Dorzolamide (hydrochloride)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dorzolamide (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dorzolamide (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.0834188
RPS12 ribosomal protein S12 0.0740721
RPL37A ribosomal protein L37a 0.0604304
RPL4 ribosomal protein L4 0.0578909
DDIT4 DNA-damage-inducible transcript 4 0.0434418
RPS3 ribosomal protein S3 0.041721
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0399103
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0376158
RPS2 ribosomal protein S2 0.036035
RPS6 ribosomal protein S6 0.0317747
RPS17 ribosomal protein S17 0.0305963
RPS19 ribosomal protein S19 0.0280256
ENO1 enolase 1, (alpha) 0.0278746
PTMA prothymosin, alpha 0.0275346
RPL26 ribosomal protein L26 0.0270122
PRRC2C proline-rich coiled-coil 2C 0.0261029
BHLHE40 basic helix-loop-helix family, member e40 0.0260602
HLA-A major histocompatibility complex, class I, A 0.0249615
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.024265
RPL5 ribosomal protein L5 0.024117
RPL9 ribosomal protein L9 0.0238899
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0232373
CCL20 chemokine (C-C motif) ligand 20 0.0232206
EIF1 eukaryotic translation initiation factor 1 0.0229458
RPL23 ribosomal protein L23 0.0225276
RPS18 ribosomal protein S18 0.0221018
RACK1 receptor for activated C kinase 1 0.0216033
RPL12 ribosomal protein L12 0.0213685
RPS8 ribosomal protein S8 0.0210216
RPS15A ribosomal protein S15a 0.0201122
RPS14 ribosomal protein S14 0.0194336
RPLP1 ribosomal protein, large, P1 0.0187971
RPL35 ribosomal protein L35 0.018647
ICAM1 intercellular adhesion molecule 1 0.0181049
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0179554
RPL37 ribosomal protein L37 0.0175937
ZFP36L1 ZFP36 ring finger protein-like 1 0.0174753
BIRC3 baculoviral IAP repeat containing 3 0.0174558
RPL18 ribosomal protein L18 0.0172562
RPL36 ribosomal protein L36 0.01655
RPL30 ribosomal protein L30 0.0158447
SET SET nuclear proto-oncogene 0.0157557
APOA1 apolipoprotein A-I 0.0155268
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0155258
IGFBP1 insulin-like growth factor binding protein 1 0.0152136
TNS1 tensin 1 0.0150895
RPL31 ribosomal protein L31 0.0149827
NACA nascent polypeptide-associated complex alpha subunit 0.0149581
FTH1 ferritin, heavy polypeptide 1 0.0147226
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0143491
RPL13A ribosomal protein L13a 0.0137714
RPL10A ribosomal protein L10a 0.0137297
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.013523
TIMP1 TIMP metallopeptidase inhibitor 1 0.0134157
RBM25 RNA binding motif protein 25 0.0132067
RPL27 ribosomal protein L27 0.0129119
RSRC2 arginine/serine-rich coiled-coil 2 0.0128805
RPL35A ribosomal protein L35a 0.0128523
ISG15 ISG15 ubiquitin-like modifier 0.0124235
VIM vimentin 0.012168
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0121155
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0120044
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.011974
SRRM1 serine/arginine repetitive matrix 1 0.0119067
GOLGA4 golgin A4 0.0117988
RPS20 ribosomal protein S20 0.0117524
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0112366
TMSB4X thymosin beta 4, X-linked 0.0110614
RPLP2 ribosomal protein, large, P2 0.0107898
BTN3A3 butyrophilin, subfamily 3, member A3 0.0107058
EGLN1 egl-9 family hypoxia-inducible factor 1 0.010694
B2M beta-2-microglobulin 0.0106871
HDGF hepatoma-derived growth factor 0.0106682
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.0103764
RPS27A ribosomal protein S27a 0.0102286
NFE2L1 nuclear factor, erythroid 2-like 1 0.0102191
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0102048
RPS29 ribosomal protein S29 0.0101924
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.00991664
TMSB10 thymosin beta 10 0.00984856
LOC102724023 ES1 protein homolog, mitochondrial 0.00961191
MXI1 MAX interactor 1, dimerization protein 0.00943546
OGA O-GlcNAcase 0.00920761
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.00915454
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.00915432
TLN1 talin 1 0.00912663
PRRC2A proline-rich coiled-coil 2A 0.00903326
SRRM2 serine/arginine repetitive matrix 2 0.00890547
PRELID2 PRELI domain containing 2 0.00885098
ATP5F1E ATP synthase F1 subunit epsilon 0.00871992
DOT1L DOT1-like histone H3K79 methyltransferase 0.00866547
GPX4 glutathione peroxidase 4 0.00859387
PABPN1 poly(A) binding protein, nuclear 1 0.00856725
RPS4X ribosomal protein S4, X-linked 0.00854928
ENO2 enolase 2 (gamma, neuronal) 0.00854346
HILPDA hypoxia inducible lipid droplet-associated 0.00852302
RPS27 ribosomal protein S27 0.00851454
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.00850108
ATF4 activating transcription factor 4 0.00849092
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00842351

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.397702
FN1 fibronectin 1 -0.284997
APOB apolipoprotein B -0.144456
