| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dorzolamide (hydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL4 | ribosomal protein L4 | 0.0363819 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0325237 |
| MKI67 | marker of proliferation Ki-67 | 0.0297454 |
| RPS2 | ribosomal protein S2 | 0.0220032 |
| CENPF | centromere protein F, 350/400kDa | 0.0219345 |
| HMGB2 | high mobility group box 2 | 0.0211213 |
| USP3 | ubiquitin specific peptidase 3 | 0.0210956 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0200516 |
| H1-4 | H1.4 linker histone, cluster member | 0.0193361 |
| RBM39 | RNA binding motif protein 39 | 0.0188735 |
| SPAG9 | sperm associated antigen 9 | 0.0180128 |
| CCNA2 | cyclin A2 | 0.0175589 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0172874 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0169345 |
| CBX3 | chromobox homolog 3 | 0.0167338 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0167222 |
| RBM25 | RNA binding motif protein 25 | 0.0161951 |
| ANLN | anillin, actin binding protein | 0.0152658 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.0151055 |
| CRY1 | cryptochrome circadian clock 1 | 0.0150914 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0150244 |
| CDC73 | cell division cycle 73 | 0.0147684 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0146706 |
| EZR | ezrin | 0.0145313 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0142761 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0141065 |
| IWS1 | IWS1 homolog (S. cerevisiae) | 0.0139979 |
| TMSB4X | thymosin beta 4, X-linked | 0.0139274 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0138931 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0136026 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0133811 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0132983 |
| RPS18 | ribosomal protein S18 | 0.0128312 |
| SUCO | SUN domain containing ossification factor | 0.0125511 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0125499 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0125176 |
| NPR2 | natriuretic peptide receptor 2 | 0.0125084 |
| ANXA5 | annexin A5 | 0.0122777 |
| TPM3 | tropomyosin 3 | 0.0120241 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0118497 |
| CENPE | centromere protein E, 312kDa | 0.0118407 |
| RHEB | Ras homolog enriched in brain | 0.0118222 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0118039 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0117924 |
| FNBP4 | formin binding protein 4 | 0.0117213 |
| SSR1 | signal sequence receptor, alpha | 0.0116129 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0115834 |
| KIF20A | kinesin family member 20A | 0.0115689 |
| C1ORF52 | chromosome 1 open reading frame 52 | 0.0114655 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0113949 |
| BRIX1 | BRX1, biogenesis of ribosomes | 0.0113693 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0113613 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0113242 |
| MEF2A | myocyte enhancer factor 2A | 0.0113092 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0112927 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0112748 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0111643 |
| NOP58 | NOP58 ribonucleoprotein | 0.0111108 |
| HSF2 | heat shock transcription factor 2 | 0.0111051 |
| KIF5B | kinesin family member 5B | 0.0110375 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0108561 |
| MTF2 | metal response element binding transcription factor 2 | 0.0107793 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0107631 |
| MTMR3 | myotubularin related protein 3 | 0.0107565 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0106173 |
| UCHL5 | ubiquitin carboxyl-terminal hydrolase L5 | 0.0104772 |
| CSNK1G3 | casein kinase 1, gamma 3 | 0.0104656 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0104412 |
| TBC1D12 | TBC1 domain family, member 12 | 0.0103618 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0103442 |
| OTUD6B | OTU domain containing 6B | 0.0102777 |
| CCNL1 | cyclin L1 | 0.0102746 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.010125 |
| WRN | Werner syndrome, RecQ helicase-like | 0.0100322 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0100205 |
| CNN3 | calponin 3, acidic | 0.00999665 |
| ABI1 | abl-interactor 1 | 0.00999517 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.00996757 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.00995808 |
| SPAG5 | sperm associated antigen 5 | 0.00984374 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.00983857 |
| CEP55 | centrosomal protein 55kDa | 0.00983834 |
| RACGAP1 | Rac GTPase activating protein 1 | 0.00980163 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 0.00976369 |
| CKAP2 | cytoskeleton associated protein 2 | 0.00972648 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.00972629 |
| NDC80 | NDC80 kinetochore complex component | 0.00969791 |
| OGA | O-GlcNAcase | 0.00960633 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.00952313 |
| FUS | FUS RNA binding protein | 0.00946994 |
| PLEKHG2 | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | 0.00941707 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.00940758 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.00931591 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.00928168 |
| PNN | pinin, desmosome associated protein | 0.00924866 |
| ATL2 | atlastin GTPase 2 | 0.00921742 |
| PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 0.00920309 |
