| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dorzolamide (hydrochloride)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.231331 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.116763 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.112682 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.105495 |
| MT2A | metallothionein 2A | 0.0962457 |
| MT1X | metallothionein 1X | 0.0957562 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0888177 |
| RBM39 | RNA binding motif protein 39 | 0.0858383 |
| RPL4 | ribosomal protein L4 | 0.07891 |
| FAM13A | family with sequence similarity 13, member A | 0.0707178 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0685435 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0681147 |
| TMSB4X | thymosin beta 4, X-linked | 0.0674186 |
| SPAG9 | sperm associated antigen 9 | 0.0635149 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0579709 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0512767 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0511007 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0494631 |
| OGA | O-GlcNAcase | 0.0491199 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0478947 |
| HLA-A | major histocompatibility complex, class I, A | 0.0475909 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0467778 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0464099 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0437627 |
| CCNY | cyclin Y | 0.0432481 |
| ENO1 | enolase 1, (alpha) | 0.043056 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0426243 |
| TXNRD1 | thioredoxin reductase 1 | 0.0424381 |
| TOP1 | topoisomerase (DNA) I | 0.0421932 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0401351 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0397676 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0378948 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0372362 |
| FNBP1L | formin binding protein 1-like | 0.0362015 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0347344 |
| VIM | vimentin | 0.0347302 |
| FAM162A | family with sequence similarity 162, member A | 0.0341095 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0334929 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0329588 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0324306 |
| CALR | calreticulin | 0.0317137 |
| EZR | ezrin | 0.0315601 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0314666 |
| MATR3 | matrin 3 | 0.0312191 |
| TPM3 | tropomyosin 3 | 0.0312098 |
| ABI1 | abl-interactor 1 | 0.0311317 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0306021 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0305919 |
| WDR45B | WD repeat domain 45B | 0.0304568 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0299162 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.029445 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0289822 |
| NUP58 | nucleoporin 58 | 0.0289758 |
| RPS2 | ribosomal protein S2 | 0.0289146 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0286739 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0284176 |
| INSIG2 | insulin induced gene 2 | 0.0277268 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0273355 |
| BRD2 | bromodomain containing 2 | 0.0271066 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | 0.0270767 |
| RLF | rearranged L-myc fusion | 0.0267851 |
| GOLGA4 | golgin A4 | 0.0267716 |
| USP3 | ubiquitin specific peptidase 3 | 0.0267585 |
| YBX1 | Y box binding protein 1 | 0.0263732 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0262601 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0259982 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0258764 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0258592 |
| RBM25 | RNA binding motif protein 25 | 0.0258142 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0256162 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0255269 |
| TMEM51 | transmembrane protein 51 | 0.0253901 |
| RNF149 | ring finger protein 149 | 0.0250674 |
| ZNF292 | zinc finger protein 292 | 0.025004 |
| CCNL1 | cyclin L1 | 0.0249325 |
| RAP2B | RAP2B, member of RAS oncogene family | 0.0248745 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0245778 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.02443 |
| PNN | pinin, desmosome associated protein | 0.0242013 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0238854 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | 0.0238739 |
| TFG | TRK-fused gene | 0.0238044 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0237426 |
| ACTG1 | actin gamma 1 | 0.0236525 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0229403 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0224947 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0221582 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0221229 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0221212 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0220137 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0218203 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0218138 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0217608 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0217592 |
| HMGB2 | high mobility group box 2 | 0.0215775 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0215553 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0215477 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0215419 |
| RIOK3 | RIO kinase 3 | 0.0215175 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0214782 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SAMD4A | sterile alpha motif domain containing 4A | -0.137856 |
| MMP7 | matrix metallopeptidase 7 | -0.118217 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.112788 |
| EFNA5 | ephrin-A5 | -0.110477 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.104316 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.103418 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.10225 |
| CP | ceruloplasmin (ferroxidase) | -0.093569 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0867534 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0832435 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0782202 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0773663 |
| RNF213 | ring finger protein 213 | -0.077098 |
| RAD51B | RAD51 paralog B | -0.0732066 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0709882 |
| TMSB10 | thymosin beta 10 | -0.0705732 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0681371 |
| LAMB3 | laminin, beta 3 | -0.067262 |
| LMO7 | LIM domain 7 | -0.066679 |
| ANXA2 | annexin A2 | -0.0660744 |
| RASAL2 | RAS protein activator like 2 | -0.0650429 |
| NRG3 | neuregulin 3 | -0.0648833 |
| PRKCA | protein kinase C, alpha | -0.0639313 |
| AHNAK | AHNAK nucleoprotein | -0.06373 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0631449 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0624379 |
| PARD3 | par-3 family cell polarity regulator | -0.0616668 |
| EHBP1 | EH domain binding protein 1 | -0.058925 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0586925 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0583241 |
| DST | dystonin | -0.0582898 |
| NABP1 | nucleic acid binding protein 1 | -0.0581015 |
| CDK6 | cyclin-dependent kinase 6 | -0.0577752 |
| TJP1 | tight junction protein 1 | -0.0537214 |
| HLA-B | major histocompatibility complex, class I, B | -0.052039 |
| APOL1 | apolipoprotein L, 1 | -0.0514863 |
| MX1 | MX dynamin-like GTPase 1 | -0.0514549 |
| LAMC2 | laminin, gamma 2 | -0.051178 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0503472 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0496946 |
| NCKAP5 | NCK-associated protein 5 | -0.0490194 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0484545 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0483895 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0476681 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0472819 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0464864 |
| RUNX1 | runt-related transcription factor 1 | -0.046368 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0463046 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0462976 |
| PCDH7 | protocadherin 7 | -0.0462921 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0462886 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0446721 |
| OSMR | oncostatin M receptor | -0.0445152 |
| LAMA4 | laminin, alpha 4 | -0.0444975 |
| HMGA2 | high mobility group AT-hook 2 | -0.0444089 |
| CMIP | c-Maf inducing protein | -0.0442661 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.043636 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0435755 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0434636 |
| MX2 | MX dynamin-like GTPase 2 | -0.0427367 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0425133 |
| EGFR | epidermal growth factor receptor | -0.042299 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0411283 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0410283 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0406126 |
| MYO1E | myosin IE | -0.0404842 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0404669 |
| HDAC9 | histone deacetylase 9 | -0.0397949 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0396265 |
| DSG2 | desmoglein 2 | -0.0394952 |
| MCU | mitochondrial calcium uniporter | -0.0391245 |
| INTS6 | integrator complex subunit 6 | -0.0389949 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.038872 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0381412 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.037935 |
| SVIL | supervillin | -0.0375768 |
| RCOR1 | REST corepressor 1 | -0.0371473 |
| KYNU | kynureninase | -0.0371289 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0367782 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.036769 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0358409 |
| BPTF | bromodomain PHD finger transcription factor | -0.0355175 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0352451 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0351597 |
| SP100 | SP100 nuclear antigen | -0.0351299 |
| PCNX4 | pecanex 4 | -0.035065 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0349198 |
| NDRG1 | N-myc downstream regulated 1 | -0.0348057 |
| DNAH11 | dynein, axonemal, heavy chain 11 | -0.0347771 |
| NUMB | numb homolog (Drosophila) | -0.0347264 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0344961 |
| ATXN1 | ataxin 1 | -0.0341718 |
| TMC5 | transmembrane channel-like 5 | -0.0341072 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.033399 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0333421 |
| ST8SIA6 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 | -0.0331644 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0330378 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0330111 |
| FBXO11 | F-box protein 11 | -0.0329241 |
| EGR1 | early growth response 1 | -0.0328526 |
