| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dorzolamide (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS12 | ribosomal protein S12 | 0.0880565 |
| RPL4 | ribosomal protein L4 | 0.0783405 |
| RPS2 | ribosomal protein S2 | 0.0624794 |
| RPL37A | ribosomal protein L37a | 0.0494096 |
| RPS3 | ribosomal protein S3 | 0.048535 |
| PTMA | prothymosin, alpha | 0.0453515 |
| RPS17 | ribosomal protein S17 | 0.044819 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0432692 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0430249 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0375256 |
| CALB1 | calbindin 1, 28kDa | 0.0372968 |
| RPS6 | ribosomal protein S6 | 0.0298696 |
| DSPP | dentin sialophosphoprotein | 0.0287094 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0269706 |
| RPL9 | ribosomal protein L9 | 0.0252811 |
| ITGB4 | integrin, beta 4 | 0.0248268 |
| CLDN4 | claudin 4 | 0.0219505 |
| SET | SET nuclear proto-oncogene | 0.0216798 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0216737 |
| RPS15A | ribosomal protein S15a | 0.0206378 |
| RBM25 | RNA binding motif protein 25 | 0.0205941 |
| RPL18 | ribosomal protein L18 | 0.020543 |
| S100A6 | S100 calcium binding protein A6 | 0.0192137 |
| HLA-A | major histocompatibility complex, class I, A | 0.0177538 |
| TMF1 | TATA element modulatory factor 1 | 0.0171411 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.0170143 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0170143 |
| RPS18 | ribosomal protein S18 | 0.0169906 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.016867 |
| HDGF | hepatoma-derived growth factor | 0.0168376 |
| NPSR1 | neuropeptide S receptor 1 | 0.0164235 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.016308 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0162996 |
| KRT19 | keratin 19, type I | 0.0156467 |
| SLK | STE20-like kinase | 0.0151799 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0149468 |
| CAV2 | caveolin 2 | 0.0145632 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0144661 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0143832 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | 0.0136548 |
| JUP | junction plakoglobin | 0.0133271 |
| RPS8 | ribosomal protein S8 | 0.0133007 |
| RPS14 | ribosomal protein S14 | 0.0128337 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0127812 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.0121969 |
| RPL27 | ribosomal protein L27 | 0.0119298 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0112358 |
| DNM2 | dynamin 2 | 0.0111336 |
| UBXN4 | UBX domain protein 4 | 0.010948 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.0109039 |
| RPL36 | ribosomal protein L36 | 0.0108839 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0108346 |
| PFN1 | profilin 1 | 0.0108048 |
| KCNK6 | potassium channel, two pore domain subfamily K, member 6 | 0.0107679 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.010674 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0104923 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0104601 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0104528 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0103379 |
| TPM3 | tropomyosin 3 | 0.0102147 |
| DHFR | dihydrofolate reductase | 0.0101095 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.010028 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.00991368 |
| PNN | pinin, desmosome associated protein | 0.00979611 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.00965275 |
| POTEF | POTE ankyrin domain family, member F | 0.00963706 |
| RPL31 | ribosomal protein L31 | 0.00959217 |
| EZR | ezrin | 0.00956875 |
| IGF2 | insulin-like growth factor 2 | 0.00954341 |
| GOLGA4 | golgin A4 | 0.0093227 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.00922198 |
| RAD23A | RAD23 homolog A (S. cerevisiae) | 0.00914706 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0091058 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | 0.00908352 |
| FOSL1 | FOS-like antigen 1 | 0.00900809 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.00895215 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0089357 |
| INHBA | inhibin, beta A | 0.008882 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.00871019 |
| MIDN | midnolin | 0.00857502 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.00852452 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.00851605 |
| HLA-B | major histocompatibility complex, class I, B | 0.00851063 |
| PERP | PERP, TP53 apoptosis effector | 0.00843136 |
| HMGA1 | high mobility group AT-hook 1 | 0.00840441 |
| COL17A1 | collagen, type XVII, alpha 1 | 0.00838331 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.00827898 |
| PGM3 | phosphoglucomutase 3 | 0.00826562 |
| TPI1 | triosephosphate isomerase 1 | 0.00819631 |
| FAM120A | family with sequence similarity 120A | 0.00816604 |
| NRDC | nardilysin convertase | 0.00815654 |
| RPS27 | ribosomal protein S27 | 0.00813866 |
| LIMA1 | LIM domain and actin binding 1 | 0.00794598 |
| VEGFA | vascular endothelial growth factor A | 0.00790271 |
| KLK10 | kallikrein-related peptidase 10 | 0.00788652 |
