| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dorzolamide (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| INHBA | inhibin, beta A | 0.245022 |
| STC1 | stanniocalcin 1 | 0.134773 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0819399 |
| HDAC4 | histone deacetylase 4 | 0.0805647 |
| EGFR | epidermal growth factor receptor | 0.0791657 |
| HMGA2 | high mobility group AT-hook 2 | 0.0772927 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0771044 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0736851 |
| CNKSR3 | CNKSR family member 3 | 0.0722436 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0716429 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0705147 |
| RBM39 | RNA binding motif protein 39 | 0.06988 |
| KLF6 | Kruppel-like factor 6 | 0.0689644 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0661074 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.064209 |
| TMSB4X | thymosin beta 4, X-linked | 0.0631094 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0624892 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0612445 |
| RUNX1 | runt-related transcription factor 1 | 0.0603569 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0596024 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0585419 |
| CLTC | clathrin, heavy chain (Hc) | 0.0578097 |
| DSPP | dentin sialophosphoprotein | 0.0566527 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0551412 |
| FOXJ3 | forkhead box J3 | 0.0542822 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0542173 |
| RPS3 | ribosomal protein S3 | 0.0541719 |
| HLA-B | major histocompatibility complex, class I, B | 0.0540998 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.0530988 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0530066 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0526744 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0523079 |
| RPL34 | ribosomal protein L34 | 0.0520554 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0517899 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0516374 |
| BPTF | bromodomain PHD finger transcription factor | 0.0511984 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0507536 |
| ITGA6 | integrin, alpha 6 | 0.0489003 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | 0.0488802 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0482013 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0480971 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0472301 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0465457 |
| CTBP2 | C-terminal binding protein 2 | 0.0459054 |
| MORF4L2 | mortality factor 4 like 2 | 0.0455365 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0455032 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0446859 |
| IER3 | immediate early response 3 | 0.0444644 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0428078 |
| RPS24 | ribosomal protein S24 | 0.042594 |
| LMO7 | LIM domain 7 | 0.0422684 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0422095 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0406966 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0403916 |
| PRKCA | protein kinase C, alpha | 0.0402974 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0391728 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0390747 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0388483 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0378638 |
| RPL11 | ribosomal protein L11 | 0.0378526 |
| MYO9A | myosin IXA | 0.0377692 |
| EZR | ezrin | 0.0373062 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0372931 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0372383 |
| NAV2 | neuron navigator 2 | 0.037224 |
| TXNIP | thioredoxin interacting protein | 0.0370354 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0367551 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0366497 |
| MAP4 | microtubule-associated protein 4 | 0.0362408 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0360854 |
| CMIP | c-Maf inducing protein | 0.0353642 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0350195 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0345786 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0345429 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0344691 |
| MYOF | myoferlin | 0.0342695 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0342261 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0341436 |
| COPA | coatomer protein complex, subunit alpha | 0.0330855 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0330135 |
| ACTN4 | actinin, alpha 4 | 0.0326086 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0325845 |
| LSAMP | limbic system-associated membrane protein | 0.0321426 |
| RPS8 | ribosomal protein S8 | 0.0319351 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0319206 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0318923 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0315782 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0314192 |
| RPL18 | ribosomal protein L18 | 0.0311538 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.031104 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0303615 |
| RAD51B | RAD51 paralog B | 0.0301356 |
| SMYD3 | SET and MYND domain containing 3 | 0.028514 |
| FLNB | filamin B, beta | 0.0283682 |
| RPL26 | ribosomal protein L26 | 0.0282647 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0281078 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0280364 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0279438 |
| TOP1 | topoisomerase (DNA) I | 0.0267836 |
