Dorzolamide (hydrochloride)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dorzolamide (hydrochloride) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dorzolamide (hydrochloride)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.0907893
MT2A metallothionein 2A 0.0889251
HLA-B major histocompatibility complex, class I, B 0.0752074
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0690981
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0649969
B2M beta-2-microglobulin 0.0637607
HLA-A major histocompatibility complex, class I, A 0.0477535
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0456908
RPS6 ribosomal protein S6 0.0439256
ENO1 enolase 1, (alpha) 0.0429634
RPL35A ribosomal protein L35a 0.0403161
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0401738
RPLP2 ribosomal protein, large, P2 0.039821
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0391346
RPL4 ribosomal protein L4 0.0378309
SET SET nuclear proto-oncogene 0.0366119
EIF1 eukaryotic translation initiation factor 1 0.036382
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0352026
RPS8 ribosomal protein S8 0.0329064
RPL35 ribosomal protein L35 0.0312495
RPL12 ribosomal protein L12 0.031048
BASP1 brain abundant, membrane attached signal protein 1 0.0307334
HMGB1 high mobility group box 1 0.0299725
RPL23 ribosomal protein L23 0.0298221
IFI6 interferon, alpha-inducible protein 6 0.0290166
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0289681
TPT1 tumor protein, translationally-controlled 1 0.0286263
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0277506
CALR calreticulin 0.0276766
RPLP1 ribosomal protein, large, P1 0.0268672
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0267195
TMSB4X thymosin beta 4, X-linked 0.0264467
HMGB2 high mobility group box 2 0.026299
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0254543
RPL26 ribosomal protein L26 0.0253124
RPS19 ribosomal protein S19 0.0252407
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0245168
MYH9 myosin, heavy chain 9, non-muscle 0.0239196
RPS2 ribosomal protein S2 0.0234567
RBM39 RNA binding motif protein 39 0.0232715
RPL5 ribosomal protein L5 0.0231942
PRRC2C proline-rich coiled-coil 2C 0.0231727
PTMA prothymosin, alpha 0.0230529
HMGN2 high mobility group nucleosomal binding domain 2 0.0230416
RPL37 ribosomal protein L37 0.0230324
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0217306
RBM25 RNA binding motif protein 25 0.0213818
AHNAK AHNAK nucleoprotein 0.0211635
RPL11 ribosomal protein L11 0.0206766
KRT7 keratin 7, type II 0.0203661
TMSB10 thymosin beta 10 0.0198586
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0197311
ACTG1 actin gamma 1 0.019684
PARP14 poly (ADP-ribose) polymerase family, member 14 0.019489
IFITM3 interferon induced transmembrane protein 3 0.0194168
LOC112694756 uncharaterized LOC112694756 0.0193983
KRT8 keratin 8, type II 0.0193696
CCND1 cyclin D1 0.0193513
RACK1 receptor for activated C kinase 1 0.0191152
SQSTM1 sequestosome 1 0.0189763
ASPH aspartate beta-hydroxylase 0.0186945
RPL34 ribosomal protein L34 0.0186467
PLSCR1 phospholipid scramblase 1 0.0186328
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0186296
VCL vinculin 0.0179513
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0179329
RPL19 ribosomal protein L19 0.0178405
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0177325
FUS FUS RNA binding protein 0.0173022
TUBB4B tubulin, beta 4B class IVb 0.0171347
BZW1 basic leucine zipper and W2 domains 1 0.0170901
RPS12 ribosomal protein S12 0.0168446
CD44 CD44 molecule (Indian blood group) 0.0167822
CAVIN1 caveolae associated protein 1 0.0166825
KRT18 keratin 18, type I 0.0166385
MT1X metallothionein 1X 0.0165063
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0159107
IFITM1 interferon induced transmembrane protein 1 0.0158225
RPS21 ribosomal protein S21 0.0157064
YBX3 Y box binding protein 3 0.0157014
RPS17 ribosomal protein S17 0.0156918
IFI27 interferon, alpha-inducible protein 27 0.0155282
WWOX WW domain containing oxidoreductase 0.0151258
SENP5 SUMO1/sentrin specific peptidase 5 0.0151245
H1-4 H1.4 linker histone, cluster member 0.0150083
RPL30 ribosomal protein L30 0.0149701
RPS3 ribosomal protein S3 0.0149194
MKI67 marker of proliferation Ki-67 0.0147742
ELL2 elongation factor, RNA polymerase II, 2 0.0147578
RPL7 ribosomal protein L7 0.0147455
RPS23 ribosomal protein S23 0.014662
ZNFX1 zinc finger, NFX1-type containing 1 0.0144776
RPS16 ribosomal protein S16 0.014471
BHLHE40 basic helix-loop-helix family, member e40 0.0143814
RPLP0 ribosomal protein, large, P0 0.0143626
RPL27A ribosomal protein L27a 0.0143432
RPL14 ribosomal protein L14 0.0141788
YBX1 Y box binding protein 1 0.0140267
ARF1 ADP-ribosylation factor 1 0.0139877
PA2G4 proliferation-associated 2G4, 38kDa 0.0139426

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.158687
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.156522
IGFBP3 insulin-like growth factor binding protein 3 -0.149994
