Dorzolamide (hydrochloride)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dorzolamide (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dorzolamide (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.197424
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.166025
TMSB10 thymosin beta 10 0.147356
TMSB4X thymosin beta 4, X-linked 0.114552
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.107519
LAMB3 laminin, beta 3 0.107452
S100A6 S100 calcium binding protein A6 0.0827253
IFI27 interferon, alpha-inducible protein 27 0.0787363
RPL4 ribosomal protein L4 0.0755385
POTEF POTE ankyrin domain family, member F 0.0743358
SOX4 SRY (sex determining region Y)-box 4 0.0740431
ZFP36L1 ZFP36 ring finger protein-like 1 0.0698457
FBXO32 F-box protein 32 0.0697626
RBM25 RNA binding motif protein 25 0.0694991
MT2A metallothionein 2A 0.061472
BASP1 brain abundant, membrane attached signal protein 1 0.0613665
IGFBP3 insulin-like growth factor binding protein 3 0.0573927
CSTB cystatin B (stefin B) 0.0534484
RPS12 ribosomal protein S12 0.0534038
PRRC2C proline-rich coiled-coil 2C 0.0510866
FTH1 ferritin, heavy polypeptide 1 0.0502998
JUP junction plakoglobin 0.049458
MYO6 myosin VI 0.0492434
FTL ferritin, light polypeptide 0.0491981
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0487681
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0483887
TMF1 TATA element modulatory factor 1 0.0481753
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0470131
ENO1 enolase 1, (alpha) 0.0460714
TOP2A topoisomerase (DNA) II alpha 170kDa 0.045946
IFITM1 interferon induced transmembrane protein 1 0.0458026
RPL18 ribosomal protein L18 0.0456958
GOLGA4 golgin A4 0.0455991
TPI1 triosephosphate isomerase 1 0.0455598
CBX3 chromobox homolog 3 0.0454843
ERRFI1 ERBB receptor feedback inhibitor 1 0.0452387
RACK1 receptor for activated C kinase 1 0.0447449
HLA-A major histocompatibility complex, class I, A 0.0442979
IFI6 interferon, alpha-inducible protein 6 0.0434277
RPS19 ribosomal protein S19 0.043206
LMO7 LIM domain 7 0.0430556
GPX4 glutathione peroxidase 4 0.0429746
KRT7 keratin 7, type II 0.0413065
CLDN4 claudin 4 0.0411365
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0399039
HMGN2 high mobility group nucleosomal binding domain 2 0.0394702
RRBP1 ribosome binding protein 1 0.0388385
CDCP1 CUB domain containing protein 1 0.0388232
RPL30 ribosomal protein L30 0.0388128
TPM3 tropomyosin 3 0.0377255
RPS2 ribosomal protein S2 0.0369299
LOC112694756 uncharaterized LOC112694756 0.0364656
FAM3C family with sequence similarity 3, member C 0.0360741
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0352134
EFNA5 ephrin-A5 0.0350735
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0346061
LMNA lamin A/C 0.0339612
RPL12 ribosomal protein L12 0.0334032
HMGB2 high mobility group box 2 0.0332767
RPL26 ribosomal protein L26 0.0329614
HMGA1 high mobility group AT-hook 1 0.0329503
LY6E lymphocyte antigen 6 complex, locus E 0.0329231
BZW1 basic leucine zipper and W2 domains 1 0.0328884
AKAP9 A kinase (PRKA) anchor protein 9 0.0328422
DSPP dentin sialophosphoprotein 0.0327234
RPL35 ribosomal protein L35 0.0323107
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.031319
ISG15 ISG15 ubiquitin-like modifier 0.0311961
MACC1 metastasis associated in colon cancer 1 0.0311045
TM4SF1 transmembrane 4 L six family member 1 0.0309688
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0306075
SET SET nuclear proto-oncogene 0.0304377
TXNIP thioredoxin interacting protein 0.0303035
VGLL3 vestigial-like family member 3 0.0301197
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0300502
ACBD3 acyl-CoA binding domain containing 3 0.0295039
TMEM165 transmembrane protein 165 0.0293871
S100A11 S100 calcium binding protein A11 0.0292982
ITCH itchy E3 ubiquitin protein ligase 0.0290693
MAP1B microtubule-associated protein 1B 0.0289357
KRT19 keratin 19, type I 0.0285139
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0283715
LPP LIM domain containing preferred translocation partner in lipoma 0.0282338
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0278856
S100A9 S100 calcium binding protein A9 0.0278115
MDK midkine (neurite growth-promoting factor 2) 0.0277082
RPS3 ribosomal protein S3 0.0276897
RPL34 ribosomal protein L34 0.0274073
IFITM3 interferon induced transmembrane protein 3 0.0270631
ERBIN erbb2 interacting protein 0.0270496
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 0.0269933
RPL37 ribosomal protein L37 0.0267433
PFN1 profilin 1 0.0266427
DUSP10 dual specificity phosphatase 10 0.0264911
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0260612
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0259396
KRT18 keratin 18, type I 0.0259346
TUBB4B tubulin, beta 4B class IVb 0.0259008
HDGF hepatoma-derived growth factor 0.0256855
MAML2 mastermind-like 2 (Drosophila) 0.0256069

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.316305
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.165365
