| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dorzolamide (hydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL4 | ribosomal protein L4 | 0.146122 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.11179 |
| SET | SET nuclear proto-oncogene | 0.0805197 |
| OGA | O-GlcNAcase | 0.0547626 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0507593 |
| RPS12 | ribosomal protein S12 | 0.0453211 |
| RPL26 | ribosomal protein L26 | 0.0437096 |
| RRBP1 | ribosome binding protein 1 | 0.0432893 |
| RPS2 | ribosomal protein S2 | 0.0412507 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0410834 |
| RPS3 | ribosomal protein S3 | 0.0386221 |
| HMGB2 | high mobility group box 2 | 0.0356117 |
| RBM39 | RNA binding motif protein 39 | 0.0352178 |
| RPS18 | ribosomal protein S18 | 0.0349503 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0344177 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0342486 |
| RPL14 | ribosomal protein L14 | 0.0307753 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0293073 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0279254 |
| CAPRIN2 | caprin family member 2 | 0.0275377 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0272631 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0271477 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0271166 |
| PRELID2 | PRELI domain containing 2 | 0.026823 |
| RPL13A | ribosomal protein L13a | 0.0264846 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0264337 |
| HLA-A | major histocompatibility complex, class I, A | 0.0258733 |
| PNN | pinin, desmosome associated protein | 0.025778 |
| STK4 | serine/threonine kinase 4 | 0.0257197 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0254901 |
| RBM25 | RNA binding motif protein 25 | 0.0242812 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0242146 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0238054 |
| RPL37A | ribosomal protein L37a | 0.0223284 |
| TPM3 | tropomyosin 3 | 0.0220004 |
| NAA35 | N(alpha)-acetyltransferase 35, NatC auxiliary subunit | 0.0219015 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.021665 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0214167 |
| MKI67 | marker of proliferation Ki-67 | 0.0213544 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0208751 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0202563 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0201048 |
| PTMA | prothymosin, alpha | 0.0199364 |
| KIAA1958 | KIAA1958 | 0.0197195 |
| WAPL | WAPL cohesin release factor | 0.0194817 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0194131 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0193826 |
| TMF1 | TATA element modulatory factor 1 | 0.0189096 |
| TPX2 | TPX2, microtubule-associated | 0.0186875 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0185236 |
| RPS15A | ribosomal protein S15a | 0.0184323 |
| TLN1 | talin 1 | 0.018424 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0182468 |
| HGS | hepatocyte growth factor-regulated tyrosine kinase substrate | 0.0181749 |
| CEP95 | centrosomal protein 95kDa | 0.0180248 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0180237 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0177999 |
| RPL35 | ribosomal protein L35 | 0.017777 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0175856 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0175789 |
| THOC2 | THO complex 2 | 0.0175518 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0173033 |
| SGO2 | shugoshin 2 | 0.0171754 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0170536 |
| KIF18B | kinesin family member 18B | 0.0169251 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0168181 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0167893 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0167147 |
| CDC37 | cell division cycle 37 | 0.0166369 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.016583 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.016563 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0163295 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.016278 |
| RPL5 | ribosomal protein L5 | 0.0162723 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0161525 |
| THOC1 | THO complex 1 | 0.0160377 |
| ELOC | elongin C | 0.0159695 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0159613 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0158816 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.015677 |
| SCAPER | S-phase cyclin A-associated protein in the ER | 0.0156435 |
| ZNF146 | zinc finger protein 146 | 0.0156241 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0156113 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0151668 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0148771 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0148521 |
| DSPP | dentin sialophosphoprotein | 0.0147012 |
| GOLGA2 | golgin A2 | 0.014575 |
| SBF2 | SET binding factor 2 | 0.0145175 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0144468 |
| FNBP4 | formin binding protein 4 | 0.0144193 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0142978 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0142505 |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | 0.0142461 |
| RPL9 | ribosomal protein L9 | 0.0141917 |
| RPL41 | ribosomal protein L41 | 0.0141512 |
| SERINC1 | serine incorporator 1 | 0.0140846 |
| ZNF544 | zinc finger protein 544 | 0.0140803 |
| RPL12 | ribosomal protein L12 | 0.0139853 |
