| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dorzolamide (hydrochloride)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.201873 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.154177 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.104525 |
| VIM | vimentin | 0.101032 |
| STC1 | stanniocalcin 1 | 0.0930215 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0748381 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0700506 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0690337 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0686563 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0674994 |
| PTMA | prothymosin, alpha | 0.0656487 |
| RPL4 | ribosomal protein L4 | 0.0650747 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0643959 |
| CANX | calnexin | 0.0588208 |
| RPS2 | ribosomal protein S2 | 0.0569979 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0549357 |
| GOLGA4 | golgin A4 | 0.0547264 |
| FTL | ferritin, light polypeptide | 0.0537397 |
| ENO1 | enolase 1, (alpha) | 0.0520789 |
| MAP1B | microtubule-associated protein 1B | 0.0510008 |
| YBX1 | Y box binding protein 1 | 0.0506299 |
| PRRC2C | proline-rich coiled-coil 2C | 0.050517 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0477299 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0476576 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0470019 |
| TXNIP | thioredoxin interacting protein | 0.045939 |
| RBM39 | RNA binding motif protein 39 | 0.0445448 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0443414 |
| INHBA | inhibin, beta A | 0.0441679 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0430353 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0419857 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0417655 |
| NDRG1 | N-myc downstream regulated 1 | 0.0409887 |
| FAM13A | family with sequence similarity 13, member A | 0.0404129 |
| TPI1 | triosephosphate isomerase 1 | 0.0403759 |
| TUBB | tubulin, beta class I | 0.0398558 |
| TMSB4X | thymosin beta 4, X-linked | 0.0398346 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.039479 |
| YBX3 | Y box binding protein 3 | 0.0392463 |
| ANLN | anillin, actin binding protein | 0.0391629 |
| RTN4 | reticulon 4 | 0.0388422 |
| TXNRD1 | thioredoxin reductase 1 | 0.0387116 |
| SBF2 | SET binding factor 2 | 0.037795 |
| OGA | O-GlcNAcase | 0.0376472 |
| HMGB2 | high mobility group box 2 | 0.0371963 |
| TMSB10 | thymosin beta 10 | 0.0368866 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0363512 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0359429 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0357103 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0346042 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0343257 |
| HELZ | helicase with zinc finger | 0.0338198 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0338013 |
| MT1X | metallothionein 1X | 0.0336204 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0335234 |
| RPS4X | ribosomal protein S4, X-linked | 0.0334812 |
| SETD5 | SET domain containing 5 | 0.0330354 |
| ATP13A3 | ATPase type 13A3 | 0.032986 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0328822 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.032296 |
| NOP58 | NOP58 ribonucleoprotein | 0.0321039 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0320068 |
| RAI1 | retinoic acid induced 1 | 0.031881 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0317322 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0313228 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0309499 |
| CLTC | clathrin, heavy chain (Hc) | 0.0305134 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0304627 |
| TLN1 | talin 1 | 0.0304552 |
| CALR | calreticulin | 0.0301861 |
| ANXA5 | annexin A5 | 0.0301826 |
| MT2A | metallothionein 2A | 0.0300623 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0298594 |
| RACK1 | receptor for activated C kinase 1 | 0.0297593 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0296593 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0295819 |
| SET | SET nuclear proto-oncogene | 0.0294165 |
| RLF | rearranged L-myc fusion | 0.029372 |
| RPL18 | ribosomal protein L18 | 0.0292212 |
| JUN | jun proto-oncogene | 0.0290282 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0289892 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0288866 |
| COG5 | component of oligomeric golgi complex 5 | 0.0286009 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0282853 |
| HDLBP | high density lipoprotein binding protein | 0.0278515 |
| TUBA1B | tubulin, alpha 1b | 0.0274917 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0273596 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0272806 |
| SMAD3 | SMAD family member 3 | 0.0270245 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0267668 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0267412 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0260813 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0260562 |
| TPR | translocated promoter region, nuclear basket protein | 0.0259732 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0258422 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0257601 |
| TPM4 | tropomyosin 4 | 0.0257143 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0255612 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0255114 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0254516 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.220411 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.103672 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.100703 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0950495 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0928664 |
