| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dorzolamide (hydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.177745 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.137637 |
| RPS16 | ribosomal protein S16 | 0.107461 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0964182 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0756911 |
| RTN4 | reticulon 4 | 0.0723931 |
| FBL | fibrillarin | 0.0557608 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0538255 |
| TMEM41B | transmembrane protein 41B | 0.048526 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0470822 |
| TXNRD1 | thioredoxin reductase 1 | 0.0461097 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0460664 |
| FOSL1 | FOS-like antigen 1 | 0.0421251 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | 0.0379159 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0373341 |
| ANXA2 | annexin A2 | 0.0373217 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0360061 |
| S100A6 | S100 calcium binding protein A6 | 0.0348069 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0347435 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0343213 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0335869 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0326925 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0293665 |
| RPLP0 | ribosomal protein, large, P0 | 0.0290939 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0289752 |
| ZFP36 | ZFP36 ring finger protein | 0.0285017 |
| CD44 | CD44 molecule (Indian blood group) | 0.0273096 |
| ARRDC3 | arrestin domain containing 3 | 0.0271564 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0269581 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0260725 |
| ANGPTL4 | angiopoietin-like 4 | 0.0257269 |
| PTMA | prothymosin, alpha | 0.0247191 |
| YBX1 | Y box binding protein 1 | 0.0245083 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0244427 |
| FTL | ferritin, light polypeptide | 0.0243354 |
| TMEM123 | transmembrane protein 123 | 0.0235969 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0231232 |
| RPL4 | ribosomal protein L4 | 0.0229051 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0226032 |
| MATR3 | matrin 3 | 0.0225434 |
| ZNF292 | zinc finger protein 292 | 0.0225368 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0220144 |
| CDK19 | cyclin-dependent kinase 19 | 0.0210979 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0210613 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0207828 |
| RPS2 | ribosomal protein S2 | 0.0205558 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0205537 |
| ENO1 | enolase 1, (alpha) | 0.0199706 |
| SNX9 | sorting nexin 9 | 0.0197111 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0196095 |
| DSTN | destrin (actin depolymerizing factor) | 0.0194812 |
| NUP58 | nucleoporin 58 | 0.0193235 |
| AXL | AXL receptor tyrosine kinase | 0.0193216 |
| KLF6 | Kruppel-like factor 6 | 0.0192849 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.018823 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0188067 |
| WDR45B | WD repeat domain 45B | 0.0186299 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0185083 |
| GOLGA4 | golgin A4 | 0.0183383 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0183208 |
| CDCP1 | CUB domain containing protein 1 | 0.018248 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0182314 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0180986 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0179097 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0179076 |
| B2M | beta-2-microglobulin | 0.0175508 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0174156 |
| ACTN4 | actinin, alpha 4 | 0.0173381 |
| JMJD1C | jumonji domain containing 1C | 0.0173304 |
| USP3 | ubiquitin specific peptidase 3 | 0.0171104 |
| SNX14 | sorting nexin 14 | 0.0170964 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0168823 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0168619 |
| RPL12 | ribosomal protein L12 | 0.0167295 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0166133 |
| MKI67 | marker of proliferation Ki-67 | 0.0163695 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0160914 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0159283 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0158919 |
| SESN2 | sestrin 2 | 0.0158662 |
| UBC | ubiquitin C | 0.0156347 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0153093 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0152801 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0152713 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0151174 |
| TMEM87A | transmembrane protein 87A | 0.0151066 |
| MAP1B | microtubule-associated protein 1B | 0.0150603 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.015002 |
| RPS5 | ribosomal protein S5 | 0.0148912 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0148686 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0146911 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.014691 |
| XPO1 | exportin 1 | 0.0146596 |
| MT2A | metallothionein 2A | 0.0146378 |
| FHL2 | four and a half LIM domains 2 | 0.0145801 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0144235 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.014342 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0143151 |
| NOP58 | NOP58 ribonucleoprotein | 0.014288 |
| TNRC6A | trinucleotide repeat containing 6A | 0.014249 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.239424 |
