| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dorzolamide (hydrochloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.19057 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0832826 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0561477 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0360107 |
| MT2A | metallothionein 2A | 0.0332337 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0280058 |
| FAM13A | family with sequence similarity 13, member A | 0.0276679 |
| CDCP1 | CUB domain containing protein 1 | 0.0238513 |
| AXL | AXL receptor tyrosine kinase | 0.0215903 |
| USP3 | ubiquitin specific peptidase 3 | 0.0215318 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0205714 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0202645 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0198209 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0197488 |
| NGLY1 | N-glycanase 1 | 0.0180668 |
| ZNF292 | zinc finger protein 292 | 0.0172711 |
| ARRDC3 | arrestin domain containing 3 | 0.0163863 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0156013 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.015319 |
| SYAP1 | synapse associated protein 1 | 0.0152402 |
| NUP58 | nucleoporin 58 | 0.0152348 |
| GOLGA4 | golgin A4 | 0.0151182 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0147506 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0135658 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0135521 |
| RNF145 | ring finger protein 145 | 0.0133404 |
| ATP13A3 | ATPase type 13A3 | 0.0129281 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0126164 |
| SPAG9 | sperm associated antigen 9 | 0.0124572 |
| WDR45B | WD repeat domain 45B | 0.0122966 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.012183 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0121533 |
| FOSL1 | FOS-like antigen 1 | 0.0121218 |
| UBC | ubiquitin C | 0.0120161 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0119984 |
| RTN4 | reticulon 4 | 0.0119683 |
| MT1X | metallothionein 1X | 0.0119347 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0118653 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0117197 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0116182 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0115204 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0108178 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0105957 |
| DOT1L | DOT1-like histone H3K79 methyltransferase | 0.0104983 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0104276 |
| NECTIN2 | nectin cell adhesion molecule 2 | 0.0104088 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0102887 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0102189 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0101942 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0101833 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0101794 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.00997007 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.00995976 |
| RPL4 | ribosomal protein L4 | 0.00991739 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.00977183 |
| SNX9 | sorting nexin 9 | 0.00970188 |
| RBM39 | RNA binding motif protein 39 | 0.00968602 |
| RLF | rearranged L-myc fusion | 0.00968115 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.00966797 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0095898 |
| ZNF148 | zinc finger protein 148 | 0.00957131 |
| CCNL1 | cyclin L1 | 0.00955809 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | 0.00954418 |
| YBX3 | Y box binding protein 3 | 0.0095202 |
| TXNIP | thioredoxin interacting protein | 0.0094812 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.00929904 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.00929848 |
| RPS18 | ribosomal protein S18 | 0.00925889 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0092223 |
| TXNRD1 | thioredoxin reductase 1 | 0.00912598 |
| RNF24 | ring finger protein 24 | 0.00909137 |
| CD109 | CD109 molecule | 0.00906284 |
| ADM | adrenomedullin | 0.00889709 |
| PER1 | period circadian clock 1 | 0.00877988 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.00867195 |
| STC1 | stanniocalcin 1 | 0.00854339 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | 0.00854017 |
| EGR1 | early growth response 1 | 0.00844426 |
| HJURP | Holliday junction recognition protein | 0.00834011 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.00829813 |
| JUN | jun proto-oncogene | 0.00826978 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.00822541 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.00821519 |
| CENPF | centromere protein F, 350/400kDa | 0.0081946 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.00813043 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.00810119 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0080846 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.00795928 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0079193 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.00781048 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0077849 |
| CKAP2 | cytoskeleton associated protein 2 | 0.00777232 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.00775606 |
| G0S2 | G0/G1 switch 2 | 0.00765274 |
| FTL | ferritin, light polypeptide | 0.00762757 |
| CLEC1B | C-type lectin domain family 1, member B | 0.00761943 |
| CDK17 | cyclin-dependent kinase 17 | 0.00749631 |
| CSNK1E | casein kinase 1, epsilon | 0.00745715 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.00745608 |
