Dorzolamide (hydrochloride)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dorzolamide (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dorzolamide (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.153125
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.102905
RPS3 ribosomal protein S3 0.0943653
BBX bobby sox homolog (Drosophila) 0.0926037
RPL4 ribosomal protein L4 0.0919029
RPLP1 ribosomal protein, large, P1 0.0869072
RPL37A ribosomal protein L37a 0.0854424
RPS6 ribosomal protein S6 0.0853804
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0803844
NALF1 NALCN channel auxiliary factor 1 0.0771864
TMSB10 thymosin beta 10 0.0729798
RPS12 ribosomal protein S12 0.0694744
RPS27 ribosomal protein S27 0.069309
RPS19 ribosomal protein S19 0.0677203
RPL30 ribosomal protein L30 0.066448
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0651194
RPL23 ribosomal protein L23 0.0649436
TRA2A transformer 2 alpha homolog (Drosophila) 0.0635737
RPS17 ribosomal protein S17 0.0625403
RPL5 ribosomal protein L5 0.0620648
KTN1 kinectin 1 (kinesin receptor) 0.060719
RPS2 ribosomal protein S2 0.0581517
AKAP9 A kinase (PRKA) anchor protein 9 0.056835
PDE4D phosphodiesterase 4D, cAMP-specific 0.056516
NAP1L1 nucleosome assembly protein 1-like 1 0.0560631
RPL31 ribosomal protein L31 0.0559537
KMT2C lysine (K)-specific methyltransferase 2C 0.0557341
RPL37 ribosomal protein L37 0.0551526
RPL19 ribosomal protein L19 0.0534821
GPHN gephyrin 0.0528228
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0525417
RORA RAR-related orphan receptor A 0.0520579
RPS27A ribosomal protein S27a 0.0518634
FTL ferritin, light polypeptide 0.0516345
RPS8 ribosomal protein S8 0.0504506
RSRC2 arginine/serine-rich coiled-coil 2 0.0502102
RPL12 ribosomal protein L12 0.0501712
SRRM2 serine/arginine repetitive matrix 2 0.0490917
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0477842
LDHA lactate dehydrogenase A 0.0477445
SCAF11 SR-related CTD-associated factor 11 0.047527
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0473644
RPLP2 ribosomal protein, large, P2 0.0469957
WSB1 WD repeat and SOCS box containing 1 0.0455677
LOC112694756 uncharaterized LOC112694756 0.0453112
GSK3B glycogen synthase kinase 3 beta 0.0449116
TTC3 tetratricopeptide repeat domain 3 0.0444388
OGA O-GlcNAcase 0.0443511
MT2A metallothionein 2A 0.0442751
SET SET nuclear proto-oncogene 0.0439155
RPS5 ribosomal protein S5 0.043297
PKM pyruvate kinase, muscle 0.0427034
RPS13 ribosomal protein S13 0.0425065
ENO1 enolase 1, (alpha) 0.0422213
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0419059
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0411198
PRRC2C proline-rich coiled-coil 2C 0.0400972
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0389507
RPLP0 ribosomal protein, large, P0 0.0388656
RPL34 ribosomal protein L34 0.0382969
NUP58 nucleoporin 58 0.0382622
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0380843
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0379574
RPL26 ribosomal protein L26 0.0372703
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0358594
GNAS GNAS complex locus 0.035848
ZFP36L1 ZFP36 ring finger protein-like 1 0.0347634
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0347035
MED13L mediator complex subunit 13-like 0.0342937
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0337823
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0330954
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0322419
RPL35A ribosomal protein L35a 0.0313596
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0296146
SPAG9 sperm associated antigen 9 0.0291403
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0289446
DTNA dystrobrevin, alpha 0.0274195
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0269981
RPS25 ribosomal protein S25 0.0266083
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0263514
PNISR PNN-interacting serine/arginine-rich protein 0.0261649
APLP2 amyloid beta (A4) precursor-like protein 2 0.0259552
RPL13A ribosomal protein L13a 0.0257353
FMNL2 formin-like 2 0.0256611
MBNL1 muscleblind-like splicing regulator 1 0.0253557
ZCCHC7 zinc finger, CCHC domain containing 7 0.024773
EZR ezrin 0.0246564
PCBP2 poly(rC) binding protein 2 0.0244571
PRELID2 PRELI domain containing 2 0.024289
EFNA5 ephrin-A5 0.0241575
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.023926
USP9X ubiquitin specific peptidase 9, X-linked 0.0232128
RACK1 receptor for activated C kinase 1 0.0229131
NAMPT nicotinamide phosphoribosyltransferase 0.0225381
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0218576
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.021696
TENM3 teneurin transmembrane protein 3 0.0212301
FTH1 ferritin, heavy polypeptide 1 0.0204089
NCOR1 nuclear receptor corepressor 1 0.0197925
ANKRD12 ankyrin repeat domain 12 0.0195827

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.097146