| VCL | vinculin | -0.16415 |
| AHNAK | AHNAK nucleoprotein | -0.153037 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.14275 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.110452 |
| DST | dystonin | -0.1073 |
| FNDC3B | fibronectin type III domain containing 3B | -0.086012 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0845789 |
| INTS6 | integrator complex subunit 6 | -0.0814373 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0795146 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.075791 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0695821 |
| PTK2 | protein tyrosine kinase 2 | -0.0668552 |
| HMGA2 | high mobility group AT-hook 2 | -0.0645575 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0635192 |
| TNS3 | tensin 3 | -0.0615512 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0589903 |
| ATG7 | autophagy related 7 | -0.0544327 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0538742 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0535928 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0516283 |
| NUP98 | nucleoporin 98kDa | -0.0510064 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0506409 |
| EGFR | epidermal growth factor receptor | -0.0504722 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0496266 |
| CTBP2 | C-terminal binding protein 2 | -0.0489298 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0480258 |
| DIAPH2 | diaphanous-related formin 2 | -0.0477736 |
| MYOF | myoferlin | -0.0463186 |
| EXOC4 | exocyst complex component 4 | -0.0461049 |
| RAD51B | RAD51 paralog B | -0.045455 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0452666 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0446517 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.044132 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0428267 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0423221 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0421331 |
| CARD18 | caspase recruitment domain family, member 18 | -0.0415799 |
| NAV2 | neuron navigator 2 | -0.0412566 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0405086 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0398369 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0397409 |
| SEPTIN9 | septin 9 | -0.0387954 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0383739 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0382939 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0382224 |
| CMIP | c-Maf inducing protein | -0.0377048 |
| MYO1E | myosin IE | -0.0371344 |
| EHBP1 | EH domain binding protein 1 | -0.0368611 |
| ZNF407 | zinc finger protein 407 | -0.0367281 |
| ZNF780B | zinc finger protein 780B | -0.0365311 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0363901 |
| RNF220 | ring finger protein 220 | -0.0363753 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0361457 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0354953 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0352778 |
| ATXN1 | ataxin 1 | -0.0347872 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -0.0345988 |
| RASAL2 | RAS protein activator like 2 | -0.0345487 |
| NEK10 | NIMA-related kinase 10 | -0.0344957 |
| PRELID2 | PRELI domain containing 2 | -0.0343688 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0339352 |
| ASPH | aspartate beta-hydroxylase | -0.0330499 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0326798 |
| NF1 | neurofibromin 1 | -0.0326245 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0322847 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0321578 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0321014 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0317477 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0316887 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0316224 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.031469 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0314375 |
| EFNA5 | ephrin-A5 | -0.0314242 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0309318 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0305479 |
| KRT8 | keratin 8, type II | -0.0301764 |
| ST3GAL3 | ST3 beta-galactoside alpha-2,3-sialyltransferase 3 | -0.0301138 |
| ATM | ATM serine/threonine kinase | -0.0300904 |
| NHSL1 | NHS-like 1 | -0.029874 |
| CUX1 | cut-like homeobox 1 | -0.0286537 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.028375 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0283339 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0282889 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.028207 |
| PRKCA | protein kinase C, alpha | -0.0280846 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0278707 |
| UBAP2 | ubiquitin associated protein 2 | -0.0278397 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0278294 |
| CDK13 | cyclin-dependent kinase 13 | -0.0277685 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0276444 |
| MYO10 | myosin X | -0.0272858 |
| MCL1 | myeloid cell leukemia 1 | -0.027095 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.026699 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0266764 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0266251 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0265631 |
| GLIS3 | GLIS family zinc finger 3 | -0.0264359 |
| SBF2 | SET binding factor 2 | -0.0263675 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0258564 |
