Dorzolamide (hydrochloride)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dorzolamide (hydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dorzolamide (hydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.296842
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.194985
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.187111
EGFR epidermal growth factor receptor 0.127932
VIM vimentin 0.122925
EZR ezrin 0.107523
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.105507
EFNA5 ephrin-A5 0.1042
LMO7 LIM domain 7 0.0976666
DOCK5 dedicator of cytokinesis 5 0.0935232
PSD3 pleckstrin and Sec7 domain containing 3 0.0885258
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0877643
FLNB filamin B, beta 0.0856805
ASPH aspartate beta-hydroxylase 0.082482
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0817329
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0763425
VCAN versican 0.0642776
VCL vinculin 0.0636441
ITGA6 integrin, alpha 6 0.0614692
AHNAK AHNAK nucleoprotein 0.0610121
PRSS3 protease, serine, 3 0.0587013
GREB1L growth regulation by estrogen in breast cancer-like 0.0585974
ERRFI1 ERBB receptor feedback inhibitor 1 0.0567172
DSPP dentin sialophosphoprotein 0.0564799
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0557122
PRRC2C proline-rich coiled-coil 2C 0.0540975
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0535984
SLC38A2 solute carrier family 38, member 2 0.0531198
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0530032
ITPRID2 ITPR interacting domain containing 2 0.0526068
PTPRR protein tyrosine phosphatase, receptor type, R 0.0512443
TMSB10 thymosin beta 10 0.0511335
TM4SF1 transmembrane 4 L six family member 1 0.0500244
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0496386
SACK1A scaffolding CK1 anchoring protein A 0.0482551
MYOF myoferlin 0.0480546
AKAP13 A kinase (PRKA) anchor protein 13 0.0478037
PTMA prothymosin, alpha 0.0475954
EIF1 eukaryotic translation initiation factor 1 0.0466128
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0463004
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0454536
TPM4 tropomyosin 4 0.0452945
NPSR1 neuropeptide S receptor 1 0.0446068
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0441311
MPRIP myosin phosphatase Rho interacting protein 0.0434739
JMJD1C jumonji domain containing 1C 0.0424579
RABGAP1L RAB GTPase activating protein 1-like 0.0410947
SMAD3 SMAD family member 3 0.0410513
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.040842
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0405747
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.040244
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.0401103
RPL4 ribosomal protein L4 0.0398649
B2M beta-2-microglobulin 0.0396493
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0392462
ARHGAP5 Rho GTPase activating protein 5 0.039185
NCOA3 nuclear receptor coactivator 3 0.0387394
CD59 CD59 molecule, complement regulatory protein 0.0382061
CFLAR CASP8 and FADD-like apoptosis regulator 0.0382018
PLAUR plasminogen activator, urokinase receptor 0.0381631
ACTN4 actinin, alpha 4 0.0378798
RRBP1 ribosome binding protein 1 0.0374155
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0367555
PRELID2 PRELI domain containing 2 0.0366213
DSG2 desmoglein 2 0.0357447
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0357444
FNDC3B fibronectin type III domain containing 3B 0.0352908
TRIP12 thyroid hormone receptor interactor 12 0.0351122
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0349811
KTN1 kinectin 1 (kinesin receptor) 0.034713
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0345692
ARHGAP42 Rho GTPase activating protein 42 0.034526
SLC35F3 solute carrier family 35, member F3 0.0338702
S100A10 S100 calcium binding protein A10 0.033343
CAPN2 calpain 2, (m/II) large subunit 0.0330513
BCL2L1 BCL2-like 1 0.032687
PDLIM5 PDZ and LIM domain 5 0.0325736
RPS21 ribosomal protein S21 0.0325245
LAMA4 laminin, alpha 4 0.0322571
HMGA2 high mobility group AT-hook 2 0.0318386
COL17A1 collagen, type XVII, alpha 1 0.0317358
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0316565
ZBTB20 zinc finger and BTB domain containing 20 0.0316146
PLEC plectin 0.0314382
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0310406
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0309856
KMT2C lysine (K)-specific methyltransferase 2C 0.0307818
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0306879
LOC112694756 uncharaterized LOC112694756 0.0306518
ACTG1 actin gamma 1 0.0306389
S100A4 S100 calcium binding protein A4 0.0303657
EHBP1 EH domain binding protein 1 0.0292721
OGA O-GlcNAcase 0.0292667
F3 coagulation factor III (thromboplastin, tissue factor) 0.0290157
MED13L mediator complex subunit 13-like 0.0288374
BCAR3 breast cancer anti-estrogen resistance 3 0.0287788
KLF6 Kruppel-like factor 6 0.0284213
TRIO trio Rho guanine nucleotide exchange factor 0.0279827
LY6E lymphocyte antigen 6 complex, locus E 0.0278465
ITGB4 integrin, beta 4 0.027838

decreased expression

Symbol Name Standardized Value
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0887526
NDRG1 N-myc downstream regulated 1 -0.0868297
LAMB3 laminin, beta 3 -0.0648732
