Dorzolamide (hydrochloride)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dorzolamide (hydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dorzolamide (hydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 0.206671
FTH1 ferritin, heavy polypeptide 1 0.110305
PTMA prothymosin, alpha 0.0881738
MT2A metallothionein 2A 0.0843003
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0762323
RPS3 ribosomal protein S3 0.0760229
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0545065
TMSB10 thymosin beta 10 0.052385
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0462511
RPL12 ribosomal protein L12 0.0428804
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0424496
RPS12 ribosomal protein S12 0.0394138
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0378202
RPL35A ribosomal protein L35a 0.0375131
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0356108
RPS19 ribosomal protein S19 0.0346278
RPS6 ribosomal protein S6 0.0321238
FTL ferritin, light polypeptide 0.0314536
SET SET nuclear proto-oncogene 0.0312535
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0300885
SLC38A1 solute carrier family 38, member 1 0.0292542
S100A8 S100 calcium binding protein A8 0.0289256
RPL9 ribosomal protein L9 0.0288188
ZFP36L1 ZFP36 ring finger protein-like 1 0.0286312
CEMIP cell migration inducing protein, hyaluronan binding 0.0278278
RPS27 ribosomal protein S27 0.0276719
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0273201
RPS8 ribosomal protein S8 0.0272814
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0261739
RPS2 ribosomal protein S2 0.0260877
EIF1 eukaryotic translation initiation factor 1 0.0258809
RPS17 ribosomal protein S17 0.0258669
RBM25 RNA binding motif protein 25 0.0258205
B2M beta-2-microglobulin 0.0254042
EGR1 early growth response 1 0.0251874
CBX3 chromobox homolog 3 0.0251446
RPL19 ribosomal protein L19 0.0251423
RPLP1 ribosomal protein, large, P1 0.0247014
AREG amphiregulin 0.0242086
S100A14 S100 calcium binding protein A14 0.023376
RPL26 ribosomal protein L26 0.022038
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0219537
RPL36 ribosomal protein L36 0.0218665
RPL18 ribosomal protein L18 0.0216581
RPL31 ribosomal protein L31 0.0214153
PRRC2C proline-rich coiled-coil 2C 0.0200749
RACK1 receptor for activated C kinase 1 0.019961
S100A6 S100 calcium binding protein A6 0.0199586
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.019818
VIM vimentin 0.0197822
RPL37A ribosomal protein L37a 0.0194331
NDUFA4 NDUFA4, mitochondrial complex associated 0.0183925
NDRG1 N-myc downstream regulated 1 0.0181379
PNRC1 proline-rich nuclear receptor coactivator 1 0.0180623
RPL5 ribosomal protein L5 0.0177625
PABPN1 poly(A) binding protein, nuclear 1 0.0177249
COX6C cytochrome c oxidase subunit VIc 0.0174786
RPS14 ribosomal protein S14 0.0172041
RPL35 ribosomal protein L35 0.017128
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0168747
TMEM165 transmembrane protein 165 0.0166349
ATF4 activating transcription factor 4 0.0161629
ENO2 enolase 2 (gamma, neuronal) 0.0161085
VEGFA vascular endothelial growth factor A 0.0157459
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0157077
S100A11 S100 calcium binding protein A11 0.0154949
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0154678
MIEN1 migration and invasion enhancer 1 0.0152941
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0152575
RPL30 ribosomal protein L30 0.0152261
RPLP2 ribosomal protein, large, P2 0.0151992
PFN1 profilin 1 0.0149642
GRB7 growth factor receptor-bound protein 7 0.0145599
BIRC3 baculoviral IAP repeat containing 3 0.0145122
MYL12B myosin, light chain 12B, regulatory 0.0144368
CENPF centromere protein F, 350/400kDa 0.0143462
TPT1 tumor protein, translationally-controlled 1 0.0142943
RPL37 ribosomal protein L37 0.0140843
RPL4 ribosomal protein L4 0.0139304
SPTSSA serine palmitoyltransferase, small subunit A 0.0138994
RPL27 ribosomal protein L27 0.0138923
SRSF11 serine/arginine-rich splicing factor 11 0.0137916
BRD2 bromodomain containing 2 0.0137753
RPS13 ribosomal protein S13 0.0137053
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0135505
RPS27A ribosomal protein S27a 0.0134512
FBXO32 F-box protein 32 0.0133406
EIF5B eukaryotic translation initiation factor 5B 0.0132709
RPL7 ribosomal protein L7 0.0132278
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 0.0130819
RPL32 ribosomal protein L32 0.0130193
HILPDA hypoxia inducible lipid droplet-associated 0.0130183
PNISR PNN-interacting serine/arginine-rich protein 0.0129692
LMNA lamin A/C 0.0128764
RPL11 ribosomal protein L11 0.0128748
DDIT4 DNA-damage-inducible transcript 4 0.0128649
RPLP0 ribosomal protein, large, P0 0.0127093
RPL34 ribosomal protein L34 0.0126962
RPS20 ribosomal protein S20 0.0126718
SERF2 small EDRK-rich factor 2 0.0126485

decreased expression

Symbol Name Standardized Value
ACACA acetyl-CoA carboxylase alpha -0.125879
CDK12 cyclin-dependent kinase 12 -0.122821
ZMYND8 zinc finger, MYND-type containing 8 -0.102832
