| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dorzolamide (hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.131671 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.101568 |
| RPL4 | ribosomal protein L4 | 0.0911666 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0709474 |
| RPS2 | ribosomal protein S2 | 0.0655738 |
| NDRG1 | N-myc downstream regulated 1 | 0.0646115 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0544372 |
| OGA | O-GlcNAcase | 0.0490528 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.048473 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0428493 |
| RPS6 | ribosomal protein S6 | 0.0424949 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.039416 |
| HLA-A | major histocompatibility complex, class I, A | 0.0367773 |
| FAM117B | family with sequence similarity 117, member B | 0.0367414 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0358433 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0349625 |
| HELZ | helicase with zinc finger | 0.0336435 |
| RPS18 | ribosomal protein S18 | 0.0326217 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0319611 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0311213 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0311029 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.031023 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0306094 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0303921 |
| RBM39 | RNA binding motif protein 39 | 0.0296347 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0295388 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0293496 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0291799 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0291534 |
| RUNX1 | runt-related transcription factor 1 | 0.0289411 |
| RNF24 | ring finger protein 24 | 0.0281546 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0269499 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0267275 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0258111 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0254931 |
| MT2A | metallothionein 2A | 0.0252143 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0250217 |
| ATF4 | activating transcription factor 4 | 0.0249761 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0236897 |
| INSIG2 | insulin induced gene 2 | 0.0230595 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0230043 |
| RPS12 | ribosomal protein S12 | 0.0229893 |
| YEATS2 | YEATS domain containing 2 | 0.0229307 |
| RPS8 | ribosomal protein S8 | 0.0226816 |
| GOLGA4 | golgin A4 | 0.0225045 |
| ZNF292 | zinc finger protein 292 | 0.0222546 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0222264 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0222173 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0217106 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0215371 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0214732 |
| NUP58 | nucleoporin 58 | 0.0214349 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0210393 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0208606 |
| TPM3 | tropomyosin 3 | 0.0208191 |
| RPL18 | ribosomal protein L18 | 0.0206618 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0198529 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0195757 |
| TLN1 | talin 1 | 0.0195301 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0192143 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0189984 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.018993 |
| POM121C | POM121 transmembrane nucleoporin C | 0.0186899 |
| PEX3 | peroxisomal biogenesis factor 3 | 0.0186416 |
| ZNF395 | zinc finger protein 395 | 0.0184641 |
| YBX1 | Y box binding protein 1 | 0.0184502 |
| SET | SET nuclear proto-oncogene | 0.0181755 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0181209 |
| DSPP | dentin sialophosphoprotein | 0.0178036 |
| ANGPTL4 | angiopoietin-like 4 | 0.017549 |
| ARRDC3 | arrestin domain containing 3 | 0.0175257 |
| WDR45B | WD repeat domain 45B | 0.0174902 |
| USP37 | ubiquitin specific peptidase 37 | 0.017476 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0172575 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 0.0171727 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0168995 |
| RPL26 | ribosomal protein L26 | 0.0168183 |
| VEGFA | vascular endothelial growth factor A | 0.0167529 |
| SPAG9 | sperm associated antigen 9 | 0.0166515 |
| BRD2 | bromodomain containing 2 | 0.0165425 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0165135 |
| RRBP1 | ribosome binding protein 1 | 0.0164895 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0164378 |
| SH3GL1 | SH3-domain GRB2-like 1 | 0.0161927 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0161921 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | 0.0161689 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.015858 |
| H1-4 | H1.4 linker histone, cluster member | 0.0155521 |
| FAM13A | family with sequence similarity 13, member A | 0.0155067 |
| ENO1 | enolase 1, (alpha) | 0.0154888 |
| KIF5B | kinesin family member 5B | 0.0154333 |
| RBM25 | RNA binding motif protein 25 | 0.0153654 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0153653 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0152826 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.015282 |
| RPL9 | ribosomal protein L9 | 0.0152546 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0150329 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0150267 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.015007 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0148658 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FAT1 | FAT atypical cadherin 1 | -0.318534 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.238448 |