| IWS1 | IWS1 homolog (S. cerevisiae) | 0.0139768 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.216202 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.147886 |
| POTEF | POTE ankyrin domain family, member F | -0.124495 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.114207 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.106967 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0861113 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0841745 |
| HMGA1 | high mobility group AT-hook 1 | -0.0835747 |
| FRMD6 | FERM domain containing 6 | -0.0764351 |
| ACTG1 | actin gamma 1 | -0.0662936 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.065994 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.065748 |
| RPL8 | ribosomal protein L8 | -0.0654669 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0652964 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0648384 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.063734 |
| PARD3 | par-3 family cell polarity regulator | -0.0632048 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0609568 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0599078 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0597396 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0589132 |
| RPLP0 | ribosomal protein, large, P0 | -0.0574896 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0574492 |
| NAV3 | neuron navigator 3 | -0.0565634 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0560814 |
| RTN4 | reticulon 4 | -0.0544137 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0539238 |
| ATP13A3 | ATPase type 13A3 | -0.0532904 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0524148 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0521269 |
| USP3 | ubiquitin specific peptidase 3 | -0.0521034 |
| ZNF438 | zinc finger protein 438 | -0.0512998 |
| PTK2 | protein tyrosine kinase 2 | -0.0509099 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0497095 |
| AHNAK | AHNAK nucleoprotein | -0.0495992 |
| SRPK2 | SRSF protein kinase 2 | -0.0495181 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.049244 |
| PKM | pyruvate kinase, muscle | -0.0491888 |
| CORO1C | coronin, actin binding protein, 1C | -0.0480292 |
| LDHA | lactate dehydrogenase A | -0.0469655 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0459447 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0454884 |
| FLNB | filamin B, beta | -0.0453667 |
| STC1 | stanniocalcin 1 | -0.0447107 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.04428 |
| FBXO11 | F-box protein 11 | -0.0442454 |
| FTL | ferritin, light polypeptide | -0.0441202 |
| NDRG1 | N-myc downstream regulated 1 | -0.0433931 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.043359 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0430969 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.042504 |
| RPL7A | ribosomal protein L7a | -0.0420875 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0413364 |
| NUP58 | nucleoporin 58 | -0.0413218 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0411018 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0410308 |
| SGMS2 | sphingomyelin synthase 2 | -0.0408878 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0403334 |
| TMSB10 | thymosin beta 10 | -0.0399154 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0397053 |
| JMJD1C | jumonji domain containing 1C | -0.0391903 |
| ERBIN | erbb2 interacting protein | -0.039154 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0391066 |
| BRD4 | bromodomain containing 4 | -0.0390436 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0388348 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0382167 |
| RYBP | RING1 and YY1 binding protein | -0.0374933 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0373309 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0365398 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0361362 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.0354735 |
| RPS23 | ribosomal protein S23 | -0.0351491 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0350801 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0349203 |
| NABP1 | nucleic acid binding protein 1 | -0.0345956 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0344571 |
| BNC2 | basonuclin 2 | -0.0344439 |
| MT2A | metallothionein 2A | -0.0344269 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0343395 |
| RPL19 | ribosomal protein L19 | -0.0341277 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0340974 |
| CCNL1 | cyclin L1 | -0.0336973 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0334182 |
| PGK1 | phosphoglycerate kinase 1 | -0.0333316 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0330506 |
| SETD5 | SET domain containing 5 | -0.0329872 |
| RASA2 | RAS p21 protein activator 2 | -0.0328735 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0328364 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.032757 |
| EGR1 | early growth response 1 | -0.0325545 |
| GLG1 | golgi glycoprotein 1 | -0.0323241 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0321734 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0321007 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0319072 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.0318529 |
| RHEB | Ras homolog enriched in brain | -0.031503 |
| RLF | rearranged L-myc fusion | -0.0308622 |
| ANXA2 | annexin A2 | -0.0307218 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0307205 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0306887 |