PRKCA protein kinase C, alpha -0.0811908
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0769829
VCL vinculin -0.0700207
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0664096
ANXA2 annexin A2 -0.065843
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0649213
SBF2 SET binding factor 2 -0.0620847
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0616499
MACF1 microtubule-actin crosslinking factor 1 -0.0585583
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0585456
DLG1 discs, large homolog 1 (Drosophila) -0.058393
EXT1 exostosin glycosyltransferase 1 -0.0569949
FOXN3 forkhead box N3 -0.0532316
EREG epiregulin -0.052981
PDIA6 protein disulfide isomerase family A, member 6 -0.0510001
LPP LIM domain containing preferred translocation partner in lipoma -0.0506692
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0495655
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0483832
STC1 stanniocalcin 1 -0.0472698
HDLBP high density lipoprotein binding protein -0.0472364
IQGAP1 IQ motif containing GTPase activating protein 1 -0.046842
TNRC6A trinucleotide repeat containing 6A -0.0467332
MED13 mediator complex subunit 13 -0.0465501
TPT1 tumor protein, translationally-controlled 1 -0.0457432
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0456253
GPC6 glypican 6 -0.0451055
WNK1 WNK lysine deficient protein kinase 1 -0.0444108
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0432038
PHF3 PHD finger protein 3 -0.0431594
ACTN4 actinin, alpha 4 -0.042802
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0427335
NAV1 neuron navigator 1 -0.0423673
SP100 SP100 nuclear antigen -0.0417818
FRYL FRY-like -0.0413018
CDC73 cell division cycle 73 -0.0412105
TXNIP thioredoxin interacting protein -0.0411134
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0410036
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0407316
FRMD5 FERM domain containing 5 -0.0402705
TRPS1 trichorhinophalangeal syndrome I -0.0395327
ANKRD11 ankyrin repeat domain 11 -0.0395223
FAT1 FAT atypical cadherin 1 -0.0390861
CALR calreticulin -0.0384727
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0383943
TLK1 tousled-like kinase 1 -0.0382791
AREG amphiregulin -0.0382698
ZNF148 zinc finger protein 148 -0.0379653
MPHOSPH8 M-phase phosphoprotein 8 -0.0376953
LMNA lamin A/C -0.037671
KDM2A lysine (K)-specific demethylase 2A -0.0374711
PRRC1 proline-rich coiled-coil 1 -0.0374497
SLC38A1 solute carrier family 38, member 1 -0.0367981
BTBD9 BTB (POZ) domain containing 9 -0.036217
CALU calumenin -0.0360027
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.03595
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0358695
ZBTB20 zinc finger and BTB domain containing 20 -0.0356652
PTK2 protein tyrosine kinase 2 -0.0352567
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0352419
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0350708
FLNB filamin B, beta -0.034463
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0342199
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0339728
GOLGB1 golgin B1 -0.0330825
SEC23A Sec23 homolog A (S. cerevisiae) -0.0328288
PATJ PATJ crumbs cell polarity complex component -0.0324726
SLMAP sarcolemma associated protein -0.0318401
MON2 MON2 homolog (S. cerevisiae) -0.0314163
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0313657
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0311223
PLSCR1 phospholipid scramblase 1 -0.0301628
EHBP1 EH domain binding protein 1 -0.0299147
RAB2A RAB2A, member RAS oncogene family -0.0296764
ETNK1 ethanolamine kinase 1 -0.0286309
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0285037
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0284815
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0283441
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0280494
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0271587
CD2AP CD2-associated protein -0.026798
ZFAND3 zinc finger, AN1-type domain 3 -0.0263149
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0262856
NCOA1 nuclear receptor coactivator 1 -0.0261209
SGMS1 sphingomyelin synthase 1 -0.0260803
CFAP96 cilia and flagella associated protein 96 -0.0259555
CEMIP cell migration inducing protein, hyaluronan binding -0.02566
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.0254363
MCL1 myeloid cell leukemia 1 -0.0254157
DIAPH2 diaphanous-related formin 2 -0.0251837
MORF4L2 mortality factor 4 like 2 -0.0251141
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0245451
LMO7 LIM domain 7 -0.0245252
FOXJ3 forkhead box J3 -0.024515
CDC42 cell division cycle 42 -0.0245113
MBNL2 muscleblind-like splicing regulator 2 -0.0242504
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0238838
GAPVD1 GTPase activating protein and VPS9 domains 1 -0.0235102
COL5A1 collagen, type V, alpha 1 -0.0234953
AHNAK AHNAK nucleoprotein -0.0234276