Dorzolamide (hydrochloride)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dorzolamide (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dorzolamide (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.240743
EEF2 eukaryotic translation elongation factor 2 0.103225
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0872713
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0855701
TPM3 tropomyosin 3 0.0754549
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0714561
UBC ubiquitin C 0.0647265
ENO1 enolase 1, (alpha) 0.0611641
RPL4 ribosomal protein L4 0.0584566
OGA O-GlcNAcase 0.0531929
SET SET nuclear proto-oncogene 0.0476735
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0415213
KTN1 kinectin 1 (kinesin receptor) 0.0413813
GOLGA4 golgin A4 0.040709
PCBP2 poly(rC) binding protein 2 0.0396331
YBX1 Y box binding protein 1 0.0394179
RPS27A ribosomal protein S27a 0.0379932
EIF1 eukaryotic translation initiation factor 1 0.0374429
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.037397
VIM vimentin 0.0343232
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0335376
XPO1 exportin 1 0.0327314
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0320226
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0310723
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0310411
RPS3 ribosomal protein S3 0.0309108
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0297674
RPS2 ribosomal protein S2 0.0293467
SRRM1 serine/arginine repetitive matrix 1 0.0291916
RBM39 RNA binding motif protein 39 0.0290125
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0285941
KRT18 keratin 18, type I 0.0283215
RAB6A RAB6A, member RAS oncogene family 0.028209
CSDE1 cold shock domain containing E1, RNA-binding 0.0270094
RPS18 ribosomal protein S18 0.0269012
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0265538
TLN1 talin 1 0.0263301
RPS8 ribosomal protein S8 0.0262256
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0257721
EIF4B eukaryotic translation initiation factor 4B 0.0253685
PRRC2C proline-rich coiled-coil 2C 0.0250349
PER1 period circadian clock 1 0.0244951
PDIA4 protein disulfide isomerase family A, member 4 0.024006
KDM3A lysine (K)-specific demethylase 3A 0.0239793
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0238531
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0236568
PTMA prothymosin, alpha 0.0233157
PKM pyruvate kinase, muscle 0.0230588
RPL37A ribosomal protein L37a 0.0229053
MYO6 myosin VI 0.0224056
WDR45B WD repeat domain 45B 0.0222812
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0222107
SEPTIN7 septin 7 0.0221801
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0221292
RPL5 ribosomal protein L5 0.0220438
PREPL prolyl endopeptidase-like 0.0214657
AKAP9 A kinase (PRKA) anchor protein 9 0.0211332
KIF5B kinesin family member 5B 0.0207573
PPME1 protein phosphatase methylesterase 1 0.0204167
TFG TRK-fused gene 0.0204103
NAP1L1 nucleosome assembly protein 1-like 1 0.020386
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0203204
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0200903
NONO non-POU domain containing, octamer-binding 0.0199623
SRRM2 serine/arginine repetitive matrix 2 0.0198743
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0198363
RPL3 ribosomal protein L3 0.0196663
GIGYF2 GRB10 interacting GYF protein 2 0.0196206
RBM33 RNA binding motif protein 33 0.019171
RBM25 RNA binding motif protein 25 0.0190055
RPL23 ribosomal protein L23 0.0189098
TPI1 triosephosphate isomerase 1 0.0187789
CALR calreticulin 0.018466
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.018464
RPS12 ribosomal protein S12 0.0184057
CKAP5 cytoskeleton associated protein 5 0.018331
HMGB2 high mobility group box 2 0.0182208
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0181918
TOP2B topoisomerase (DNA) II beta 180kDa 0.0179199
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0178714
ACBD3 acyl-CoA binding domain containing 3 0.0178294
SRP54 signal recognition particle 54kDa 0.0176669
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0176614
UBA6 ubiquitin-like modifier activating enzyme 6 0.017623
RNMT RNA (guanine-7-) methyltransferase 0.0174136
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0172871
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.017256
DENR density-regulated protein 0.0171627
HDGF hepatoma-derived growth factor 0.0170617
KMT2E lysine (K)-specific methyltransferase 2E 0.0170445
RPL37 ribosomal protein L37 0.017015
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0170109
RPL26 ribosomal protein L26 0.0169527
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0169132
HLA-A major histocompatibility complex, class I, A 0.0168904
ZFC3H1 zinc finger, C3H1-type containing 0.016794
ESYT2 extended synaptotagmin-like protein 2 0.0167348
PDIA6 protein disulfide isomerase family A, member 6 0.0167103
SRSF11 serine/arginine-rich splicing factor 11 0.0167032
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0165369

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.211229