| UBE2S | ubiquitin-conjugating enzyme E2S | 0.00917965 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.00913807 |
| RPL13A | ribosomal protein L13a | 0.00909686 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | -0.279136 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.274758 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.177602 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.1713 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.165135 |
| CADM2 | cell adhesion molecule 2 | -0.151239 |
| COL5A2 | collagen, type V, alpha 2 | -0.137035 |
| TENM3 | teneurin transmembrane protein 3 | -0.123684 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.123401 |
| VIM | vimentin | -0.113742 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.112799 |
| ITGAV | integrin, alpha V | -0.0987212 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0890134 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0874046 |
| FNDC3B | fibronectin type III domain containing 3B | -0.08323 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0760033 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0758091 |
| LRRC4C | leucine rich repeat containing 4C | -0.0754326 |
| PCDH9 | protocadherin 9 | -0.0735702 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0734316 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.071196 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0692075 |
| GPC3 | glypican 3 | -0.0685994 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0673584 |
| PHIP | pleckstrin homology domain interacting protein | -0.0669058 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0656565 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0651971 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0648232 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.064503 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0640884 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0635125 |
| CDH19 | cadherin 19, type 2 | -0.0619198 |
| SYT1 | synaptotagmin I | -0.0611057 |
| ANK2 | ankyrin 2, neuronal | -0.058832 |
| NTM | neurotrimin | -0.0587085 |
| DST | dystonin | -0.057689 |
| TMSB10 | thymosin beta 10 | -0.055482 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0552049 |
| HDAC9 | histone deacetylase 9 | -0.0539173 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.053833 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0537655 |
| PGK1 | phosphoglycerate kinase 1 | -0.0532572 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0528556 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0527372 |
| PCDH7 | protocadherin 7 | -0.0522687 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.052001 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0492168 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0490597 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0488665 |
| ACTG1 | actin gamma 1 | -0.048323 |
| MEIS2 | Meis homeobox 2 | -0.0468192 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.0458613 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0458508 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0451478 |
| NHSL1 | NHS-like 1 | -0.04507 |
| ENO1 | enolase 1, (alpha) | -0.0435745 |
| NEBL | nebulette | -0.0433844 |
| NRG1 | neuregulin 1 | -0.0429185 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0425288 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0416938 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0416483 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0415142 |
| LDHA | lactate dehydrogenase A | -0.0407665 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0406492 |
| HMCN1 | hemicentin 1 | -0.0404951 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0403593 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0399647 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0389967 |
| RPS16 | ribosomal protein S16 | -0.0384341 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0382602 |
| PLPP1 | phospholipid phosphatase 1 | -0.0381596 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0379252 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0378219 |
| AHNAK | AHNAK nucleoprotein | -0.0376099 |
| COL3A1 | collagen, type III, alpha 1 | -0.0374672 |
| COL1A2 | collagen, type I, alpha 2 | -0.0371016 |
| FOXP2 | forkhead box P2 | -0.0366693 |
| TENM2 | teneurin transmembrane protein 2 | -0.0365721 |
| CCN2 | cellular communication network factor 2 | -0.0362671 |
| PEG10 | paternally expressed 10 | -0.0357318 |
| UTRN | utrophin | -0.0352876 |
| JMJD1C | jumonji domain containing 1C | -0.0349767 |
| GNAS | GNAS complex locus | -0.0338087 |
| GLI3 | GLI family zinc finger 3 | -0.033762 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0333346 |
| DENND5B | DENN/MADD domain containing 5B | -0.0333014 |
| SNX6 | sorting nexin 6 | -0.0332953 |
| NCOA2 | nuclear receptor coactivator 2 | -0.031836 |
| PRTG | protogenin | -0.0317833 |
| RPS8 | ribosomal protein S8 | -0.0312025 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0309335 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0307668 |
| RAD51B | RAD51 paralog B | -0.0302666 |
| TBL1X | transducin (beta)-like 1X-linked | -0.0302579 |
| USP34 | ubiquitin specific peptidase 34 | -0.0300099 |
| SHROOM3 | shroom family member 3 | -0.0292429 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0292164 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0292106 |
| RBM20 | RNA binding motif protein 20 | -0.0290044 |
| FAM171B | family with sequence similarity 171, member B | -0.0289055 |