CLTC clathrin, heavy chain (Hc) -0.0913248
TRPS1 trichorhinophalangeal syndrome I -0.0912239
VMP1 vacuole membrane protein 1 -0.0854714
THSD4 thrombospondin, type I, domain containing 4 -0.078487
CATSPERB catsper channel auxiliary subunit beta -0.0768592
NCOA3 nuclear receptor coactivator 3 -0.0757471
PTPRK protein tyrosine phosphatase, receptor type, K -0.0737787
LPP LIM domain containing preferred translocation partner in lipoma -0.0702365
ITCH itchy E3 ubiquitin protein ligase -0.0676472
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0658842
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0657592
TRIO trio Rho guanine nucleotide exchange factor -0.064159
PTK2 protein tyrosine kinase 2 -0.0634032
FBXL20 F-box and leucine-rich repeat protein 20 -0.0616841
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0614005
AHNAK AHNAK nucleoprotein -0.0560532
CEP250 centrosomal protein 250kDa -0.0554145
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0536048
SMYD3 SET and MYND domain containing 3 -0.0490035
RIMS2 regulating synaptic membrane exocytosis 2 -0.0483128
DNAH14 dynein, axonemal, heavy chain 14 -0.0478874
RAB22A RAB22A, member RAS oncogene family -0.0463472
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0462851
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0458863
APP amyloid beta (A4) precursor protein -0.0451303
VCP valosin containing protein -0.0442719
PATJ PATJ crumbs cell polarity complex component -0.0433364
TMEM123 transmembrane protein 123 -0.0433356
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0423296
SAMD12 sterile alpha motif domain containing 12 -0.0421889
DENND1A DENN/MADD domain containing 1A -0.0420836
NCOA6 nuclear receptor coactivator 6 -0.0417641
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0406826
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0402352
STAU1 staufen double-stranded RNA binding protein 1 -0.0398831
ZNF217 zinc finger protein 217 -0.0396033
ENAH enabled homolog (Drosophila) -0.0378806
UBE2H ubiquitin-conjugating enzyme E2H -0.037436
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0374305
GMDS GDP-mannose 4,6-dehydratase -0.0373056
ZFAND3 zinc finger, AN1-type domain 3 -0.0372807
PBX1 pre-B-cell leukemia homeobox 1 -0.0372591
LIMCH1 LIM and calponin homology domains 1 -0.037005
NF1 neurofibromin 1 -0.0362325
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0361682
ASPH aspartate beta-hydroxylase -0.0359909
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0358784
PARD3 par-3 family cell polarity regulator -0.0351865
JMJD1C jumonji domain containing 1C -0.035064
MSI2 musashi RNA-binding protein 2 -0.0350175
EFNA5 ephrin-A5 -0.0343251
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0335761
PRRC2B proline-rich coiled-coil 2B -0.0335356
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0328107
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0327721
CCND1 cyclin D1 -0.0325279
LARP4B La ribonucleoprotein domain family, member 4B -0.0322915
KRT8 keratin 8, type II -0.0322587
EXOC4 exocyst complex component 4 -0.0318319
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.031763
PRKCA protein kinase C, alpha -0.0312399
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0311802
MIPOL1 mirror-image polydactyly 1 -0.0307774
MYH9 myosin, heavy chain 9, non-muscle -0.0307192
FNDC3A fibronectin type III domain containing 3A -0.030524
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0305124
SHROOM3 shroom family member 3 -0.0302043
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0297402
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0296166
DUSP16 dual specificity phosphatase 16 -0.0292155
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0290903
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0288228
GSK3B glycogen synthase kinase 3 beta -0.0286325
CD164 CD164 molecule, sialomucin -0.0284146
KIAA1217 KIAA1217 -0.0279607
CLIP1 CAP-GLY domain containing linker protein 1 -0.0277377
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.027671
TAOK1 TAO kinase 1 -0.0276136
STRN3 striatin, calmodulin binding protein 3 -0.0273538
ANKRD36C ankyrin repeat domain 36C -0.0272548
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 -0.0272459
FNDC3B fibronectin type III domain containing 3B -0.0271981
SP100 SP100 nuclear antigen -0.0271521
ARHGAP32 Rho GTPase activating protein 32 -0.0269152
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0267261
MYOF myoferlin -0.026717
SEPTIN11 septin 11 -0.0266522
RBM47 RNA binding motif protein 47 -0.0264642
BZW1 basic leucine zipper and W2 domains 1 -0.0263492
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0260586
AHCTF1 AT hook containing transcription factor 1 -0.025996
RABGAP1 RAB GTPase activating protein 1 -0.0259544
DTNA dystrobrevin, alpha -0.0259273
SBF2 SET binding factor 2 -0.0256978
KRT18 keratin 18, type I -0.0256949
PLSCR1 phospholipid scramblase 1 -0.0256456
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0256359