| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dorzolamide (hydrochloride)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.109321 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0816867 |
| VGF | VGF nerve growth factor inducible | 0.0650997 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0635219 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0611366 |
| TPR | translocated promoter region, nuclear basket protein | 0.0556394 |
| CDC73 | cell division cycle 73 | 0.0522338 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0503457 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0492521 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0484837 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0479325 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0459856 |
| VIM | vimentin | 0.0455548 |
| RBM39 | RNA binding motif protein 39 | 0.0432732 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0427396 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0417778 |
| FMNL2 | formin-like 2 | 0.041027 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0391409 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0381021 |
| PTK2 | protein tyrosine kinase 2 | 0.0379656 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0378872 |
| RRBP1 | ribosome binding protein 1 | 0.0376042 |
| CD109 | CD109 molecule | 0.0375223 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0369117 |
| PHF21A | PHD finger protein 21A | 0.0362034 |
| CALR | calreticulin | 0.0344019 |
| HELZ | helicase with zinc finger | 0.0337529 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0333745 |
| GOLGA4 | golgin A4 | 0.0331198 |
| ENO1 | enolase 1, (alpha) | 0.0330921 |
| VGLL4 | vestigial-like family member 4 | 0.0329101 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0323259 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0322687 |
| ZNF292 | zinc finger protein 292 | 0.0321202 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0296355 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0288851 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0288479 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0288428 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.0288172 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0284932 |
| ADM | adrenomedullin | 0.0283462 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0278603 |
| MED13L | mediator complex subunit 13-like | 0.0270376 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0269613 |
| IER3 | immediate early response 3 | 0.0266183 |
| WDR45B | WD repeat domain 45B | 0.0264208 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0264125 |
| FOXJ3 | forkhead box J3 | 0.0261371 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0257646 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0255613 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0253662 |
| ZC3H7A | zinc finger CCCH-type containing 7A | 0.0252107 |
| HLA-B | major histocompatibility complex, class I, B | 0.0251208 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0251142 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0250927 |
| RPL4 | ribosomal protein L4 | 0.0247636 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0244584 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0244413 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0242326 |
| CERT1 | ceramide transporter 1 | 0.0235756 |
| PYGB | phosphorylase, glycogen; brain | 0.0235058 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0233222 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0233032 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0228759 |
| ANXA5 | annexin A5 | 0.022771 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0227434 |
| PIK3C3 | phosphatidylinositol 3-kinase, catalytic subunit type 3 | 0.022627 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.0225568 |
| LMO7 | LIM domain 7 | 0.0219783 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.021864 |
| MXI1 | MAX interactor 1, dimerization protein | 0.021806 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0217667 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0214587 |
| RLF | rearranged L-myc fusion | 0.0211272 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0208199 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0207922 |
| HBP1 | HMG-box transcription factor 1 | 0.0207046 |
| FUS | FUS RNA binding protein | 0.0206906 |
| OGA | O-GlcNAcase | 0.0203764 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0203735 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0202862 |
| FLNB | filamin B, beta | 0.020266 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0202283 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0199173 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.0198093 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0197934 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0197031 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0196842 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0195364 |
| TFRC | transferrin receptor | 0.0195047 |
| NPR2 | natriuretic peptide receptor 2 | 0.0194187 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.019291 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0192063 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0190847 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 0.0190184 |
| S100A6 | S100 calcium binding protein A6 | 0.0189773 |
| TMEM123 | transmembrane protein 123 | 0.0186802 |
