Dorzolamide (hydrochloride)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dorzolamide (hydrochloride) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dorzolamide (hydrochloride)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.21121
RPL23 ribosomal protein L23 0.10916
RPL37A ribosomal protein L37a 0.0992948
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0947239
EIF1 eukaryotic translation initiation factor 1 0.0933013
VIM vimentin 0.0913766
RPS6 ribosomal protein S6 0.0904071
RPL4 ribosomal protein L4 0.0838256
AKAP12 A kinase (PRKA) anchor protein 12 0.078589
RPS12 ribosomal protein S12 0.0781572
TMSB10 thymosin beta 10 0.0738399
PRRC2C proline-rich coiled-coil 2C 0.0714213
RPS3 ribosomal protein S3 0.0708742
RPLP1 ribosomal protein, large, P1 0.070009
RPL35A ribosomal protein L35a 0.0672394
HMGB2 high mobility group box 2 0.0659242
RPL26 ribosomal protein L26 0.0646248
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0604239
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0592212
SET SET nuclear proto-oncogene 0.0579095
ZBTB20 zinc finger and BTB domain containing 20 0.0555617
RPS8 ribosomal protein S8 0.055369
RPS2 ribosomal protein S2 0.053849
RPL12 ribosomal protein L12 0.0533044
RPL19 ribosomal protein L19 0.0494276
COL1A1 collagen, type I, alpha 1 0.0483348
RPS27A ribosomal protein S27a 0.0469244
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0463591
RACK1 receptor for activated C kinase 1 0.0462278
NRG1 neuregulin 1 0.0461012
LSAMP limbic system-associated membrane protein 0.0460888
ENO1 enolase 1, (alpha) 0.0451701
RPS19 ribosomal protein S19 0.0450784
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0442245
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.043907
LMNA lamin A/C 0.0422766
RPL36 ribosomal protein L36 0.0422092
RPS17 ribosomal protein S17 0.0409188
FTL ferritin, light polypeptide 0.0398654
TPT1 tumor protein, translationally-controlled 1 0.0396579
RPL35 ribosomal protein L35 0.0386398
RPL31 ribosomal protein L31 0.0383805
RPL34 ribosomal protein L34 0.0382418
RPL27 ribosomal protein L27 0.0368733
PLAT plasminogen activator, tissue 0.0360783
RPL18 ribosomal protein L18 0.036006
CENPF centromere protein F, 350/400kDa 0.0357928
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0357046
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.035372
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0340979
ACTG1 actin gamma 1 0.0337338
ATF4 activating transcription factor 4 0.0336726
NAP1L1 nucleosome assembly protein 1-like 1 0.0335195
CRH corticotropin releasing hormone 0.0331901
RPS27 ribosomal protein S27 0.0331079
PACS1 phosphofurin acidic cluster sorting protein 1 0.0309481
NALF1 NALCN channel auxiliary factor 1 0.0307698
RPS29 ribosomal protein S29 0.030198
HLA-A major histocompatibility complex, class I, A 0.0300201
RPS4X ribosomal protein S4, X-linked 0.0299986
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0287906
ZC3H13 zinc finger CCCH-type containing 13 0.0284579
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.02838
RPS14 ribosomal protein S14 0.0282276
MKI67 marker of proliferation Ki-67 0.0279606
RPL37 ribosomal protein L37 0.0279089
S100A9 S100 calcium binding protein A9 0.0277193
KLF6 Kruppel-like factor 6 0.0277138
EGFR epidermal growth factor receptor 0.0275975
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0273646
RPL13A ribosomal protein L13a 0.0271377
RPS20 ribosomal protein S20 0.027085
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0270288
TOP2A topoisomerase (DNA) II alpha 170kDa 0.027
KPNB1 karyopherin (importin) beta 1 0.0269619
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0269263
CALD1 caldesmon 1 0.0264368
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0263302
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0263003
RPL9 ribosomal protein L9 0.0262821
SRSF11 serine/arginine-rich splicing factor 11 0.0262413
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0261818
MT2A metallothionein 2A 0.0259872
CHD4 chromodomain helicase DNA binding protein 4 0.0259842
MACF1 microtubule-actin crosslinking factor 1 0.0257707
RPL36A ribosomal protein L36a 0.0256543
VCL vinculin 0.0255228
RBM25 RNA binding motif protein 25 0.02535
EIF5B eukaryotic translation initiation factor 5B 0.0250952
RPL38 ribosomal protein L38 0.0247258
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0247108
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0246321
RPLP2 ribosomal protein, large, P2 0.0246047
RPL11 ribosomal protein L11 0.0242644
CBX3 chromobox homolog 3 0.0241336
EXT1 exostosin glycosyltransferase 1 0.0235684
CUX1 cut-like homeobox 1 0.0235544
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0235501
RPL5 ribosomal protein L5 0.0234064
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0232128

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.325048
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.172349
HELZ helicase with zinc finger -0.0754981
MEIS2 Meis homeobox 2 -0.0734504
