| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dorzolamide (hydrochloride)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL4 | ribosomal protein L4 | 0.112716 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0641174 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0618413 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0610876 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0501918 |
| NECTIN2 | nectin cell adhesion molecule 2 | 0.0483868 |
| VCL | vinculin | 0.0453638 |
| ASPH | aspartate beta-hydroxylase | 0.0422139 |
| RPS2 | ribosomal protein S2 | 0.0410211 |
| RBM39 | RNA binding motif protein 39 | 0.040851 |
| LAMB3 | laminin, beta 3 | 0.0371923 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0365533 |
| MKI67 | marker of proliferation Ki-67 | 0.0362833 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0338482 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0332731 |
| OGA | O-GlcNAcase | 0.03274 |
| STK24 | serine/threonine kinase 24 | 0.0326689 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0326471 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0323951 |
| ACTN4 | actinin, alpha 4 | 0.0320727 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0320165 |
| HMGB2 | high mobility group box 2 | 0.0319486 |
| RRBP1 | ribosome binding protein 1 | 0.0309728 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0304453 |
| SET | SET nuclear proto-oncogene | 0.02774 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0275114 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0274949 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0273034 |
| ETV6 | ets variant 6 | 0.0271079 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0269426 |
| SEPTIN9 | septin 9 | 0.0263909 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0249032 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0248842 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0247259 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0244778 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0242486 |
| HMGB1 | high mobility group box 1 | 0.0234824 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0233389 |
| EZR | ezrin | 0.0231615 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0229292 |
| SMAD3 | SMAD family member 3 | 0.0228717 |
| JUP | junction plakoglobin | 0.0226948 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0220921 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.022011 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0217929 |
| PRELID2 | PRELI domain containing 2 | 0.0217797 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0216667 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0214093 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0213259 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 0.0213136 |
| LAMA4 | laminin, alpha 4 | 0.0205821 |
| SH3BP2 | SH3-domain binding protein 2 | 0.0202216 |
| SMYD3 | SET and MYND domain containing 3 | 0.0200128 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | 0.0198168 |
| AHNAK | AHNAK nucleoprotein | 0.0196866 |
| TXNRD1 | thioredoxin reductase 1 | 0.0194136 |
| CTTNBP2NL | CTTNBP2 N-terminal like | 0.0192653 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0189706 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0188975 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0186427 |
| KRT19 | keratin 19, type I | 0.0185927 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0184794 |
| SDC4 | syndecan 4 | 0.0184626 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0182899 |
| RPL13A | ribosomal protein L13a | 0.0181851 |
| TMEM45B | transmembrane protein 45B | 0.0181225 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | 0.0180886 |
| APOL1 | apolipoprotein L, 1 | 0.0179103 |
| MYO6 | myosin VI | 0.0178785 |
| RPS18 | ribosomal protein S18 | 0.017537 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.017506 |
| BCL2L1 | BCL2-like 1 | 0.0173886 |
| TMC5 | transmembrane channel-like 5 | 0.0173256 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0172845 |
| PTPRH | protein tyrosine phosphatase, receptor type, H | 0.0172456 |
| LSR | lipolysis stimulated lipoprotein receptor | 0.0171724 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0170482 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0169718 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0169134 |
| KRT17 | keratin 17, type I | 0.0168342 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0168166 |
| MMP7 | matrix metallopeptidase 7 | 0.0166711 |
| RAD51B | RAD51 paralog B | 0.0166548 |
| TPR | translocated promoter region, nuclear basket protein | 0.0166029 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0165278 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.016373 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0161701 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0161482 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0161348 |
| PLEC | plectin | 0.016123 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0159828 |
| YPEL2 | yippee-like 2 (Drosophila) | 0.0159806 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0159292 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0159174 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.0158584 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0157134 |
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | 0.0154457 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0154026 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0153922 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | 0.0153647 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.216864 |