MXD1 MAX dimerization protein 1 -0.0473553
LMTK2 lemur tyrosine kinase 2 -0.0313137
EGR1 early growth response 1 -0.0312365
KLK10 kallikrein-related peptidase 10 -0.028547
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0272207
POTEF POTE ankyrin domain family, member F -0.026053
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0221207
RAB7A RAB7A, member RAS oncogene family -0.0200932
HMGA1 high mobility group AT-hook 1 -0.0200691
SEC24A SEC24 family member A -0.018465
PDIA3 protein disulfide isomerase family A, member 3 -0.0181866
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0178968
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0178908
MUC17 mucin 17, cell surface associated -0.016953
NUP58 nucleoporin 58 -0.0165008
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0164779
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0163197
ANXA1 annexin A1 -0.0160681
BLZF1 basic leucine zipper nuclear factor 1 -0.0156009
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0155427
USP3 ubiquitin specific peptidase 3 -0.014873
QKI QKI, KH domain containing, RNA binding -0.0144348
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0143626
PNPLA8 patatin-like phospholipase domain containing 8 -0.0142559
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0142537
WAC WW domain containing adaptor with coiled-coil -0.0141455
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0138611
HBP1 HMG-box transcription factor 1 -0.0137795
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0135486
COPA coatomer protein complex, subunit alpha -0.0134994
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0134261
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0133446
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0132858
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -0.0130642
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0126954
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0124962
SRP54 signal recognition particle 54kDa -0.012191
VEGFA vascular endothelial growth factor A -0.0119178
WDFY2 WD repeat and FYVE domain containing 2 -0.0116713
YTHDC1 YTH domain containing 1 -0.011559
FGFR1 fibroblast growth factor receptor 1 -0.0114525
MYO5B myosin VB -0.0113348
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0110767
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0108722
NAP1L4 nucleosome assembly protein 1-like 4 -0.0108593
MSN moesin -0.0108333
FOSL1 FOS-like antigen 1 -0.010738
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -0.0105651
TBC1D15 TBC1 domain family, member 15 -0.0104508
THBD thrombomodulin -0.0104077
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0104016
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 -0.0103802
UBAP1 ubiquitin associated protein 1 -0.0103545
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0103064
ARHGAP12 Rho GTPase activating protein 12 -0.0102924
PRRC1 proline-rich coiled-coil 1 -0.0102904
SPDYA speedy/RINGO cell cycle regulator family member A -0.0101762
COPB1 coatomer protein complex, subunit beta 1 -0.0101494
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0101173
LCN2 lipocalin 2 -0.00999129
HM13 histocompatibility (minor) 13 -0.00989958
CSTB cystatin B (stefin B) -0.009783
DPY19L1 dpy-19-like 1 (C. elegans) -0.00973275
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.00971947
HSPA8 heat shock 70kDa protein 8 -0.00969935
INPP1 inositol polyphosphate-1-phosphatase -0.00963707
TRA2B transformer 2 beta homolog (Drosophila) -0.00959185
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.00958083
PDCD10 programmed cell death 10 -0.0095622
MORF4L2 mortality factor 4 like 2 -0.00954573
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.00947895
SEC23IP SEC23 interacting protein -0.0094451
DDIT4 DNA-damage-inducible transcript 4 -0.00927005
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.009104
NIBAN1 niban apoptosis regulator 1 -0.00899954
MYRF myelin regulatory factor -0.00899814
FOS FBJ murine osteosarcoma viral oncogene homolog -0.00894789
PICALM phosphatidylinositol binding clathrin assembly protein -0.00890757
ZC3H3 zinc finger CCCH-type containing 3 -0.00887785
UFM1 ubiquitin-fold modifier 1 -0.00881698
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -0.00869581
VEZT vezatin, adherens junctions transmembrane protein -0.00864053
GDAP2 ganglioside induced differentiation associated protein 2 -0.00862738
RAB11FIP5 RAB11 family interacting protein 5 (class I) -0.00852738
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.00847855
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.00847706
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 -0.0083636
CD164 CD164 molecule, sialomucin -0.0083407
CCNT2 cyclin T2 -0.008291
RAI14 retinoic acid induced 14 -0.00828968
LRP5 low density lipoprotein receptor-related protein 5 -0.00825226
MGST1 microsomal glutathione S-transferase 1 -0.00818667
P4HB prolyl 4-hydroxylase, beta polypeptide -0.00817963
MLF1 myeloid leukemia factor 1 -0.00815834
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme -0.00811123
TRAF3 TNF receptor-associated factor 3 -0.00807295
MIMS1 mitochondrial inner membrane scaffold 1 -0.00801709