| RPL4 | ribosomal protein L4 | 0.0267819 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.181815 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.107876 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.101501 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0925175 |
| MYO1E | myosin IE | -0.0903072 |
| POTEF | POTE ankyrin domain family, member F | -0.0831632 |
| TMSB10 | thymosin beta 10 | -0.0802538 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0768552 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0764509 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0710317 |
| NDRG1 | N-myc downstream regulated 1 | -0.0691735 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0666021 |
| RNF145 | ring finger protein 145 | -0.0661727 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.061633 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0601044 |
| SPAG9 | sperm associated antigen 9 | -0.0595676 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0590265 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.058498 |
| FTL | ferritin, light polypeptide | -0.0583785 |
| HBP1 | HMG-box transcription factor 1 | -0.0580906 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0579562 |
| CCNI | cyclin I | -0.0576425 |
| TXNRD1 | thioredoxin reductase 1 | -0.0575619 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0559449 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0555656 |
| S100A10 | S100 calcium binding protein A10 | -0.0551011 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0547033 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0532744 |
| NF1 | neurofibromin 1 | -0.0530317 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0520064 |
| FN1 | fibronectin 1 | -0.0516169 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0508142 |
| RLF | rearranged L-myc fusion | -0.0503108 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0502012 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0496988 |
| TPR | translocated promoter region, nuclear basket protein | -0.0493084 |
| CD109 | CD109 molecule | -0.0492315 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0485704 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0483097 |
| PTK2 | protein tyrosine kinase 2 | -0.0478949 |
| RPL21 | ribosomal protein L21 | -0.0471027 |
| LAMC2 | laminin, gamma 2 | -0.0458278 |
| KLHL24 | kelch-like family member 24 | -0.0454279 |
| FBXO11 | F-box protein 11 | -0.0453903 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0447406 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0446554 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0443069 |
| MYO1D | myosin ID | -0.043744 |
| RRBP1 | ribosome binding protein 1 | -0.0436494 |
| ACTG1 | actin gamma 1 | -0.042783 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0419841 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0416075 |
| RNF24 | ring finger protein 24 | -0.0414241 |
| JMJD1C | jumonji domain containing 1C | -0.0414053 |
| ADNP | activity-dependent neuroprotector homeobox | -0.041312 |
| KRT17 | keratin 17, type I | -0.0411762 |
| RPS27 | ribosomal protein S27 | -0.0408138 |
| FMN1 | formin 1 | -0.0408097 |
| RPL12 | ribosomal protein L12 | -0.0407308 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0403929 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0398729 |
| PHIP | pleckstrin homology domain interacting protein | -0.039239 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0392102 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0390281 |
| ATP11B | ATPase, class VI, type 11B | -0.0389672 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0389037 |
| ENO1 | enolase 1, (alpha) | -0.0388498 |
| EXOC4 | exocyst complex component 4 | -0.0386361 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0382835 |
| USP3 | ubiquitin specific peptidase 3 | -0.0381663 |
| FOXO3 | forkhead box O3 | -0.0377943 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.037605 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0375768 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0374318 |
| RBM25 | RNA binding motif protein 25 | -0.037119 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0366048 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0365048 |
| RPS14 | ribosomal protein S14 | -0.0364943 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | -0.0362284 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0359955 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0352768 |
| RPLP1 | ribosomal protein, large, P1 | -0.0351992 |
| RAB10 | RAB10, member RAS oncogene family | -0.0350843 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0350099 |
| RTN4 | reticulon 4 | -0.0348987 |
| COG5 | component of oligomeric golgi complex 5 | -0.0348398 |
| S100A6 | S100 calcium binding protein A6 | -0.0345789 |
| PTGES2 | prostaglandin E synthase 2 | -0.0343007 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0332543 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0329892 |
| AUTS2 | autism susceptibility candidate 2 | -0.0329818 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0329004 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0321147 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0320897 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0314366 |
| RPS15 | ribosomal protein S15 | -0.0309068 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | -0.0306651 |
| RYBP | RING1 and YY1 binding protein | -0.0303886 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0295288 |
| ETNK1 | ethanolamine kinase 1 | -0.029396 |
