Dorzolamide (hydrochloride)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dorzolamide (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dorzolamide (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.0800335
HLA-A major histocompatibility complex, class I, A 0.0541454
IGFBP3 insulin-like growth factor binding protein 3 0.0436915
RPS6 ribosomal protein S6 0.040936
RPL4 ribosomal protein L4 0.0378517
RPS12 ribosomal protein S12 0.0357429
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0334352
RPS2 ribosomal protein S2 0.0277376
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0273857
B2M beta-2-microglobulin 0.0266425
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0249714
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0247728
WARS1 tryptophanyl-tRNA synthetase 1 0.0242544
RPS14 ribosomal protein S14 0.0217572
EIF1 eukaryotic translation initiation factor 1 0.0216086
SOX4 SRY (sex determining region Y)-box 4 0.0208468
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0206531
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0204148
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0203461
ENO2 enolase 2 (gamma, neuronal) 0.020263
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0200102
FTH1 ferritin, heavy polypeptide 1 0.0198615
S100A6 S100 calcium binding protein A6 0.0196885
SET SET nuclear proto-oncogene 0.0196521
LMNA lamin A/C 0.0194842
PTMA prothymosin, alpha 0.019448
KTN1 kinectin 1 (kinesin receptor) 0.0191301
STC1 stanniocalcin 1 0.0188974
TPM3 tropomyosin 3 0.0185624
SRRM2 serine/arginine repetitive matrix 2 0.0180205
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0177579
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0171399
RPL12 ribosomal protein L12 0.0169439
PFN1 profilin 1 0.0166304
LSAMP limbic system-associated membrane protein 0.0164298
RPS17 ribosomal protein S17 0.0163561
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0163019
RPS19 ribosomal protein S19 0.0156146
RPL18 ribosomal protein L18 0.0152666
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0150522
LAMA5 laminin, alpha 5 0.015013
RPL37A ribosomal protein L37a 0.0149718
ASTN2 astrotactin 2 0.014526
RPS18 ribosomal protein S18 0.01441
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0143983
OASL 2'-5'-oligoadenylate synthetase-like 0.0143982
MGST1 microsomal glutathione S-transferase 1 0.0143946
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.014232
RPS8 ribosomal protein S8 0.0141349
IGFBP6 insulin-like growth factor binding protein 6 0.0136772
ZFHX3 zinc finger homeobox 3 0.0135877
TPI1 triosephosphate isomerase 1 0.0135043
POTEF POTE ankyrin domain family, member F 0.0131044
LOC102724023 ES1 protein homolog, mitochondrial 0.0129209
NCOR2 nuclear receptor corepressor 2 0.0128839
RPL9 ribosomal protein L9 0.012841
TUBA1B tubulin, alpha 1b 0.0128136
HDGF hepatoma-derived growth factor 0.0127406
ENO1 enolase 1, (alpha) 0.0126378
AKAP12 A kinase (PRKA) anchor protein 12 0.012607
HILPDA hypoxia inducible lipid droplet-associated 0.0125826
TENT5A terminal nucleotidyltransferase 5A 0.0122238
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.012071
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.011915
AKAP13 A kinase (PRKA) anchor protein 13 0.011782
PLAUR plasminogen activator, urokinase receptor 0.0117202
RPLP2 ribosomal protein, large, P2 0.0116442
SOX9 SRY (sex determining region Y)-box 9 0.0115344
PCBP2 poly(rC) binding protein 2 0.0115112
IL6 interleukin 6 0.0114048
PGM2L1 phosphoglucomutase 2-like 1 0.0114032
PABPN1 poly(A) binding protein, nuclear 1 0.0112679
RPL3 ribosomal protein L3 0.0112577
LGALS3 lectin, galactoside-binding, soluble, 3 0.0111868
FTL ferritin, light polypeptide 0.0111384
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0110985
EEF2 eukaryotic translation elongation factor 2 0.0110944
TMSB10 thymosin beta 10 0.0109561
RPS3 ribosomal protein S3 0.0109231
TIMP1 TIMP metallopeptidase inhibitor 1 0.0107889
PKM pyruvate kinase, muscle 0.0107736
IRS2 insulin receptor substrate 2 0.0107536
RACK1 receptor for activated C kinase 1 0.0106156
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0106075
RPL26 ribosomal protein L26 0.0104978
MAP7 microtubule-associated protein 7 0.0104267
RPL5 ribosomal protein L5 0.0103773
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0102994
EGR1 early growth response 1 0.0101766
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0101337
TENM2 teneurin transmembrane protein 2 0.0101033
XYLT1 xylosyltransferase I 0.00991484
PRSS23 protease, serine, 23 0.00990999
MIDN midnolin 0.00977536
CXXC1 CXXC finger protein 1 0.00977504
SLK STE20-like kinase 0.00976459
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.00972601
CBX3 chromobox homolog 3 0.00962929
MT2A metallothionein 2A 0.00945738
ZMIZ1 zinc finger, MIZ-type containing 1 0.00936843

decreased expression

Symbol Name Standardized Value
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.188016
