| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dorzolamide (hydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.0852884 |
| RPL4 | ribosomal protein L4 | 0.0809049 |
| RPS12 | ribosomal protein S12 | 0.0597225 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0532203 |
| RPS2 | ribosomal protein S2 | 0.0489073 |
| SET | SET nuclear proto-oncogene | 0.0484675 |
| RPS3 | ribosomal protein S3 | 0.0439169 |
| RPL37A | ribosomal protein L37a | 0.0374496 |
| PTMA | prothymosin, alpha | 0.0367312 |
| RPL26 | ribosomal protein L26 | 0.0352975 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0343563 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0323446 |
| RPL18 | ribosomal protein L18 | 0.0322952 |
| B2M | beta-2-microglobulin | 0.0318116 |
| RPS19 | ribosomal protein S19 | 0.031316 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0309204 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0291464 |
| RPL12 | ribosomal protein L12 | 0.0289602 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0286637 |
| RPL13A | ribosomal protein L13a | 0.0283957 |
| RBM25 | RNA binding motif protein 25 | 0.0269479 |
| RPL9 | ribosomal protein L9 | 0.0250741 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0249613 |
| RBM39 | RNA binding motif protein 39 | 0.0248328 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0247864 |
| RPS17 | ribosomal protein S17 | 0.0245433 |
| RPL35 | ribosomal protein L35 | 0.0240172 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0239007 |
| OGA | O-GlcNAcase | 0.0238807 |
| PNN | pinin, desmosome associated protein | 0.0229687 |
| RPS18 | ribosomal protein S18 | 0.0223143 |
| RPS6 | ribosomal protein S6 | 0.0222741 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0217027 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0216355 |
| RPS15A | ribosomal protein S15a | 0.0211902 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0211437 |
| RPL37 | ribosomal protein L37 | 0.0208677 |
| RPL5 | ribosomal protein L5 | 0.0208677 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0201296 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0200646 |
| TPM3 | tropomyosin 3 | 0.0199313 |
| GPX4 | glutathione peroxidase 4 | 0.0198882 |
| CLDN4 | claudin 4 | 0.0198185 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0196312 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0191068 |
| JUP | junction plakoglobin | 0.0185046 |
| RPL36 | ribosomal protein L36 | 0.018421 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0181336 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0177085 |
| CBX3 | chromobox homolog 3 | 0.0175131 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0170625 |
| RPS8 | ribosomal protein S8 | 0.0169438 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0166504 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0163559 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0162188 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.015993 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0159638 |
| RPL35A | ribosomal protein L35a | 0.0158306 |
| ATF4 | activating transcription factor 4 | 0.0153472 |
| AXL | AXL receptor tyrosine kinase | 0.0153184 |
| RPS27 | ribosomal protein S27 | 0.0153182 |
| DHFR | dihydrofolate reductase | 0.0151894 |
| RPL14 | ribosomal protein L14 | 0.0149679 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0149652 |
| YBX3 | Y box binding protein 3 | 0.0149478 |
| RPL23 | ribosomal protein L23 | 0.0147376 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0145715 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0145706 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0143836 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.0143651 |
| DNAJC7 | DnaJ (Hsp40) homolog, subfamily C, member 7 | 0.014174 |
| ANKZF1 | ankyrin repeat and zinc finger domain containing 1 | 0.0138747 |
| HGS | hepatocyte growth factor-regulated tyrosine kinase substrate | 0.0138357 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0138013 |
| RPS27A | ribosomal protein S27a | 0.0137061 |
| ZBTB7A | zinc finger and BTB domain containing 7A | 0.013607 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0134014 |
| KIF5B | kinesin family member 5B | 0.0131614 |
| RPL27 | ribosomal protein L27 | 0.0130988 |
| RPL30 | ribosomal protein L30 | 0.0130603 |
| HMGB2 | high mobility group box 2 | 0.0128239 |
| ATP5ME | ATP synthase membrane subunit e | 0.0126212 |
| DHX40 | DEAH (Asp-Glu-Ala-His) box polypeptide 40 | 0.0125561 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0125496 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0125131 |
| RPLP1 | ribosomal protein, large, P1 | 0.0123812 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0123279 |
| MT1X | metallothionein 1X | 0.0122482 |
| PDCD5 | programmed cell death 5 | 0.0122352 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.0122134 |
| BCAM | basal cell adhesion molecule (Lutheran blood group) | 0.0121156 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0120219 |
| RPL23A | ribosomal protein L23a | 0.0119917 |
| RAD23A | RAD23 homolog A (S. cerevisiae) | 0.0119677 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0119137 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0118568 |
| UBXN4 | UBX domain protein 4 | 0.0117585 |
| MSL2 | male-specific lethal 2 homolog (Drosophila) | 0.0117523 |
| TMF1 | TATA element modulatory factor 1 | 0.011632 |
