| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dorzolamide (hydrochloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.172146 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.127093 |
| GOLGA4 | golgin A4 | 0.121874 |
| RBM39 | RNA binding motif protein 39 | 0.105307 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0891741 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0769133 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0696938 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0687106 |
| RPL4 | ribosomal protein L4 | 0.060849 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0595892 |
| OGA | O-GlcNAcase | 0.0592098 |
| FAM13A | family with sequence similarity 13, member A | 0.0543345 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0485633 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.04678 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0456008 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0451829 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0450919 |
| SMAD3 | SMAD family member 3 | 0.0431736 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0415997 |
| SPAG9 | sperm associated antigen 9 | 0.0413139 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0409197 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0408285 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0407207 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0406527 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0390228 |
| SBF2 | SET binding factor 2 | 0.0378065 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0366025 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.035278 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0346565 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0346094 |
| MYOF | myoferlin | 0.0341358 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0340069 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0332892 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0327561 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0325631 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0325198 |
| RUNX1 | runt-related transcription factor 1 | 0.0324595 |
| SRP54 | signal recognition particle 54kDa | 0.0322088 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0316073 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0309659 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0304563 |
| NGLY1 | N-glycanase 1 | 0.0302904 |
| COG5 | component of oligomeric golgi complex 5 | 0.0302768 |
| USP34 | ubiquitin specific peptidase 34 | 0.0296259 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0290979 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0289134 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0287077 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0286455 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0285533 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0282463 |
| SUCO | SUN domain containing ossification factor | 0.0281342 |
| ZNF292 | zinc finger protein 292 | 0.0277975 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.027758 |
| KIF5B | kinesin family member 5B | 0.0277112 |
| CALR | calreticulin | 0.0276469 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0272408 |
| NRG4 | neuregulin 4 | 0.0270106 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0267234 |
| POM121 | POM121 transmembrane nucleoporin | 0.0266596 |
| CALU | calumenin | 0.0266049 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0258459 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.025762 |
| RIOK3 | RIO kinase 3 | 0.0256574 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0255457 |
| CANX | calnexin | 0.0255341 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0250251 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0249852 |
| POM121C | POM121 transmembrane nucleoporin C | 0.0249532 |
| XPO1 | exportin 1 | 0.0249507 |
| ANXA1 | annexin A1 | 0.0246905 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0244327 |
| TPR | translocated promoter region, nuclear basket protein | 0.0241674 |
| YME1L1 | YME1-like 1 ATPase | 0.0241399 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0240682 |
| USP37 | ubiquitin specific peptidase 37 | 0.0237428 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0232211 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0227587 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.022756 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0226073 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0223817 |
| RPS2 | ribosomal protein S2 | 0.0223062 |
| RAB5A | RAB5A, member RAS oncogene family | 0.0221947 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0220931 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0220079 |
| LRRC49 | leucine rich repeat containing 49 | 0.0219692 |
| FAM107B | family with sequence similarity 107, member B | 0.021896 |
| EZR | ezrin | 0.0218638 |
| SLTM | SAFB-like, transcription modulator | 0.0218552 |
| MORF4L2 | mortality factor 4 like 2 | 0.021701 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0215823 |
| SEC24A | SEC24 family member A | 0.0215238 |
| INSIG2 | insulin induced gene 2 | 0.0213948 |
| SCFD1 | sec1 family domain containing 1 | 0.021315 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0212611 |
| SYAP1 | synapse associated protein 1 | 0.0211689 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0210326 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | 0.020977 |
| EMSY | EMSY transcriptional repressor, BRCA2 interacting | 0.0209286 |
| HELZ | helicase with zinc finger | 0.0208909 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0208773 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.182841 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.143018 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.126678 |
| HMGA2 | high mobility group AT-hook 2 | -0.125321 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.123583 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.118965 |
| TMSB10 | thymosin beta 10 | -0.115953 |
| CDH13 | cadherin 13 | -0.1137 |
| NRG1 | neuregulin 1 | -0.10841 |
| GLCCI1 | glucocorticoid induced 1 | -0.0951402 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0858442 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0839301 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0799024 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0787939 |
| MTSS1 | metastasis suppressor 1 | -0.0759509 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0754308 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0721437 |
| FAM20C | family with sequence similarity 20, member C | -0.0707644 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0697125 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0661928 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0647687 |
| LOX | lysyl oxidase | -0.0613084 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0592338 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0589788 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0579585 |
| AADAC | arylacetamide deacetylase | -0.0569278 |
| FBN1 | fibrillin 1 | -0.0497227 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0490195 |
| NTN4 | netrin 4 | -0.0486312 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0482094 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0475957 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0463759 |
| GLIS3 | GLIS family zinc finger 3 | -0.0443742 |
| CDK14 | cyclin-dependent kinase 14 | -0.0441268 |
| IFI44L | interferon-induced protein 44-like | -0.0438086 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0436547 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0432433 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0431421 |
| FTL | ferritin, light polypeptide | -0.04274 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0417529 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0417461 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0409419 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.040661 |
| NDRG1 | N-myc downstream regulated 1 | -0.0391445 |
| SEPTIN9 | septin 9 | -0.0388667 |
| WLS | wntless Wnt ligand secretion mediator | -0.0378555 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0371669 |
| ANXA10 | annexin A10 | -0.0367808 |
| CLMP | CXADR-like membrane protein | -0.0366713 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0355524 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0350992 |
| RASAL2 | RAS protein activator like 2 | -0.0350658 |
| OXR1 | oxidation resistance 1 | -0.0348502 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0346942 |
| ZNF804A | zinc finger protein 804A | -0.0344289 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0336806 |
| INTS6 | integrator complex subunit 6 | -0.0334493 |
| NAV1 | neuron navigator 1 | -0.0330652 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0329224 |
| EGR1 | early growth response 1 | -0.0328595 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0328161 |
| IL1B | interleukin 1, beta | -0.032738 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0326561 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0324258 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0322826 |
| RAI14 | retinoic acid induced 14 | -0.0321595 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0319345 |
| DIAPH2 | diaphanous-related formin 2 | -0.0319024 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0317541 |
| RPS19 | ribosomal protein S19 | -0.031739 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0313997 |
| NRP1 | neuropilin 1 | -0.031202 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0311755 |
| DST | dystonin | -0.0311309 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.0310226 |
| MECOM | MDS1 and EVI1 complex locus | -0.0302803 |
| VRK2 | vaccinia related kinase 2 | -0.0301834 |
| PRRX1 | paired related homeobox 1 | -0.0300664 |
| CUX1 | cut-like homeobox 1 | -0.0299782 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0297582 |
| TGM2 | transglutaminase 2 | -0.0295888 |
| RNF213 | ring finger protein 213 | -0.0295432 |
| RAD51B | RAD51 paralog B | -0.029529 |
| TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | -0.0294331 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0293893 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.029335 |
| RPL37A | ribosomal protein L37a | -0.0290337 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0289942 |
| GPC6 | glypican 6 | -0.028915 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0287943 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0283031 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.028181 |
| VCL | vinculin | -0.0281394 |
| PRKCA | protein kinase C, alpha | -0.0273472 |
| TMEM165 | transmembrane protein 165 | -0.0270037 |
| SYT1 | synaptotagmin I | -0.0269501 |
| DNER | delta/notch-like EGF repeat containing | -0.0269076 |
| ATXN1 | ataxin 1 | -0.0268578 |
| HMGA1 | high mobility group AT-hook 1 | -0.0262913 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0261627 |
