgi complex 5 | -0.0516466 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0506051 |
| CANX | calnexin | -0.0503421 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0495436 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0491838 |
| CTSD | cathepsin D | -0.049059 |
| HM13 | histocompatibility (minor) 13 | -0.0472817 |
| RPS23 | ribosomal protein S23 | -0.0458289 |
| CADM1 | cell adhesion molecule 1 | -0.045457 |
| INTS6 | integrator complex subunit 6 | -0.0453609 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0452159 |
| MORF4L2 | mortality factor 4 like 2 | -0.0449246 |
| S100A10 | S100 calcium binding protein A10 | -0.044887 |
| ANXA2 | annexin A2 | -0.0442415 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | -0.0440742 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0432572 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0428281 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.04267 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0426628 |
| GOLGB1 | golgin B1 | -0.0419413 |
| TRAM1 | translocation associated membrane protein 1 | -0.0417049 |
| TUBA1B | tubulin, alpha 1b | -0.0415331 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0412172 |
| NUP98 | nucleoporin 98kDa | -0.0407945 |
| PLIN2 | perilipin 2 | -0.0406883 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0402831 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0397086 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0395332 |
| PALLD | palladin, cytoskeletal associated protein | -0.0394736 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0393463 |
| RPS24 | ribosomal protein S24 | -0.0391807 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0390128 |
| ACTG1 | actin gamma 1 | -0.038579 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0376494 |
| RND3 | Rho family GTPase 3 | -0.0376401 |
| KYNU | kynureninase | -0.0375687 |
| MAP1B | microtubule-associated protein 1B | -0.0374442 |
| CTBP2 | C-terminal binding protein 2 | -0.0372728 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0369034 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0367533 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0367235 |
| NIBAN1 | niban apoptosis regulator 1 | -0.036641 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0360659 |
| RPS15 | ribosomal protein S15 | -0.0360145 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0359853 |
| TXNRD1 | thioredoxin reductase 1 | -0.0355925 |
| ANXA5 | annexin A5 | -0.0353133 |
| SUCO | SUN domain containing ossification factor | -0.0349713 |
| RPL7 | ribosomal protein L7 | -0.0345862 |
| SEC24D | SEC24 family member D | -0.0345718 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0345529 |
| SETX | senataxin | -0.0338451 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0335368 |
| TMEM263 | transmembrane protein 263 | -0.0333196 |
| SPAG9 | sperm associated antigen 9 | -0.0332219 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0330075 |
| ATP13A3 | ATPase type 13A3 | -0.0329955 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0329304 |
| TPM4 | tropomyosin 4 | -0.032752 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | -0.0327226 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0325497 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0320478 |
| HLA-E | major histocompatibility complex, class I, E | -0.0320294 |
| COG6 | component of oligomeric golgi complex 6 | -0.0319246 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0313196 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0311492 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0311181 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.03099 |