EFNA5 ephrin-A5 -0.168793
PDE4D phosphodiesterase 4D, cAMP-specific -0.132817
NAMPT nicotinamide phosphoribosyltransferase -0.13279
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.127077
ASPH aspartate beta-hydroxylase -0.126291
PDE10A phosphodiesterase 10A -0.108047
FN1 fibronectin 1 -0.101447
PSD3 pleckstrin and Sec7 domain containing 3 -0.0958579
TRIO trio Rho guanine nucleotide exchange factor -0.0852101
GDA guanine deaminase -0.0794609
TXNRD1 thioredoxin reductase 1 -0.0729442
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0657906
NRCAM neuronal cell adhesion molecule -0.0657519
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0635629
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0619714
GRAMD1B GRAM domain containing 1B -0.0615293
LIMCH1 LIM and calponin homology domains 1 -0.0613192
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0611101
KYNU kynureninase -0.0606512
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0565128
TFPI2 tissue factor pathway inhibitor 2 -0.0547705
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0545947
NEK7 NIMA-related kinase 7 -0.0501313
COL8A1 collagen, type VIII, alpha 1 -0.0499001
PCBP3 poly(rC) binding protein 3 -0.0485838
CXCL8 chemokine (C-X-C motif) ligand 8 -0.048383
TNPO1 transportin 1 -0.0467381
MYOF myoferlin -0.045838
CANX calnexin -0.0454763
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0452006
DOCK4 dedicator of cytokinesis 4 -0.043234
SMYD3 SET and MYND domain containing 3 -0.0430554
COL5A2 collagen, type V, alpha 2 -0.0429676
COL4A5 collagen, type IV, alpha 5 -0.0415615
SAMD4A sterile alpha motif domain containing 4A -0.0396322
DST dystonin -0.0392609
NCOA7 nuclear receptor coactivator 7 -0.0392491
MAML3 mastermind-like 3 (Drosophila) -0.0376666
ELL2 elongation factor, RNA polymerase II, 2 -0.0359457
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0355945
TM4SF1 transmembrane 4 L six family member 1 -0.0353305
PDLIM5 PDZ and LIM domain 5 -0.0350789
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0342237
IGF1R insulin-like growth factor 1 receptor -0.0324465
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0322069
CDH13 cadherin 13 -0.0321076
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0319495
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0313798
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0305479
NALF1 NALCN channel auxiliary factor 1 -0.0301155
AHNAK AHNAK nucleoprotein -0.0298596
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0298563
NPAS2 neuronal PAS domain protein 2 -0.0298126
RTN4 reticulon 4 -0.0288626
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0284655
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0282618
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0281281
BZW1 basic leucine zipper and W2 domains 1 -0.0280594
FNDC3B fibronectin type III domain containing 3B -0.0279594
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0278401
NT5C2 5'-nucleotidase, cytosolic II -0.0275448
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0272383
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0268841
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0263657
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0263364
AOPEP aminopeptidase O (putative) -0.0258431
RPH3AL rabphilin 3A-like (without C2 domains) -0.0252001
RPS24 ribosomal protein S24 -0.0249074
PALLD palladin, cytoskeletal associated protein -0.0247797
PGK1 phosphoglycerate kinase 1 -0.0247533
ENAH enabled homolog (Drosophila) -0.0246172
CTSC cathepsin C -0.0243126
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0242591
PRKN parkin RBR E3 ubiquitin protein ligase -0.0241302
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0240045
NF1 neurofibromin 1 -0.023676
LAMA1 laminin, alpha 1 -0.0235502
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0233427
SH3KBP1 SH3-domain kinase binding protein 1 -0.0232793
AGFG1 ArfGAP with FG repeats 1 -0.0232538
ANXA2 annexin A2 -0.0232082
IARS1 isoleucyl-tRNA synthetase 1 -0.0230864
ANKRD17 ankyrin repeat domain 17 -0.0229948
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0228646
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.02278
BCAR3 breast cancer anti-estrogen resistance 3 -0.022765
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0226182
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0223162
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0221043
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0219351
ADGRD1 adhesion G protein-coupled receptor D1 -0.021723
PUM2 pumilio RNA-binding family member 2 -0.0215485
PBX1 pre-B-cell leukemia homeobox 1 -0.0215044
TUSC3 tumor suppressor candidate 3 -0.0214099
ALPK2 alpha-kinase 2 -0.0208472
TGFBI transforming growth factor, beta-induced, 68kDa -0.0208106
ANKRD28 ankyrin repeat domain 28 -0.0207722
OSMR oncostatin M receptor -0.020638
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0206357