Dorzolamide (hydrochloride)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dorzolamide (hydrochloride) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dorzolamide (hydrochloride)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.0915053
RPS3 ribosomal protein S3 0.0655455
RPS6 ribosomal protein S6 0.06298
TMSB10 thymosin beta 10 0.0572506
RPS12 ribosomal protein S12 0.0570765
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0569891
RPL37A ribosomal protein L37a 0.0520655
EIF1 eukaryotic translation initiation factor 1 0.0469992
RPL4 ribosomal protein L4 0.0462636
FTL ferritin, light polypeptide 0.0462135
RPL23 ribosomal protein L23 0.0421723
RPL12 ribosomal protein L12 0.0416069
RPS19 ribosomal protein S19 0.0403954
RPL26 ribosomal protein L26 0.0399433
RPS2 ribosomal protein S2 0.0393208
MT2A metallothionein 2A 0.0376766
RPS17 ribosomal protein S17 0.0329559
RPS8 ribosomal protein S8 0.0323522
RPL36 ribosomal protein L36 0.0310854
RPL35A ribosomal protein L35a 0.0302454
RPL5 ribosomal protein L5 0.0294901
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.028331
RACK1 receptor for activated C kinase 1 0.0277623
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0266549
RPL18 ribosomal protein L18 0.0261782
RPL13A ribosomal protein L13a 0.0255578
RPLP1 ribosomal protein, large, P1 0.0254669
YBX3 Y box binding protein 3 0.0237641
RPL9 ribosomal protein L9 0.0232336
RPL31 ribosomal protein L31 0.0228113
RPLP2 ribosomal protein, large, P2 0.0226534
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0224545
RPL35 ribosomal protein L35 0.0221032
RPL37 ribosomal protein L37 0.0201469
RPS27A ribosomal protein S27a 0.0195487
PRRC2C proline-rich coiled-coil 2C 0.0191812
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0189383
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0188878
RPS14 ribosomal protein S14 0.0188756
RPL19 ribosomal protein L19 0.0186064
RBM25 RNA binding motif protein 25 0.0182732
RPL30 ribosomal protein L30 0.0171722
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0170911
RPS15A ribosomal protein S15a 0.0169044
KTN1 kinectin 1 (kinesin receptor) 0.0167585
RPS13 ribosomal protein S13 0.0167479
NUP58 nucleoporin 58 0.0166638
SET SET nuclear proto-oncogene 0.0165777
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0165509
TPI1 triosephosphate isomerase 1 0.0164836
NAP1L1 nucleosome assembly protein 1-like 1 0.01634
ZNF292 zinc finger protein 292 0.0161193
RPS27 ribosomal protein S27 0.0158879
FTH1 ferritin, heavy polypeptide 1 0.0155648
ENO1 enolase 1, (alpha) 0.0153914
PNISR PNN-interacting serine/arginine-rich protein 0.0150765
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0150644
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0150126
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0149662
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0148476
WSB1 WD repeat and SOCS box containing 1 0.0145284
RPL27 ribosomal protein L27 0.0145221
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0144726
DDIT4 DNA-damage-inducible transcript 4 0.0144658
NACA nascent polypeptide-associated complex alpha subunit 0.0142394
RPL11 ribosomal protein L11 0.0138147
ATF4 activating transcription factor 4 0.0136121
NOP58 NOP58 ribonucleoprotein 0.0135686
RPS18 ribosomal protein S18 0.0135609
GOLGA4 golgin A4 0.0134117
ENO2 enolase 2 (gamma, neuronal) 0.0132628
KIF5B kinesin family member 5B 0.0132251
YBX1 Y box binding protein 1 0.0132044
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0130583
RPS4X ribosomal protein S4, X-linked 0.0129549
VIM vimentin 0.0126482
RPL34 ribosomal protein L34 0.0123469
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0121173
PFN1 profilin 1 0.0120636
SRRM2 serine/arginine repetitive matrix 2 0.0119671
IGFBP3 insulin-like growth factor binding protein 3 0.0119357
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0118727
RPS16 ribosomal protein S16 0.0117975
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0117871
RPL7 ribosomal protein L7 0.0115539
RPL10A ribosomal protein L10a 0.0114505
EGLN1 egl-9 family hypoxia-inducible factor 1 0.011315
RNF145 ring finger protein 145 0.011065
KMT2E lysine (K)-specific methyltransferase 2E 0.0110271
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0109753
TLN1 talin 1 0.0109107
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0109101
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0108186
RPL14 ribosomal protein L14 0.0107039
TPM3 tropomyosin 3 0.0106138
MXI1 MAX interactor 1, dimerization protein 0.0104222
PABPN1 poly(A) binding protein, nuclear 1 0.0103734
HDGF hepatoma-derived growth factor 0.0103496
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0103137
SEC61G Sec61 gamma subunit 0.0102143

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.120041
EXT1 exostosin glycosyltransferase 1 -0.0983194
PRKG1 protein kinase, cGMP-dependent, type I -0.0679998