FBF1 Fas (TNFRSF6) binding factor 1 -0.12383
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.119367
FNDC3B fibronectin type III domain containing 3B -0.102778
GPC6 glypican 6 -0.0950609
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0949869
EHBP1 EH domain binding protein 1 -0.0931276
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0808244
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0795404
MAML2 mastermind-like 2 (Drosophila) -0.0793942
SLC38A2 solute carrier family 38, member 2 -0.0777164
AKAP12 A kinase (PRKA) anchor protein 12 -0.0718629
DST dystonin -0.0706098
LRMDA leucine rich melanocyte differentiation associated -0.0685761
PEG3 paternally expressed 3 -0.0646191
VCL vinculin -0.0644413
C3 complement component 3 -0.0624091
SAMD4A sterile alpha motif domain containing 4A -0.0619577
GMDS GDP-mannose 4,6-dehydratase -0.0598934
GPC3 glypican 3 -0.0593847
NPAS2 neuronal PAS domain protein 2 -0.0564818
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0549255
TPT1 tumor protein, translationally-controlled 1 -0.05409
TMEM123 transmembrane protein 123 -0.0538123
PTPRM protein tyrosine phosphatase, receptor type, M -0.0530459
ATXN1 ataxin 1 -0.0529562
STAU1 staufen double-stranded RNA binding protein 1 -0.0529491
DOCK4 dedicator of cytokinesis 4 -0.0507606
ITGAV integrin, alpha V -0.0504647
TRIO trio Rho guanine nucleotide exchange factor -0.0502072
TM4SF1 transmembrane 4 L six family member 1 -0.0492539
EML4 echinoderm microtubule associated protein like 4 -0.0491673
ELL2 elongation factor, RNA polymerase II, 2 -0.0488522
NKD1 naked cuticle homolog 1 (Drosophila) -0.0480185
A2M alpha-2-macroglobulin -0.0477
FRMD5 FERM domain containing 5 -0.0476261
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0475081
ZBTB20 zinc finger and BTB domain containing 20 -0.046456
PTCHD4 patched domain containing 4 -0.0452524
EXT1 exostosin glycosyltransferase 1 -0.0450566
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.042858
IGF1R insulin-like growth factor 1 receptor -0.0423659
PDLIM5 PDZ and LIM domain 5 -0.0414802
SESTD1 SEC14 and spectrin domains 1 -0.0411609
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0402174
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0400013
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0390473
TRIM26 tripartite motif containing 26 -0.0385696
JMJD1C jumonji domain containing 1C -0.038415
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0384088
FMNL2 formin-like 2 -0.0383309
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0372777
LPP LIM domain containing preferred translocation partner in lipoma -0.0372754
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0370533
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0370208
PAWR PRKC, apoptosis, WT1, regulator -0.036424
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0364229
ZFAND3 zinc finger, AN1-type domain 3 -0.036373
PTPRK protein tyrosine phosphatase, receptor type, K -0.0358333
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0353059
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0350242
FOXP1 forkhead box P1 -0.0349268
AK1 adenylate kinase 1 -0.0347983
CP ceruloplasmin (ferroxidase) -0.0341407
APOA2 apolipoprotein A-II -0.0340662
CNKSR3 CNKSR family member 3 -0.034
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0335366
OSBPL10 oxysterol binding protein-like 10 -0.0333988
RUNX1 runt-related transcription factor 1 -0.0333799
SOD2 superoxide dismutase 2, mitochondrial -0.0333524
LCOR ligand dependent nuclear receptor corepressor -0.033046
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0327875
DLC1 DLC1 Rho GTPase activating protein -0.0327777
DNAH17 dynein, axonemal, heavy chain 17 -0.0323287
DSPP dentin sialophosphoprotein -0.0321647
PDIA3 protein disulfide isomerase family A, member 3 -0.0321469
TCF12 transcription factor 12 -0.0318971
PARD3 par-3 family cell polarity regulator -0.0318288
MBNL2 muscleblind-like splicing regulator 2 -0.0315228
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0314543
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0310642
MBNL3 muscleblind-like splicing regulator 3 -0.0308496
SOX5 SRY (sex determining region Y)-box 5 -0.0303045
RPS24 ribosomal protein S24 -0.0293094
GLG1 golgi glycoprotein 1 -0.0291877
FAT1 FAT atypical cadherin 1 -0.0291526
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0289989
VMP1 vacuole membrane protein 1 -0.0288708
LMCD1 LIM and cysteine-rich domains 1 -0.0287378
TPM4 tropomyosin 4 -0.0287141
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0286355
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0286316
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0285594
USP34 ubiquitin specific peptidase 34 -0.0284807
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0282581
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0281753
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0277194
ITGA1 integrin, alpha 1 -0.0277083