Dorzolamide (hydrochloride)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dorzolamide (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dorzolamide (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.158019
RPS3 ribosomal protein S3 0.136896
MT2A metallothionein 2A 0.105124
RPL37A ribosomal protein L37a 0.0890541
PTMA prothymosin, alpha 0.0869973
RPS12 ribosomal protein S12 0.0692745
RPL4 ribosomal protein L4 0.0653173
RPL35A ribosomal protein L35a 0.0574573
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0558372
RPLP1 ribosomal protein, large, P1 0.0554379
EIF1 eukaryotic translation initiation factor 1 0.0515825
RPS8 ribosomal protein S8 0.0513741
FTL ferritin, light polypeptide 0.0511206
SEC61G Sec61 gamma subunit 0.0473821
RPS17 ribosomal protein S17 0.0457911
RPL31 ribosomal protein L31 0.0454158
RPS27A ribosomal protein S27a 0.0439094
RPS6 ribosomal protein S6 0.0425587
RPL34 ribosomal protein L34 0.0415337
RPL26 ribosomal protein L26 0.0406094
RPS27 ribosomal protein S27 0.0391801
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0389361
ATF4 activating transcription factor 4 0.0378946
RPL5 ribosomal protein L5 0.0378472
RPS19 ribosomal protein S19 0.0373815
RPL37 ribosomal protein L37 0.0370063
S100P S100 calcium binding protein P 0.036943
RPL12 ribosomal protein L12 0.0369366
SLC38A1 solute carrier family 38, member 1 0.0366752
RPS2 ribosomal protein S2 0.0357326
RPL30 ribosomal protein L30 0.0352183
PRRC2C proline-rich coiled-coil 2C 0.0343555
ASPH aspartate beta-hydroxylase 0.0331654
IFI6 interferon, alpha-inducible protein 6 0.0326889
RPS14 ribosomal protein S14 0.0323832
EGFR epidermal growth factor receptor 0.0317906
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0315254
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0301589
EGR1 early growth response 1 0.0300963
B2M beta-2-microglobulin 0.0295768
RACK1 receptor for activated C kinase 1 0.0293372
RPL36 ribosomal protein L36 0.0291514
RPL23 ribosomal protein L23 0.0290742
RPL9 ribosomal protein L9 0.0290691
LAMB3 laminin, beta 3 0.027737
CST3 cystatin C 0.0275145
EFNA5 ephrin-A5 0.0270691
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0268767
RPL19 ribosomal protein L19 0.0267908
RPLP2 ribosomal protein, large, P2 0.0265632
UQCRB ubiquinol-cytochrome c reductase binding protein 0.026521
PTPRM protein tyrosine phosphatase, receptor type, M 0.0264813
HLA-B major histocompatibility complex, class I, B 0.0262827
ENO1 enolase 1, (alpha) 0.0259495
RPL13A ribosomal protein L13a 0.0256091
RPL11 ribosomal protein L11 0.0254292
RPS29 ribosomal protein S29 0.0251429
AKR1C1 aldo-keto reductase family 1, member C1 0.0244819
NACA nascent polypeptide-associated complex alpha subunit 0.0244727
S100A11 S100 calcium binding protein A11 0.0243932
SRRM2 serine/arginine repetitive matrix 2 0.0229455
RPS15A ribosomal protein S15a 0.0228611
RPL18 ribosomal protein L18 0.0222312
RBM25 RNA binding motif protein 25 0.0216764
TPT1 tumor protein, translationally-controlled 1 0.0205089
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0202499
SP100 SP100 nuclear antigen 0.0200397
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0199169
ACTG1 actin gamma 1 0.0198538
RPL35 ribosomal protein L35 0.0196903
HLA-A major histocompatibility complex, class I, A 0.0196194
RPL27 ribosomal protein L27 0.0196041
ANGPTL4 angiopoietin-like 4 0.0194025
TRIM56 tripartite motif containing 56 0.0192518
SERF2 small EDRK-rich factor 2 0.0191431
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0185623
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0185318
AREG amphiregulin 0.0184308
RPS24 ribosomal protein S24 0.0182945
ENO2 enolase 2 (gamma, neuronal) 0.018226
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0180866
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0180481
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0179745
RPL7 ribosomal protein L7 0.0179274
MKI67 marker of proliferation Ki-67 0.0174914
NSUN6 NOP2/Sun domain family, member 6 0.0174205
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0169477
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0168392
S100A6 S100 calcium binding protein A6 0.0166407
LPP LIM domain containing preferred translocation partner in lipoma 0.0166201
LGALS12 lectin, galactoside-binding, soluble, 12 0.0165011
VIM vimentin 0.0163059
RPS4X ribosomal protein S4, X-linked 0.016282
RPS16 ribosomal protein S16 0.0162188
RPS13 ribosomal protein S13 0.01614
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0160389
WSB1 WD repeat and SOCS box containing 1 0.0157489
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0157294
MGST1 microsomal glutathione S-transferase 1 0.0156284
NAP1L1 nucleosome assembly protein 1-like 1 0.0155825

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.350104
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.232257
NDRG1 N-myc downstream regulated 1 -0.093035
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0916816