THSD4 thrombospondin, type I, domain containing 4 -0.145116
OSMR oncostatin M receptor -0.124926
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.123804
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.115527
GRAMD1B GRAM domain containing 1B -0.1013
YBX3 Y box binding protein 3 -0.0949732
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0852655
PDE10A phosphodiesterase 10A -0.0761457
IGF1R insulin-like growth factor 1 receptor -0.076023
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0754584
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0745999
RIMS2 regulating synaptic membrane exocytosis 2 -0.0744077
HMGA2 high mobility group AT-hook 2 -0.0741598
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0737335
VCL vinculin -0.071879
EXT1 exostosin glycosyltransferase 1 -0.0717628
EXOC4 exocyst complex component 4 -0.0712124
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0696097
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0684085
RAD51B RAD51 paralog B -0.0683647
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0676681
TAS2R14 taste receptor, type 2, member 14 -0.0666832
NABP1 nucleic acid binding protein 1 -0.0650016
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0641771
PDE4D phosphodiesterase 4D, cAMP-specific -0.0623557
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0581373
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0579321
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0546595
FBXO11 F-box protein 11 -0.0545434
NCOA7 nuclear receptor coactivator 7 -0.0544326
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.053713
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0513534
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0506487
EML4 echinoderm microtubule associated protein like 4 -0.0502774
EGR1 early growth response 1 -0.0485768
MCL1 myeloid cell leukemia 1 -0.0478777
DNAH14 dynein, axonemal, heavy chain 14 -0.0474466
EGFR epidermal growth factor receptor -0.0473647
CDK17 cyclin-dependent kinase 17 -0.0470918
AFF3 AF4/FMR2 family, member 3 -0.0470327
PRH1 proline-rich protein HaeIII subfamily 1 -0.0463434
NF1 neurofibromin 1 -0.0462769
ACTG1 actin gamma 1 -0.0462427
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0456028
DOCK5 dedicator of cytokinesis 5 -0.0455708
FMNL2 formin-like 2 -0.0449402
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0439558
RNF213 ring finger protein 213 -0.0438918
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0435468
TRIO trio Rho guanine nucleotide exchange factor -0.0433979
ELL2 elongation factor, RNA polymerase II, 2 -0.0426365
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0420065
PTK2 protein tyrosine kinase 2 -0.0415544
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0413473
WNT2B wingless-type MMTV integration site family, member 2B -0.0402045
SENP6 SUMO1/sentrin specific peptidase 6 -0.0396726
FNDC3B fibronectin type III domain containing 3B -0.0388785
PDLIM5 PDZ and LIM domain 5 -0.0385521
EHBP1 EH domain binding protein 1 -0.0384251
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0376845
DENND5B DENN/MADD domain containing 5B -0.0374317
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0370863
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0370628
ATXN1 ataxin 1 -0.03649
SLC38A2 solute carrier family 38, member 2 -0.0364533
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0363479
PYGL phosphorylase, glycogen, liver -0.0361351
PLSCR1 phospholipid scramblase 1 -0.0354585
USP34 ubiquitin specific peptidase 34 -0.0351139
E2F3 E2F transcription factor 3 -0.0350627
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0346688
BICD1 bicaudal D homolog 1 (Drosophila) -0.0344985
DOCK1 dedicator of cytokinesis 1 -0.0344177
ATG7 autophagy related 7 -0.0342884
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0341638
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.033994
CCDC91 coiled-coil domain containing 91 -0.0337657
INTS6 integrator complex subunit 6 -0.0336079
AEBP2 AE binding protein 2 -0.0335242
PRKCE protein kinase C, epsilon -0.0333234
ATF6 activating transcription factor 6 -0.0330217
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.033009
IFI6 interferon, alpha-inducible protein 6 -0.0329956
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0326385
RAB7A RAB7A, member RAS oncogene family -0.0324593
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0323677
CUX1 cut-like homeobox 1 -0.0321735
YAP1 Yes-associated protein 1 -0.0320556
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0318233
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0313506
ZFAND3 zinc finger, AN1-type domain 3 -0.0312118
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0310944
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0309015
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0300365
WDR70 WD repeat domain 70 -0.0299784
CALD1 caldesmon 1 -0.0299383
STC1 stanniocalcin 1 -0.0298454
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0297155
ATP11A ATPase, class VI, type 11A -0.0296811