| ZBTB7A | zinc finger and BTB domain containing 7A | 0.00786867 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.00783974 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0077707 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.00775824 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.00774563 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.259789 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.231366 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.114089 |
| RPLP1 | ribosomal protein, large, P1 | -0.112609 |
| RPS23 | ribosomal protein S23 | -0.0915115 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0876397 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0782825 |
| MYO1E | myosin IE | -0.0780736 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0748563 |
| TXNRD1 | thioredoxin reductase 1 | -0.0731187 |
| FAT1 | FAT atypical cadherin 1 | -0.0724485 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0698855 |
| LMO7 | LIM domain 7 | -0.0676876 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0635238 |
| RPLP0 | ribosomal protein, large, P0 | -0.0603452 |
| SHROOM3 | shroom family member 3 | -0.0582538 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0548206 |
| RPS25 | ribosomal protein S25 | -0.0543512 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0543489 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0540193 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0538528 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0529389 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0505831 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0505042 |
| RPS24 | ribosomal protein S24 | -0.0479051 |
| CANX | calnexin | -0.0460228 |
| FOXO1 | forkhead box O1 | -0.0454654 |
| ACTG1 | actin gamma 1 | -0.0443926 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0439426 |
| ANXA2 | annexin A2 | -0.0421416 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0418679 |
| AHNAK | AHNAK nucleoprotein | -0.0416441 |
| FLNB | filamin B, beta | -0.0412428 |
| RPL32 | ribosomal protein L32 | -0.0399402 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.039731 |
| RPL8 | ribosomal protein L8 | -0.0394624 |
| TRIM2 | tripartite motif containing 2 | -0.0391824 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0390308 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0384944 |
| WWC1 | WW and C2 domain containing 1 | -0.038345 |
| SERINC5 | serine incorporator 5 | -0.0381194 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0378787 |
| RPS16 | ribosomal protein S16 | -0.037429 |
| MYO1D | myosin ID | -0.0373729 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0366235 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0362638 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0362141 |
| ITGA6 | integrin, alpha 6 | -0.0361286 |
| RPS29 | ribosomal protein S29 | -0.0361016 |
| ACTN4 | actinin, alpha 4 | -0.0359969 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0359716 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0358842 |
| RPS13 | ribosomal protein S13 | -0.0358409 |
| VCL | vinculin | -0.0353657 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.0352637 |
| COG5 | component of oligomeric golgi complex 5 | -0.0345385 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0343231 |
| PCDHB16 | protocadherin beta 16 | -0.0343171 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0341154 |
| MYOF | myoferlin | -0.0340986 |
| PKP2 | plakophilin 2 | -0.0340236 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0338674 |
| RPS21 | ribosomal protein S21 | -0.0336043 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0335815 |
| FOXP1 | forkhead box P1 | -0.0332239 |
| RPLP2 | ribosomal protein, large, P2 | -0.0330313 |
| IER3 | immediate early response 3 | -0.0329136 |
| RPS15 | ribosomal protein S15 | -0.032894 |
| RPL27A | ribosomal protein L27a | -0.0327298 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0326854 |
| PRSS3 | protease, serine, 3 | -0.0326693 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0325972 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0316967 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0316915 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0316602 |
| JMJD1C | jumonji domain containing 1C | -0.0316588 |
| SMYD3 | SET and MYND domain containing 3 | -0.0315132 |
| USP3 | ubiquitin specific peptidase 3 | -0.0314069 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0312258 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0309638 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0308179 |
| NF1 | neurofibromin 1 | -0.0306928 |
| RIGI | RNA sensor RIG-I | -0.0305881 |
| EREG | epiregulin | -0.0304532 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0303741 |
| TCF12 | transcription factor 12 | -0.0303708 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0299834 |
| KLF6 | Kruppel-like factor 6 | -0.0299829 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0299205 |
| CCND2 | cyclin D2 | -0.0296916 |
| RPL38 | ribosomal protein L38 | -0.0296198 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.029494 |
| RNF213 | ring finger protein 213 | -0.0294411 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0291331 |
| MSI2 | musashi RNA-binding protein 2 | -0.0291227 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0291212 |
| RPS11 | ribosomal protein S11 | -0.0287252 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0286951 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0285479 |
| RPL7A | ribosomal protein L7a | -0.0285382 |