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0814893
NAMPT nicotinamide phosphoribosyltransferase -0.0757162
FAM13A family with sequence similarity 13, member A -0.0718603
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0652528
SOD2 superoxide dismutase 2, mitochondrial -0.0621238
PDIA3 protein disulfide isomerase family A, member 3 -0.0557058
KCMF1 potassium channel modulatory factor 1 -0.0542263
GSK3B glycogen synthase kinase 3 beta -0.0535914
FNDC3B fibronectin type III domain containing 3B -0.0533411
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0529862
SPAG9 sperm associated antigen 9 -0.052059
ARRDC3 arrestin domain containing 3 -0.0516263
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0503261
PDE8A phosphodiesterase 8A -0.0500171
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0486572
TSC22D2 TSC22 domain family, member 2 -0.0483814
HELZ helicase with zinc finger -0.0464479
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0456203
KMT2E lysine (K)-specific methyltransferase 2E -0.0451334
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0437384
TMEM165 transmembrane protein 165 -0.0431085
ELL2 elongation factor, RNA polymerase II, 2 -0.0425527
CDCP1 CUB domain containing protein 1 -0.0405225
UBA6 ubiquitin-like modifier activating enzyme 6 -0.039495
CCNL1 cyclin L1 -0.037679
NGLY1 N-glycanase 1 -0.037314
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0368077
ADAM17 ADAM metallopeptidase domain 17 -0.0365095
UBC ubiquitin C -0.0357075
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0354932
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0350055
RAB1A RAB1A, member RAS oncogene family -0.0349804
ATP13A3 ATPase type 13A3 -0.0348125
PUM2 pumilio RNA-binding family member 2 -0.034463
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0342101
JMJD1C jumonji domain containing 1C -0.0339938
USP3 ubiquitin specific peptidase 3 -0.0337277
RAP1B RAP1B, member of RAS oncogene family -0.0337268
ZC3H11A zinc finger CCCH-type containing 11A -0.0335156
HILPDA hypoxia inducible lipid droplet-associated -0.0330372
KDM6A lysine (K)-specific demethylase 6A -0.0325632
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0325433
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0325223
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0314867
UVRAG UV radiation resistance associated -0.031185
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0308973
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0306083
BIRC6 baculoviral IAP repeat containing 6 -0.0305967
KDM2A lysine (K)-specific demethylase 2A -0.0305858
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0298322
TOP1 topoisomerase (DNA) I -0.0292678
HYOU1 hypoxia up-regulated 1 -0.0292474
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0292439
BRWD1 bromodomain and WD repeat domain containing 1 -0.0285775
WASF2 WAS protein family, member 2 -0.0285641
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0280034
SUCO SUN domain containing ossification factor -0.0275457
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0269006
GLS2 glutaminase 2 (liver, mitochondrial) -0.0268826
MYOF myoferlin -0.0268578
PDIA6 protein disulfide isomerase family A, member 6 -0.0268351
WDR45B WD repeat domain 45B -0.0267434
RNF145 ring finger protein 145 -0.026679
RUNX1 runt-related transcription factor 1 -0.0266516
SETD5 SET domain containing 5 -0.0264486
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0263384
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0262724
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0262344
SEC31A SEC31 homolog A (S. cerevisiae) -0.025935
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0255952
MORF4L2 mortality factor 4 like 2 -0.0253028
BRWD3 bromodomain and WD repeat domain containing 3 -0.0249312
DTNA dystrobrevin, alpha -0.024766
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0244329
CYLD cylindromatosis (turban tumor syndrome) -0.0243872
NPTN neuroplastin -0.0243175
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0239033
ANKRD17 ankyrin repeat domain 17 -0.0238696
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0238628
NCKAP1 NCK-associated protein 1 -0.0238492
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0237028
TPD52 tumor protein D52 -0.0234529
ADAM9 ADAM metallopeptidase domain 9 -0.0234406
LDHA lactate dehydrogenase A -0.0232607
COPA coatomer protein complex, subunit alpha -0.0231978
USP9X ubiquitin specific peptidase 9, X-linked -0.0229892
TAOK1 TAO kinase 1 -0.0228698
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0228535
ANXA5 annexin A5 -0.0228182
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0226387
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0225922
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0224594
ATP11B ATPase, class VI, type 11B -0.0223811
STRN3 striatin, calmodulin binding protein 3 -0.0222042
SMAD3 SMAD family member 3 -0.022071
GPC6 glypican 6 -0.0220233