| FN1 | fibronectin 1 | -0.0865747 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0856666 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0712415 |
| INTS6 | integrator complex subunit 6 | -0.0632335 |
| HLA-B | major histocompatibility complex, class I, B | -0.0564223 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0491096 |
| IGF2 | insulin-like growth factor 2 | -0.045541 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0450681 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0441966 |
| FNDC3B | fibronectin type III domain containing 3B | -0.04385 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0438175 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0421414 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0401912 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0400745 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0396088 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0391075 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0358547 |
| COL5A1 | collagen, type V, alpha 1 | -0.0355383 |
| VCL | vinculin | -0.0345431 |
| HIP1 | huntingtin interacting protein 1 | -0.0343777 |
| KYNU | kynureninase | -0.0336563 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0324311 |
| RIGI | RNA sensor RIG-I | -0.0323597 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0321781 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0312879 |
| NLGN1 | neuroligin 1 | -0.0311518 |
| DIAPH2 | diaphanous-related formin 2 | -0.0310227 |
| DGKI | diacylglycerol kinase, iota | -0.0302651 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0301787 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0301337 |
| PRELID2 | PRELI domain containing 2 | -0.0299329 |
| ACTG1 | actin gamma 1 | -0.029491 |
| AUTS2 | autism susceptibility candidate 2 | -0.0293373 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.029045 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.028452 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0283236 |
| OXR1 | oxidation resistance 1 | -0.0283015 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0282423 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.0278647 |
| ZNF804A | zinc finger protein 804A | -0.027591 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0272433 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.027089 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0270755 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0265467 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0260398 |
| CLIC4 | chloride intracellular channel 4 | -0.0259166 |
| SYT1 | synaptotagmin I | -0.025467 |
| BPTF | bromodomain PHD finger transcription factor | -0.0251234 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0250497 |
| LRRC23 | leucine rich repeat containing 23 | -0.0248218 |
| XYLT1 | xylosyltransferase I | -0.0246557 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0245592 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0245095 |
| TNS3 | tensin 3 | -0.0243536 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0242096 |
| SEPTIN9 | septin 9 | -0.0239717 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0237249 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.023602 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0235062 |
| EGFR | epidermal growth factor receptor | -0.0234698 |
| RUNX1 | runt-related transcription factor 1 | -0.0234636 |
| RPL19 | ribosomal protein L19 | -0.0233903 |
| PTCHD4 | patched domain containing 4 | -0.0232505 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0231631 |
| CSTF3 | cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa | -0.0230558 |
| RPL37A | ribosomal protein L37a | -0.0229607 |
| MAGT1 | magnesium transporter 1 | -0.0227858 |
| GLCCI1 | glucocorticoid induced 1 | -0.0227374 |
| PALLD | palladin, cytoskeletal associated protein | -0.0226263 |
| VEGFA | vascular endothelial growth factor A | -0.022526 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0225199 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0223979 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0220494 |
| FBXO11 | F-box protein 11 | -0.0220215 |
| ABR | active BCR-related | -0.0219606 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0218936 |
| FNIP1 | folliculin interacting protein 1 | -0.0218903 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0217583 |
| FGF13 | fibroblast growth factor 13 | -0.0215573 |
| CDH13 | cadherin 13 | -0.0214174 |
| SPMIP6 | sperm microtubule inner protein 6 | -0.0213512 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.021273 |
| RPS25 | ribosomal protein S25 | -0.0211499 |
| POTEF | POTE ankyrin domain family, member F | -0.0211057 |
| ADM | adrenomedullin | -0.0210531 |
| ZFYVE28 | zinc finger, FYVE domain containing 28 | -0.0209975 |
| SETX | senataxin | -0.0208137 |
| TENM3 | teneurin transmembrane protein 3 | -0.0207676 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | -0.0205669 |
| USP34 | ubiquitin specific peptidase 34 | -0.0204806 |
| NAV1 | neuron navigator 1 | -0.0204288 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0203579 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0203116 |
| RPS23 | ribosomal protein S23 | -0.0202389 |
| RPL31 | ribosomal protein L31 | -0.0201727 |
