| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dorzolamide (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL4 | ribosomal protein L4 | 0.0520157 |
| RPS12 | ribosomal protein S12 | 0.0514512 |
| RPS2 | ribosomal protein S2 | 0.0405069 |
| MT2A | metallothionein 2A | 0.0387953 |
| RPL36 | ribosomal protein L36 | 0.0325089 |
| PTMA | prothymosin, alpha | 0.029054 |
| RPS3 | ribosomal protein S3 | 0.0285456 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0235994 |
| RPL18 | ribosomal protein L18 | 0.0224213 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0215156 |
| RPL37A | ribosomal protein L37a | 0.0214927 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0211785 |
| RPS17 | ribosomal protein S17 | 0.0198896 |
| RPS18 | ribosomal protein S18 | 0.0193471 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0180287 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0179695 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0173763 |
| EGR1 | early growth response 1 | 0.0155744 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0151692 |
| RPS19 | ribosomal protein S19 | 0.0151388 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0143729 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0143061 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0134655 |
| RPL23 | ribosomal protein L23 | 0.0134374 |
| UBE2C | ubiquitin-conjugating enzyme E2C | 0.0129497 |
| HDGF | hepatoma-derived growth factor | 0.0128213 |
| RPL26 | ribosomal protein L26 | 0.0127672 |
| FTL | ferritin, light polypeptide | 0.012626 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0124579 |
| RPL9 | ribosomal protein L9 | 0.0123963 |
| RPS15A | ribosomal protein S15a | 0.0123536 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0122023 |
| RPL13A | ribosomal protein L13a | 0.0120881 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0119445 |
| TMSB10 | thymosin beta 10 | 0.01174 |
| TPM3 | tropomyosin 3 | 0.011627 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0114326 |
| BRD2 | bromodomain containing 2 | 0.0114268 |
| RPL27 | ribosomal protein L27 | 0.0112461 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0110196 |
| RPS27 | ribosomal protein S27 | 0.0110014 |
| RPL37 | ribosomal protein L37 | 0.0106509 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0105884 |
| SET | SET nuclear proto-oncogene | 0.0102665 |
| HMGB2 | high mobility group box 2 | 0.0101879 |
| PFN1 | profilin 1 | 0.0101418 |
| PER1 | period circadian clock 1 | 0.00976359 |
| RPL12 | ribosomal protein L12 | 0.00964017 |
| SPAG5 | sperm associated antigen 5 | 0.00963032 |
| HGS | hepatocyte growth factor-regulated tyrosine kinase substrate | 0.00961349 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.00957428 |
| UBE2S | ubiquitin-conjugating enzyme E2S | 0.00948818 |
| HSPA8 | heat shock 70kDa protein 8 | 0.00940666 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.00939669 |
| RANBP1 | RAN binding protein 1 | 0.009341 |
| RPL35 | ribosomal protein L35 | 0.00929168 |
| GPX4 | glutathione peroxidase 4 | 0.00927759 |
| KIF2C | kinesin family member 2C | 0.00926225 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | 0.00902047 |
| PNN | pinin, desmosome associated protein | 0.00890505 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.00888076 |
| ROMO1 | reactive oxygen species modulator 1 | 0.00887216 |
| ATF4 | activating transcription factor 4 | 0.00862206 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.00860425 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.00856241 |
| PTMS | parathymosin | 0.00819656 |
| KIF18B | kinesin family member 18B | 0.0081788 |
| NUTF2 | nuclear transport factor 2 | 0.00813341 |
| PRC1 | protein regulator of cytokinesis 1 | 0.00806575 |
| PFDN2 | prefoldin subunit 2 | 0.00801945 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.00800144 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0079927 |
| GANAB | glucosidase, alpha; neutral AB | 0.00797032 |
| PELP1 | proline, glutamate and leucine rich protein 1 | 0.00790954 |
| DHFR | dihydrofolate reductase | 0.00781408 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.00769165 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.00767596 |
| SNX32 | sorting nexin 32 | 0.00764176 |
| SSRP1 | structure specific recognition protein 1 | 0.00748943 |
| KIF20A | kinesin family member 20A | 0.00735705 |
| MKI67 | marker of proliferation Ki-67 | 0.00728513 |
| PTTG1 | pituitary tumor-transforming 1 | 0.00725477 |
| MRPL51 | mitochondrial ribosomal protein L51 | 0.00725425 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.00724996 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.00722782 |
| RPL3 | ribosomal protein L3 | 0.00718754 |
| CENPE | centromere protein E, 312kDa | 0.00718366 |
| CNTROB | centrobin, centrosomal BRCA2 interacting protein | 0.00716712 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.00710487 |
| KIFC1 | kinesin family member C1 | 0.00707146 |
| HLA-A | major histocompatibility complex, class I, A | 0.00700542 |
| CBX3 | chromobox homolog 3 | 0.00695893 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0069561 |
| YBX1 | Y box binding protein 1 | 0.0069537 |
| PPRC1 | peroxisome proliferator-activated receptor gamma, coactivator-related 1 | 0.0069339 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 0.00693194 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.00681271 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.00680596 |
| RPL5 | ribosomal protein L5 | 0.0067982 |
