| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dorzolamide (hydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0805456 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0618208 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0545191 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0483742 |
| STC1 | stanniocalcin 1 | 0.0445585 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0367192 |
| PALLD | palladin, cytoskeletal associated protein | 0.0344812 |
| VIM | vimentin | 0.0305169 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0300861 |
| GOLGA4 | golgin A4 | 0.0268765 |
| RSU1 | Ras suppressor protein 1 | 0.0265211 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0264245 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0263619 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0250649 |
| MT1X | metallothionein 1X | 0.0250245 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0250144 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0243304 |
| INHBA | inhibin, beta A | 0.024245 |
| CSPP1 | centrosome and spindle pole associated protein 1 | 0.0235506 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0227495 |
| RPS2 | ribosomal protein S2 | 0.0212153 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0207875 |
| RPL4 | ribosomal protein L4 | 0.0206121 |
| RPS6 | ribosomal protein S6 | 0.0201322 |
| ANKRD28 | ankyrin repeat domain 28 | 0.019814 |
| FAM107B | family with sequence similarity 107, member B | 0.0194947 |
| COG5 | component of oligomeric golgi complex 5 | 0.0192243 |
| SQLE | squalene epoxidase | 0.0191748 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0189438 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0188353 |
| CALU | calumenin | 0.0186202 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0183623 |
| VMP1 | vacuole membrane protein 1 | 0.0182586 |
| B2M | beta-2-microglobulin | 0.0182532 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0182426 |
| RBM39 | RNA binding motif protein 39 | 0.0176288 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0175309 |
| TBC1D10A | TBC1 domain family, member 10A | 0.0173514 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0173397 |
| GPR107 | G protein-coupled receptor 107 | 0.0172813 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.017256 |
| RASA2 | RAS p21 protein activator 2 | 0.017224 |
| WRN | Werner syndrome, RecQ helicase-like | 0.0171766 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0170056 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0165819 |
| SPAG9 | sperm associated antigen 9 | 0.0164416 |
| SBF2 | SET binding factor 2 | 0.0162354 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0162022 |
| SEPTIN2 | septin 2 | 0.0160267 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0160107 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0159042 |
| LOX | lysyl oxidase | 0.0155739 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0155538 |
| PCMT1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | 0.0155312 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | 0.0153704 |
| UBE3C | ubiquitin protein ligase E3C | 0.0153369 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.015075 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0149873 |
| CUL3 | cullin 3 | 0.0149417 |
| MTMR3 | myotubularin related protein 3 | 0.0147563 |
| SUCO | SUN domain containing ossification factor | 0.0145033 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0145005 |
| TXNRD1 | thioredoxin reductase 1 | 0.01448 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0144134 |
| OGA | O-GlcNAcase | 0.0142839 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0142817 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0142724 |
| DENND5A | DENN/MADD domain containing 5A | 0.0141268 |
| TMF1 | TATA element modulatory factor 1 | 0.0140877 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0140211 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0140071 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0139853 |
| LIMA1 | LIM domain and actin binding 1 | 0.0137827 |
| CFDP1 | craniofacial development protein 1 | 0.0137758 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0137699 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0136137 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0133488 |
| RBM25 | RNA binding motif protein 25 | 0.0132666 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0131621 |
| DIAPH1 | diaphanous-related formin 1 | 0.0131619 |
| CCND1 | cyclin D1 | 0.013154 |
| FNBP1L | formin binding protein 1-like | 0.0130865 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0130649 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0130589 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0129651 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | 0.0129493 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0129013 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0128124 |
| PITPNB | phosphatidylinositol transfer protein, beta | 0.012743 |
| TMSB4X | thymosin beta 4, X-linked | 0.0127414 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | 0.0126515 |
| HBS1L | HBS1-like translational GTPase | 0.0126187 |
| TMEM123 | transmembrane protein 123 | 0.0126095 |
| SNX4 | sorting nexin 4 | 0.0125852 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0124816 |
| CMPK1 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic | 0.0124454 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0123018 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.012287 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0122461 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | 0.0122362 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.445482 |