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.057773
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0561852
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0547719
FNDC3B fibronectin type III domain containing 3B -0.0547353
SOS1 son of sevenless homolog 1 (Drosophila) -0.046958
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0466643
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha -0.0455536
LPIN1 lipin 1 -0.0425174
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0396587
WDR45B WD repeat domain 45B -0.0386345
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0382465
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0378672
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0374635
AOPEP aminopeptidase O (putative) -0.0373178
FMN1 formin 1 -0.0364237
MED13 mediator complex subunit 13 -0.0363089
ZMYM2 zinc finger, MYM-type 2 -0.0345976
WAC WW domain containing adaptor with coiled-coil -0.0345062
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0342584
HILPDA hypoxia inducible lipid droplet-associated -0.0340799
FAM13A family with sequence similarity 13, member A -0.0338354
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0331162
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0326785
NPEPPS aminopeptidase puromycin sensitive -0.0326559
USP3 ubiquitin specific peptidase 3 -0.0325096
PICALM phosphatidylinositol binding clathrin assembly protein -0.0324625
PHIP pleckstrin homology domain interacting protein -0.0323399
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0320494
QKI QKI, KH domain containing, RNA binding -0.0317148
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0315235
IGF2 insulin-like growth factor 2 -0.0310515
ANKRD17 ankyrin repeat domain 17 -0.0308684
MBNL2 muscleblind-like splicing regulator 2 -0.0308574
RNF150 ring finger protein 150 -0.0304164
STRN3 striatin, calmodulin binding protein 3 -0.0295425
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0295133
LMAN1 lectin, mannose-binding, 1 -0.0288801
PTK2 protein tyrosine kinase 2 -0.0288091
PTEN phosphatase and tensin homolog -0.0287411
KDM2A lysine (K)-specific demethylase 2A -0.0283927
MARCHF6 membrane associated ring-CH-type finger 6 -0.028216
GLG1 golgi glycoprotein 1 -0.0279935
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0276315
NDRG1 N-myc downstream regulated 1 -0.0275067
ZNF292 zinc finger protein 292 -0.027472
ADGRG6 adhesion G protein-coupled receptor G6 -0.0269833
UBC ubiquitin C -0.0269349
CSDE1 cold shock domain containing E1, RNA-binding -0.0264763
RAB1A RAB1A, member RAS oncogene family -0.0264586
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0261779
SUCO SUN domain containing ossification factor -0.0260881
NEK7 NIMA-related kinase 7 -0.0258912
DGKH diacylglycerol kinase, eta -0.0257176
PLPP1 phospholipid phosphatase 1 -0.0257006
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0256436
CD46 CD46 molecule, complement regulatory protein -0.0255289
SYT1 synaptotagmin I -0.0255146
HMBOX1 homeobox containing 1 -0.0253517
C1ORF21 chromosome 1 open reading frame 21 -0.0252187
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0251894
COPA coatomer protein complex, subunit alpha -0.0251079
ZFR zinc finger RNA binding protein -0.0249398
SETD5 SET domain containing 5 -0.0249289
KMT2E lysine (K)-specific methyltransferase 2E -0.0247134
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.024683
RNF145 ring finger protein 145 -0.0246451
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0244385
BRWD1 bromodomain and WD repeat domain containing 1 -0.0244165
SSBP2 single-stranded DNA binding protein 2 -0.0241289
PHF21A PHD finger protein 21A -0.0239617
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0238795
ENAH enabled homolog (Drosophila) -0.0238765
TENT5A terminal nucleotidyltransferase 5A -0.0238305
TAOK1 TAO kinase 1 -0.0237546
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0236252
RAB6A RAB6A, member RAS oncogene family -0.0235982
APP amyloid beta (A4) precursor protein -0.0233269
RO60 Ro60, Y RNA binding protein -0.0232689
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0231627
ANXA2 annexin A2 -0.023035
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0226441
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0224928
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0223467
GLS2 glutaminase 2 (liver, mitochondrial) -0.0222614
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0221337
AUTS2 autism susceptibility candidate 2 -0.0220774
PUM2 pumilio RNA-binding family member 2 -0.0219887
KDM6A lysine (K)-specific demethylase 6A -0.0218886
UNC5C unc-5 homolog C (C. elegans) -0.0216661
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.0216444
TMEM123 transmembrane protein 123 -0.021562
AHNAK AHNAK nucleoprotein -0.0215305
PRTG protogenin -0.0212073
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0212003
MBNL1 muscleblind-like splicing regulator 1 -0.0211048
NRP1 neuropilin 1 -0.0210638