FN1 fibronectin 1 -0.141014
NALF1 NALCN channel auxiliary factor 1 -0.135346
TRIO trio Rho guanine nucleotide exchange factor -0.1305
GLIS3 GLIS family zinc finger 3 -0.104547
DLG1 discs, large homolog 1 (Drosophila) -0.0839412
F3 coagulation factor III (thromboplastin, tissue factor) -0.0803943
ATP13A3 ATPase type 13A3 -0.0787667
ABI3BP ABI family, member 3 (NESH) binding protein -0.0640365
SOD2 superoxide dismutase 2, mitochondrial -0.0613839
PHACTR1 phosphatase and actin regulator 1 -0.058576
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0575595
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0549618
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0542663
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0506842
MMP12 matrix metallopeptidase 12 -0.0490742
FNDC3B fibronectin type III domain containing 3B -0.0490542
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0489596
SLC12A8 solute carrier family 12, member 8 -0.0473042
AKAP12 A kinase (PRKA) anchor protein 12 -0.0468381
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0460121
TGFB2 transforming growth factor, beta 2 -0.0449218
PLIN2 perilipin 2 -0.0422306
RAI14 retinoic acid induced 14 -0.0418782
FLNB filamin B, beta -0.0404685
SLIT2 slit homolog 2 (Drosophila) -0.0403376
CCBE1 collagen and calcium binding EGF domains 1 -0.0396841
VEGFC vascular endothelial growth factor C -0.0375577
PDIA3 protein disulfide isomerase family A, member 3 -0.0374987
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0367845
ADM adrenomedullin -0.0347118
COL5A1 collagen, type V, alpha 1 -0.0344649
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0335202
UGCG UDP-glucose ceramide glucosyltransferase -0.0334368
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0330361
LOX lysyl oxidase -0.0329871
CANX calnexin -0.0327576
EXT1 exostosin glycosyltransferase 1 -0.0323135
SDK1 sidekick cell adhesion molecule 1 -0.0311194
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0307896
COL5A2 collagen, type V, alpha 2 -0.0306085
VEGFA vascular endothelial growth factor A -0.0304878
PTBP3 polypyrimidine tract binding protein 3 -0.0304576
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0291344
NUP58 nucleoporin 58 -0.0279114
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0272158
ARF4 ADP-ribosylation factor 4 -0.0264316
WSB1 WD repeat and SOCS box containing 1 -0.0262954
MBNL1 muscleblind-like splicing regulator 1 -0.0260324
CTSD cathepsin D -0.0257432
MAP4 microtubule-associated protein 4 -0.0257185
PICALM phosphatidylinositol binding clathrin assembly protein -0.0256686
KIF13A kinesin family member 13A -0.0255839
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0255246
DIPK2A divergent protein kinase domain 2A -0.0255123
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0253575
PIAS2 protein inhibitor of activated STAT, 2 -0.0250573
CUL4B cullin 4B -0.0245025
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0244198
BMPER BMP binding endothelial regulator -0.0243969
SAMD12 sterile alpha motif domain containing 12 -0.0242989
ENO2 enolase 2 (gamma, neuronal) -0.0242715
ZBTB20 zinc finger and BTB domain containing 20 -0.0240324
COPB1 coatomer protein complex, subunit beta 1 -0.0238462
TAOK1 TAO kinase 1 -0.0236417
POTEF POTE ankyrin domain family, member F -0.023561
PLCB4 phospholipase C, beta 4 -0.0234032
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0232928
EGFR epidermal growth factor receptor -0.0230289
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0229947
RNF144B ring finger protein 144B -0.0228246
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0227642
ANXA1 annexin A1 -0.0226425
TMEM178B transmembrane protein 178B -0.0222809
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0222637
BIRC6 baculoviral IAP repeat containing 6 -0.0221284
KDM2A lysine (K)-specific demethylase 2A -0.0218732
ITGA1 integrin, alpha 1 -0.0217422
SBF2 SET binding factor 2 -0.0216868
SULF1 sulfatase 1 -0.0215168
PGK1 phosphoglycerate kinase 1 -0.0214581
COPA coatomer protein complex, subunit alpha -0.0213771
TMEM165 transmembrane protein 165 -0.021342
TNIK TRAF2 and NCK interacting kinase -0.0212414
BTG1 B-cell translocation gene 1, anti-proliferative -0.0211258
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0210829
PTPRF protein tyrosine phosphatase, receptor type, F -0.0209762
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0207042
LYPD6B LY6/PLAUR domain containing 6B -0.0206596
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0206074
HILPDA hypoxia inducible lipid droplet-associated -0.0205582
LIMCH1 LIM and calponin homology domains 1 -0.0204585
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0203336
ZEB2 zinc finger E-box binding homeobox 2 -0.0203182
AGTPBP1 ATP/GTP binding protein 1 -0.0203121
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0198228
HPS3 Hermansky-Pudlak syndrome 3 -0.0197578
NSD2 nuclear receptor binding SET domain protein 2 -0.0197056