| FOSL1 | FOS-like antigen 1 | 0.0115828 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.416199 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.147416 |
| AHNAK | AHNAK nucleoprotein | -0.121967 |
| ACTG1 | actin gamma 1 | -0.10765 |
| ASPH | aspartate beta-hydroxylase | -0.106102 |
| LDHA | lactate dehydrogenase A | -0.10148 |
| ANXA2 | annexin A2 | -0.0959129 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.084361 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0819712 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0793785 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0777214 |
| KRT7 | keratin 7, type II | -0.0761563 |
| POTEF | POTE ankyrin domain family, member F | -0.0722319 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0720835 |
| SVIL | supervillin | -0.0683256 |
| ITGB8 | integrin, beta 8 | -0.0667238 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0657295 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0657075 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0646437 |
| S100A10 | S100 calcium binding protein A10 | -0.062826 |
| ECT2 | epithelial cell transforming 2 | -0.0606787 |
| NDRG1 | N-myc downstream regulated 1 | -0.0604269 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0602882 |
| APP | amyloid beta (A4) precursor protein | -0.0591141 |
| CCND1 | cyclin D1 | -0.0585312 |
| PKM | pyruvate kinase, muscle | -0.0579711 |
| ACTN4 | actinin, alpha 4 | -0.0570235 |
| PAX8 | paired box 8 | -0.055189 |
| CD44 | CD44 molecule (Indian blood group) | -0.0546859 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0520319 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0515807 |
| BPTF | bromodomain PHD finger transcription factor | -0.0515416 |
| CANX | calnexin | -0.0506147 |
| TPM4 | tropomyosin 4 | -0.0504302 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0502804 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0485503 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0476062 |
| HMGA2 | high mobility group AT-hook 2 | -0.0471134 |
| TAOK1 | TAO kinase 1 | -0.046599 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0465771 |
| PRELID2 | PRELI domain containing 2 | -0.0459351 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0455752 |
| NF1 | neurofibromin 1 | -0.0454058 |
| WWC1 | WW and C2 domain containing 1 | -0.0441547 |
| LAMC2 | laminin, gamma 2 | -0.0438672 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0437417 |
| RAD51B | RAD51 paralog B | -0.043638 |
| TXNRD1 | thioredoxin reductase 1 | -0.0434974 |
| EGFR | epidermal growth factor receptor | -0.0429755 |
| MAP4 | microtubule-associated protein 4 | -0.0429025 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0428433 |
| FLNB | filamin B, beta | -0.0427836 |
| LAMA4 | laminin, alpha 4 | -0.0424925 |
| DSG2 | desmoglein 2 | -0.0423659 |
| SETD5 | SET domain containing 5 | -0.041939 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0418206 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0417153 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0414382 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0406397 |
| SMAD3 | SMAD family member 3 | -0.040087 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0391329 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.0386269 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0381998 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0380682 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0380316 |
| CTBP2 | C-terminal binding protein 2 | -0.0372711 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0372264 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0363643 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0361288 |
| PTK2 | protein tyrosine kinase 2 | -0.0359758 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.035025 |
| SSH2 | slingshot protein phosphatase 2 | -0.0346906 |
| FHIT | fragile histidine triad | -0.0346563 |
| RHOA | ras homolog family member A | -0.0345401 |
| MYO1D | myosin ID | -0.0343965 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0343158 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0338337 |
| PGK1 | phosphoglycerate kinase 1 | -0.0337235 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0336101 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0332576 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0331207 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0327394 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.032684 |
| HMGA1 | high mobility group AT-hook 1 | -0.0325637 |
| DPP4 | dipeptidyl-peptidase 4 | -0.0322235 |
| SMYD3 | SET and MYND domain containing 3 | -0.0317111 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0316193 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0315447 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0313513 |
| VMP1 | vacuole membrane protein 1 | -0.0310971 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.031023 |
| UBC | ubiquitin C | -0.0309744 |
| PARD3 | par-3 family cell polarity regulator | -0.0309686 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0309464 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0308469 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0296942 |
| FLNA | filamin A, alpha | -0.0296834 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0296095 |
| CLTC | clathrin, heavy chain (Hc) | -0.0296088 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0295814 |