| NDRG1 | N-myc downstream regulated 1 | -0.236262 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.155132 |
| COL6A3 | collagen, type VI, alpha 3 | -0.146206 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.118321 |
| COL1A2 | collagen, type I, alpha 2 | -0.0958991 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.093423 |
| CDH13 | cadherin 13 | -0.0869197 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0864746 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.084509 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0812359 |
| FBN1 | fibrillin 1 | -0.0791671 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0784156 |
| CADM1 | cell adhesion molecule 1 | -0.0782916 |
| COL5A1 | collagen, type V, alpha 1 | -0.0747624 |
| TMSB10 | thymosin beta 10 | -0.0667219 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0662708 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0660755 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0654672 |
| LOXL2 | lysyl oxidase-like 2 | -0.0608401 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0586204 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0551907 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0547993 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0532738 |
| RUNX1 | runt-related transcription factor 1 | -0.0521814 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0511496 |
| TPM4 | tropomyosin 4 | -0.0493455 |
| NAV1 | neuron navigator 1 | -0.0492806 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0490697 |
| ENO1 | enolase 1, (alpha) | -0.0480686 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0478116 |
| EGFR | epidermal growth factor receptor | -0.0473944 |
| PRELID2 | PRELI domain containing 2 | -0.0473826 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0470368 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0449909 |
| VEGFA | vascular endothelial growth factor A | -0.0439941 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0396738 |
| ATXN1 | ataxin 1 | -0.0376473 |
| ASPH | aspartate beta-hydroxylase | -0.0367611 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0362282 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.035818 |
| IER3 | immediate early response 3 | -0.0355451 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0353772 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0353498 |
| CD44 | CD44 molecule (Indian blood group) | -0.0346347 |
| COL6A1 | collagen, type VI, alpha 1 | -0.034513 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0340911 |
| PTK2 | protein tyrosine kinase 2 | -0.0325687 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0314572 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0313687 |
| IL6 | interleukin 6 | -0.0310963 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0300924 |
| NRP1 | neuropilin 1 | -0.0299984 |
| AHNAK | AHNAK nucleoprotein | -0.0299052 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0297275 |
| FTL | ferritin, light polypeptide | -0.0293955 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0290402 |
| CNTN5 | contactin 5 | -0.0290036 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0275629 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0274773 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.027466 |
| BBX | bobby sox homolog (Drosophila) | -0.0274116 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0271107 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.0265516 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.026338 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0251932 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0250884 |
| TNS1 | tensin 1 | -0.0249376 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0248567 |
| PTMA | prothymosin, alpha | -0.0248144 |
| TBC1D5 | TBC1 domain family, member 5 | -0.024078 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0240156 |
| CANX | calnexin | -0.0239274 |
| RBFOX1 | RNA binding protein, fox-1 homolog (C. elegans) 1 | -0.0238264 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0233476 |
| RPS19 | ribosomal protein S19 | -0.022962 |
| NUCB2 | nucleobindin 2 | -0.0228107 |
| ARRDC3 | arrestin domain containing 3 | -0.0228089 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0226198 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.022594 |
| TMEM165 | transmembrane protein 165 | -0.0220381 |
| COL1A1 | collagen, type I, alpha 1 | -0.0220137 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0219687 |
| RTN4 | reticulon 4 | -0.0215813 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0214255 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0214054 |
| IL6ST | interleukin 6 signal transducer | -0.0211949 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0211175 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0207849 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0206489 |
| SLC22A23 | solute carrier family 22, member 23 | -0.020428 |
| RPS3 | ribosomal protein S3 | -0.0202789 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0201227 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0200243 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0200075 |
| HDAC9 | histone deacetylase 9 | -0.0199593 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0199402 |
| FOSL1 | FOS-like antigen 1 | -0.0197723 |
| LMAN1 | lectin, mannose-binding, 1 | -0.019767 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0197402 |