| NPTN | neuroplastin | 0.00741401 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.219288 |
| HMGA2 | high mobility group AT-hook 2 | -0.187722 |
| COL5A1 | collagen, type V, alpha 1 | -0.152759 |
| CDH13 | cadherin 13 | -0.146822 |
| EXT1 | exostosin glycosyltransferase 1 | -0.125194 |
| ASPH | aspartate beta-hydroxylase | -0.122303 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.105177 |
| NAV1 | neuron navigator 1 | -0.10351 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0943466 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0773252 |
| FN1 | fibronectin 1 | -0.074403 |
| AHNAK | AHNAK nucleoprotein | -0.0697518 |
| MYO10 | myosin X | -0.068781 |
| DST | dystonin | -0.0652381 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0643356 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0623641 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0617655 |
| PRELID2 | PRELI domain containing 2 | -0.0596429 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0590239 |
| VCL | vinculin | -0.0559271 |
| GLIS3 | GLIS family zinc finger 3 | -0.055131 |
| ATXN1 | ataxin 1 | -0.0539366 |
| RAI14 | retinoic acid induced 14 | -0.0523754 |
| DIAPH2 | diaphanous-related formin 2 | -0.0514308 |
| FMN1 | formin 1 | -0.0497436 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0489097 |
| PRKCA | protein kinase C, alpha | -0.0488806 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0478117 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0475384 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0471916 |
| ACTG1 | actin gamma 1 | -0.0465557 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0461415 |
| EGFR | epidermal growth factor receptor | -0.0460286 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0456663 |
| RAD51B | RAD51 paralog B | -0.0451311 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0443195 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0438756 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0423054 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0422006 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0416352 |
| SMYD3 | SET and MYND domain containing 3 | -0.0415965 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0409637 |
| PTK2 | protein tyrosine kinase 2 | -0.0407958 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0404175 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0394694 |
| EFNA5 | ephrin-A5 | -0.0393308 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0389115 |
| TMSB10 | thymosin beta 10 | -0.038764 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0381841 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0377478 |
| ANXA2 | annexin A2 | -0.0373657 |
| INTS6 | integrator complex subunit 6 | -0.0370603 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0362479 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0361081 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0357893 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0352981 |
| NABP1 | nucleic acid binding protein 1 | -0.03525 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0342253 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0340679 |
| KIAA1549L | KIAA1549-like | -0.0339154 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0329082 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0321701 |
| FRMD4A | FERM domain containing 4A | -0.0321001 |
| LAMB3 | laminin, beta 3 | -0.0320836 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0315777 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0312849 |
| DTNA | dystrobrevin, alpha | -0.0310716 |
| CCDC91 | coiled-coil domain containing 91 | -0.0309961 |
| CLMP | CXADR-like membrane protein | -0.0308931 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0299759 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0298496 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0297434 |
| CFAP20DC | CFAP20 domain containing | -0.0295507 |
| FER | fer (fps/fes related) tyrosine kinase | -0.029517 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.029497 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0291672 |
| WWOX | WW domain containing oxidoreductase | -0.0285688 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0285332 |
| CANX | calnexin | -0.0284895 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0284159 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0283252 |
| CUX1 | cut-like homeobox 1 | -0.0282619 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0281109 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0279931 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0272381 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0269052 |
| ANKRD12 | ankyrin repeat domain 12 | -0.026826 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0263112 |
| AEBP2 | AE binding protein 2 | -0.0260675 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.025763 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0256711 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0256376 |
| PRSS23 | protease, serine, 23 | -0.0253257 |
| ATG7 | autophagy related 7 | -0.0252762 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0252711 |
| NDRG1 | N-myc downstream regulated 1 | -0.0252594 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0247525 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0247254 |
| NAV3 | neuron navigator 3 | -0.0246813 |
| CDK6 | cyclin-dependent kinase 6 | -0.0245088 |