| FTL | ferritin, light polypeptide | -0.182591 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.154132 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.121615 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.121604 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.101027 |
| LDHA | lactate dehydrogenase A | -0.0874301 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0839035 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.082889 |
| LYZ | lysozyme | -0.081327 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0690376 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0667337 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0610833 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0589687 |
| POTEF | POTE ankyrin domain family, member F | -0.0585466 |
| HMGA1 | high mobility group AT-hook 1 | -0.0533417 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.052989 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0520167 |
| GOLGA4 | golgin A4 | -0.0481365 |
| RPL21 | ribosomal protein L21 | -0.0478486 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0474344 |
| AGR2 | anterior gradient 2 | -0.0474189 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0472494 |
| TMEM65 | transmembrane protein 65 | -0.0471399 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0464444 |
| CANX | calnexin | -0.0458645 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0452696 |
| PKM | pyruvate kinase, muscle | -0.0442727 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0440988 |
| WASF2 | WAS protein family, member 2 | -0.0439814 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0437759 |
| DSTN | destrin (actin depolymerizing factor) | -0.0434589 |
| ANXA2 | annexin A2 | -0.0430319 |
| ATXN1 | ataxin 1 | -0.0428113 |
| TRAM1 | translocation associated membrane protein 1 | -0.0424877 |
| PCBP2 | poly(rC) binding protein 2 | -0.0421384 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0413187 |
| VEGFA | vascular endothelial growth factor A | -0.0395398 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0391428 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0391326 |
| TMSB10 | thymosin beta 10 | -0.0387761 |
| DGKH | diacylglycerol kinase, eta | -0.038212 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0367809 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0354407 |
| RPS13 | ribosomal protein S13 | -0.0350937 |
| SERP1 | stress-associated endoplasmic reticulum protein 1 | -0.0350551 |
| HM13 | histocompatibility (minor) 13 | -0.0345884 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0345404 |
| ZFP36 | ZFP36 ring finger protein | -0.0342264 |
| RPL19 | ribosomal protein L19 | -0.0341691 |
| TMCO3 | transmembrane and coiled-coil domains 3 | -0.0332614 |
| RPL27A | ribosomal protein L27a | -0.0330062 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0329943 |
| MAPK6 | mitogen-activated protein kinase 6 | -0.0326798 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.032587 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0325315 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0322097 |
| MAGT1 | magnesium transporter 1 | -0.0319593 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -0.0319557 |
| CCNI | cyclin I | -0.031893 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0318895 |
| RPS5 | ribosomal protein S5 | -0.0318681 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.031736 |
| FAM135A | family with sequence similarity 135, member A | -0.0316682 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0316369 |
| FAM13A | family with sequence similarity 13, member A | -0.0316096 |
| RPS11 | ribosomal protein S11 | -0.0312332 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0311882 |
| BPTF | bromodomain PHD finger transcription factor | -0.0310714 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0310093 |
| UBC | ubiquitin C | -0.0308806 |
| TJP1 | tight junction protein 1 | -0.0307789 |
| EGR1 | early growth response 1 | -0.030287 |
| TMEM123 | transmembrane protein 123 | -0.0301571 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.0300648 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.029642 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0292483 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0292006 |
| ARF4 | ADP-ribosylation factor 4 | -0.0290976 |
| MORF4L2 | mortality factor 4 like 2 | -0.0290322 |
| HYOU1 | hypoxia up-regulated 1 | -0.0287735 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0287165 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0284871 |
| UBN2 | ubinuclein 2 | -0.02832 |
| ASTN2 | astrotactin 2 | -0.0280323 |
| RTN3 | reticulon 3 | -0.0279122 |
| INTS6 | integrator complex subunit 6 | -0.0278239 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | -0.0277694 |
| RPL8 | ribosomal protein L8 | -0.0277152 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0276231 |
| PATJ | PATJ crumbs cell polarity complex component | -0.027589 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0275866 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0272662 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0269552 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0268263 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0268239 |
| COG5 | component of oligomeric golgi complex 5 | -0.0266413 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0265909 |
| RPS19 | ribosomal protein S19 | -0.0265769 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.0265611 |