EFNA5 ephrin-A5 -0.0620599
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.060414
GPC6 glypican 6 -0.058373
AKAP12 A kinase (PRKA) anchor protein 12 -0.057237
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0554381
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0550056
PTPRG protein tyrosine phosphatase, receptor type, G -0.0513559
AHNAK AHNAK nucleoprotein -0.0492154
NALF1 NALCN channel auxiliary factor 1 -0.0468746
LSAMP limbic system-associated membrane protein -0.0466529
SAMD3 sterile alpha motif domain containing 3 -0.0442103
MMP12 matrix metallopeptidase 12 -0.0426673
TRIO trio Rho guanine nucleotide exchange factor -0.0408411
KIAA1549L KIAA1549-like -0.0408351
NTM neurotrimin -0.0387897
RUNX1 runt-related transcription factor 1 -0.0373261
ASPH aspartate beta-hydroxylase -0.0367169
PHACTR1 phosphatase and actin regulator 1 -0.0352857
CDH13 cadherin 13 -0.0344096
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0338337
VCL vinculin -0.0335926
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0331286
PTK2 protein tyrosine kinase 2 -0.032715
SAMD4A sterile alpha motif domain containing 4A -0.0325232
MYO10 myosin X -0.0324275
PBX3 pre-B-cell leukemia homeobox 3 -0.0322427
KIAA1217 KIAA1217 -0.0311657
NAV1 neuron navigator 1 -0.0306828
SDCCAG8 serologically defined colon cancer antigen 8 -0.030519
CDK6 cyclin-dependent kinase 6 -0.0302305
HMGA2 high mobility group AT-hook 2 -0.0291975
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0267211
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0265579
CD44 CD44 molecule (Indian blood group) -0.0262059
FRMD6 FERM domain containing 6 -0.0260192
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0252807
DST dystonin -0.0244565
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0244119
MSR1 macrophage scavenger receptor 1 -0.0240519
ADAM19 ADAM metallopeptidase domain 19 -0.0239183
MACF1 microtubule-actin crosslinking factor 1 -0.0238868
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.02362
USP34 ubiquitin specific peptidase 34 -0.0234722
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0234074
FNDC3B fibronectin type III domain containing 3B -0.0224638
TMPRSS15 transmembrane protease, serine 15 -0.0220318
DOCK4 dedicator of cytokinesis 4 -0.021751
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0214102
LPP LIM domain containing preferred translocation partner in lipoma -0.0213089
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0210823
MAML2 mastermind-like 2 (Drosophila) -0.0210801
TPT1 tumor protein, translationally-controlled 1 -0.0209285
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0209177
ALCAM activated leukocyte cell adhesion molecule -0.0202097
FN1 fibronectin 1 -0.0201958
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0201844
DSCAM Down syndrome cell adhesion molecule -0.0201685
ZNF804A zinc finger protein 804A -0.019825
C2CD2 C2 calcium-dependent domain containing 2 -0.0198221
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.019419
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 -0.0193843
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0193333
ANO6 anoctamin 6 -0.0189029
BMAL2 basic helix-loop-helix ARNT like 2 -0.018771
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0186861
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0186084
FOXP1 forkhead box P1 -0.018496
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0183929
ANTXR2 anthrax toxin receptor 2 -0.0183727
SASH1 SAM and SH3 domain containing 1 -0.0183009
LIMCH1 LIM and calponin homology domains 1 -0.018117
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0181062
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.018088
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0174133
ZEB1 zinc finger E-box binding homeobox 1 -0.017253
DPYD dihydropyrimidine dehydrogenase -0.0171791
PTCHD4 patched domain containing 4 -0.0169696
TNNC1 troponin C type 1 (slow) -0.0168112
NABP1 nucleic acid binding protein 1 -0.0167082
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0166668
CDK14 cyclin-dependent kinase 14 -0.0166641
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0165572
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0161814
CALD1 caldesmon 1 -0.0160571
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0156181
RAI14 retinoic acid induced 14 -0.0154113
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0154105
ELL2 elongation factor, RNA polymerase II, 2 -0.0154001
PARD3 par-3 family cell polarity regulator -0.015339
BPTF bromodomain PHD finger transcription factor -0.015231
PDE4D phosphodiesterase 4D, cAMP-specific -0.0150672
RIGI RNA sensor RIG-I -0.0149629
JMJD1C jumonji domain containing 1C -0.0149348
FMNL2 formin-like 2 -0.0148117
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0147545
CTSB cathepsin B -0.0147148
PTPRK protein tyrosine phosphatase, receptor type, K -0.0146796