| WDR43 | WD repeat domain 43 | 0.0184496 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0184219 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0182951 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.371334 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.209443 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.149494 |
| GPC6 | glypican 6 | -0.132587 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.103525 |
| NLGN1 | neuroligin 1 | -0.101045 |
| FMN1 | formin 1 | -0.0938012 |
| MT2A | metallothionein 2A | -0.0885672 |
| COL19A1 | collagen, type XIX, alpha 1 | -0.0695146 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0691498 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0670348 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0630969 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0623926 |
| EGR1 | early growth response 1 | -0.0574351 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0567006 |
| TMSB10 | thymosin beta 10 | -0.0471598 |
| TNNC1 | troponin C type 1 (slow) | -0.0454008 |
| PCDH7 | protocadherin 7 | -0.045082 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0446899 |
| FRMD4A | FERM domain containing 4A | -0.0440288 |
| PDE10A | phosphodiesterase 10A | -0.0435393 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.043118 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0428762 |
| VCL | vinculin | -0.0428486 |
| EHBP1 | EH domain binding protein 1 | -0.0416587 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0415625 |
| EXOC4 | exocyst complex component 4 | -0.0399551 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | -0.0397575 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | -0.0391387 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.037705 |
| CALD1 | caldesmon 1 | -0.0373194 |
| CTTNBP2 | cortactin binding protein 2 | -0.0373156 |
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | -0.0370622 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0354334 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0347803 |
| NAV3 | neuron navigator 3 | -0.0341153 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0337434 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0333514 |
| RPS3 | ribosomal protein S3 | -0.0324562 |
| TAGLN2 | transgelin 2 | -0.032167 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0315082 |
| RPL37A | ribosomal protein L37a | -0.0304625 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0304109 |
| OXR1 | oxidation resistance 1 | -0.0301372 |
| PAX3 | paired box 3 | -0.0296546 |
| NBEA | neurobeachin | -0.0296453 |
| NHSL1 | NHS-like 1 | -0.0291876 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0290947 |
| RPS19 | ribosomal protein S19 | -0.0288463 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0281243 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.0279435 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0277281 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0276128 |
| SCFD2 | sec1 family domain containing 2 | -0.0271336 |
| GHR | growth hormone receptor | -0.0265454 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0265261 |
| RUNX1 | runt-related transcription factor 1 | -0.0261446 |
| HMCN1 | hemicentin 1 | -0.0258249 |
| ACTN1 | actinin, alpha 1 | -0.0256203 |
| TRIM2 | tripartite motif containing 2 | -0.0255404 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.025378 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | -0.0252826 |
| TPI1 | triosephosphate isomerase 1 | -0.0252762 |
| MITF | microphthalmia-associated transcription factor | -0.0251228 |
| EBF1 | early B-cell factor 1 | -0.0248135 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.024745 |
| DCT | dopachrome tautomerase | -0.0246569 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.024509 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0238998 |
| STRIP2 | striatin interacting protein 2 | -0.0237641 |
| LAMB1 | laminin, beta 1 | -0.0236008 |
| MACROD2 | MACRO domain containing 2 | -0.0235814 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0233782 |
| SEM1 | SEM1 26S proteasome subunit | -0.02322 |
| FHIT | fragile histidine triad | -0.0231328 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | -0.0230138 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.022998 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0229252 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.0229219 |
| NAV1 | neuron navigator 1 | -0.0225616 |
| RPS12 | ribosomal protein S12 | -0.0225471 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | -0.0225186 |
| SETBP1 | SET binding protein 1 | -0.0225134 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | -0.0224422 |
| RANBP17 | RAN binding protein 17 | -0.0223741 |
| RPL19 | ribosomal protein L19 | -0.0223719 |
| ZNF644 | zinc finger protein 644 | -0.0220988 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0220502 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0217674 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.021628 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0212936 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | -0.0209684 |
| CPQ | carboxypeptidase Q | -0.0207695 |
| POTEF | POTE ankyrin domain family, member F | -0.020482 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0200833 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0200114 |
| CABIN1 | calcineurin binding protein 1 | -0.0199993 |
| TRRAP | transformation/transcription domain-associated protein | -0.0199268 |
| PTCHD4 | patched domain containing 4 | -0.019773 |
| RPS17 | ribosomal protein S17 | -0.019633 |