FN1 fibronectin 1 -0.14214
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.120514
TPT1 tumor protein, translationally-controlled 1 -0.0866966
RPS23 ribosomal protein S23 -0.0754512
RHEB Ras homolog enriched in brain -0.0539536
RPS29 ribosomal protein S29 -0.0537481
TSC22D2 TSC22 domain family, member 2 -0.0489373
ZFAND3 zinc finger, AN1-type domain 3 -0.0473489
RPS25 ribosomal protein S25 -0.0472346
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0464702
UPP1 uridine phosphorylase 1 -0.042151
PTMA prothymosin, alpha -0.0417399
ANXA2 annexin A2 -0.0402337
CANX calnexin -0.0394311
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0387744
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0378723
UBC ubiquitin C -0.0376754
NAMPT nicotinamide phosphoribosyltransferase -0.0374859
PTK2 protein tyrosine kinase 2 -0.0372812
FNDC3B fibronectin type III domain containing 3B -0.0367969
RPL38 ribosomal protein L38 -0.0366239
RPS10 ribosomal protein S10 -0.0364538
MCL1 myeloid cell leukemia 1 -0.0360994
IFRD1 interferon-related developmental regulator 1 -0.0359978
RPS13 ribosomal protein S13 -0.0347053
PARD3 par-3 family cell polarity regulator -0.0345111
RYBP RING1 and YY1 binding protein -0.0343684
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0337828
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0334493
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0331895
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0329388
UGDH UDP-glucose 6-dehydrogenase -0.0329203
INTS6 integrator complex subunit 6 -0.032838
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0327572
RHOA ras homolog family member A -0.032069
TFRC transferrin receptor -0.0319654
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0317581
AHNAK AHNAK nucleoprotein -0.0317494
SETD5 SET domain containing 5 -0.0316741
SAMD4A sterile alpha motif domain containing 4A -0.0314212
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0311955
SQSTM1 sequestosome 1 -0.0310966
USP3 ubiquitin specific peptidase 3 -0.0310936
RPS24 ribosomal protein S24 -0.0309646
MARCHF6 membrane associated ring-CH-type finger 6 -0.0302898
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0295462
RPL7A ribosomal protein L7a -0.0293051
RLF rearranged L-myc fusion -0.0288419
VDAC1 voltage-dependent anion channel 1 -0.0284558
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.02808
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0279732
NAP1L4 nucleosome assembly protein 1-like 4 -0.0278128
IARS1 isoleucyl-tRNA synthetase 1 -0.0277664
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0270247
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0269142
MXD1 MAX dimerization protein 1 -0.0268482
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0266532
IER3 immediate early response 3 -0.0264339
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0263231
RPL8 ribosomal protein L8 -0.0256218
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0254343
S100A10 S100 calcium binding protein A10 -0.0252242
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0250709
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0248296
FAM13A family with sequence similarity 13, member A -0.0247629
FBXO11 F-box protein 11 -0.0247425
NDRG1 N-myc downstream regulated 1 -0.0246046
QKI QKI, KH domain containing, RNA binding -0.0240504
SSBP2 single-stranded DNA binding protein 2 -0.0238839
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0237291
CTBP2 C-terminal binding protein 2 -0.0233452
RPL28 ribosomal protein L28 -0.0229877
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0229147
ANKRD11 ankyrin repeat domain 11 -0.022912
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0228777
TMEM263 transmembrane protein 263 -0.0222826
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0222555
GARS1 glycyl-tRNA synthetase 1 -0.0220913
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0220855
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0220234
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0219696
CCNL1 cyclin L1 -0.0215192
NUMB numb homolog (Drosophila) -0.021502
USP53 ubiquitin specific peptidase 53 -0.021429
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0214178
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.021315
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0212725
MON2 MON2 homolog (S. cerevisiae) -0.0211565
APP amyloid beta (A4) precursor protein -0.021154
KDM3A lysine (K)-specific demethylase 3A -0.0210544
RHOBTB3 Rho-related BTB domain containing 3 -0.0210516
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0210515
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0209526
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0206458
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0206443
CAVIN1 caveolae associated protein 1 -0.0204496
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0204091
TRAF3 TNF receptor-associated factor 3 -0.0200601