| AHNAK | AHNAK nucleoprotein | -0.219206 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0840897 |
| TENM3 | teneurin transmembrane protein 3 | -0.0808794 |
| CANX | calnexin | -0.072211 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0693898 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0689238 |
| MED13L | mediator complex subunit 13-like | -0.0664423 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0660039 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0651361 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0593115 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0580122 |
| SERINC5 | serine incorporator 5 | -0.0576088 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0571646 |
| MSI2 | musashi RNA-binding protein 2 | -0.0565648 |
| JMJD1C | jumonji domain containing 1C | -0.0543055 |
| VCL | vinculin | -0.0540617 |
| FRMD5 | FERM domain containing 5 | -0.0531533 |
| PARD3 | par-3 family cell polarity regulator | -0.0530525 |
| NF1 | neurofibromin 1 | -0.052416 |
| TMSB10 | thymosin beta 10 | -0.0521939 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0520104 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0518092 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0510747 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.050985 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0497434 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0488997 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0478626 |
| ZNRF3 | zinc and ring finger 3 | -0.0464879 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0455602 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0445925 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0445581 |
| RAD51B | RAD51 paralog B | -0.0440677 |
| ARF4 | ADP-ribosylation factor 4 | -0.0427857 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0427735 |
| NFIA | nuclear factor I/A | -0.042256 |
| SMYD3 | SET and MYND domain containing 3 | -0.0422149 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0417271 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0403669 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.039813 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0389474 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.038916 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0384315 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.038429 |
| SHROOM3 | shroom family member 3 | -0.0377991 |
| PGK1 | phosphoglycerate kinase 1 | -0.0376803 |
| PTK2 | protein tyrosine kinase 2 | -0.0375558 |
| BPTF | bromodomain PHD finger transcription factor | -0.0373572 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0372272 |
| KRT18 | keratin 18, type I | -0.036936 |
| APP | amyloid beta (A4) precursor protein | -0.0369177 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0369109 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0368786 |
| TCF12 | transcription factor 12 | -0.0368605 |
| TBC1D4 | TBC1 domain family, member 4 | -0.0367425 |
| ERBIN | erbb2 interacting protein | -0.0363185 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0361323 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0357104 |
| CLOCK | clock circadian regulator | -0.0356884 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0356535 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0355321 |
| CDK13 | cyclin-dependent kinase 13 | -0.0352233 |
| SCFD2 | sec1 family domain containing 2 | -0.0350265 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0347993 |
| PKM | pyruvate kinase, muscle | -0.0347312 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0345692 |
| RNF43 | ring finger protein 43 | -0.0344043 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0343553 |
| EHBP1 | EH domain binding protein 1 | -0.0343406 |
| MKI67 | marker of proliferation Ki-67 | -0.0342123 |
| BBX | bobby sox homolog (Drosophila) | -0.0341639 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0332739 |
| CUX1 | cut-like homeobox 1 | -0.0332588 |
| ZFHX3 | zinc finger homeobox 3 | -0.0330576 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0327319 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0327176 |
| OLA1 | Obg-like ATPase 1 | -0.032544 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0324357 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0321633 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0320445 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0320361 |
| RNF213 | ring finger protein 213 | -0.0319473 |
| MYO1D | myosin ID | -0.0316476 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0315006 |
| SETD5 | SET domain containing 5 | -0.0314408 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0311728 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0310783 |
| TPM4 | tropomyosin 4 | -0.0310311 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0310189 |
| AK1 | adenylate kinase 1 | -0.0309931 |
| EXOC4 | exocyst complex component 4 | -0.0309225 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0308048 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0307954 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0306202 |
| DENND1A | DENN/MADD domain containing 1A | -0.0305386 |
| SATB2 | SATB homeobox 2 | -0.0302163 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0298264 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0297482 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0296104 |
