| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dorzolamide (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0977776 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0901328 |
| RPL4 | ribosomal protein L4 | 0.0895471 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0697115 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0665765 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0647955 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0629821 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0627059 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0578681 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0542828 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.046006 |
| VIM | vimentin | 0.0449473 |
| UBC | ubiquitin C | 0.0449176 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0430489 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0389128 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0371867 |
| USP3 | ubiquitin specific peptidase 3 | 0.036478 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0351781 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0347428 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0342932 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0341536 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0336419 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0336408 |
| TXNRD1 | thioredoxin reductase 1 | 0.0331914 |
| OGA | O-GlcNAcase | 0.0317215 |
| PGK1 | phosphoglycerate kinase 1 | 0.0310961 |
| TKT | transketolase | 0.0303302 |
| ENO1 | enolase 1, (alpha) | 0.0297 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0296116 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.02912 |
| ACTG1 | actin gamma 1 | 0.0286392 |
| NUP58 | nucleoporin 58 | 0.0281613 |
| FBL | fibrillarin | 0.0276463 |
| WDR45B | WD repeat domain 45B | 0.0260426 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0257142 |
| HELZ | helicase with zinc finger | 0.0253872 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0252191 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0248936 |
| ANLN | anillin, actin binding protein | 0.0247396 |
| SPAG9 | sperm associated antigen 9 | 0.0241572 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0238696 |
| CA12 | carbonic anhydrase XII | 0.0236795 |
| MATR3 | matrin 3 | 0.023561 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0234195 |
| RTN4 | reticulon 4 | 0.0231763 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0229408 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0229031 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0225766 |
| GOLGA4 | golgin A4 | 0.0222307 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0220338 |
| TFG | TRK-fused gene | 0.0219162 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0218815 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0218627 |
| TMSB4X | thymosin beta 4, X-linked | 0.0216258 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0210167 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0209217 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0209174 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0208157 |
| EREG | epiregulin | 0.0207716 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0206286 |
| KRT18 | keratin 18, type I | 0.0204829 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0204448 |
| RPLP0 | ribosomal protein, large, P0 | 0.0202518 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0202429 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0196786 |
| CDC27 | cell division cycle 27 | 0.0194191 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0194127 |
| LDHA | lactate dehydrogenase A | 0.019346 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0189444 |
| FAM107B | family with sequence similarity 107, member B | 0.0185479 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0185415 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0184417 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0183797 |
| INSIG2 | insulin induced gene 2 | 0.0183407 |
| RPS2 | ribosomal protein S2 | 0.0182875 |
| KIF5B | kinesin family member 5B | 0.0177546 |
| SET | SET nuclear proto-oncogene | 0.0173517 |
| MKI67 | marker of proliferation Ki-67 | 0.0172293 |
| NGLY1 | N-glycanase 1 | 0.0172125 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0171684 |
| RBM39 | RNA binding motif protein 39 | 0.0171285 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0169349 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0169075 |
| KCTD9 | potassium channel tetramerization domain containing 9 | 0.0167959 |
| TNPO1 | transportin 1 | 0.0167167 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0163088 |
| YBX1 | Y box binding protein 1 | 0.0162659 |
| DENND4C | DENN/MADD domain containing 4C | 0.0161493 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0161393 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0159857 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0159736 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0158773 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.015704 |
| S100A10 | S100 calcium binding protein A10 | 0.0156992 |
| PRR11 | proline rich 11 | 0.015571 |
| NOP58 | NOP58 ribonucleoprotein | 0.0155672 |
| TPR | translocated promoter region, nuclear basket protein | 0.0154361 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0153982 |
| CDCA2 | cell division cycle associated 2 | 0.0153767 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0153503 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.394633 |
| EFNA5 | ephrin-A5 | -0.163102 |
| PDE10A | phosphodiesterase 10A | -0.12805 |
| EGFR | epidermal growth factor receptor | -0.124042 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.096269 |
| TMSB10 | thymosin beta 10 | -0.0945394 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0919184 |
| KYNU | kynureninase | -0.0900713 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.082623 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0784955 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0768653 |
| VCL | vinculin | -0.0753528 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0749706 |
| AUTS2 | autism susceptibility candidate 2 | -0.074553 |
| NDRG1 | N-myc downstream regulated 1 | -0.0741627 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0682448 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0670022 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0647769 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0644912 |
| HMGA2 | high mobility group AT-hook 2 | -0.0631482 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0601384 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0599394 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0584847 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0575024 |
| EXT1 | exostosin glycosyltransferase 1 | -0.05714 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0519654 |
| EHBP1 | EH domain binding protein 1 | -0.0515197 |
| PARD3 | par-3 family cell polarity regulator | -0.0511111 |
| MCL1 | myeloid cell leukemia 1 | -0.0497553 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.048926 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0481713 |
| PRKCA | protein kinase C, alpha | -0.0475536 |
| MYO1E | myosin IE | -0.046223 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0453175 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.045241 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0450135 |
| ASPH | aspartate beta-hydroxylase | -0.0448206 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0446384 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0437507 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0432878 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0428156 |
| INTS6 | integrator complex subunit 6 | -0.0414642 |
| RNF213 | ring finger protein 213 | -0.0409256 |
| RAD51B | RAD51 paralog B | -0.0402294 |
| FBXO11 | F-box protein 11 | -0.0400508 |
| TNS3 | tensin 3 | -0.0389682 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0388723 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0376778 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0373649 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0370011 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0366547 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0365451 |
| CTBP2 | C-terminal binding protein 2 | -0.0363587 |
| ST6GAL2 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 | -0.0363577 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0361871 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0361543 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0351667 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0351262 |
| DUSP16 | dual specificity phosphatase 16 | -0.0350992 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0344251 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0342135 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0334159 |
| GOLGB1 | golgin B1 | -0.0333826 |
| ANXA2 | annexin A2 | -0.0333109 |
| EGR1 | early growth response 1 | -0.0330349 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | -0.0327421 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0326486 |
| RPS19 | ribosomal protein S19 | -0.0322723 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0322177 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0321311 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.0318624 |
| VMP1 | vacuole membrane protein 1 | -0.0317143 |
| ETNK1 | ethanolamine kinase 1 | -0.0314574 |
| OSMR | oncostatin M receptor | -0.0309018 |
| LMO7 | LIM domain 7 | -0.0306509 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0306274 |
| AADAC | arylacetamide deacetylase | -0.0305788 |
| CDKL5 | cyclin-dependent kinase-like 5 | -0.029871 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0291583 |
| BICC1 | BicC family RNA binding protein 1 | -0.0290103 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0283502 |
| NRG1 | neuregulin 1 | -0.0281642 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0279598 |
| TPM1 | tropomyosin 1 (alpha) | -0.0279298 |
| LAMA5 | laminin, alpha 5 | -0.0278654 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0276596 |
| FRMD6 | FERM domain containing 6 | -0.0274635 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.0272117 |
| FLNB | filamin B, beta | -0.0267841 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0267337 |
| PALLD | palladin, cytoskeletal associated protein | -0.0259544 |
| RPL37A | ribosomal protein L37a | -0.0259137 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.025687 |
| ERBIN | erbb2 interacting protein | -0.0255386 |
| CDK13 | cyclin-dependent kinase 13 | -0.0254608 |
| RCOR1 | REST corepressor 1 | -0.0254167 |
| ZNF638 | zinc finger protein 638 | -0.0253854 |
| NABP1 | nucleic acid binding protein 1 | -0.0252282 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0251414 |
| MED13L | mediator complex subunit 13-like | -0.0250808 |