| CKAP2 | cytoskeleton associated protein 2 | 0.00679726 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.3348 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.266574 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.171523 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.141279 |
| GRAMD1B | GRAM domain containing 1B | -0.115156 |
| VIM | vimentin | -0.111578 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.108529 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0997905 |
| PARD3 | par-3 family cell polarity regulator | -0.0974929 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0974893 |
| TXNRD1 | thioredoxin reductase 1 | -0.0961128 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0958561 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0924186 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0880945 |
| CMIP | c-Maf inducing protein | -0.0802967 |
| SVIL | supervillin | -0.0800426 |
| ACTG1 | actin gamma 1 | -0.0799426 |
| DST | dystonin | -0.0668865 |
| BICC1 | BicC family RNA binding protein 1 | -0.0666881 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0654844 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0653774 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0649959 |
| LDHA | lactate dehydrogenase A | -0.063498 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0621982 |
| AHNAK | AHNAK nucleoprotein | -0.0617208 |
| IER3 | immediate early response 3 | -0.0605545 |
| ASPH | aspartate beta-hydroxylase | -0.060485 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0571863 |
| ERBIN | erbb2 interacting protein | -0.0570758 |
| FMNL2 | formin-like 2 | -0.0562603 |
| KYNU | kynureninase | -0.0553472 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0539235 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0530926 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0524662 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.052439 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0517998 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0517747 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0497087 |
| UTRN | utrophin | -0.0496964 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0495017 |
| S100A6 | S100 calcium binding protein A6 | -0.0493775 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0491664 |
| PTK2 | protein tyrosine kinase 2 | -0.0489431 |
| CAVIN1 | caveolae associated protein 1 | -0.0488531 |
| USP34 | ubiquitin specific peptidase 34 | -0.0483529 |
| EGFR | epidermal growth factor receptor | -0.04794 |
| STC1 | stanniocalcin 1 | -0.0477628 |
| NEGR1 | neuronal growth regulator 1 | -0.0477183 |
| EFNA5 | ephrin-A5 | -0.0475174 |
| GLIS3 | GLIS family zinc finger 3 | -0.0471396 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0471072 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0469119 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0467671 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0465384 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0464152 |
| PYGL | phosphorylase, glycogen, liver | -0.046278 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0462147 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0452961 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0452443 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0447046 |
| NRG1 | neuregulin 1 | -0.0442554 |
| FAM107B | family with sequence similarity 107, member B | -0.0437678 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0436738 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0436462 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0432977 |
| IGF2 | insulin-like growth factor 2 | -0.0429304 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0425893 |
| MYOF | myoferlin | -0.042313 |
| APP | amyloid beta (A4) precursor protein | -0.0419952 |
| EHBP1 | EH domain binding protein 1 | -0.0413002 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0411705 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0411104 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0410337 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0395965 |
| FLNB | filamin B, beta | -0.0394962 |
| HDAC9 | histone deacetylase 9 | -0.0388567 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0387779 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0387218 |
| S100A10 | S100 calcium binding protein A10 | -0.0386247 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0385409 |
| NEBL | nebulette | -0.0384585 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0384488 |
| POTEF | POTE ankyrin domain family, member F | -0.0377045 |
| OSMR | oncostatin M receptor | -0.0376168 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0367133 |
| AK1 | adenylate kinase 1 | -0.0365822 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0365419 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0364597 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0361847 |
| TPM4 | tropomyosin 4 | -0.0359263 |
| RAD51B | RAD51 paralog B | -0.0354221 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0351949 |
| CUX1 | cut-like homeobox 1 | -0.0350157 |
| ANXA2 | annexin A2 | -0.0347072 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0343996 |
| GLG1 | golgi glycoprotein 1 | -0.0339912 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0339262 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0336448 |
| RASAL2 | RAS protein activator like 2 | -0.033644 |
| RAB10 | RAB10, member RAS oncogene family | -0.0335042 |
